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Anecdotal Failures in the Diagnosis of Serotonin Syndrome
Clinical Question: What is the validity of commonly held beliefs regarding serotonin syndrome (SS)? Background: SS is a potentially life-...
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Restrictive Blood Transfusion Strategies May Increase the Risk of Mortality, Morbidity for Elderly Patients Undergoing Orthopedic Surgery
Are there particular groups of patients in which lower transfusion thresholds (transfusion only at lower hemoglobin levels) may be harmful?
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Loss of Independence after Surgery and Subsequent Outcomes in Older Patients
What is the incidence of loss of independence (LOI) for older adults after surgery, and is there an association between LOI and readmission or...
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Euthanasia and Physician-Assisted Suicide Remain Rare and Primarily Involve Cancer Patients
What data are available regarding the attitudes toward and the practice of euthanasia and physician-assisted suicide (PAS)?
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Goals of Care Infrequently Discussed among Hospitalized Long-Term Care Residents
How often are goals of care (GOC) discussed during hospitalization of long-term care residents, and what patient characteristics make this more...
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Hand Hygiene Improves Patient Safety
Does improving hand hygiene compliance from a high level to a very high level reduce healthcare-associated infections?
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Traditional Hand Hygiene Audits Can Lead to Inaccurate Conclusions about Physician Performance
Does direct observation underestimate physician compliance with hand hygiene (HH) compared to other professional groups due to the Hawthorne...
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Long-Term Mortality in Nondiabetic Patients Favors Coronary Artery Bypass Over Intervention with Drug-Eluting Stents
Is there a mortality difference in nondiabetic patients with multivessel coronary artery disease (CAD) treated with coronary artery bypass graft (...
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Prolonged Ceftaroline Exposure Associated with High Incidence of Neutropenia
What is the incidence of neutropenia in patients treated with prolonged courses of ceftaroline?
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How Should a Hospitalized Patient with Newly Diagnosed Cirrhosis Be Evaluated and Managed?
The Case A 50-year-old man with no known medical history presents with two months of increasing abdominal distension. Exam is notable for scleral...
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Disinfection Caps Reduce CLABSI, BCC in Hematology-Oncology Patients
Clinical question: Does the use of disinfection caps on catheter hubs on central venous catheters (CVCs) reduce central-line-associated...
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Isopropyl Alcohol Nasal Inhalation Effective Treatment for ED Nausea
Clinical question: Does inhaled isopropyl alcohol alleviate nausea as compared to inhaled saline solution among patients presenting to the ED with...
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Chronic Kidney Disease Risk with Proton Pump Inhibitors
Clinical question: What is the association between proton pump inhibitor (PPI) use and incident chronic kidney disease (CKD)? Background:...
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Risk Factors for Pseudomonas, MRSA in Healthcare-Associated Pneumonia
Clinical question: What risk factors could predict the likelihood of Pseudomonas and methicillin-resistant Staphylococcus aureus (MRSA) in...
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Updated CHEST Guidelines for Antithrombotic Therapy of VTE
Clinical question: What are the current recommendations for antithrombotic therapy in various venous thromboembolism (VTE) scenarios? Background...