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Key clinical point: Over a 10-year period, an unexpected high prevalence of vitamin D overdosing was observed in patients with cystic fibrosis with odds of overdose higher in patients suffering from exocrine pancreatic insufficiency (EPI).
Major finding: Severe vitamin D overdose was observed in 5.3% of patients, with 2 patients developing clinical toxicity and presenting with severe hypercalcemia, hypercalciuria, and acute kidney injury necessitating hospitalization and monitoring. Patients experiencing vitamin D overdose were more likely to suffer from EPI or were homozygous for F508del.
Study details: Findings are from a retrospective review of 244 patients with a diagnosis of cystic fibrosis and at least 1 measure of serum 25(OH)D.
Disclosures: No specific funding source was identified. The authors declared no conflicts of interest.
Source: Planté-Bordeneuve T et al. Sci Rep. 2021 Apr 8. doi: 10.1038/s41598-021-87099-w.
Key clinical point: Over a 10-year period, an unexpected high prevalence of vitamin D overdosing was observed in patients with cystic fibrosis with odds of overdose higher in patients suffering from exocrine pancreatic insufficiency (EPI).
Major finding: Severe vitamin D overdose was observed in 5.3% of patients, with 2 patients developing clinical toxicity and presenting with severe hypercalcemia, hypercalciuria, and acute kidney injury necessitating hospitalization and monitoring. Patients experiencing vitamin D overdose were more likely to suffer from EPI or were homozygous for F508del.
Study details: Findings are from a retrospective review of 244 patients with a diagnosis of cystic fibrosis and at least 1 measure of serum 25(OH)D.
Disclosures: No specific funding source was identified. The authors declared no conflicts of interest.
Source: Planté-Bordeneuve T et al. Sci Rep. 2021 Apr 8. doi: 10.1038/s41598-021-87099-w.
Key clinical point: Over a 10-year period, an unexpected high prevalence of vitamin D overdosing was observed in patients with cystic fibrosis with odds of overdose higher in patients suffering from exocrine pancreatic insufficiency (EPI).
Major finding: Severe vitamin D overdose was observed in 5.3% of patients, with 2 patients developing clinical toxicity and presenting with severe hypercalcemia, hypercalciuria, and acute kidney injury necessitating hospitalization and monitoring. Patients experiencing vitamin D overdose were more likely to suffer from EPI or were homozygous for F508del.
Study details: Findings are from a retrospective review of 244 patients with a diagnosis of cystic fibrosis and at least 1 measure of serum 25(OH)D.
Disclosures: No specific funding source was identified. The authors declared no conflicts of interest.
Source: Planté-Bordeneuve T et al. Sci Rep. 2021 Apr 8. doi: 10.1038/s41598-021-87099-w.