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WASHINGTON — The risk of a nosocomial Clostridium difficile infection was doubled in one intensive care unit when patients occupied rooms that were previously occupied by an infected patient.
The finding was seen in a retrospective cohort study. Records were reviewed from 1,844 patients admitted over an 18-month period to a 20-bed intensive care unit at a large tertiary care hospital in Michigan. The increased risk was noted even though the unit observed cleaning protocols, and it persisted after correcting for other risk factors associated with C. difficile infection (CDI), according to Dr. Megan Shaughnessy of the University of Michigan, Ann Arbor.
In the study, 47 patients had CDI prior to or at the time of ICU admission and were excluded from the analysis. Another 91 patients were not infected and were placed in rooms previously occupied by patients with CDI; 10 (11%) developed CDI. Of the other 1,679 patients, 77 (4.6%) developed CDI.
The difference was statistically significant, with a P value of .002. Difference in risk remained significant, with a hazard ratio of 2.35 and P value of .01, even after researchers controlled for other risk factors associated with CDI, including patient age, Acute Physiology and Chronic Health Evaluation (APACHE) III score, proton pump inhibitor use, and antibiotic use.
“These findings have implications for room placement and isolation, room-cleaning practices, and hospital design,” Dr. Shaughnessy said at the jointly held annual Interscience Conference on Antimicrobial Agents and Chemotherapy and annual meeting of the Infectious Diseases Society of America.
Protocols for the intensive care unit dictated that bathrooms in patient rooms were cleaned daily with bleach, and that the rooms themselves were cleaned with bleach upon patient discharge. Further, infection risk didn't appear to vary depending on where in the room a patient was placed, according to Dr. Shaughnessy.
Dr. Shaughnessy stated that she had no disclosures.
WASHINGTON — The risk of a nosocomial Clostridium difficile infection was doubled in one intensive care unit when patients occupied rooms that were previously occupied by an infected patient.
The finding was seen in a retrospective cohort study. Records were reviewed from 1,844 patients admitted over an 18-month period to a 20-bed intensive care unit at a large tertiary care hospital in Michigan. The increased risk was noted even though the unit observed cleaning protocols, and it persisted after correcting for other risk factors associated with C. difficile infection (CDI), according to Dr. Megan Shaughnessy of the University of Michigan, Ann Arbor.
In the study, 47 patients had CDI prior to or at the time of ICU admission and were excluded from the analysis. Another 91 patients were not infected and were placed in rooms previously occupied by patients with CDI; 10 (11%) developed CDI. Of the other 1,679 patients, 77 (4.6%) developed CDI.
The difference was statistically significant, with a P value of .002. Difference in risk remained significant, with a hazard ratio of 2.35 and P value of .01, even after researchers controlled for other risk factors associated with CDI, including patient age, Acute Physiology and Chronic Health Evaluation (APACHE) III score, proton pump inhibitor use, and antibiotic use.
“These findings have implications for room placement and isolation, room-cleaning practices, and hospital design,” Dr. Shaughnessy said at the jointly held annual Interscience Conference on Antimicrobial Agents and Chemotherapy and annual meeting of the Infectious Diseases Society of America.
Protocols for the intensive care unit dictated that bathrooms in patient rooms were cleaned daily with bleach, and that the rooms themselves were cleaned with bleach upon patient discharge. Further, infection risk didn't appear to vary depending on where in the room a patient was placed, according to Dr. Shaughnessy.
Dr. Shaughnessy stated that she had no disclosures.
WASHINGTON — The risk of a nosocomial Clostridium difficile infection was doubled in one intensive care unit when patients occupied rooms that were previously occupied by an infected patient.
The finding was seen in a retrospective cohort study. Records were reviewed from 1,844 patients admitted over an 18-month period to a 20-bed intensive care unit at a large tertiary care hospital in Michigan. The increased risk was noted even though the unit observed cleaning protocols, and it persisted after correcting for other risk factors associated with C. difficile infection (CDI), according to Dr. Megan Shaughnessy of the University of Michigan, Ann Arbor.
In the study, 47 patients had CDI prior to or at the time of ICU admission and were excluded from the analysis. Another 91 patients were not infected and were placed in rooms previously occupied by patients with CDI; 10 (11%) developed CDI. Of the other 1,679 patients, 77 (4.6%) developed CDI.
The difference was statistically significant, with a P value of .002. Difference in risk remained significant, with a hazard ratio of 2.35 and P value of .01, even after researchers controlled for other risk factors associated with CDI, including patient age, Acute Physiology and Chronic Health Evaluation (APACHE) III score, proton pump inhibitor use, and antibiotic use.
“These findings have implications for room placement and isolation, room-cleaning practices, and hospital design,” Dr. Shaughnessy said at the jointly held annual Interscience Conference on Antimicrobial Agents and Chemotherapy and annual meeting of the Infectious Diseases Society of America.
Protocols for the intensive care unit dictated that bathrooms in patient rooms were cleaned daily with bleach, and that the rooms themselves were cleaned with bleach upon patient discharge. Further, infection risk didn't appear to vary depending on where in the room a patient was placed, according to Dr. Shaughnessy.
Dr. Shaughnessy stated that she had no disclosures.