CLINICAL UPDATE A Novel TNF Inhibitor for RA: An Update

Examining Cardiovascular Risk in Systemic Lupus Erythematosus
Susan Manzi, MD, MPH
Associate Professor of Medicine
Division of Rheumatology and Clinical Immunology
Co-Director of the Lupus Center of Excellence
University of Pittsburgh Medical Center
Dr. Manzi has nothing to disclose.

Managing Cardiovascular Risk in Systemic Lupus Erythematosus
Daniel Edmundowicz, MD
Associate Professor of Medicine
Director, Preventive Cardiology
University of Pittsburgh Medical Center
Dr. Edmundowicz has no financial relationships to report. He discusses the off-label/investigational uses of commercial products.

The following educational activity is for primary care physicians and rheumatologists who provide care for patients with systemic lupus erythematosus.

As diagnosis and management of systemic lupus erythematosus (SLE) have improved, patient survival has increased substantially. In the process, the focus of care has shifted toward management of long-term consequences of the disease. In particular, cardiovascular disease (CVD) has emerged as a major source of morbidity and mortality among patients with SLE. Not uncommonly, SLE is associated with multiple CVD risk factors, resulting in a pathologic collaboration that greatly increases the risk of atherosclerosis and myocardial infarction in patients with SLE. The onus is on physicians to monitor CVD risk closely in patients with SLE to improve the chances of early recognition and afford the opportunity for aggressive intervention to keep risk factors at bay.

After completing this educational activity, participants should be able to:

• Understand and appreciate the increased CVD risk faced by patients with SLE.

• Identify CVD risk factors that can be minimized by intervention.

• Recognize the need for ongoing clinical vigilance, early recognition, and aggressive treatment of CVD risk factors.

• Identify therapies that can help reduce the CVD risk in patients with SLE.

This activity has been planned and implemented in accordance with the Essential Areas and Policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of the Elsevier Office of Continuing Medical Education (EOCME) and Rheumatology News. The EOCME is accredited by the ACCME to provide continuing medical education (CME) for physicians.

The EOCME designates this educational activity for a maximum of 1 AMA PRA Category 1 Credit^TM. Physicians should only claim credit commensurate with the extent of their participation in the activity.

Term of Approval: May 2007-May 31, 2008.

Copyright © 2007 Elsevier Inc.

Examining Cardiovascular Risk in Systemic Lupus Erythematosus
Susan Manzi, MD, MPH
Associate Professor of Medicine
Division of Rheumatology and Clinical Immunology
Co-Director of the Lupus Center of Excellence
University of Pittsburgh Medical Center
Dr. Manzi has nothing to disclose.

Managing Cardiovascular Risk in Systemic Lupus Erythematosus
Daniel Edmundowicz, MD
Associate Professor of Medicine
Director, Preventive Cardiology
University of Pittsburgh Medical Center
Dr. Edmundowicz has no financial relationships to report. He discusses the off-label/investigational uses of commercial products.

The following educational activity is for primary care physicians and rheumatologists who provide care for patients with systemic lupus erythematosus.

As diagnosis and management of systemic lupus erythematosus (SLE) have improved, patient survival has increased substantially. In the process, the focus of care has shifted toward management of long-term consequences of the disease. In particular, cardiovascular disease (CVD) has emerged as a major source of morbidity and mortality among patients with SLE. Not uncommonly, SLE is associated with multiple CVD risk factors, resulting in a pathologic collaboration that greatly increases the risk of atherosclerosis and myocardial infarction in patients with SLE. The onus is on physicians to monitor CVD risk closely in patients with SLE to improve the chances of early recognition and afford the opportunity for aggressive intervention to keep risk factors at bay.

After completing this educational activity, participants should be able to:

• Understand and appreciate the increased CVD risk faced by patients with SLE.

• Identify CVD risk factors that can be minimized by intervention.

• Recognize the need for ongoing clinical vigilance, early recognition, and aggressive treatment of CVD risk factors.

• Identify therapies that can help reduce the CVD risk in patients with SLE.

This activity has been planned and implemented in accordance with the Essential Areas and Policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of the Elsevier Office of Continuing Medical Education (EOCME) and Rheumatology News. The EOCME is accredited by the ACCME to provide continuing medical education (CME) for physicians.

The EOCME designates this educational activity for a maximum of 1 AMA PRA Category 1 Credit^TM. Physicians should only claim credit commensurate with the extent of their participation in the activity.

Term of Approval: May 2007-May 31, 2008.

Copyright © 2007 Elsevier Inc.

Examining Cardiovascular Risk in Systemic Lupus Erythematosus
Susan Manzi, MD, MPH
Associate Professor of Medicine
Division of Rheumatology and Clinical Immunology
Co-Director of the Lupus Center of Excellence
University of Pittsburgh Medical Center
Dr. Manzi has nothing to disclose.

Managing Cardiovascular Risk in Systemic Lupus Erythematosus
Daniel Edmundowicz, MD
Associate Professor of Medicine
Director, Preventive Cardiology
University of Pittsburgh Medical Center
Dr. Edmundowicz has no financial relationships to report. He discusses the off-label/investigational uses of commercial products.

The following educational activity is for primary care physicians and rheumatologists who provide care for patients with systemic lupus erythematosus.

As diagnosis and management of systemic lupus erythematosus (SLE) have improved, patient survival has increased substantially. In the process, the focus of care has shifted toward management of long-term consequences of the disease. In particular, cardiovascular disease (CVD) has emerged as a major source of morbidity and mortality among patients with SLE. Not uncommonly, SLE is associated with multiple CVD risk factors, resulting in a pathologic collaboration that greatly increases the risk of atherosclerosis and myocardial infarction in patients with SLE. The onus is on physicians to monitor CVD risk closely in patients with SLE to improve the chances of early recognition and afford the opportunity for aggressive intervention to keep risk factors at bay.

After completing this educational activity, participants should be able to:

• Understand and appreciate the increased CVD risk faced by patients with SLE.

• Identify CVD risk factors that can be minimized by intervention.

• Recognize the need for ongoing clinical vigilance, early recognition, and aggressive treatment of CVD risk factors.

• Identify therapies that can help reduce the CVD risk in patients with SLE.

This activity has been planned and implemented in accordance with the Essential Areas and Policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of the Elsevier Office of Continuing Medical Education (EOCME) and Rheumatology News. The EOCME is accredited by the ACCME to provide continuing medical education (CME) for physicians.

The EOCME designates this educational activity for a maximum of 1 AMA PRA Category 1 Credit^TM. Physicians should only claim credit commensurate with the extent of their participation in the activity.

Term of Approval: May 2007-May 31, 2008.

Copyright © 2007 Elsevier Inc.