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Men with prostate cancer may be wise to watch their waistlines, according to the findings of a large observational study in which patients with the highest waist measurements had a higher chance of dying from prostate cancer.
Researchers found that, over a 10.8-year period, men with the largest waist circumferences appeared 35% more likely to die from prostate cancer, when compared to men with the smallest waist circumferences (hazard ratio = 1.35, 95% confidence interval [CI], 1.05–1.73).
Men in the highest quartile for waist-to-hip ratio measurements also had a 34% higher risk of dying from prostate cancer, when compared to men in the lowest quartile (HR = 1.34, 95% CI, 1.04–1.72).
There was no association between the total body fat percentage (HR = 1.00, 95% CI, 0.79–1.28) or body mass index (HR = 1.00, 95% CI, 0.78–1.28) and the risk for prostate cancer death.
The findings – reported in a late-breaking poster at the European and International Conference on Obesity (ECOICO) – provide further insight into how fat and its distribution may be associated with prostate cancer death.
A ‘complex’ relationship
“Obesity is a known risk factor for many cancer sites, but its association with prostate cancer is less clear. It’s very complex,” said study investigator Aurora Pérez-Cornago, PhD, a nutritional epidemiologist in the Nuffield Department of Population Health at University of Oxford, England.
Three years ago, Dr. Pérez-Cornago and collaborators looked for risk factors for prostate cancer among men who had volunteered to participate in the prospective UK Biobank cohort study.
One of the group’s findings was that excess adiposity and body fat were not associated with an increase in the development of prostate cancer (Br J Cancer. 2017 Nov 7;117[10]:1562-71). In fact, these factors were associated with a lower risk. This inverse association likely had more to do with prostate-specific antigen screening than a true effect of body weight, as men with obesity were potentially less likely to be screened or have lower prostate-specific antigen levels, Dr. Pérez-Cornago said.
For the present study, attention was turned to men with aggressive prostate tumors as “these are the kind of tumors we are more interested in because they are the ones that can kill these men,” Dr. Pérez-Cornago said.
There was also previous evidence suggesting that adiposity may be associated with a higher risk of aggressive disease.
Data on 218,225 men with no previous cancer when they enrolled in the UK Biobank cohort study were linked to health care administrative databases that provided information on prostate cancer deaths. This showed that 571 men died from prostate cancer over a 10.8-year follow-up period.
“When we looked at the association of adiposity measurements – we looked at [body mass index] and body fat percentage as markers of total adiposity, and waist circumference and waist-to-hip ratio as markers of central adiposity – we found that the association seems to be more specific for fat located around the waist,” Dr. Pérez-Cornago said.
“Excessive fat accumulation around your belly is likely to be visceral fat, which may induce metabolic and hormonal dysfunction that, in turn, may help prostate cancer cells to develop and to progress,” she added.
Study strengths and next steps
As this was an observational study, the researchers could not confirm a causal association between central adiposity and prostate cancer death. That is why Dr. Perez-Cornago and collaborators plan to do further work that will include biomarker studies. The team also will look at stage and grade data when available in the UK Biobank.
“There is strong evidence that men with greater body fat are at a higher risk of advanced and fatal prostate cancer. It is time to build on this,” said Barbra Dickerman, PhD, who has looked at the relationship between obesity and prostate cancer progression (Cancer. 2019 Aug 15;125[16]:2877-85).
“First, predictive analyses of directly measured body fat distribution may sharpen our view of who is at the highest risk,” observed Dr. Dickerman, a research fellow in the department of epidemiology at Harvard T.H. Chan School of Public Health in Boston.
“Second, causal analyses of precisely defined energy balance strategies may help to identify targeted prevention strategies that minimize that risk,” she added.
One of the strengths of Dr. Pérez-Cornago’s work was that it used data from a large, prospective study to examine the link between adiposity and the risk of fatal prostate cancer, observed Ying Wang, PhD, a senior principal scientist of epidemiology research at The American Cancer Society.
“In addition to the large sample size, anthropometric measurements were obtained by trained research clinic staff rather than self-reported by participants, which is a strength compared with many other studies,” Dr. Wang noted.
Furthermore, Dr. Wang said, “The study was also able to control for multiple confounders, including lifestyle factors such as smoking and physical activity. Future studies need to confirm their findings.”
The study was supported by a fellowship from Cancer Research UK. The investigators, Dr. Dickerman, and Dr. Wang had no conflicts of interest to disclose.
SOURCE: Pérez-Cornago A et al. ECOICO 2020. LBP-075.
Men with prostate cancer may be wise to watch their waistlines, according to the findings of a large observational study in which patients with the highest waist measurements had a higher chance of dying from prostate cancer.
Researchers found that, over a 10.8-year period, men with the largest waist circumferences appeared 35% more likely to die from prostate cancer, when compared to men with the smallest waist circumferences (hazard ratio = 1.35, 95% confidence interval [CI], 1.05–1.73).
Men in the highest quartile for waist-to-hip ratio measurements also had a 34% higher risk of dying from prostate cancer, when compared to men in the lowest quartile (HR = 1.34, 95% CI, 1.04–1.72).
There was no association between the total body fat percentage (HR = 1.00, 95% CI, 0.79–1.28) or body mass index (HR = 1.00, 95% CI, 0.78–1.28) and the risk for prostate cancer death.
The findings – reported in a late-breaking poster at the European and International Conference on Obesity (ECOICO) – provide further insight into how fat and its distribution may be associated with prostate cancer death.
A ‘complex’ relationship
“Obesity is a known risk factor for many cancer sites, but its association with prostate cancer is less clear. It’s very complex,” said study investigator Aurora Pérez-Cornago, PhD, a nutritional epidemiologist in the Nuffield Department of Population Health at University of Oxford, England.
Three years ago, Dr. Pérez-Cornago and collaborators looked for risk factors for prostate cancer among men who had volunteered to participate in the prospective UK Biobank cohort study.
One of the group’s findings was that excess adiposity and body fat were not associated with an increase in the development of prostate cancer (Br J Cancer. 2017 Nov 7;117[10]:1562-71). In fact, these factors were associated with a lower risk. This inverse association likely had more to do with prostate-specific antigen screening than a true effect of body weight, as men with obesity were potentially less likely to be screened or have lower prostate-specific antigen levels, Dr. Pérez-Cornago said.
For the present study, attention was turned to men with aggressive prostate tumors as “these are the kind of tumors we are more interested in because they are the ones that can kill these men,” Dr. Pérez-Cornago said.
There was also previous evidence suggesting that adiposity may be associated with a higher risk of aggressive disease.
Data on 218,225 men with no previous cancer when they enrolled in the UK Biobank cohort study were linked to health care administrative databases that provided information on prostate cancer deaths. This showed that 571 men died from prostate cancer over a 10.8-year follow-up period.
“When we looked at the association of adiposity measurements – we looked at [body mass index] and body fat percentage as markers of total adiposity, and waist circumference and waist-to-hip ratio as markers of central adiposity – we found that the association seems to be more specific for fat located around the waist,” Dr. Pérez-Cornago said.
“Excessive fat accumulation around your belly is likely to be visceral fat, which may induce metabolic and hormonal dysfunction that, in turn, may help prostate cancer cells to develop and to progress,” she added.
Study strengths and next steps
As this was an observational study, the researchers could not confirm a causal association between central adiposity and prostate cancer death. That is why Dr. Perez-Cornago and collaborators plan to do further work that will include biomarker studies. The team also will look at stage and grade data when available in the UK Biobank.
“There is strong evidence that men with greater body fat are at a higher risk of advanced and fatal prostate cancer. It is time to build on this,” said Barbra Dickerman, PhD, who has looked at the relationship between obesity and prostate cancer progression (Cancer. 2019 Aug 15;125[16]:2877-85).
“First, predictive analyses of directly measured body fat distribution may sharpen our view of who is at the highest risk,” observed Dr. Dickerman, a research fellow in the department of epidemiology at Harvard T.H. Chan School of Public Health in Boston.
“Second, causal analyses of precisely defined energy balance strategies may help to identify targeted prevention strategies that minimize that risk,” she added.
One of the strengths of Dr. Pérez-Cornago’s work was that it used data from a large, prospective study to examine the link between adiposity and the risk of fatal prostate cancer, observed Ying Wang, PhD, a senior principal scientist of epidemiology research at The American Cancer Society.
“In addition to the large sample size, anthropometric measurements were obtained by trained research clinic staff rather than self-reported by participants, which is a strength compared with many other studies,” Dr. Wang noted.
Furthermore, Dr. Wang said, “The study was also able to control for multiple confounders, including lifestyle factors such as smoking and physical activity. Future studies need to confirm their findings.”
The study was supported by a fellowship from Cancer Research UK. The investigators, Dr. Dickerman, and Dr. Wang had no conflicts of interest to disclose.
SOURCE: Pérez-Cornago A et al. ECOICO 2020. LBP-075.
Men with prostate cancer may be wise to watch their waistlines, according to the findings of a large observational study in which patients with the highest waist measurements had a higher chance of dying from prostate cancer.
Researchers found that, over a 10.8-year period, men with the largest waist circumferences appeared 35% more likely to die from prostate cancer, when compared to men with the smallest waist circumferences (hazard ratio = 1.35, 95% confidence interval [CI], 1.05–1.73).
Men in the highest quartile for waist-to-hip ratio measurements also had a 34% higher risk of dying from prostate cancer, when compared to men in the lowest quartile (HR = 1.34, 95% CI, 1.04–1.72).
There was no association between the total body fat percentage (HR = 1.00, 95% CI, 0.79–1.28) or body mass index (HR = 1.00, 95% CI, 0.78–1.28) and the risk for prostate cancer death.
The findings – reported in a late-breaking poster at the European and International Conference on Obesity (ECOICO) – provide further insight into how fat and its distribution may be associated with prostate cancer death.
A ‘complex’ relationship
“Obesity is a known risk factor for many cancer sites, but its association with prostate cancer is less clear. It’s very complex,” said study investigator Aurora Pérez-Cornago, PhD, a nutritional epidemiologist in the Nuffield Department of Population Health at University of Oxford, England.
Three years ago, Dr. Pérez-Cornago and collaborators looked for risk factors for prostate cancer among men who had volunteered to participate in the prospective UK Biobank cohort study.
One of the group’s findings was that excess adiposity and body fat were not associated with an increase in the development of prostate cancer (Br J Cancer. 2017 Nov 7;117[10]:1562-71). In fact, these factors were associated with a lower risk. This inverse association likely had more to do with prostate-specific antigen screening than a true effect of body weight, as men with obesity were potentially less likely to be screened or have lower prostate-specific antigen levels, Dr. Pérez-Cornago said.
For the present study, attention was turned to men with aggressive prostate tumors as “these are the kind of tumors we are more interested in because they are the ones that can kill these men,” Dr. Pérez-Cornago said.
There was also previous evidence suggesting that adiposity may be associated with a higher risk of aggressive disease.
Data on 218,225 men with no previous cancer when they enrolled in the UK Biobank cohort study were linked to health care administrative databases that provided information on prostate cancer deaths. This showed that 571 men died from prostate cancer over a 10.8-year follow-up period.
“When we looked at the association of adiposity measurements – we looked at [body mass index] and body fat percentage as markers of total adiposity, and waist circumference and waist-to-hip ratio as markers of central adiposity – we found that the association seems to be more specific for fat located around the waist,” Dr. Pérez-Cornago said.
“Excessive fat accumulation around your belly is likely to be visceral fat, which may induce metabolic and hormonal dysfunction that, in turn, may help prostate cancer cells to develop and to progress,” she added.
Study strengths and next steps
As this was an observational study, the researchers could not confirm a causal association between central adiposity and prostate cancer death. That is why Dr. Perez-Cornago and collaborators plan to do further work that will include biomarker studies. The team also will look at stage and grade data when available in the UK Biobank.
“There is strong evidence that men with greater body fat are at a higher risk of advanced and fatal prostate cancer. It is time to build on this,” said Barbra Dickerman, PhD, who has looked at the relationship between obesity and prostate cancer progression (Cancer. 2019 Aug 15;125[16]:2877-85).
“First, predictive analyses of directly measured body fat distribution may sharpen our view of who is at the highest risk,” observed Dr. Dickerman, a research fellow in the department of epidemiology at Harvard T.H. Chan School of Public Health in Boston.
“Second, causal analyses of precisely defined energy balance strategies may help to identify targeted prevention strategies that minimize that risk,” she added.
One of the strengths of Dr. Pérez-Cornago’s work was that it used data from a large, prospective study to examine the link between adiposity and the risk of fatal prostate cancer, observed Ying Wang, PhD, a senior principal scientist of epidemiology research at The American Cancer Society.
“In addition to the large sample size, anthropometric measurements were obtained by trained research clinic staff rather than self-reported by participants, which is a strength compared with many other studies,” Dr. Wang noted.
Furthermore, Dr. Wang said, “The study was also able to control for multiple confounders, including lifestyle factors such as smoking and physical activity. Future studies need to confirm their findings.”
The study was supported by a fellowship from Cancer Research UK. The investigators, Dr. Dickerman, and Dr. Wang had no conflicts of interest to disclose.
SOURCE: Pérez-Cornago A et al. ECOICO 2020. LBP-075.
FROM ECOICO 2020