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Journal of Supportive Oncology
| doi:10.1016/j.suponc.2011.04.009 |
| Permissions & Reprints |
Review
Joanne M. Bowen PhD, Rachel J. Gibson PhD, Dorothy M.K. Keefe MD, FRACP
Received 28 February 2011; Accepted 25 April 2011. Available online 24 September 2011.
Abstract
Alimentary mucositis is a major acute complication in the clinical setting, occurring in a large percentage of patients undergoing cytotoxic therapy. One of the major problems with alimentary mucositis is that the underlying mechanisms behind its development are not entirely understood, which makes it extremely difficult to develop effective interventions. Animal models provide a critical source of knowledge when sampling from patients is unavailable or interventions are yet to be fully tested. This review focuses on the animal models used to increase our understanding of the mechanisms of mucositis and translate new antimucotoxic agents into clinical trials.Correspondence to: Joanne M. Bowen, PhD, School of Medical Sciences, University of Adelaide, North Terrace, Adelaide, South Australia 5005; telephone: +61-8-83131374; fax: +61-8-8303 4408; email [email protected]
Volume 9, Issue 5, September-October 2011, Pages 161-168
Journal of Supportive Oncology
| doi:10.1016/j.suponc.2011.04.009 |
| Permissions & Reprints |
Review
Joanne M. Bowen PhD, Rachel J. Gibson PhD, Dorothy M.K. Keefe MD, FRACP
Received 28 February 2011; Accepted 25 April 2011. Available online 24 September 2011.
Abstract
Alimentary mucositis is a major acute complication in the clinical setting, occurring in a large percentage of patients undergoing cytotoxic therapy. One of the major problems with alimentary mucositis is that the underlying mechanisms behind its development are not entirely understood, which makes it extremely difficult to develop effective interventions. Animal models provide a critical source of knowledge when sampling from patients is unavailable or interventions are yet to be fully tested. This review focuses on the animal models used to increase our understanding of the mechanisms of mucositis and translate new antimucotoxic agents into clinical trials.Correspondence to: Joanne M. Bowen, PhD, School of Medical Sciences, University of Adelaide, North Terrace, Adelaide, South Australia 5005; telephone: +61-8-83131374; fax: +61-8-8303 4408; email [email protected]
Volume 9, Issue 5, September-October 2011, Pages 161-168
Journal of Supportive Oncology
| doi:10.1016/j.suponc.2011.04.009 |
| Permissions & Reprints |
Review
Joanne M. Bowen PhD, Rachel J. Gibson PhD, Dorothy M.K. Keefe MD, FRACP
Received 28 February 2011; Accepted 25 April 2011. Available online 24 September 2011.
Abstract
Alimentary mucositis is a major acute complication in the clinical setting, occurring in a large percentage of patients undergoing cytotoxic therapy. One of the major problems with alimentary mucositis is that the underlying mechanisms behind its development are not entirely understood, which makes it extremely difficult to develop effective interventions. Animal models provide a critical source of knowledge when sampling from patients is unavailable or interventions are yet to be fully tested. This review focuses on the animal models used to increase our understanding of the mechanisms of mucositis and translate new antimucotoxic agents into clinical trials.Correspondence to: Joanne M. Bowen, PhD, School of Medical Sciences, University of Adelaide, North Terrace, Adelaide, South Australia 5005; telephone: +61-8-83131374; fax: +61-8-8303 4408; email [email protected]
Volume 9, Issue 5, September-October 2011, Pages 161-168