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Key clinical point: Heparin-binding protein (HBP) may outperform the conventional biomarkers in predicting disease progression in children with severe community-acquired pneumonia (CAP).
Main finding: After adjusting for age, high HBP levels showed an independent correlation with respiratory failure (RF; odds ratio [OR] 1.008; 95% CI 1.003-1.013) in children with severe CAP. Among other biomarkers, HBP exhibited the highest predictive power for identifying children developing RF or sepsis, yielding areas under the receiver operating characteristic curves of 0.68 and 0.85, respectively, along with the best specificity at 96.3%.
Study details: Findings are from a retrospective observational study on 157 children who were admitted to an ICU ward for severe CAP, of which 106 presented with RF and 48 developed sepsis.
Disclosures: The study was sponsored by the Changsha Science and Technology Bureau Science Foundation, China. The authors declared no conflict of interests.
Source: Huang C et al. Front Pediatr. 2021 (Oct 28). Doi: 10.3389/fped.2021.759535.
Key clinical point: Heparin-binding protein (HBP) may outperform the conventional biomarkers in predicting disease progression in children with severe community-acquired pneumonia (CAP).
Main finding: After adjusting for age, high HBP levels showed an independent correlation with respiratory failure (RF; odds ratio [OR] 1.008; 95% CI 1.003-1.013) in children with severe CAP. Among other biomarkers, HBP exhibited the highest predictive power for identifying children developing RF or sepsis, yielding areas under the receiver operating characteristic curves of 0.68 and 0.85, respectively, along with the best specificity at 96.3%.
Study details: Findings are from a retrospective observational study on 157 children who were admitted to an ICU ward for severe CAP, of which 106 presented with RF and 48 developed sepsis.
Disclosures: The study was sponsored by the Changsha Science and Technology Bureau Science Foundation, China. The authors declared no conflict of interests.
Source: Huang C et al. Front Pediatr. 2021 (Oct 28). Doi: 10.3389/fped.2021.759535.
Key clinical point: Heparin-binding protein (HBP) may outperform the conventional biomarkers in predicting disease progression in children with severe community-acquired pneumonia (CAP).
Main finding: After adjusting for age, high HBP levels showed an independent correlation with respiratory failure (RF; odds ratio [OR] 1.008; 95% CI 1.003-1.013) in children with severe CAP. Among other biomarkers, HBP exhibited the highest predictive power for identifying children developing RF or sepsis, yielding areas under the receiver operating characteristic curves of 0.68 and 0.85, respectively, along with the best specificity at 96.3%.
Study details: Findings are from a retrospective observational study on 157 children who were admitted to an ICU ward for severe CAP, of which 106 presented with RF and 48 developed sepsis.
Disclosures: The study was sponsored by the Changsha Science and Technology Bureau Science Foundation, China. The authors declared no conflict of interests.
Source: Huang C et al. Front Pediatr. 2021 (Oct 28). Doi: 10.3389/fped.2021.759535.