Severe mental illness raises risk for serious long-term diabetic complications in T2D

Key clinical point: Patients with type 2 diabetes (T2D) and severe mental illness (SMI) are at a higher risk of developing nephropathy, lower limp amputations, and cardiovascular diseases (CVD), but not retinopathy, compared with those with T2D and without SMI.

Major finding: Compared with patients with T2D and without SMI, those with T2D and SMI had a higher incidence rate (IR) of nephropathy (IR ratio [IRR] 1.15; 95% CI 1.12-1.18), amputations (IRR 1.15; 95% CI 1.04-1.28), and CVD (men IRR 1.10; 95% CI 1.06-1.15, and women IRR 1.18; 95% CI 1.13-1.22), but a lower IR of retinopathy (IRR 0.75; 95% CI 0.70-0.81).

Study details: Findings are from a population-based dynamic cohort study including 371,625 patients with T2D, of which 30,102 had a coexisting SMI.

Disclosures: This study did not receive any funding. Some authors declared owning shares or receiving research grants from various sources.

Source: Scheuer SH et al. Severe mental illness and the risk of diabetes complications. A nationwide register-based cohort study. J Clin Endocrinol Metab. 2022 (Mar 31). Doi: 10.1210/clinem/dgac204

Key clinical point: Patients with type 2 diabetes (T2D) and severe mental illness (SMI) are at a higher risk of developing nephropathy, lower limp amputations, and cardiovascular diseases (CVD), but not retinopathy, compared with those with T2D and without SMI.

Major finding: Compared with patients with T2D and without SMI, those with T2D and SMI had a higher incidence rate (IR) of nephropathy (IR ratio [IRR] 1.15; 95% CI 1.12-1.18), amputations (IRR 1.15; 95% CI 1.04-1.28), and CVD (men IRR 1.10; 95% CI 1.06-1.15, and women IRR 1.18; 95% CI 1.13-1.22), but a lower IR of retinopathy (IRR 0.75; 95% CI 0.70-0.81).

Study details: Findings are from a population-based dynamic cohort study including 371,625 patients with T2D, of which 30,102 had a coexisting SMI.

Disclosures: This study did not receive any funding. Some authors declared owning shares or receiving research grants from various sources.

Source: Scheuer SH et al. Severe mental illness and the risk of diabetes complications. A nationwide register-based cohort study. J Clin Endocrinol Metab. 2022 (Mar 31). Doi: 10.1210/clinem/dgac204

Key clinical point: Patients with type 2 diabetes (T2D) and severe mental illness (SMI) are at a higher risk of developing nephropathy, lower limp amputations, and cardiovascular diseases (CVD), but not retinopathy, compared with those with T2D and without SMI.

Major finding: Compared with patients with T2D and without SMI, those with T2D and SMI had a higher incidence rate (IR) of nephropathy (IR ratio [IRR] 1.15; 95% CI 1.12-1.18), amputations (IRR 1.15; 95% CI 1.04-1.28), and CVD (men IRR 1.10; 95% CI 1.06-1.15, and women IRR 1.18; 95% CI 1.13-1.22), but a lower IR of retinopathy (IRR 0.75; 95% CI 0.70-0.81).

Study details: Findings are from a population-based dynamic cohort study including 371,625 patients with T2D, of which 30,102 had a coexisting SMI.

Disclosures: This study did not receive any funding. Some authors declared owning shares or receiving research grants from various sources.

Source: Scheuer SH et al. Severe mental illness and the risk of diabetes complications. A nationwide register-based cohort study. J Clin Endocrinol Metab. 2022 (Mar 31). Doi: 10.1210/clinem/dgac204