Biliopancreatic endoscopic drainage improves EPI in patients with unresectable pancreatic cancer

Key clinical point: Among patients with unresectable pancreatic cancer undergoing endoscopic retrograde cholangiopancreatography (ERCP), biliopancreatic, but not biliary endoscopic drainage, was associated with improvement and normalization of exocrine pancreatic function.

Major finding: At baseline, 80% of patients had exocrine pancreatic insufficiency (EPI). The median absolute improvement of ¹³C-cumulative recovery rate was significantly higher after biliopancreatic vs biliary drainage (23.75% vs −1.92%; P = .015). Normalization of pancreatic function was observed in all patients after biliopancreatic drainage vs only 1 patient after biliary drainage.

Study details: Findings are from a prospective analysis of 20 adult patients with obstructive jaundice secondary to unresectable pancreatic cancer who underwent ERCP and were randomly assigned to receive either biliary drainage (n=7) or biliopancreatic drainage (n=6).

Disclosures: This study was supported by the Health Research Institute of Santiago de Compostela, Spain. The authors declared no conflict of interests.

Source: Domínguez-Muñoz JE et al. Pancreas. 2021 May 20. doi: 10.1097/MPA.0000000000001817.

Key clinical point: Among patients with unresectable pancreatic cancer undergoing endoscopic retrograde cholangiopancreatography (ERCP), biliopancreatic, but not biliary endoscopic drainage, was associated with improvement and normalization of exocrine pancreatic function.

Major finding: At baseline, 80% of patients had exocrine pancreatic insufficiency (EPI). The median absolute improvement of ¹³C-cumulative recovery rate was significantly higher after biliopancreatic vs biliary drainage (23.75% vs −1.92%; P = .015). Normalization of pancreatic function was observed in all patients after biliopancreatic drainage vs only 1 patient after biliary drainage.

Study details: Findings are from a prospective analysis of 20 adult patients with obstructive jaundice secondary to unresectable pancreatic cancer who underwent ERCP and were randomly assigned to receive either biliary drainage (n=7) or biliopancreatic drainage (n=6).

Disclosures: This study was supported by the Health Research Institute of Santiago de Compostela, Spain. The authors declared no conflict of interests.

Source: Domínguez-Muñoz JE et al. Pancreas. 2021 May 20. doi: 10.1097/MPA.0000000000001817.

Key clinical point: Among patients with unresectable pancreatic cancer undergoing endoscopic retrograde cholangiopancreatography (ERCP), biliopancreatic, but not biliary endoscopic drainage, was associated with improvement and normalization of exocrine pancreatic function.

Major finding: At baseline, 80% of patients had exocrine pancreatic insufficiency (EPI). The median absolute improvement of ¹³C-cumulative recovery rate was significantly higher after biliopancreatic vs biliary drainage (23.75% vs −1.92%; P = .015). Normalization of pancreatic function was observed in all patients after biliopancreatic drainage vs only 1 patient after biliary drainage.

Study details: Findings are from a prospective analysis of 20 adult patients with obstructive jaundice secondary to unresectable pancreatic cancer who underwent ERCP and were randomly assigned to receive either biliary drainage (n=7) or biliopancreatic drainage (n=6).

Disclosures: This study was supported by the Health Research Institute of Santiago de Compostela, Spain. The authors declared no conflict of interests.

Source: Domínguez-Muñoz JE et al. Pancreas. 2021 May 20. doi: 10.1097/MPA.0000000000001817.