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Key clinical point: Concentrations of echinocandin penetration into wound secretions may be sub-therapeutic in some patients, and the relevance to clinical outcomes in patients with severe invasive candidiasis infections remains unclear.
Major finding: Concentrations of echinocandins in wound secretions were significantly lower than simultaneous plasma concentrations, and measured less than 0.025 mg/L-2.25 mg/L for anidulafungin; 0.025 mg/L-2.53 mg/L for micafungin; and 0.18 mg/L-4.04 mg/L for caspofungin.
Study details: The data come from 21 critically ill adults with suspected or confirmed invasive fungal infections who were treated with an echinocandins anidulafungin (AFG), micafungin (MFG), and caspofungin (CAS); concentrations in wound secretion were measured using liquid chromatography or tandem mass spectrometry detection.
Disclosures: The study was supported by the University of Innsbruck and Medical University of Innsbruck, and by the Austrian Science Fund. The researchers had no financial conflicts to disclose.
Source: Gasperetti T et al. Infection. 2021 Apr 20. doi: 10.1007/s15010-021-01604-x.
Key clinical point: Concentrations of echinocandin penetration into wound secretions may be sub-therapeutic in some patients, and the relevance to clinical outcomes in patients with severe invasive candidiasis infections remains unclear.
Major finding: Concentrations of echinocandins in wound secretions were significantly lower than simultaneous plasma concentrations, and measured less than 0.025 mg/L-2.25 mg/L for anidulafungin; 0.025 mg/L-2.53 mg/L for micafungin; and 0.18 mg/L-4.04 mg/L for caspofungin.
Study details: The data come from 21 critically ill adults with suspected or confirmed invasive fungal infections who were treated with an echinocandins anidulafungin (AFG), micafungin (MFG), and caspofungin (CAS); concentrations in wound secretion were measured using liquid chromatography or tandem mass spectrometry detection.
Disclosures: The study was supported by the University of Innsbruck and Medical University of Innsbruck, and by the Austrian Science Fund. The researchers had no financial conflicts to disclose.
Source: Gasperetti T et al. Infection. 2021 Apr 20. doi: 10.1007/s15010-021-01604-x.
Key clinical point: Concentrations of echinocandin penetration into wound secretions may be sub-therapeutic in some patients, and the relevance to clinical outcomes in patients with severe invasive candidiasis infections remains unclear.
Major finding: Concentrations of echinocandins in wound secretions were significantly lower than simultaneous plasma concentrations, and measured less than 0.025 mg/L-2.25 mg/L for anidulafungin; 0.025 mg/L-2.53 mg/L for micafungin; and 0.18 mg/L-4.04 mg/L for caspofungin.
Study details: The data come from 21 critically ill adults with suspected or confirmed invasive fungal infections who were treated with an echinocandins anidulafungin (AFG), micafungin (MFG), and caspofungin (CAS); concentrations in wound secretion were measured using liquid chromatography or tandem mass spectrometry detection.
Disclosures: The study was supported by the University of Innsbruck and Medical University of Innsbruck, and by the Austrian Science Fund. The researchers had no financial conflicts to disclose.
Source: Gasperetti T et al. Infection. 2021 Apr 20. doi: 10.1007/s15010-021-01604-x.