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NEW ORLEANS – An association has been reported between elevated proteoglycan biopsy results and severe mitral valve prolapse.
Dr. Paolo Romanelli and his associates compared eight patients with echocardiography-proven severe mitral valve prolapse (MVP) and six controls with no cardiac symptoms. They took two 4-mm punch biopsies from normal-appearing forearm skin of each participant to test for proteoglycan mucin levels.
Dr. Romanelli’s study, presented at the annual meeting of the American Academy of Dermatology demonstrated that quantitative proteoglycan analysis was greater among patients with MVP (0.6 mg/g), compared with controls (0.4 mg/g). In addition, semiquantitative assessment of proteoglycan deposition by hematoxylin-eosin staining and colloidal iron staining showed a mean 3.4 in MVP patients, compared with 1.0 in controls, noted Dr. Romanelli of the University of Miami. All participants were younger than 55 years. All of the MVP patients were comorbid with conditions that included atrial fibrillation, palpitations, and mild chest discomfort.
The study findings need to be validated, Dr. Romanelli said. Nevertheless, he said he foresees a time when a skin biopsy will predict the subset of patients at greatest risk for arrhythmias and sudden death from MVP.
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Dr. Romanelli said that he had no relevant disclosures.
NEW ORLEANS – An association has been reported between elevated proteoglycan biopsy results and severe mitral valve prolapse.
Dr. Paolo Romanelli and his associates compared eight patients with echocardiography-proven severe mitral valve prolapse (MVP) and six controls with no cardiac symptoms. They took two 4-mm punch biopsies from normal-appearing forearm skin of each participant to test for proteoglycan mucin levels.
Dr. Romanelli’s study, presented at the annual meeting of the American Academy of Dermatology demonstrated that quantitative proteoglycan analysis was greater among patients with MVP (0.6 mg/g), compared with controls (0.4 mg/g). In addition, semiquantitative assessment of proteoglycan deposition by hematoxylin-eosin staining and colloidal iron staining showed a mean 3.4 in MVP patients, compared with 1.0 in controls, noted Dr. Romanelli of the University of Miami. All participants were younger than 55 years. All of the MVP patients were comorbid with conditions that included atrial fibrillation, palpitations, and mild chest discomfort.
The study findings need to be validated, Dr. Romanelli said. Nevertheless, he said he foresees a time when a skin biopsy will predict the subset of patients at greatest risk for arrhythmias and sudden death from MVP.
I have checked the following facts in my story: (Please initial each.)
Dr. Romanelli said that he had no relevant disclosures.
NEW ORLEANS – An association has been reported between elevated proteoglycan biopsy results and severe mitral valve prolapse.
Dr. Paolo Romanelli and his associates compared eight patients with echocardiography-proven severe mitral valve prolapse (MVP) and six controls with no cardiac symptoms. They took two 4-mm punch biopsies from normal-appearing forearm skin of each participant to test for proteoglycan mucin levels.
Dr. Romanelli’s study, presented at the annual meeting of the American Academy of Dermatology demonstrated that quantitative proteoglycan analysis was greater among patients with MVP (0.6 mg/g), compared with controls (0.4 mg/g). In addition, semiquantitative assessment of proteoglycan deposition by hematoxylin-eosin staining and colloidal iron staining showed a mean 3.4 in MVP patients, compared with 1.0 in controls, noted Dr. Romanelli of the University of Miami. All participants were younger than 55 years. All of the MVP patients were comorbid with conditions that included atrial fibrillation, palpitations, and mild chest discomfort.
The study findings need to be validated, Dr. Romanelli said. Nevertheless, he said he foresees a time when a skin biopsy will predict the subset of patients at greatest risk for arrhythmias and sudden death from MVP.
I have checked the following facts in my story: (Please initial each.)
Dr. Romanelli said that he had no relevant disclosures.