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LOS ANGELES — Malignant and benign secondary brain tumors are a significant problem in childhood cancer survivors, especially those surviving leukemia and brain tumors, according to findings from the Childhood Cancer Survivor Study.
Exposure to cranial radiation increases the risk of these secondary tumors, which may arise years after treatment for the initial cancer, Joseph P. Neglia, M.D., reported at the annual meeting of the Child Neurology Society.
Of 14,327 survivors of childhood cancer—defined as those diagnosed with cancer before the age of 20—in the Childhood Cancer Survivor Study, 116 developed secondary brain tumors between 5 and 28 years after initial diagnosis. The tumors included 66 meningiomas, 40 gliomas, 6 primitive neuroectodermal tumors, 1 lymphoma, and 3 tumors for which the histology could not be determined. A total of 33 of the tumors—30 of the gliomas and 3 of the meningiomas—were malignant. The gliomas occurred sooner after the initial diagnosis (median 9 years) than the meningiomas (median 17 years) and were more common after primary leukemia, while meningiomas occurred more frequently after primary brain tumors, said Dr. Neglia of the University of Minnesota in Minneapolis.
“Radiation therapy exposure was associated with significant increased risks for the development of gliomas, meningiomas, or any central nervous system brain tumors,” he said.
Additionally, the study revealed a radiation dose-response relationship with glioma development.
“Patients who received radiotherapy doses between 3,000 and 4,490 cGy had the highest rate of glioma diagnoses,” Dr. Neglia said.
LOS ANGELES — Malignant and benign secondary brain tumors are a significant problem in childhood cancer survivors, especially those surviving leukemia and brain tumors, according to findings from the Childhood Cancer Survivor Study.
Exposure to cranial radiation increases the risk of these secondary tumors, which may arise years after treatment for the initial cancer, Joseph P. Neglia, M.D., reported at the annual meeting of the Child Neurology Society.
Of 14,327 survivors of childhood cancer—defined as those diagnosed with cancer before the age of 20—in the Childhood Cancer Survivor Study, 116 developed secondary brain tumors between 5 and 28 years after initial diagnosis. The tumors included 66 meningiomas, 40 gliomas, 6 primitive neuroectodermal tumors, 1 lymphoma, and 3 tumors for which the histology could not be determined. A total of 33 of the tumors—30 of the gliomas and 3 of the meningiomas—were malignant. The gliomas occurred sooner after the initial diagnosis (median 9 years) than the meningiomas (median 17 years) and were more common after primary leukemia, while meningiomas occurred more frequently after primary brain tumors, said Dr. Neglia of the University of Minnesota in Minneapolis.
“Radiation therapy exposure was associated with significant increased risks for the development of gliomas, meningiomas, or any central nervous system brain tumors,” he said.
Additionally, the study revealed a radiation dose-response relationship with glioma development.
“Patients who received radiotherapy doses between 3,000 and 4,490 cGy had the highest rate of glioma diagnoses,” Dr. Neglia said.
LOS ANGELES — Malignant and benign secondary brain tumors are a significant problem in childhood cancer survivors, especially those surviving leukemia and brain tumors, according to findings from the Childhood Cancer Survivor Study.
Exposure to cranial radiation increases the risk of these secondary tumors, which may arise years after treatment for the initial cancer, Joseph P. Neglia, M.D., reported at the annual meeting of the Child Neurology Society.
Of 14,327 survivors of childhood cancer—defined as those diagnosed with cancer before the age of 20—in the Childhood Cancer Survivor Study, 116 developed secondary brain tumors between 5 and 28 years after initial diagnosis. The tumors included 66 meningiomas, 40 gliomas, 6 primitive neuroectodermal tumors, 1 lymphoma, and 3 tumors for which the histology could not be determined. A total of 33 of the tumors—30 of the gliomas and 3 of the meningiomas—were malignant. The gliomas occurred sooner after the initial diagnosis (median 9 years) than the meningiomas (median 17 years) and were more common after primary leukemia, while meningiomas occurred more frequently after primary brain tumors, said Dr. Neglia of the University of Minnesota in Minneapolis.
“Radiation therapy exposure was associated with significant increased risks for the development of gliomas, meningiomas, or any central nervous system brain tumors,” he said.
Additionally, the study revealed a radiation dose-response relationship with glioma development.
“Patients who received radiotherapy doses between 3,000 and 4,490 cGy had the highest rate of glioma diagnoses,” Dr. Neglia said.