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LOS ANGELES — Patients with hereditary pancreatitis face an 87-fold elevated risk of being diagnosed with pancreatic adenocarcinoma, and if they smoke, the risk is even greater, according to a national cohort study of 78 affected families in France.
Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene (PRSS1) that is inherited in an autosomal dominant pattern. Whether inherited or not, chronic pancreatitis is known to be associated with pancreatic cancer.
To determine the incidence and risk factors for pancreatic cancer in patients with the hereditary form of pancreatitis, French investigators, led by Dr. Vinciane Rebours, studied 200 patients representing 6,673 person-years who either carried the gene mutation or had a strong family history of pancreatitis in relatives who did not have other notable risk factors for chronic pancreatitis, such as alcoholism (two or more first-degree relatives or at least three second-degree relatives).
Dr. Rebours, of the gastroenterology service at Beaujon Hospital in Clichy, reported the results at the annual Digestive Disease Week.
At enrollment, the median age of the cohort was 30 years, with a range of 1–84 years; about one-third of the cohort smoked.
Of these patients, 10 were diagnosed with pancreatic adenocarcinoma at a median age of 55 years, with a range of 39–78 years, Dr. Rebours reported.
By comparing the cohort with the general population, the researchers determined that individuals with hereditary pancreatitis had an 87-fold elevated risk of pancreatic cancer. Among all patients with chronic pancreatitis, there is a historically quoted 27-fold increase in pancreatic cancer incidence.
The chance of being diagnosed with pancreatic adenocarcinoma increased with age, for a cumulative risk of 11%, 16%, and 49% for males at ages 50, 60, and 70 years. The cumulative risk for females was 8%, 22%, and 55% at ages 50, 60, and 70 years. Smokers faced even worse odds, with a risk of pancreatic adenocarcinoma at age 75 of 61% for males and 70% for females.
Other important risk factors were diabetes mellitus and the absence of acute pancreatitis, Dr. Rebours said.
LOS ANGELES — Patients with hereditary pancreatitis face an 87-fold elevated risk of being diagnosed with pancreatic adenocarcinoma, and if they smoke, the risk is even greater, according to a national cohort study of 78 affected families in France.
Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene (PRSS1) that is inherited in an autosomal dominant pattern. Whether inherited or not, chronic pancreatitis is known to be associated with pancreatic cancer.
To determine the incidence and risk factors for pancreatic cancer in patients with the hereditary form of pancreatitis, French investigators, led by Dr. Vinciane Rebours, studied 200 patients representing 6,673 person-years who either carried the gene mutation or had a strong family history of pancreatitis in relatives who did not have other notable risk factors for chronic pancreatitis, such as alcoholism (two or more first-degree relatives or at least three second-degree relatives).
Dr. Rebours, of the gastroenterology service at Beaujon Hospital in Clichy, reported the results at the annual Digestive Disease Week.
At enrollment, the median age of the cohort was 30 years, with a range of 1–84 years; about one-third of the cohort smoked.
Of these patients, 10 were diagnosed with pancreatic adenocarcinoma at a median age of 55 years, with a range of 39–78 years, Dr. Rebours reported.
By comparing the cohort with the general population, the researchers determined that individuals with hereditary pancreatitis had an 87-fold elevated risk of pancreatic cancer. Among all patients with chronic pancreatitis, there is a historically quoted 27-fold increase in pancreatic cancer incidence.
The chance of being diagnosed with pancreatic adenocarcinoma increased with age, for a cumulative risk of 11%, 16%, and 49% for males at ages 50, 60, and 70 years. The cumulative risk for females was 8%, 22%, and 55% at ages 50, 60, and 70 years. Smokers faced even worse odds, with a risk of pancreatic adenocarcinoma at age 75 of 61% for males and 70% for females.
Other important risk factors were diabetes mellitus and the absence of acute pancreatitis, Dr. Rebours said.
LOS ANGELES — Patients with hereditary pancreatitis face an 87-fold elevated risk of being diagnosed with pancreatic adenocarcinoma, and if they smoke, the risk is even greater, according to a national cohort study of 78 affected families in France.
Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene (PRSS1) that is inherited in an autosomal dominant pattern. Whether inherited or not, chronic pancreatitis is known to be associated with pancreatic cancer.
To determine the incidence and risk factors for pancreatic cancer in patients with the hereditary form of pancreatitis, French investigators, led by Dr. Vinciane Rebours, studied 200 patients representing 6,673 person-years who either carried the gene mutation or had a strong family history of pancreatitis in relatives who did not have other notable risk factors for chronic pancreatitis, such as alcoholism (two or more first-degree relatives or at least three second-degree relatives).
Dr. Rebours, of the gastroenterology service at Beaujon Hospital in Clichy, reported the results at the annual Digestive Disease Week.
At enrollment, the median age of the cohort was 30 years, with a range of 1–84 years; about one-third of the cohort smoked.
Of these patients, 10 were diagnosed with pancreatic adenocarcinoma at a median age of 55 years, with a range of 39–78 years, Dr. Rebours reported.
By comparing the cohort with the general population, the researchers determined that individuals with hereditary pancreatitis had an 87-fold elevated risk of pancreatic cancer. Among all patients with chronic pancreatitis, there is a historically quoted 27-fold increase in pancreatic cancer incidence.
The chance of being diagnosed with pancreatic adenocarcinoma increased with age, for a cumulative risk of 11%, 16%, and 49% for males at ages 50, 60, and 70 years. The cumulative risk for females was 8%, 22%, and 55% at ages 50, 60, and 70 years. Smokers faced even worse odds, with a risk of pancreatic adenocarcinoma at age 75 of 61% for males and 70% for females.
Other important risk factors were diabetes mellitus and the absence of acute pancreatitis, Dr. Rebours said.