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MAO inhibitors
To the Editor: I wish to point out an error in the excellent review of MAO inhibitors published in the December 2010 issue of the Cleveland Clinic Journal of Medicine. The authors state, “The only selective MAO inhibitor now available in the United States is selegiline, which inhibits MAO-B at low doses but loses its selectivity at dosages greater than 20 mg/day” (on page 861). In fact, a second selective MAO inhibitor has been available in the United States for several years. Rasagiline, developed by Teva Pharmaceuticals and marketed under the brand name Azilect, is a highly selective MAO-B inhibitor indicated for treating the symptoms of Parkinson disease, either as monotherapy or as adjunct therapy to carbidopa-levodopa. However, rasagiline is not indicated for the treatment of depression. Perhaps the authors meant to say that selegiline is the only selective MAO-B inhibitor indicated for treating depression in the United States.
To the Editor: I wish to point out an error in the excellent review of MAO inhibitors published in the December 2010 issue of the Cleveland Clinic Journal of Medicine. The authors state, “The only selective MAO inhibitor now available in the United States is selegiline, which inhibits MAO-B at low doses but loses its selectivity at dosages greater than 20 mg/day” (on page 861). In fact, a second selective MAO inhibitor has been available in the United States for several years. Rasagiline, developed by Teva Pharmaceuticals and marketed under the brand name Azilect, is a highly selective MAO-B inhibitor indicated for treating the symptoms of Parkinson disease, either as monotherapy or as adjunct therapy to carbidopa-levodopa. However, rasagiline is not indicated for the treatment of depression. Perhaps the authors meant to say that selegiline is the only selective MAO-B inhibitor indicated for treating depression in the United States.
To the Editor: I wish to point out an error in the excellent review of MAO inhibitors published in the December 2010 issue of the Cleveland Clinic Journal of Medicine. The authors state, “The only selective MAO inhibitor now available in the United States is selegiline, which inhibits MAO-B at low doses but loses its selectivity at dosages greater than 20 mg/day” (on page 861). In fact, a second selective MAO inhibitor has been available in the United States for several years. Rasagiline, developed by Teva Pharmaceuticals and marketed under the brand name Azilect, is a highly selective MAO-B inhibitor indicated for treating the symptoms of Parkinson disease, either as monotherapy or as adjunct therapy to carbidopa-levodopa. However, rasagiline is not indicated for the treatment of depression. Perhaps the authors meant to say that selegiline is the only selective MAO-B inhibitor indicated for treating depression in the United States.