Pandemic H1N1 Virus May Hit U.S. in Waves

Americans may need to brace for a long winter of “rising and falling” waves of pandemic influenza A(H1N1) outbreaks, Kathleen Sebelius, Secretary of the Department of Health and Human Services, warned during a telebriefing.

The notion that the H1N1 pandemic may have peaked in October, as it became widespread in 46 states, “may be overly optimistic,” she said. “It is totally unpredictable what's going to happen. How many [bell] curves we will see, our scientists tell me they don't know.”

During the 1950s, rolling waves of serious influenza outbreaks buffeted various regions of the country, with peaks occurring both in the fall and the winter. The same phenomenon may occur this year and even into the spring, she said.

“We could see months of disease outbreaks rising and falling.”

According to the most recent figures available, more than 97,000 Americans had been hospitalized for H1N1 influenza anrough Oct. 17, and 3,983 patients died, of whom 540 were children.

Unlike most years, this year's powerful fall influenza season followed a spike last spring of cases and hospitalizations, most from the H1N1 strain.

Both Sec. Sebelius and Janet Napolitano, Secretary of the Department of Homeland Security, offered reassurances at their joint press conference that widespread vaccine shortages would ease.

Unforeseen problems with manufacturing of the H1N1 vaccine led to sluggish production in the early weeks of an outbreak that quickly spread throughout the country, outpacing health officials' ability to provide inoculations to groups considered at high risk of complications, including pregnant women, children and young adults, caregivers of infants, health care workers, and people with underlying medical conditions.

Sec. Sebelius explained that the H1N1 virus strain proved to grow slowly using 50-year-old egg-based technology, which is considered safe but sluggish in comparison with experimental cell-based technologies that have yet to be fully evaluated and approved.

Vaccine distribution also was hampered by early problems with manufacturers' stepped-up production line schedule, which she compared to glitches associated with the “roll-out of a new restaurant.”

When scenarios were first conceived about how to ramp up production and distribution in anticipation of the fall outbreak, “it seems that we were getting some pretty rosy scenarios,” she said.

It turned out that the “yield was lower than anticipated.”

Subsequently, however, a “robust” supply of a safe and efficacious vaccine was on its way to 150,000 vaccination sites from five manufacturers, with state and local governments deciding who to vaccinate first, where, and when, she said.

“It is frustrating to stand in line and wait for vaccine,” Sec. Napolitano acknowledged.

“For those who are ill or whose loved ones have passed away, our sympathies couldn't be higher,” she said. “But this is not a situation that is cause for panic. We have vaccine. It is being produced. It is being distributed.”

All 50 states and U.S. territories have ordered vaccine, which is distributed on a per capita basis, she noted.

Sec. Napolitano emphasized that the specifics of vaccine clinics and prioritization of recipients are managed on a state and local level, analogous to national disaster response.

The federal government in this case is providing “actions and assistance … well grounded in science and well grounded in facts.” But “nobody is sitting here in [Washington]” deciding, for example, where pregnant women in Arizona should go for a vaccine.

Sec. Sebelius said some school-based clinics in Maryland that had already planned to administer seasonal flu shots decided to direct limited H1N1 vaccine supplies there first.

In Illinois and some states in the Northeast, ob.gyns. were directly calling their pregnant patients into their offices for H1N1 vaccination.

Other localities decided to concentrate on vaccinating health care workers as their highest priority.

Such choices were expected to become less difficult as a result of distribution of a total of 250 million doses of vaccine — far more than the 100 million doses of seasonal influenza vaccine typically produced for the nation, she said.

Sec. Sebelius directed consumers to flu.gov

A new link on the Web site (flu.gov/evaluation

'We could see months of disease outbreaks rising and falling.'

Source SEC. SEBELIUS

Americans may need to brace for a long winter of “rising and falling” waves of pandemic influenza A(H1N1) outbreaks, Kathleen Sebelius, Secretary of the Department of Health and Human Services, warned during a telebriefing.

The notion that the H1N1 pandemic may have peaked in October, as it became widespread in 46 states, “may be overly optimistic,” she said. “It is totally unpredictable what's going to happen. How many [bell] curves we will see, our scientists tell me they don't know.”

During the 1950s, rolling waves of serious influenza outbreaks buffeted various regions of the country, with peaks occurring both in the fall and the winter. The same phenomenon may occur this year and even into the spring, she said.

“We could see months of disease outbreaks rising and falling.”

According to the most recent figures available, more than 97,000 Americans had been hospitalized for H1N1 influenza anrough Oct. 17, and 3,983 patients died, of whom 540 were children.

Unlike most years, this year's powerful fall influenza season followed a spike last spring of cases and hospitalizations, most from the H1N1 strain.

Both Sec. Sebelius and Janet Napolitano, Secretary of the Department of Homeland Security, offered reassurances at their joint press conference that widespread vaccine shortages would ease.

Unforeseen problems with manufacturing of the H1N1 vaccine led to sluggish production in the early weeks of an outbreak that quickly spread throughout the country, outpacing health officials' ability to provide inoculations to groups considered at high risk of complications, including pregnant women, children and young adults, caregivers of infants, health care workers, and people with underlying medical conditions.

Sec. Sebelius explained that the H1N1 virus strain proved to grow slowly using 50-year-old egg-based technology, which is considered safe but sluggish in comparison with experimental cell-based technologies that have yet to be fully evaluated and approved.

Vaccine distribution also was hampered by early problems with manufacturers' stepped-up production line schedule, which she compared to glitches associated with the “roll-out of a new restaurant.”

When scenarios were first conceived about how to ramp up production and distribution in anticipation of the fall outbreak, “it seems that we were getting some pretty rosy scenarios,” she said.

It turned out that the “yield was lower than anticipated.”

Subsequently, however, a “robust” supply of a safe and efficacious vaccine was on its way to 150,000 vaccination sites from five manufacturers, with state and local governments deciding who to vaccinate first, where, and when, she said.

“It is frustrating to stand in line and wait for vaccine,” Sec. Napolitano acknowledged.

“For those who are ill or whose loved ones have passed away, our sympathies couldn't be higher,” she said. “But this is not a situation that is cause for panic. We have vaccine. It is being produced. It is being distributed.”

All 50 states and U.S. territories have ordered vaccine, which is distributed on a per capita basis, she noted.

Sec. Napolitano emphasized that the specifics of vaccine clinics and prioritization of recipients are managed on a state and local level, analogous to national disaster response.

The federal government in this case is providing “actions and assistance … well grounded in science and well grounded in facts.” But “nobody is sitting here in [Washington]” deciding, for example, where pregnant women in Arizona should go for a vaccine.

Sec. Sebelius said some school-based clinics in Maryland that had already planned to administer seasonal flu shots decided to direct limited H1N1 vaccine supplies there first.

In Illinois and some states in the Northeast, ob.gyns. were directly calling their pregnant patients into their offices for H1N1 vaccination.

Other localities decided to concentrate on vaccinating health care workers as their highest priority.

Such choices were expected to become less difficult as a result of distribution of a total of 250 million doses of vaccine — far more than the 100 million doses of seasonal influenza vaccine typically produced for the nation, she said.

Sec. Sebelius directed consumers to flu.gov

A new link on the Web site (flu.gov/evaluation

'We could see months of disease outbreaks rising and falling.'

Source SEC. SEBELIUS

Americans may need to brace for a long winter of “rising and falling” waves of pandemic influenza A(H1N1) outbreaks, Kathleen Sebelius, Secretary of the Department of Health and Human Services, warned during a telebriefing.

The notion that the H1N1 pandemic may have peaked in October, as it became widespread in 46 states, “may be overly optimistic,” she said. “It is totally unpredictable what's going to happen. How many [bell] curves we will see, our scientists tell me they don't know.”

During the 1950s, rolling waves of serious influenza outbreaks buffeted various regions of the country, with peaks occurring both in the fall and the winter. The same phenomenon may occur this year and even into the spring, she said.

“We could see months of disease outbreaks rising and falling.”

According to the most recent figures available, more than 97,000 Americans had been hospitalized for H1N1 influenza anrough Oct. 17, and 3,983 patients died, of whom 540 were children.

Unlike most years, this year's powerful fall influenza season followed a spike last spring of cases and hospitalizations, most from the H1N1 strain.

Both Sec. Sebelius and Janet Napolitano, Secretary of the Department of Homeland Security, offered reassurances at their joint press conference that widespread vaccine shortages would ease.

Unforeseen problems with manufacturing of the H1N1 vaccine led to sluggish production in the early weeks of an outbreak that quickly spread throughout the country, outpacing health officials' ability to provide inoculations to groups considered at high risk of complications, including pregnant women, children and young adults, caregivers of infants, health care workers, and people with underlying medical conditions.

Sec. Sebelius explained that the H1N1 virus strain proved to grow slowly using 50-year-old egg-based technology, which is considered safe but sluggish in comparison with experimental cell-based technologies that have yet to be fully evaluated and approved.

Vaccine distribution also was hampered by early problems with manufacturers' stepped-up production line schedule, which she compared to glitches associated with the “roll-out of a new restaurant.”

When scenarios were first conceived about how to ramp up production and distribution in anticipation of the fall outbreak, “it seems that we were getting some pretty rosy scenarios,” she said.

It turned out that the “yield was lower than anticipated.”

Subsequently, however, a “robust” supply of a safe and efficacious vaccine was on its way to 150,000 vaccination sites from five manufacturers, with state and local governments deciding who to vaccinate first, where, and when, she said.

“It is frustrating to stand in line and wait for vaccine,” Sec. Napolitano acknowledged.

“For those who are ill or whose loved ones have passed away, our sympathies couldn't be higher,” she said. “But this is not a situation that is cause for panic. We have vaccine. It is being produced. It is being distributed.”

All 50 states and U.S. territories have ordered vaccine, which is distributed on a per capita basis, she noted.

Sec. Napolitano emphasized that the specifics of vaccine clinics and prioritization of recipients are managed on a state and local level, analogous to national disaster response.

The federal government in this case is providing “actions and assistance … well grounded in science and well grounded in facts.” But “nobody is sitting here in [Washington]” deciding, for example, where pregnant women in Arizona should go for a vaccine.

Sec. Sebelius said some school-based clinics in Maryland that had already planned to administer seasonal flu shots decided to direct limited H1N1 vaccine supplies there first.

In Illinois and some states in the Northeast, ob.gyns. were directly calling their pregnant patients into their offices for H1N1 vaccination.

Other localities decided to concentrate on vaccinating health care workers as their highest priority.

Such choices were expected to become less difficult as a result of distribution of a total of 250 million doses of vaccine — far more than the 100 million doses of seasonal influenza vaccine typically produced for the nation, she said.

Sec. Sebelius directed consumers to flu.gov

A new link on the Web site (flu.gov/evaluation

'We could see months of disease outbreaks rising and falling.'

Source SEC. SEBELIUS