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Oral step-down therapy for infective endocarditis
What is oral step-down therapy’s relative clinical effectiveness, compared with prolonged IV antibiotics for infective endocarditis (IE)?
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Anticoagulant choice in antiphospholipid syndrome–associated thrombosis
Are direct oral anticoagulants (DOACs) as efficacious and safe as vitamin K antagonists (VKAs) in treating thrombosis secondary to...
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Timing of initiation of renal-replacement therapy in acute kidney injury
In critically ill patients, does early renal-replacement therapy (RRT), compared with standard therapy, improve death from any cause at 90 days?...
Article
Radiologically Isolated Syndrome: A condition that often precedes an MS diagnosis in children
Article
Early-Stage NSCLC Highlights From ESMO 2021
Highlights in early NSCLC from ESMO 2021 include data on postoperative radiotherapy, combination regimens in stage III disease, and results with...
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Unplanned Pregnancy: Unmuting the Discussion
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Prophylactic haloperidol does not improve survival in critically ill patients
Does prophylactic use of haloperidol in critically ill patients at high risk of delirium improve survival at 28 days?
Article
Depression Screening and Treatment: A Missed Opportunity in Lung Cancer Care
The integrated VA system is well positioned to be a leader in depression screening and treatment, and VA clinicians who care for patients with...
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Multifaceted pharmacist intervention may reduce postdischarge ED visits and readmissions
Can a multifaceted intervention by a clinical pharmacist reduce the rate of ED visits and readmission over the subsequent 180 days?
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Balanced fluid resuscitation vs. saline does not decrease hospital-free days
Does balanced crystalloid fluid improve outcomes versus saline in noncritically ill patients who are hospitalized?
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Myeloproliferative neoplasms increase risk for arterial and venous thrombosis
What are the risks for arterial and venous thrombosis in patients with myeloproliferative neoplasms (MPNs)?
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Steroids do not reduce mortality in patients with septic shock
Among patients with septic shock undergoing mechanical ventilation, does hydrocortisone reduce 90-day mortality?