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Key clinical point: Multiple bodily symptoms, female sex, and prior use of proton pump inhibitors (PPI) are the risk factors for irritable bowel syndrome (IBS) onset, with prior psychiatric disorder being the strongest risk factor.
Major finding: The presence of ≥2 prior psychiatric disorders was the strongest predictor of subsequent IBS (odds ratio [OR] 2.74; P = .006), with other risk factors in patients with prior psychiatric disorders being female sex (OR 1.87) and prior use of PPI (OR 1.73; both P < .001). Among patients without prior psychiatric disorder history, female sex (OR 4.24), fibromyalgia (OR 1.88), and prior PPI use (OR 1.73; all P < .001) most strongly predicted IBS onset.
Study details: Findings are from a prospective, population-based cohort study including 132,922 participants without prior IBS or IBS medication use at baseline who were followed-up twice during subsequent 3 years.
Disclosures: This study did not receive any funding. No conflicts of interest were declared.
Source: Creed F. Risk factors for self-reported irritable bowel syndrome with prior psychiatric disorder: The Lifelines cohort study. J Neurogastroenterol Motil. 2022;28(3):442-453 (Jul 30). Doi: 10.5056/jnm21041
Key clinical point: Multiple bodily symptoms, female sex, and prior use of proton pump inhibitors (PPI) are the risk factors for irritable bowel syndrome (IBS) onset, with prior psychiatric disorder being the strongest risk factor.
Major finding: The presence of ≥2 prior psychiatric disorders was the strongest predictor of subsequent IBS (odds ratio [OR] 2.74; P = .006), with other risk factors in patients with prior psychiatric disorders being female sex (OR 1.87) and prior use of PPI (OR 1.73; both P < .001). Among patients without prior psychiatric disorder history, female sex (OR 4.24), fibromyalgia (OR 1.88), and prior PPI use (OR 1.73; all P < .001) most strongly predicted IBS onset.
Study details: Findings are from a prospective, population-based cohort study including 132,922 participants without prior IBS or IBS medication use at baseline who were followed-up twice during subsequent 3 years.
Disclosures: This study did not receive any funding. No conflicts of interest were declared.
Source: Creed F. Risk factors for self-reported irritable bowel syndrome with prior psychiatric disorder: The Lifelines cohort study. J Neurogastroenterol Motil. 2022;28(3):442-453 (Jul 30). Doi: 10.5056/jnm21041
Key clinical point: Multiple bodily symptoms, female sex, and prior use of proton pump inhibitors (PPI) are the risk factors for irritable bowel syndrome (IBS) onset, with prior psychiatric disorder being the strongest risk factor.
Major finding: The presence of ≥2 prior psychiatric disorders was the strongest predictor of subsequent IBS (odds ratio [OR] 2.74; P = .006), with other risk factors in patients with prior psychiatric disorders being female sex (OR 1.87) and prior use of PPI (OR 1.73; both P < .001). Among patients without prior psychiatric disorder history, female sex (OR 4.24), fibromyalgia (OR 1.88), and prior PPI use (OR 1.73; all P < .001) most strongly predicted IBS onset.
Study details: Findings are from a prospective, population-based cohort study including 132,922 participants without prior IBS or IBS medication use at baseline who were followed-up twice during subsequent 3 years.
Disclosures: This study did not receive any funding. No conflicts of interest were declared.
Source: Creed F. Risk factors for self-reported irritable bowel syndrome with prior psychiatric disorder: The Lifelines cohort study. J Neurogastroenterol Motil. 2022;28(3):442-453 (Jul 30). Doi: 10.5056/jnm21041