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Hemoglobin Transfusion Threshold Not Associated with Differences in Morbidity, Mortality Among Patients with Septic Shock
Clinical question: Is there a difference in 90-day mortality and other outcomes when a lower versus higher hemoglobin threshold is used for blood...
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Early, Goal-Directed Therapy Doesn’t Improve Mortality in Patients with Early Septic Shock
Clinical question: Does early goal-directed therapy (EGDT) improve mortality in patients presenting to the ED with early septic shock? Background...
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Arterial Catheter Use in ICU Doesn’t Improve Hospital Mortality
Clinical question: Does the use of arterial catheters (AC) improve hospital mortality in ICU patients requiring mechanical ventilation?...
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Bedside Attention Tests May Be Useful in Detecting Delirium
Clinical question: Are simple bedside attention tests a reliable way to routinely screen for delirium? Background: Early diagnosis of delirium...
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Once-Weekly Antibiotic Might Be Effective for Treatment of Acute Bacterial Skin Infections
Research suggests intravenous dalbavancin similarly efficacious to intravenous vancomycin
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Holding Chambers (Spacers) vs. Nebulizers for Acute Asthma
Clinical question: Are beta-2 agonists as effective when administered through a holding chamber (spacer) as they are when administered by a...
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Long-Term Cognitive Impairment after Critical Illness
Clinical question: Are a longer duration of delirium and higher doses of sedatives associated with cognitive impairment in the hospital?...
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Endoscopic vs. Surgical Cystogastrostomy for Pancreatic Pseudocyst Drainage
Clinical question: How does endoscopic cystogastrostomy for pancreatic pseudocyst drainage compare to the standard surgical approach? Background...
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Single vs. Dual Antiplatelet Therapy after Stroke
Clinical question: Is dual antiplatelet therapy more beneficial or harmful than monotherapy after ischemic stroke? Background: It is recommended...
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New Oral Anticoagulants Increase GI Bleed Risk
Clinical question: Do thrombin and factor Xa inhibitors increase the risk of gastrointestinal (GI) bleeding when compared to vitamin K antagonists...
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De-Escalating Antibiotics in Sepsis
Clinical question: Does tailoring antibiotics based on known pathogens impact mortality for patients with severe sepsis or shock? Background: In...
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Three-Month Dual Antiplatelet Therapy for Zotarolimus-Eluting Stents
Clinical question: Is short-term, dual antiplatelet therapy noninferior to long-term therapy in zotarolimus-eluting stents? Background: Current...
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Antibiotic Algorithm Can Guide Therapy in Healthcare-Associated Pneumonia
Clinical question: Can an algorithm based on risk for multidrug-resistant (MDR) organisms and illness severity guide antibiotic selection in...
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Adults Hospitalized for Respiratory Syncytial Virus Infections Have High Morbidity, Mortality Rates
Clinical question: What are the complications and outcomes of respiratory syncytial virus (RSV) infection in adults requiring hospitalization?...
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ICU Pressures Improve Transfers to the Floor
Clinical question: Does ICU strain negatively affect the outcomes of patients transferred to the floor? Background: With healthcare costs...