Clinical Edge Journal Scan

Key clinical point: Biological disease-modifying antirheumatic drugs (bDMARD) significantly improved the quality of life (QoL) in patients with psoriatic arthritis (PsA) compared with placebo.

Major finding: The Health Assessment Questionnaire Disability Index (mean difference [MD] −0.21), Dermatology Life Quality Index (MD −4.36), and Short Form 36 Questionnaire physical (MD 3.76) and mental (MD 1.76; all P < .00001) component summaries improved significantly with bDMARD vs placebo. However, bDMARD showed no significant advantage or disadvantage over methotrexate or tofacitinib.

Study details: This was a meta-analysis of 37 randomized controlled trials including 14,115 patients with PsA who received non-bDMARD, placebo, or bDMARD alone or in combination with non-bDMARD.

Disclosures: This work was supported by the National Natural Science Foundation of China. The authors declared no conflicts of interest.

Source: Lu Y et al. Effects of bDMARDs on quality of life in patients with psoriatic arthritis: Meta-analysis. BMJ Open. 2022;12:e058497 (Apr 12). Doi: 10.1136/bmjopen-2021-058497

Key clinical point: Biological disease-modifying antirheumatic drugs (bDMARD) significantly improved the quality of life (QoL) in patients with psoriatic arthritis (PsA) compared with placebo.

Major finding: The Health Assessment Questionnaire Disability Index (mean difference [MD] −0.21), Dermatology Life Quality Index (MD −4.36), and Short Form 36 Questionnaire physical (MD 3.76) and mental (MD 1.76; all P < .00001) component summaries improved significantly with bDMARD vs placebo. However, bDMARD showed no significant advantage or disadvantage over methotrexate or tofacitinib.

Study details: This was a meta-analysis of 37 randomized controlled trials including 14,115 patients with PsA who received non-bDMARD, placebo, or bDMARD alone or in combination with non-bDMARD.

Disclosures: This work was supported by the National Natural Science Foundation of China. The authors declared no conflicts of interest.

Source: Lu Y et al. Effects of bDMARDs on quality of life in patients with psoriatic arthritis: Meta-analysis. BMJ Open. 2022;12:e058497 (Apr 12). Doi: 10.1136/bmjopen-2021-058497

Key clinical point: Biological disease-modifying antirheumatic drugs (bDMARD) significantly improved the quality of life (QoL) in patients with psoriatic arthritis (PsA) compared with placebo.

Major finding: The Health Assessment Questionnaire Disability Index (mean difference [MD] −0.21), Dermatology Life Quality Index (MD −4.36), and Short Form 36 Questionnaire physical (MD 3.76) and mental (MD 1.76; all P < .00001) component summaries improved significantly with bDMARD vs placebo. However, bDMARD showed no significant advantage or disadvantage over methotrexate or tofacitinib.

Study details: This was a meta-analysis of 37 randomized controlled trials including 14,115 patients with PsA who received non-bDMARD, placebo, or bDMARD alone or in combination with non-bDMARD.

Disclosures: This work was supported by the National Natural Science Foundation of China. The authors declared no conflicts of interest.

Source: Lu Y et al. Effects of bDMARDs on quality of life in patients with psoriatic arthritis: Meta-analysis. BMJ Open. 2022;12:e058497 (Apr 12). Doi: 10.1136/bmjopen-2021-058497

Key clinical point: Disease-modifying antirheumatic drug (DMARD)-naive patients with moderate vs high disease activity at baseline were more likely to achieve Clinical Disease Activity Index for Psoriatic Arthritis (PsA) treatment targets following apremilast therapy.

Major finding: At week 52, remission or low disease activity was achieved by approximately twice the number of patients with moderate vs high disease activity (61.7% vs 28.2%) at baseline, regardless of one or multiple PsA manifestations.

Study details: Findings are from a post hoc analysis of the phase 3 PALACE 4 study including 175 DMARD-naive patients with active PsA who received 30 mg apremilast.

Disclosures: This study received writing support from Amgen. Three authors declared being employees and stockholders of Amgen. The other authors reported ties with several sources, including Amgen.

Source: Mease PJ et al. Baseline disease activity predicts achievement of cDAPSA treatment targets with apremilast: Phase 3 results in DMARD-naive patients with psoriatic arthritis. J Rheumatol. 2022 (Apr 15). Doi: 10.3899/jrheum.210906

Key clinical point: Disease-modifying antirheumatic drug (DMARD)-naive patients with moderate vs high disease activity at baseline were more likely to achieve Clinical Disease Activity Index for Psoriatic Arthritis (PsA) treatment targets following apremilast therapy.

Major finding: At week 52, remission or low disease activity was achieved by approximately twice the number of patients with moderate vs high disease activity (61.7% vs 28.2%) at baseline, regardless of one or multiple PsA manifestations.

Study details: Findings are from a post hoc analysis of the phase 3 PALACE 4 study including 175 DMARD-naive patients with active PsA who received 30 mg apremilast.

Disclosures: This study received writing support from Amgen. Three authors declared being employees and stockholders of Amgen. The other authors reported ties with several sources, including Amgen.

Source: Mease PJ et al. Baseline disease activity predicts achievement of cDAPSA treatment targets with apremilast: Phase 3 results in DMARD-naive patients with psoriatic arthritis. J Rheumatol. 2022 (Apr 15). Doi: 10.3899/jrheum.210906

Key clinical point: Disease-modifying antirheumatic drug (DMARD)-naive patients with moderate vs high disease activity at baseline were more likely to achieve Clinical Disease Activity Index for Psoriatic Arthritis (PsA) treatment targets following apremilast therapy.

Major finding: At week 52, remission or low disease activity was achieved by approximately twice the number of patients with moderate vs high disease activity (61.7% vs 28.2%) at baseline, regardless of one or multiple PsA manifestations.

Study details: Findings are from a post hoc analysis of the phase 3 PALACE 4 study including 175 DMARD-naive patients with active PsA who received 30 mg apremilast.

Disclosures: This study received writing support from Amgen. Three authors declared being employees and stockholders of Amgen. The other authors reported ties with several sources, including Amgen.

Source: Mease PJ et al. Baseline disease activity predicts achievement of cDAPSA treatment targets with apremilast: Phase 3 results in DMARD-naive patients with psoriatic arthritis. J Rheumatol. 2022 (Apr 15). Doi: 10.3899/jrheum.210906

Key clinical point: Patients with psoriasis and concurrent psoriatic arthritis (PsA) reported more extensive skin disease than patients with only psoriasis, with psoriasis severity being significantly associated with higher odds of concurrent PsA.

Major finding: Body surface area scores were significantly higher in patients with psoriasis and concurrent PsA vs patients with only psoriasis (mean difference 5.31; 95% CI 1.78-8.83), with severe psoriasis being a significant predictor of concurrent PsA (odds ratio 3.34; P < .001).

Study details: This was a meta-analysis of 29 studies including adult patients with psoriasis with or without concurrent PsA or adult patients with psoriasis who developed PsA.

Disclosures: This study did not receive any funding. JM Laar declared receiving research grants and honoraria from several sources.

Source: Pouw JN et al. Do patients with psoriatic arthritis have more severe skin disease than patients with psoriasis only? A systematic review and meta-analysis. Dermatology. 2022 (May 12). Doi: 10.1159/000524231

Key clinical point: Patients with psoriasis and concurrent psoriatic arthritis (PsA) reported more extensive skin disease than patients with only psoriasis, with psoriasis severity being significantly associated with higher odds of concurrent PsA.

Major finding: Body surface area scores were significantly higher in patients with psoriasis and concurrent PsA vs patients with only psoriasis (mean difference 5.31; 95% CI 1.78-8.83), with severe psoriasis being a significant predictor of concurrent PsA (odds ratio 3.34; P < .001).

Study details: This was a meta-analysis of 29 studies including adult patients with psoriasis with or without concurrent PsA or adult patients with psoriasis who developed PsA.

Disclosures: This study did not receive any funding. JM Laar declared receiving research grants and honoraria from several sources.

Source: Pouw JN et al. Do patients with psoriatic arthritis have more severe skin disease than patients with psoriasis only? A systematic review and meta-analysis. Dermatology. 2022 (May 12). Doi: 10.1159/000524231

Key clinical point: Patients with psoriasis and concurrent psoriatic arthritis (PsA) reported more extensive skin disease than patients with only psoriasis, with psoriasis severity being significantly associated with higher odds of concurrent PsA.

Major finding: Body surface area scores were significantly higher in patients with psoriasis and concurrent PsA vs patients with only psoriasis (mean difference 5.31; 95% CI 1.78-8.83), with severe psoriasis being a significant predictor of concurrent PsA (odds ratio 3.34; P < .001).

Study details: This was a meta-analysis of 29 studies including adult patients with psoriasis with or without concurrent PsA or adult patients with psoriasis who developed PsA.

Disclosures: This study did not receive any funding. JM Laar declared receiving research grants and honoraria from several sources.

Source: Pouw JN et al. Do patients with psoriatic arthritis have more severe skin disease than patients with psoriasis only? A systematic review and meta-analysis. Dermatology. 2022 (May 12). Doi: 10.1159/000524231

Key clinical point: A substantial proportion of patients with psoriatic arthritis (PsA) who received biological disease-modifying antirheumatic drug (bDMARD) therapy showed osteoproliferative lesions on a lumbar radiograph, with osteophytes being the most common.

Major finding: Osteophytes were the most common lesions and were detected in 42.3% of patients, with 18.1% of patients being diagnosed with grade ≥2 osteophytes. At least one syndesmophyte was detected in 24.2% of patients, with 9.3% and 19.8% of patients showing bridging and corner syndesmophytes, respectively. Ambiguous lesions were detected in 7.1% of patients.

Study details: Findings are from an analysis of 182 patients with PsA who received bDMARD therapy and underwent lumbar radiography assessment.

Disclosures: This research was funded by Hacettepe Rheumatology Society, Turkey. The authors declared no conflicts of interest.

Source: Ayan G et al. Degenerative and inflammatory osteoproliferations in lumbar radiographs in psoriatic arthritis patients. J Clin Med. 2022;11(7):2009 (Apr 3). Doi: 10.3390/jcm11072009

Key clinical point: A substantial proportion of patients with psoriatic arthritis (PsA) who received biological disease-modifying antirheumatic drug (bDMARD) therapy showed osteoproliferative lesions on a lumbar radiograph, with osteophytes being the most common.

Major finding: Osteophytes were the most common lesions and were detected in 42.3% of patients, with 18.1% of patients being diagnosed with grade ≥2 osteophytes. At least one syndesmophyte was detected in 24.2% of patients, with 9.3% and 19.8% of patients showing bridging and corner syndesmophytes, respectively. Ambiguous lesions were detected in 7.1% of patients.

Study details: Findings are from an analysis of 182 patients with PsA who received bDMARD therapy and underwent lumbar radiography assessment.

Disclosures: This research was funded by Hacettepe Rheumatology Society, Turkey. The authors declared no conflicts of interest.

Source: Ayan G et al. Degenerative and inflammatory osteoproliferations in lumbar radiographs in psoriatic arthritis patients. J Clin Med. 2022;11(7):2009 (Apr 3). Doi: 10.3390/jcm11072009

Key clinical point: A substantial proportion of patients with psoriatic arthritis (PsA) who received biological disease-modifying antirheumatic drug (bDMARD) therapy showed osteoproliferative lesions on a lumbar radiograph, with osteophytes being the most common.

Major finding: Osteophytes were the most common lesions and were detected in 42.3% of patients, with 18.1% of patients being diagnosed with grade ≥2 osteophytes. At least one syndesmophyte was detected in 24.2% of patients, with 9.3% and 19.8% of patients showing bridging and corner syndesmophytes, respectively. Ambiguous lesions were detected in 7.1% of patients.

Study details: Findings are from an analysis of 182 patients with PsA who received bDMARD therapy and underwent lumbar radiography assessment.

Disclosures: This research was funded by Hacettepe Rheumatology Society, Turkey. The authors declared no conflicts of interest.

Source: Ayan G et al. Degenerative and inflammatory osteoproliferations in lumbar radiographs in psoriatic arthritis patients. J Clin Med. 2022;11(7):2009 (Apr 3). Doi: 10.3390/jcm11072009

Key clinical point: Having sent a pharyngeal sample for culture was associated with an increased risk for psoriatic arthritis (PsA) onset, indicating site of infection being associated with the increased PsA risk rather than the pathogen.

Major finding: Among all samples sent for culture, a pharyngeal sample was associated with a higher risk for PsA onset within first 50 days compared with a urine (hazard ratio [HR] 8.78; 95% CI 3.23-23.91), nasopharyngeal (HR 8.26; 95% CI 2.23-30.63), or blood (HR 25.22; 95% CI 3.12-204.13) sample; however, streptococcal infections in the pharynx or at any other site were not associated with an increased risk for PsA.

Study details: Findings are from a population-based cohort study including 313,235 bacterial cultures from 128,982 individuals.

Disclosures: The study was supported by the Landspitali University Hospital, Iceland. A Ogdie and T Love declared serving as consultants and receiving grants and reimbursement from several sources.

Source: Thrastardottir T et al. Strong site-specific association of pharyngeal cultures with the onset of psoriatic arthritis and psoriasis, regardless of pathogen. Rheumatology (Oxford). 2022 (Apr 23). Doi: 10.1093/rheumatology/keac253 

Key clinical point: Having sent a pharyngeal sample for culture was associated with an increased risk for psoriatic arthritis (PsA) onset, indicating site of infection being associated with the increased PsA risk rather than the pathogen.

Major finding: Among all samples sent for culture, a pharyngeal sample was associated with a higher risk for PsA onset within first 50 days compared with a urine (hazard ratio [HR] 8.78; 95% CI 3.23-23.91), nasopharyngeal (HR 8.26; 95% CI 2.23-30.63), or blood (HR 25.22; 95% CI 3.12-204.13) sample; however, streptococcal infections in the pharynx or at any other site were not associated with an increased risk for PsA.

Study details: Findings are from a population-based cohort study including 313,235 bacterial cultures from 128,982 individuals.

Disclosures: The study was supported by the Landspitali University Hospital, Iceland. A Ogdie and T Love declared serving as consultants and receiving grants and reimbursement from several sources.

Source: Thrastardottir T et al. Strong site-specific association of pharyngeal cultures with the onset of psoriatic arthritis and psoriasis, regardless of pathogen. Rheumatology (Oxford). 2022 (Apr 23). Doi: 10.1093/rheumatology/keac253 

Key clinical point: Having sent a pharyngeal sample for culture was associated with an increased risk for psoriatic arthritis (PsA) onset, indicating site of infection being associated with the increased PsA risk rather than the pathogen.

Major finding: Among all samples sent for culture, a pharyngeal sample was associated with a higher risk for PsA onset within first 50 days compared with a urine (hazard ratio [HR] 8.78; 95% CI 3.23-23.91), nasopharyngeal (HR 8.26; 95% CI 2.23-30.63), or blood (HR 25.22; 95% CI 3.12-204.13) sample; however, streptococcal infections in the pharynx or at any other site were not associated with an increased risk for PsA.

Study details: Findings are from a population-based cohort study including 313,235 bacterial cultures from 128,982 individuals.

Disclosures: The study was supported by the Landspitali University Hospital, Iceland. A Ogdie and T Love declared serving as consultants and receiving grants and reimbursement from several sources.

Source: Thrastardottir T et al. Strong site-specific association of pharyngeal cultures with the onset of psoriatic arthritis and psoriasis, regardless of pathogen. Rheumatology (Oxford). 2022 (Apr 23). Doi: 10.1093/rheumatology/keac253 

Key clinical point: Both first- and second-line secukinumab therapies demonstrated substantial improvement in disease activity, adequate retention rates, and a satisfactory safety profile in a real-world population of patients with psoriatic arthritis (PsA).

Major finding: Mean Disease Activity Score 28 using C-reactive protein decreased from 3.0 to 2.0 and 1.9 at the first and third years of follow-up, whereas the proportion of patients in remission/low disease activity increased from 52.1% and 71.4% to 100% after 2 years of the first- and second-line secukinumab treatments, respectively. The overall retention rates of secukinumab were 74.1%, 59.1%, and 54.2% in the first, second, and third years of treatment, respectively, with no new adverse events being reported.

Study details: This observational, retrospective analysis included 639 patients with PsA or axial spondyloarthritis from the BIOBADASER registry who had received secukinumab for >12 months. Of these patients, 350 had PsA.

Disclosures: This study was sponsored by Novartis Spain. C Sastré is an employee of Novartis. The other authors reported no conflicts of interest.

Source: Moreno-Ramos MJ et al. Real-world effectiveness and treatment retention of secukinumab in patients with psoriatic arthritis and axial spondyloarthritis: A descriptive observational analysis of the Spanish BIOBADASER Registry. Rheumatol Ther. 2022 (Apr 25). Doi: 10.1007/s40744-022-00446-9

Key clinical point: Both first- and second-line secukinumab therapies demonstrated substantial improvement in disease activity, adequate retention rates, and a satisfactory safety profile in a real-world population of patients with psoriatic arthritis (PsA).

Major finding: Mean Disease Activity Score 28 using C-reactive protein decreased from 3.0 to 2.0 and 1.9 at the first and third years of follow-up, whereas the proportion of patients in remission/low disease activity increased from 52.1% and 71.4% to 100% after 2 years of the first- and second-line secukinumab treatments, respectively. The overall retention rates of secukinumab were 74.1%, 59.1%, and 54.2% in the first, second, and third years of treatment, respectively, with no new adverse events being reported.

Study details: This observational, retrospective analysis included 639 patients with PsA or axial spondyloarthritis from the BIOBADASER registry who had received secukinumab for >12 months. Of these patients, 350 had PsA.

Disclosures: This study was sponsored by Novartis Spain. C Sastré is an employee of Novartis. The other authors reported no conflicts of interest.

Source: Moreno-Ramos MJ et al. Real-world effectiveness and treatment retention of secukinumab in patients with psoriatic arthritis and axial spondyloarthritis: A descriptive observational analysis of the Spanish BIOBADASER Registry. Rheumatol Ther. 2022 (Apr 25). Doi: 10.1007/s40744-022-00446-9

Key clinical point: Both first- and second-line secukinumab therapies demonstrated substantial improvement in disease activity, adequate retention rates, and a satisfactory safety profile in a real-world population of patients with psoriatic arthritis (PsA).

Major finding: Mean Disease Activity Score 28 using C-reactive protein decreased from 3.0 to 2.0 and 1.9 at the first and third years of follow-up, whereas the proportion of patients in remission/low disease activity increased from 52.1% and 71.4% to 100% after 2 years of the first- and second-line secukinumab treatments, respectively. The overall retention rates of secukinumab were 74.1%, 59.1%, and 54.2% in the first, second, and third years of treatment, respectively, with no new adverse events being reported.

Study details: This observational, retrospective analysis included 639 patients with PsA or axial spondyloarthritis from the BIOBADASER registry who had received secukinumab for >12 months. Of these patients, 350 had PsA.

Disclosures: This study was sponsored by Novartis Spain. C Sastré is an employee of Novartis. The other authors reported no conflicts of interest.

Source: Moreno-Ramos MJ et al. Real-world effectiveness and treatment retention of secukinumab in patients with psoriatic arthritis and axial spondyloarthritis: A descriptive observational analysis of the Spanish BIOBADASER Registry. Rheumatol Ther. 2022 (Apr 25). Doi: 10.1007/s40744-022-00446-9

Key clinical point: Men vs women with psoriatic arthritis (PsA) experienced significantly improved outcomes with methotrexate+etanercept combination therapy, whereas those with lower body mass index (BMI) experienced better outcomes with no indication of any pattern with treatment received.

Major finding: At week 24, a higher proportion of men vs women receiving methotrexate+etanercept achieved American College of Rheumatology 20% (ACR20; 71.5% vs. 58.3%; P = .0194) and minimal disease activity (MDA; 45.8% vs 25.2%; P = .0003), whereas a higher proportion of patients with a BMI of ≤30 vs >30 kg/m² in all treatment groups achieved MDA (all P < .05) and those in methotrexate+etanercept group achieved ACR20 (P = .0241).

Study details: This was a post hoc analysis of the phase 3 SEAM-PsA trial including 851 methotrexate/biologics naive patients with early PsA who were randomly assigned to receive methotrexate+placebo, etanercept+placebo, or methotrexate+etanercept.

Disclosures: This study was funded by Immunex, a subsidiary of Amgen. Two authors declared being employees of and owned stocks in Amgen. The other authors reported ties with various sources, including Amgen.

Source: Mease PJ et al. Potential impact of sex and body mass index on response to therapy in psoriatic arthritis: Post-hoc analysis of results from the SEAM-PsA trial. J Rheumatol. 2022 (Apr 15). Doi: 10.3899/jrheum.211037

Key clinical point: Men vs women with psoriatic arthritis (PsA) experienced significantly improved outcomes with methotrexate+etanercept combination therapy, whereas those with lower body mass index (BMI) experienced better outcomes with no indication of any pattern with treatment received.

Major finding: At week 24, a higher proportion of men vs women receiving methotrexate+etanercept achieved American College of Rheumatology 20% (ACR20; 71.5% vs. 58.3%; P = .0194) and minimal disease activity (MDA; 45.8% vs 25.2%; P = .0003), whereas a higher proportion of patients with a BMI of ≤30 vs >30 kg/m² in all treatment groups achieved MDA (all P < .05) and those in methotrexate+etanercept group achieved ACR20 (P = .0241).

Study details: This was a post hoc analysis of the phase 3 SEAM-PsA trial including 851 methotrexate/biologics naive patients with early PsA who were randomly assigned to receive methotrexate+placebo, etanercept+placebo, or methotrexate+etanercept.

Disclosures: This study was funded by Immunex, a subsidiary of Amgen. Two authors declared being employees of and owned stocks in Amgen. The other authors reported ties with various sources, including Amgen.

Source: Mease PJ et al. Potential impact of sex and body mass index on response to therapy in psoriatic arthritis: Post-hoc analysis of results from the SEAM-PsA trial. J Rheumatol. 2022 (Apr 15). Doi: 10.3899/jrheum.211037

Key clinical point: Men vs women with psoriatic arthritis (PsA) experienced significantly improved outcomes with methotrexate+etanercept combination therapy, whereas those with lower body mass index (BMI) experienced better outcomes with no indication of any pattern with treatment received.

Major finding: At week 24, a higher proportion of men vs women receiving methotrexate+etanercept achieved American College of Rheumatology 20% (ACR20; 71.5% vs. 58.3%; P = .0194) and minimal disease activity (MDA; 45.8% vs 25.2%; P = .0003), whereas a higher proportion of patients with a BMI of ≤30 vs >30 kg/m² in all treatment groups achieved MDA (all P < .05) and those in methotrexate+etanercept group achieved ACR20 (P = .0241).

Study details: This was a post hoc analysis of the phase 3 SEAM-PsA trial including 851 methotrexate/biologics naive patients with early PsA who were randomly assigned to receive methotrexate+placebo, etanercept+placebo, or methotrexate+etanercept.

Disclosures: This study was funded by Immunex, a subsidiary of Amgen. Two authors declared being employees of and owned stocks in Amgen. The other authors reported ties with various sources, including Amgen.

Source: Mease PJ et al. Potential impact of sex and body mass index on response to therapy in psoriatic arthritis: Post-hoc analysis of results from the SEAM-PsA trial. J Rheumatol. 2022 (Apr 15). Doi: 10.3899/jrheum.211037

Key clinical point: More than one-third of real-world patients with psoriatic arthritis (PsA) who were not in minimal disease activity (MDA) at secukinumab initiation achieved MDA after 6 months of initiating secukinumab along with improvement in other patient-reported outcomes.

Major finding: At 6 months, 36.6% of patients not in MDA at secukinumab initiation achieved MDA and 41.2%, 44.4%, 60.7%, and 75.0% of patients with ≥1 tender joint, ≥1 swollen joint, enthesitis, and dactylitis, respectively, at secukinumab initiation achieved symptom resolution along with improvement in pain, fatigue, and other scores.

Study details: Findings are from an analysis of 100 patients with PsA from the CorEvitas Psoriatic Arthritis/Spondyloarthritis Registry who initiated secukinumab and maintained the treatment at 6-month follow-up visit.

Disclosures: This study was sponsored by CorEvitas, LLC. Three authors declared being employees of CorEvitas. The other authors reported ties with several sources.

Source: Mease PJ et al. Effectiveness of 6-month use of secukinumab in patients with psoriatic arthritis in the CorEvitas Psoriatic Arthritis/Spondyloarthritis Registry. J Rheumatol. 2022 (Apr 15). Doi: 10.3899/jrheum.211033

Key clinical point: More than one-third of real-world patients with psoriatic arthritis (PsA) who were not in minimal disease activity (MDA) at secukinumab initiation achieved MDA after 6 months of initiating secukinumab along with improvement in other patient-reported outcomes.

Major finding: At 6 months, 36.6% of patients not in MDA at secukinumab initiation achieved MDA and 41.2%, 44.4%, 60.7%, and 75.0% of patients with ≥1 tender joint, ≥1 swollen joint, enthesitis, and dactylitis, respectively, at secukinumab initiation achieved symptom resolution along with improvement in pain, fatigue, and other scores.

Study details: Findings are from an analysis of 100 patients with PsA from the CorEvitas Psoriatic Arthritis/Spondyloarthritis Registry who initiated secukinumab and maintained the treatment at 6-month follow-up visit.

Disclosures: This study was sponsored by CorEvitas, LLC. Three authors declared being employees of CorEvitas. The other authors reported ties with several sources.

Source: Mease PJ et al. Effectiveness of 6-month use of secukinumab in patients with psoriatic arthritis in the CorEvitas Psoriatic Arthritis/Spondyloarthritis Registry. J Rheumatol. 2022 (Apr 15). Doi: 10.3899/jrheum.211033

Key clinical point: More than one-third of real-world patients with psoriatic arthritis (PsA) who were not in minimal disease activity (MDA) at secukinumab initiation achieved MDA after 6 months of initiating secukinumab along with improvement in other patient-reported outcomes.

Major finding: At 6 months, 36.6% of patients not in MDA at secukinumab initiation achieved MDA and 41.2%, 44.4%, 60.7%, and 75.0% of patients with ≥1 tender joint, ≥1 swollen joint, enthesitis, and dactylitis, respectively, at secukinumab initiation achieved symptom resolution along with improvement in pain, fatigue, and other scores.

Study details: Findings are from an analysis of 100 patients with PsA from the CorEvitas Psoriatic Arthritis/Spondyloarthritis Registry who initiated secukinumab and maintained the treatment at 6-month follow-up visit.

Disclosures: This study was sponsored by CorEvitas, LLC. Three authors declared being employees of CorEvitas. The other authors reported ties with several sources.

Source: Mease PJ et al. Effectiveness of 6-month use of secukinumab in patients with psoriatic arthritis in the CorEvitas Psoriatic Arthritis/Spondyloarthritis Registry. J Rheumatol. 2022 (Apr 15). Doi: 10.3899/jrheum.211033

Key clinical point: The prevalence of migraine is higher in children and adolescents with attention deficit hyperactivity disorder (ADHD) vs those without.

Major finding: The risk of developing migraine was significantly higher in patients with ADHD than in matched controls (adjusted hazard ratio [aHR] 1.92; 95% CI 1.64-2.31) with the risk being prominent in children (aHR 2.01; 95% CI 1.63-2.49) and adolescents (aHR 1.94; 95% CI 1.35-2.79) but not in young adults with ADHD.

Study details: This was a nationwide longitudinal case-cohort study including 81,441 patients (including children, adolescents, and young adults aged 3-11, 12-17, and 18-29 years, respectively) with ADHD and 81,441 matched controls without ADHD.

Disclosures: The study was supported by grants from Taipei Veterans General Hospital; Kaohsiung Veterans General Hospital; Yen Tjing Ling Medical Foundation; and the Ministry of Science and Technology, Taiwan. The authors declared no conflicts of interest.

Source: Hsu T-W et al. Attention deficit hyperactivity disorder and risk of migraine: A nationwide longitudinal study. Headache. 2022 (May 6). Doi:  10.1111/head.14306

Key clinical point: The prevalence of migraine is higher in children and adolescents with attention deficit hyperactivity disorder (ADHD) vs those without.

Major finding: The risk of developing migraine was significantly higher in patients with ADHD than in matched controls (adjusted hazard ratio [aHR] 1.92; 95% CI 1.64-2.31) with the risk being prominent in children (aHR 2.01; 95% CI 1.63-2.49) and adolescents (aHR 1.94; 95% CI 1.35-2.79) but not in young adults with ADHD.

Study details: This was a nationwide longitudinal case-cohort study including 81,441 patients (including children, adolescents, and young adults aged 3-11, 12-17, and 18-29 years, respectively) with ADHD and 81,441 matched controls without ADHD.

Disclosures: The study was supported by grants from Taipei Veterans General Hospital; Kaohsiung Veterans General Hospital; Yen Tjing Ling Medical Foundation; and the Ministry of Science and Technology, Taiwan. The authors declared no conflicts of interest.

Source: Hsu T-W et al. Attention deficit hyperactivity disorder and risk of migraine: A nationwide longitudinal study. Headache. 2022 (May 6). Doi:  10.1111/head.14306

Key clinical point: The prevalence of migraine is higher in children and adolescents with attention deficit hyperactivity disorder (ADHD) vs those without.

Major finding: The risk of developing migraine was significantly higher in patients with ADHD than in matched controls (adjusted hazard ratio [aHR] 1.92; 95% CI 1.64-2.31) with the risk being prominent in children (aHR 2.01; 95% CI 1.63-2.49) and adolescents (aHR 1.94; 95% CI 1.35-2.79) but not in young adults with ADHD.

Study details: This was a nationwide longitudinal case-cohort study including 81,441 patients (including children, adolescents, and young adults aged 3-11, 12-17, and 18-29 years, respectively) with ADHD and 81,441 matched controls without ADHD.

Disclosures: The study was supported by grants from Taipei Veterans General Hospital; Kaohsiung Veterans General Hospital; Yen Tjing Ling Medical Foundation; and the Ministry of Science and Technology, Taiwan. The authors declared no conflicts of interest.

Source: Hsu T-W et al. Attention deficit hyperactivity disorder and risk of migraine: A nationwide longitudinal study. Headache. 2022 (May 6). Doi:  10.1111/head.14306

Key clinical point: Interictal levels of plasma glutamate are elevated in patients with episodic migraine (EM) and chronic migraine (CM), thus qualifying it as a potential marker for both EM and CM.

Major finding: Plasma glutamate levels were significantly higher in patients with EM (49.73 μmol/L [95% CI 40.82-66.12] ) and CM (58.70 μmol/L [95% CI 44.64-72.46]) vs control participants (38.79 μmol/L [95% CI 29.50-53.60]; P < .001).

Study details: This single-center study included 240 women aged 19-65 years, of which 98 had EM, 92 had CM, and 50 were nonmigraine control participants.

Disclosures: The study was supported by a National Research Foundation of Korea (NRF) grant from the Korean government. MK Chu declared serving as a site investigator for a multicenter trial and an advisory member for and receiving lecture honoraria and grants from various organizations, including NRF.

Source: Park CG, Chu MK. Interictal plasma glutamate levels are elevated in individuals with episodic and chronic migraine. Sci Rep. 2022;12:6921 (Apr 28). Doi: 10.1038/s41598-022-10883-9

Key clinical point: Interictal levels of plasma glutamate are elevated in patients with episodic migraine (EM) and chronic migraine (CM), thus qualifying it as a potential marker for both EM and CM.

Major finding: Plasma glutamate levels were significantly higher in patients with EM (49.73 μmol/L [95% CI 40.82-66.12] ) and CM (58.70 μmol/L [95% CI 44.64-72.46]) vs control participants (38.79 μmol/L [95% CI 29.50-53.60]; P < .001).

Study details: This single-center study included 240 women aged 19-65 years, of which 98 had EM, 92 had CM, and 50 were nonmigraine control participants.

Disclosures: The study was supported by a National Research Foundation of Korea (NRF) grant from the Korean government. MK Chu declared serving as a site investigator for a multicenter trial and an advisory member for and receiving lecture honoraria and grants from various organizations, including NRF.

Source: Park CG, Chu MK. Interictal plasma glutamate levels are elevated in individuals with episodic and chronic migraine. Sci Rep. 2022;12:6921 (Apr 28). Doi: 10.1038/s41598-022-10883-9

Key clinical point: Interictal levels of plasma glutamate are elevated in patients with episodic migraine (EM) and chronic migraine (CM), thus qualifying it as a potential marker for both EM and CM.

Major finding: Plasma glutamate levels were significantly higher in patients with EM (49.73 μmol/L [95% CI 40.82-66.12] ) and CM (58.70 μmol/L [95% CI 44.64-72.46]) vs control participants (38.79 μmol/L [95% CI 29.50-53.60]; P < .001).

Study details: This single-center study included 240 women aged 19-65 years, of which 98 had EM, 92 had CM, and 50 were nonmigraine control participants.

Disclosures: The study was supported by a National Research Foundation of Korea (NRF) grant from the Korean government. MK Chu declared serving as a site investigator for a multicenter trial and an advisory member for and receiving lecture honoraria and grants from various organizations, including NRF.

Source: Park CG, Chu MK. Interictal plasma glutamate levels are elevated in individuals with episodic and chronic migraine. Sci Rep. 2022;12:6921 (Apr 28). Doi: 10.1038/s41598-022-10883-9