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Key clinical point: Trastuzumab deruxtecan can be considered a safe treatment option in patients with metastatic breast cancer (BC) given the low incidence of interstitial lung disease (ILD) and cardiotoxicity events and the fact that a 5.4 mg/kg dosing is significantly safer than a 6.4 mg/kg dosing.
Major finding: The incidence rate of ILD was 11.7%, with ILD being reported in a significantly higher proportion of patients receiving 6.4 mg/kg vs 5.4 mg/kg (22.7% vs 10.2%; P < .01) of trastuzumab deruxtecan. The majority (80.2%) of ILD cases were of grade 1 or 2 and mostly manageable. Cardiotoxicity measured by decreased left ventricular ejection fraction was reported in 1.95% patients.
Study details: Findings are from a meta-analysis of 15 studies including 1970 patients with metastatic BC who received ≥ 1 dose of trastuzumab deruxtecan.
Disclosures: This study did not disclose any funding source. The authors declared no conflicts of interest.
Source: Soares LR et al. Incidence of interstitial lung disease and cardiotoxicity with trastuzumab deruxtecan in breast cancer patients: A systematic review and single-arm meta-analysis. ESMO Open. 2023;8(4):101613 (Jul 21). doi: 10.1016/j.esmoop.2023.101613
Key clinical point: Trastuzumab deruxtecan can be considered a safe treatment option in patients with metastatic breast cancer (BC) given the low incidence of interstitial lung disease (ILD) and cardiotoxicity events and the fact that a 5.4 mg/kg dosing is significantly safer than a 6.4 mg/kg dosing.
Major finding: The incidence rate of ILD was 11.7%, with ILD being reported in a significantly higher proportion of patients receiving 6.4 mg/kg vs 5.4 mg/kg (22.7% vs 10.2%; P < .01) of trastuzumab deruxtecan. The majority (80.2%) of ILD cases were of grade 1 or 2 and mostly manageable. Cardiotoxicity measured by decreased left ventricular ejection fraction was reported in 1.95% patients.
Study details: Findings are from a meta-analysis of 15 studies including 1970 patients with metastatic BC who received ≥ 1 dose of trastuzumab deruxtecan.
Disclosures: This study did not disclose any funding source. The authors declared no conflicts of interest.
Source: Soares LR et al. Incidence of interstitial lung disease and cardiotoxicity with trastuzumab deruxtecan in breast cancer patients: A systematic review and single-arm meta-analysis. ESMO Open. 2023;8(4):101613 (Jul 21). doi: 10.1016/j.esmoop.2023.101613
Key clinical point: Trastuzumab deruxtecan can be considered a safe treatment option in patients with metastatic breast cancer (BC) given the low incidence of interstitial lung disease (ILD) and cardiotoxicity events and the fact that a 5.4 mg/kg dosing is significantly safer than a 6.4 mg/kg dosing.
Major finding: The incidence rate of ILD was 11.7%, with ILD being reported in a significantly higher proportion of patients receiving 6.4 mg/kg vs 5.4 mg/kg (22.7% vs 10.2%; P < .01) of trastuzumab deruxtecan. The majority (80.2%) of ILD cases were of grade 1 or 2 and mostly manageable. Cardiotoxicity measured by decreased left ventricular ejection fraction was reported in 1.95% patients.
Study details: Findings are from a meta-analysis of 15 studies including 1970 patients with metastatic BC who received ≥ 1 dose of trastuzumab deruxtecan.
Disclosures: This study did not disclose any funding source. The authors declared no conflicts of interest.
Source: Soares LR et al. Incidence of interstitial lung disease and cardiotoxicity with trastuzumab deruxtecan in breast cancer patients: A systematic review and single-arm meta-analysis. ESMO Open. 2023;8(4):101613 (Jul 21). doi: 10.1016/j.esmoop.2023.101613