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Patient-based mouse MVID model hints at mechanism
A method using gene editing at the two-cell stage recreated in mice the phenotype of a patient with two separate mutations.
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Defensiveness may drive refusal for colon cancer screening
An Irish study pinpoints excuses for putting off screening and discounting one’s risk of colorectal cancer.
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An earlier hep B biomarker for clinical outcomes?
Levels of a core-related antigen marker plunge years before a drop in the surface antigen, finds a natural history study of patients with chronic...
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MS looks homogeneous
An analysis of clinical factors and treatment responses calls for personal rather than precision medicine.
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Portable MRI has potential for MS
A blinded study showed good agreement with high-field MRI for some applications, but more development is needed.
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A better MS measure?
A ‘digital carpet’ may provide more granular information about functional decline in patients with MS.
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MOGAD: Immunotherapy predicts fewer relapses
IVIG therapy appears to be the most effective for reducing relapses.
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To prevent MS, should we target EBV?
Can a vaccine against EBV reduce MS incidence on a population level? Two experts debate.
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Differential diagnosis in MS: What to watch for
‘Red flags’ suggest something other than MS.
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Use of diagnostic mammograms is inconsistent, survey finds
Many employ diagnostic mammograms for posttreatment surveillance, but benefit is unknown.
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Colorectal cancer treatment outcomes in older adults
Disease-free survival boosted by adjuvant therapy completion, but only about half of patients finish.
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Could boosting fat taste receptors help cut calories?
In mice, fat taste receptor agonists added to food promoted satiation and weight loss.
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Interval FITs could cut colonoscopies in those at above-average risk
Two or more negative tests could suggest less need for colonoscopy at 5 years, especially in those with a family history of colon cancer.
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Marriage rates declining for Canadian adolescent mothers?
However, births to mothers younger than 18 years are rare in Canada, and births to married mothers in that age group are even rarer.
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Double CF combination safe, effective in 1- to 2-year-olds
Ivacaftor/lumacaftor combination could serve as a bridge to triple therapy.