Heidi Splete

Several office-based pediatric measures, including body mass index and systolic and diastolic blood pressure, were significant predictors of type 2 diabetes in adulthood, based on data from a pair of follow-up studies including nearly 2,000 school-aged children.

The ability to identify children who are on the path to adult type 2 diabetes may give physicians an opportunity to intervene with diet and exercise recommendations, said John A. Morrison, Ph.D., of Cincinnati Children's Hospital Medical Center.

Dr. Morrison and his colleagues reviewed data from two prospective studies. The National Growth and Health Study (NGHS) included 1,067 girls with a mean age of 10 years who were reassessed at a mean age of 19 years. The NGHS measured body mass index (BMI); systolic and diastolic blood pressure; waist circumference; HDL cholesterol, fasting insulin, glucose, and lipid profiles; and parental diabetes.

The second study, the Princeton Follow-Up Study (PFS), included 822 boys and girls 6–18 years (mean age, 12 years) who were reassessed at a mean age of 39 years. The PFS measured BMI, systolic and diastolic blood pressure, parental diabetes, triglycerides, HDL cholesterol, and fasting glucose.

The final analysis included data from 80% of the girls in the NGHS and 53% of the children in the PFS (Arch. Pediatr. Adolesc. Med. 2010;164:53–60).

After cases of diabetes were excluded at study entry, the incidence of diabetes at age 39 years in the PFS was 5%. The incidence was higher in black women than white women (10% vs. 4%) and higher in black men than white men (5% vs. 3%). In the NGHS, diabetes incidence after 9 years was 1.2% in black women and 0.2% in white women.

In the PFS, childhood systolic blood pressure, BMI in the top fifth percentile, and black race were significant predictors of type 2 diabetes at 39 years of age. Conversely, if childhood BMI, systolic blood pressure, and diastolic blood pressure all fell below the 75th percentile, the chance of type 2 diabetes at 39 years of age was 2% if the parents had diabetes and 1% if they did not.

In the PFS, “simple office and laboratory measurements and knowledge of parental diabetes usefully predicted” the development of type 2 diabetes 22–30 years later, the researchers wrote.

In the NGHS, childhood systolic blood pressure in the top fifth percentile and parental diabetes were significant predictors of type 2 diabetes at age 19 years. If childhood BMI, systolic blood pressure, and diastolic blood pressure all fell below the 75th percentile, the chance of type 2 diabetes at 19 years of age was 0.2% whether the parents had diabetes or not, and 0.3% if childhood insulin also was below the 75th percentile.

Disclosures: The researchers had no financial conflicts to disclose. The study was supported in part by grants from the National Institutes of Health, the American Heart Association, the Taft Research Fund, and the Lipoprotein Research Fund of the Jewish Hospital of Cincinnati.

The ability to identify children on the path to type 2 diabetes may provide an opportunity to intervene.

Source DR. MORRISON

Several office-based pediatric measures, including body mass index and systolic and diastolic blood pressure, were significant predictors of type 2 diabetes in adulthood, based on data from a pair of follow-up studies including nearly 2,000 school-aged children.

The ability to identify children who are on the path to adult type 2 diabetes may give physicians an opportunity to intervene with diet and exercise recommendations, said John A. Morrison, Ph.D., of Cincinnati Children's Hospital Medical Center.

Dr. Morrison and his colleagues reviewed data from two prospective studies. The National Growth and Health Study (NGHS) included 1,067 girls with a mean age of 10 years who were reassessed at a mean age of 19 years. The NGHS measured body mass index (BMI); systolic and diastolic blood pressure; waist circumference; HDL cholesterol, fasting insulin, glucose, and lipid profiles; and parental diabetes.

The second study, the Princeton Follow-Up Study (PFS), included 822 boys and girls 6–18 years (mean age, 12 years) who were reassessed at a mean age of 39 years. The PFS measured BMI, systolic and diastolic blood pressure, parental diabetes, triglycerides, HDL cholesterol, and fasting glucose.

The final analysis included data from 80% of the girls in the NGHS and 53% of the children in the PFS (Arch. Pediatr. Adolesc. Med. 2010;164:53–60).

After cases of diabetes were excluded at study entry, the incidence of diabetes at age 39 years in the PFS was 5%. The incidence was higher in black women than white women (10% vs. 4%) and higher in black men than white men (5% vs. 3%). In the NGHS, diabetes incidence after 9 years was 1.2% in black women and 0.2% in white women.

In the PFS, childhood systolic blood pressure, BMI in the top fifth percentile, and black race were significant predictors of type 2 diabetes at 39 years of age. Conversely, if childhood BMI, systolic blood pressure, and diastolic blood pressure all fell below the 75th percentile, the chance of type 2 diabetes at 39 years of age was 2% if the parents had diabetes and 1% if they did not.

In the PFS, “simple office and laboratory measurements and knowledge of parental diabetes usefully predicted” the development of type 2 diabetes 22–30 years later, the researchers wrote.

In the NGHS, childhood systolic blood pressure in the top fifth percentile and parental diabetes were significant predictors of type 2 diabetes at age 19 years. If childhood BMI, systolic blood pressure, and diastolic blood pressure all fell below the 75th percentile, the chance of type 2 diabetes at 19 years of age was 0.2% whether the parents had diabetes or not, and 0.3% if childhood insulin also was below the 75th percentile.

Disclosures: The researchers had no financial conflicts to disclose. The study was supported in part by grants from the National Institutes of Health, the American Heart Association, the Taft Research Fund, and the Lipoprotein Research Fund of the Jewish Hospital of Cincinnati.

The ability to identify children on the path to type 2 diabetes may provide an opportunity to intervene.

Source DR. MORRISON

Several office-based pediatric measures, including body mass index and systolic and diastolic blood pressure, were significant predictors of type 2 diabetes in adulthood, based on data from a pair of follow-up studies including nearly 2,000 school-aged children.

The ability to identify children who are on the path to adult type 2 diabetes may give physicians an opportunity to intervene with diet and exercise recommendations, said John A. Morrison, Ph.D., of Cincinnati Children's Hospital Medical Center.

Dr. Morrison and his colleagues reviewed data from two prospective studies. The National Growth and Health Study (NGHS) included 1,067 girls with a mean age of 10 years who were reassessed at a mean age of 19 years. The NGHS measured body mass index (BMI); systolic and diastolic blood pressure; waist circumference; HDL cholesterol, fasting insulin, glucose, and lipid profiles; and parental diabetes.

The second study, the Princeton Follow-Up Study (PFS), included 822 boys and girls 6–18 years (mean age, 12 years) who were reassessed at a mean age of 39 years. The PFS measured BMI, systolic and diastolic blood pressure, parental diabetes, triglycerides, HDL cholesterol, and fasting glucose.

The final analysis included data from 80% of the girls in the NGHS and 53% of the children in the PFS (Arch. Pediatr. Adolesc. Med. 2010;164:53–60).

After cases of diabetes were excluded at study entry, the incidence of diabetes at age 39 years in the PFS was 5%. The incidence was higher in black women than white women (10% vs. 4%) and higher in black men than white men (5% vs. 3%). In the NGHS, diabetes incidence after 9 years was 1.2% in black women and 0.2% in white women.

In the PFS, childhood systolic blood pressure, BMI in the top fifth percentile, and black race were significant predictors of type 2 diabetes at 39 years of age. Conversely, if childhood BMI, systolic blood pressure, and diastolic blood pressure all fell below the 75th percentile, the chance of type 2 diabetes at 39 years of age was 2% if the parents had diabetes and 1% if they did not.

In the PFS, “simple office and laboratory measurements and knowledge of parental diabetes usefully predicted” the development of type 2 diabetes 22–30 years later, the researchers wrote.

In the NGHS, childhood systolic blood pressure in the top fifth percentile and parental diabetes were significant predictors of type 2 diabetes at age 19 years. If childhood BMI, systolic blood pressure, and diastolic blood pressure all fell below the 75th percentile, the chance of type 2 diabetes at 19 years of age was 0.2% whether the parents had diabetes or not, and 0.3% if childhood insulin also was below the 75th percentile.

Disclosures: The researchers had no financial conflicts to disclose. The study was supported in part by grants from the National Institutes of Health, the American Heart Association, the Taft Research Fund, and the Lipoprotein Research Fund of the Jewish Hospital of Cincinnati.

The ability to identify children on the path to type 2 diabetes may provide an opportunity to intervene.

Source DR. MORRISON

More than half of the adults hospitalized in the early days of the 2009 influenza A (H1N1) pandemic in New York City were obese, and 92% of the obese patients had underlying medical conditions, according a recent review.

To quickly assess the severity of illness and identify those at greatest risk from the emerging virus, researchers at the New York City Department of Health and Mental Hygiene reviewed data from the first 99 patients with confirmed H1N1 influenza admitted to any hospital in New York City. The study population included 19 patients aged 0–4 years, 39 patients aged 5–17 years, 32 patients aged 18–49 years, 8 patients aged 50–64 years, and 1 patient aged 65 or older. The patients with H1N1 influenza were disproportionately younger compared with the general population (MMWR 2010;58:1436–40).

A total of 95 (96%) patients had fevers at admission, and 89 (90%) complained of cough. Also, 37 children (younger than 18 years) and 36 adults (aged 18 years and older) had at least one underlying medical condition known to increase the risk of flu complications, and 7 children and 10 adults had more than one such condition. Asthma, the most common underlying medical condition, was noted in 29 children (50%) and 19 adults (46%). Chronic metabolic disorders, including diabetes, were reported in 11 patients (11%).

Body mass index data were available for 28 children and 20 adults. Four of the five obese children and 11 of the 12 obese adults had underlying medical conditions, including asthma and Down syndrome. Three of the four patients who died were obese; their underlying medical conditions included asthma and Down syndrome.

Of the 76 patients treated with oseltamivir, 36 (47%) were treated within 2 days of symptom onset, but the median time to treatment from the onset of illness was 3 days. Hospital stays were shorter for patients who started antiviral therapy within 2 days.

The study was limited by several factors including the potential underreporting of cases and the difference in reporting protocol later in the pandemic, when data were collected from sentinel hospitals only.

The findings confirm that patients at high risk should be encouraged to get vaccinated, the researchers said.

More than half of the adults hospitalized in the early days of the 2009 influenza A (H1N1) pandemic in New York City were obese, and 92% of the obese patients had underlying medical conditions, according a recent review.

To quickly assess the severity of illness and identify those at greatest risk from the emerging virus, researchers at the New York City Department of Health and Mental Hygiene reviewed data from the first 99 patients with confirmed H1N1 influenza admitted to any hospital in New York City. The study population included 19 patients aged 0–4 years, 39 patients aged 5–17 years, 32 patients aged 18–49 years, 8 patients aged 50–64 years, and 1 patient aged 65 or older. The patients with H1N1 influenza were disproportionately younger compared with the general population (MMWR 2010;58:1436–40).

A total of 95 (96%) patients had fevers at admission, and 89 (90%) complained of cough. Also, 37 children (younger than 18 years) and 36 adults (aged 18 years and older) had at least one underlying medical condition known to increase the risk of flu complications, and 7 children and 10 adults had more than one such condition. Asthma, the most common underlying medical condition, was noted in 29 children (50%) and 19 adults (46%). Chronic metabolic disorders, including diabetes, were reported in 11 patients (11%).

Body mass index data were available for 28 children and 20 adults. Four of the five obese children and 11 of the 12 obese adults had underlying medical conditions, including asthma and Down syndrome. Three of the four patients who died were obese; their underlying medical conditions included asthma and Down syndrome.

Of the 76 patients treated with oseltamivir, 36 (47%) were treated within 2 days of symptom onset, but the median time to treatment from the onset of illness was 3 days. Hospital stays were shorter for patients who started antiviral therapy within 2 days.

The study was limited by several factors including the potential underreporting of cases and the difference in reporting protocol later in the pandemic, when data were collected from sentinel hospitals only.

The findings confirm that patients at high risk should be encouraged to get vaccinated, the researchers said.

More than half of the adults hospitalized in the early days of the 2009 influenza A (H1N1) pandemic in New York City were obese, and 92% of the obese patients had underlying medical conditions, according a recent review.

To quickly assess the severity of illness and identify those at greatest risk from the emerging virus, researchers at the New York City Department of Health and Mental Hygiene reviewed data from the first 99 patients with confirmed H1N1 influenza admitted to any hospital in New York City. The study population included 19 patients aged 0–4 years, 39 patients aged 5–17 years, 32 patients aged 18–49 years, 8 patients aged 50–64 years, and 1 patient aged 65 or older. The patients with H1N1 influenza were disproportionately younger compared with the general population (MMWR 2010;58:1436–40).

A total of 95 (96%) patients had fevers at admission, and 89 (90%) complained of cough. Also, 37 children (younger than 18 years) and 36 adults (aged 18 years and older) had at least one underlying medical condition known to increase the risk of flu complications, and 7 children and 10 adults had more than one such condition. Asthma, the most common underlying medical condition, was noted in 29 children (50%) and 19 adults (46%). Chronic metabolic disorders, including diabetes, were reported in 11 patients (11%).

Body mass index data were available for 28 children and 20 adults. Four of the five obese children and 11 of the 12 obese adults had underlying medical conditions, including asthma and Down syndrome. Three of the four patients who died were obese; their underlying medical conditions included asthma and Down syndrome.

Of the 76 patients treated with oseltamivir, 36 (47%) were treated within 2 days of symptom onset, but the median time to treatment from the onset of illness was 3 days. Hospital stays were shorter for patients who started antiviral therapy within 2 days.

The study was limited by several factors including the potential underreporting of cases and the difference in reporting protocol later in the pandemic, when data were collected from sentinel hospitals only.

The findings confirm that patients at high risk should be encouraged to get vaccinated, the researchers said.

WASHINGTON — Successful weight loss for patients who undergo gastric banding is significantly associated with the number of follow-up visits to a surgeon's office during the first year after the procedure, according to a study involving 113 adults who had gastric band surgery between 2005 and 2007.

Gastric band surgery can be a safe and effective strategy for weight loss, but studies have shown that the percentage of excess weight lost after the procedure ranges from −8.5% to 79% after 1 year, said Dr. Julio Teixeira of St. Luke's Roosevelt Hospital in New York.

To identify predictors of weight loss 1 year after gastric band surgery, researchers reviewed baseline demographics, body mass index, comorbidities, number of office visits, and gastric band adjustments for up to 15 months after the procedure. The single center findings were presented in a poster at the annual meeting of the Obesity Society.

The patients ranged in age from 22 to 71 years, with an average age of 41 years. The patients' BMIs ranged from 36 to 72 kg/m

Participants had an average of six follow-up visits to a surgeon's office during the first year after the procedure. There was a significant correlation between the number of follow-up visits and both the amount of weight lost and the percentage of excess weight lost.

Disclosures: Dr. Teixeira has served as an advisoer to Allergan, which manufactures an adjustable gastric banding system.

WASHINGTON — Successful weight loss for patients who undergo gastric banding is significantly associated with the number of follow-up visits to a surgeon's office during the first year after the procedure, according to a study involving 113 adults who had gastric band surgery between 2005 and 2007.

Gastric band surgery can be a safe and effective strategy for weight loss, but studies have shown that the percentage of excess weight lost after the procedure ranges from −8.5% to 79% after 1 year, said Dr. Julio Teixeira of St. Luke's Roosevelt Hospital in New York.

To identify predictors of weight loss 1 year after gastric band surgery, researchers reviewed baseline demographics, body mass index, comorbidities, number of office visits, and gastric band adjustments for up to 15 months after the procedure. The single center findings were presented in a poster at the annual meeting of the Obesity Society.

The patients ranged in age from 22 to 71 years, with an average age of 41 years. The patients' BMIs ranged from 36 to 72 kg/m

Participants had an average of six follow-up visits to a surgeon's office during the first year after the procedure. There was a significant correlation between the number of follow-up visits and both the amount of weight lost and the percentage of excess weight lost.

Disclosures: Dr. Teixeira has served as an advisoer to Allergan, which manufactures an adjustable gastric banding system.

WASHINGTON — Successful weight loss for patients who undergo gastric banding is significantly associated with the number of follow-up visits to a surgeon's office during the first year after the procedure, according to a study involving 113 adults who had gastric band surgery between 2005 and 2007.

Gastric band surgery can be a safe and effective strategy for weight loss, but studies have shown that the percentage of excess weight lost after the procedure ranges from −8.5% to 79% after 1 year, said Dr. Julio Teixeira of St. Luke's Roosevelt Hospital in New York.

To identify predictors of weight loss 1 year after gastric band surgery, researchers reviewed baseline demographics, body mass index, comorbidities, number of office visits, and gastric band adjustments for up to 15 months after the procedure. The single center findings were presented in a poster at the annual meeting of the Obesity Society.

The patients ranged in age from 22 to 71 years, with an average age of 41 years. The patients' BMIs ranged from 36 to 72 kg/m

Participants had an average of six follow-up visits to a surgeon's office during the first year after the procedure. There was a significant correlation between the number of follow-up visits and both the amount of weight lost and the percentage of excess weight lost.

Disclosures: Dr. Teixeira has served as an advisoer to Allergan, which manufactures an adjustable gastric banding system.

ORLANDO — Daily application of 3.75% imiquimod cream with a 2-week dosing cycle was well tolerated and effective for treating actinic keratoses in adults, based on data from two studies.

In current treatment regimens, some patients use a 5% concentration imiquimod (Aldara, Graceway) cream twice a week over a treatment period as long as 16 weeks, but a lower dose may allow a shorter treatment period, said Dr. Neil Swanson of Oregon Health and Science University, Portland.

Dr. Swanson and his colleagues randomized 160 patients to 3.75% imiquimod cream, 160 patients to 2.5% imiquimod cream, and 159 patients to a placebo cream. The patients, aged 18 years and older, had 5-20 clinically diagnosed actinic keratoses (AKs) on the face or balding scalp. The study results were presented in a poster at the Orlando Dermatology Aesthetic and Clinical Conference.

Both the 3.75% and 2.5% creams were significantly more effective than placebo at fully clearing AKs after 2 weeks of daily use. Overall, 36% of the 3.75% group and 31% of the 2.5% group achieved complete clearance, vs. 6% of the placebo group.

The 3.75% cream, however, was significantly better than the 2.5% cream for partial clearance and lesion reduction. Approximately 60% of the 3.75% group achieved partial clearance (defined as at least 75%), compared with 48% of the 2.5% group and 23% of the placebo group.

Both concentrations of imiquimod were well tolerated, and most local skin reactions were mild to moderate. Local skin reactions occurred in 1% of the placebo group, 21% of the 2.5% group, and 34% of the 3.75% group. The most common local skin reactions in both groups were erythema, scabbing or crusting, and erosion or ulceration.

"Median percent lesion reduction of 81.8% was comparable to that observed for imiquimod 5% cream applied for 16 weeks in treating a smaller area of fewer lesions," the researchers noted. By comparison, the median lesion reduction from baseline was 71.8% in the 2.5% group and 25% in the placebo group. The average lesion count at baseline was 11 in all three groups.

Patients applied the treatment cream or placebo daily to the treatment areas for approximately 8 hours or overnight and then removed it. The study included two 2-week cycles separated by a 2-week no-treatment period.

In a companion study also presented as a poster at the meeting, there was no significant improvement in effectiveness with either imiquimod 2.5% or 3.75% cream for treating AKs when used daily for two 3-week cycles separated by a 3-week no-treatment period. The study randomized 164 patients to a placebo cream, 164 patients to imiquimod 2.5% cream, and 162 patients to imiquimod 3.75% cream.

Both imiquimod creams were adequately tolerated and significantly more effective than placebo, reported Dr. C. William Hanke, a dermatologic surgeon in Carmel, Ind., and colleagues.

When both studies were evaluated together, though, "efficacy was better with imiquimod 3.75% than with 2.5%. Extending the cycle duration from 2 weeks to 3 weeks did not further increase efficacy," Dr. Hanke and his associates wrote.

Both studies were funded by Graceway Pharmaceuticals. Both Dr. Swanson and Dr. Hanke have served as investigators and consultants for Graceway. Coauthors on both studies include other investigators, consultants, and employees of Graceway.

ORLANDO — Daily application of 3.75% imiquimod cream with a 2-week dosing cycle was well tolerated and effective for treating actinic keratoses in adults, based on data from two studies.

In current treatment regimens, some patients use a 5% concentration imiquimod (Aldara, Graceway) cream twice a week over a treatment period as long as 16 weeks, but a lower dose may allow a shorter treatment period, said Dr. Neil Swanson of Oregon Health and Science University, Portland.

Dr. Swanson and his colleagues randomized 160 patients to 3.75% imiquimod cream, 160 patients to 2.5% imiquimod cream, and 159 patients to a placebo cream. The patients, aged 18 years and older, had 5-20 clinically diagnosed actinic keratoses (AKs) on the face or balding scalp. The study results were presented in a poster at the Orlando Dermatology Aesthetic and Clinical Conference.

Both the 3.75% and 2.5% creams were significantly more effective than placebo at fully clearing AKs after 2 weeks of daily use. Overall, 36% of the 3.75% group and 31% of the 2.5% group achieved complete clearance, vs. 6% of the placebo group.

The 3.75% cream, however, was significantly better than the 2.5% cream for partial clearance and lesion reduction. Approximately 60% of the 3.75% group achieved partial clearance (defined as at least 75%), compared with 48% of the 2.5% group and 23% of the placebo group.

Both concentrations of imiquimod were well tolerated, and most local skin reactions were mild to moderate. Local skin reactions occurred in 1% of the placebo group, 21% of the 2.5% group, and 34% of the 3.75% group. The most common local skin reactions in both groups were erythema, scabbing or crusting, and erosion or ulceration.

"Median percent lesion reduction of 81.8% was comparable to that observed for imiquimod 5% cream applied for 16 weeks in treating a smaller area of fewer lesions," the researchers noted. By comparison, the median lesion reduction from baseline was 71.8% in the 2.5% group and 25% in the placebo group. The average lesion count at baseline was 11 in all three groups.

Patients applied the treatment cream or placebo daily to the treatment areas for approximately 8 hours or overnight and then removed it. The study included two 2-week cycles separated by a 2-week no-treatment period.

In a companion study also presented as a poster at the meeting, there was no significant improvement in effectiveness with either imiquimod 2.5% or 3.75% cream for treating AKs when used daily for two 3-week cycles separated by a 3-week no-treatment period. The study randomized 164 patients to a placebo cream, 164 patients to imiquimod 2.5% cream, and 162 patients to imiquimod 3.75% cream.

Both imiquimod creams were adequately tolerated and significantly more effective than placebo, reported Dr. C. William Hanke, a dermatologic surgeon in Carmel, Ind., and colleagues.

When both studies were evaluated together, though, "efficacy was better with imiquimod 3.75% than with 2.5%. Extending the cycle duration from 2 weeks to 3 weeks did not further increase efficacy," Dr. Hanke and his associates wrote.

Both studies were funded by Graceway Pharmaceuticals. Both Dr. Swanson and Dr. Hanke have served as investigators and consultants for Graceway. Coauthors on both studies include other investigators, consultants, and employees of Graceway.

ORLANDO — Daily application of 3.75% imiquimod cream with a 2-week dosing cycle was well tolerated and effective for treating actinic keratoses in adults, based on data from two studies.

In current treatment regimens, some patients use a 5% concentration imiquimod (Aldara, Graceway) cream twice a week over a treatment period as long as 16 weeks, but a lower dose may allow a shorter treatment period, said Dr. Neil Swanson of Oregon Health and Science University, Portland.

Dr. Swanson and his colleagues randomized 160 patients to 3.75% imiquimod cream, 160 patients to 2.5% imiquimod cream, and 159 patients to a placebo cream. The patients, aged 18 years and older, had 5-20 clinically diagnosed actinic keratoses (AKs) on the face or balding scalp. The study results were presented in a poster at the Orlando Dermatology Aesthetic and Clinical Conference.

Both the 3.75% and 2.5% creams were significantly more effective than placebo at fully clearing AKs after 2 weeks of daily use. Overall, 36% of the 3.75% group and 31% of the 2.5% group achieved complete clearance, vs. 6% of the placebo group.

The 3.75% cream, however, was significantly better than the 2.5% cream for partial clearance and lesion reduction. Approximately 60% of the 3.75% group achieved partial clearance (defined as at least 75%), compared with 48% of the 2.5% group and 23% of the placebo group.

Both concentrations of imiquimod were well tolerated, and most local skin reactions were mild to moderate. Local skin reactions occurred in 1% of the placebo group, 21% of the 2.5% group, and 34% of the 3.75% group. The most common local skin reactions in both groups were erythema, scabbing or crusting, and erosion or ulceration.

"Median percent lesion reduction of 81.8% was comparable to that observed for imiquimod 5% cream applied for 16 weeks in treating a smaller area of fewer lesions," the researchers noted. By comparison, the median lesion reduction from baseline was 71.8% in the 2.5% group and 25% in the placebo group. The average lesion count at baseline was 11 in all three groups.

Patients applied the treatment cream or placebo daily to the treatment areas for approximately 8 hours or overnight and then removed it. The study included two 2-week cycles separated by a 2-week no-treatment period.

In a companion study also presented as a poster at the meeting, there was no significant improvement in effectiveness with either imiquimod 2.5% or 3.75% cream for treating AKs when used daily for two 3-week cycles separated by a 3-week no-treatment period. The study randomized 164 patients to a placebo cream, 164 patients to imiquimod 2.5% cream, and 162 patients to imiquimod 3.75% cream.

Both imiquimod creams were adequately tolerated and significantly more effective than placebo, reported Dr. C. William Hanke, a dermatologic surgeon in Carmel, Ind., and colleagues.

When both studies were evaluated together, though, "efficacy was better with imiquimod 3.75% than with 2.5%. Extending the cycle duration from 2 weeks to 3 weeks did not further increase efficacy," Dr. Hanke and his associates wrote.

Both studies were funded by Graceway Pharmaceuticals. Both Dr. Swanson and Dr. Hanke have served as investigators and consultants for Graceway. Coauthors on both studies include other investigators, consultants, and employees of Graceway.

Women of Korean, Chinese, and Filipino descent are more than twice as likely to develop gestational diabetes as Caucasian or African American women, according to a data analysis of more than 16,000 pregnant women in Hawaii published in the Ethnicity and Disease journal.

Gestational diabetes occurs in 4%-8% of all pregnant women, wrote Kathryn L. Pedula and her colleagues. Data from a pair of recent U.S. studies suggested that Asians have a higher prevalence of gestational diabetes mellitus (GDM) than do other ethnicities, but differences among subcategories of Asian populations have not been well studied.

Ms. Pedula and her associates at the Center for Health Research, Kaiser Permanente Northwest in Portland, Ore., reviewed 10 years' worth of data from 22,110 pregnancies in 16,757 women. Hawaii was chosen for the study because of its ethnically diverse population, the researchers said (Ethn. Dis. 2009;19:414-9).

A total of 353 women had pre-existing diabetes. The remaining women underwent screening for GDM between 24 and 28 weeks of pregnancy, using the 50-gram, 1-hour glucose challenge test (GCT). Women with plasma glucose levels greater than 200 mg/dL on the GCT were deemed to have GDM and were not tested further. The remaining women with a GCT value greater than 140 mg/dL underwent the 100-gram, 3-hour oral glucose tolerance test.

Overall, 20.9% of the women had a positive GCT (plasma glucose at least 140 mg/dL). Approximately 4% had GDM based on the National Diabetes Data Group (NDDG) criteria, and 7% had GDM based on the Carpenter and Coustan (C&C) criteria.

After adjusting for age, the investigators found that 10% of the Korean women had GDM based on the C&C criteria, followed by 9.8% of Chinese women and 8.3% among Filipino women. The prevalence was lowest among African Americans (3.3%) and Caucasians (4.2%).

Based on the NDDG criteria, Puerto Rican women had the highest age-adjusted prevalence of GDM (7.4%), but this was barely higher than the average when C&C criteria were applied. However, Korean, Filipino, and Chinese women had the next highest prevalences of GDM, at 6.4%, 5.8%, and 5.6%, respectively, based on the NDDG criteria. Again, Caucasians and African Americans had the lowest prevalence of GDM, at 2.5% and 2.2%, respectively.

The study included women aged 13-39 years who gave birth in Hawaii between 1995 and 2003. The Asian population was divided into five subgroups: Korean, Chinese, Japanese, Vietnamese, and Filipino. Additional groups included Samoan, Puerto Rican, Native Hawaiian, Caucasian, African American, Native American, other Hispanic, and other Pacific Islander.

The results suggest that the risks for developing GDM may vary greatly depending on specific ethnic background.

“These findings point to the need for further research along several avenues, such as maternal-child outcome differences and perhaps ethnic-specific guidelines for GDM diagnosis,” the researchers said.

Disclosures: The study was funded by the American Diabetes Association. Coauthor Dr. Teresa A. Hillier was funded by a 1-year ADA-European Association for the Study of Diabetes Trans-Atlantic Fellowship.

Using two sets of criteria, investigators found a high prevalence of GDM in Asian women.

Source ©Thye Aun Ngo/Fotolia.com

Women of Korean, Chinese, and Filipino descent are more than twice as likely to develop gestational diabetes as Caucasian or African American women, according to a data analysis of more than 16,000 pregnant women in Hawaii published in the Ethnicity and Disease journal.

Gestational diabetes occurs in 4%-8% of all pregnant women, wrote Kathryn L. Pedula and her colleagues. Data from a pair of recent U.S. studies suggested that Asians have a higher prevalence of gestational diabetes mellitus (GDM) than do other ethnicities, but differences among subcategories of Asian populations have not been well studied.

Ms. Pedula and her associates at the Center for Health Research, Kaiser Permanente Northwest in Portland, Ore., reviewed 10 years' worth of data from 22,110 pregnancies in 16,757 women. Hawaii was chosen for the study because of its ethnically diverse population, the researchers said (Ethn. Dis. 2009;19:414-9).

A total of 353 women had pre-existing diabetes. The remaining women underwent screening for GDM between 24 and 28 weeks of pregnancy, using the 50-gram, 1-hour glucose challenge test (GCT). Women with plasma glucose levels greater than 200 mg/dL on the GCT were deemed to have GDM and were not tested further. The remaining women with a GCT value greater than 140 mg/dL underwent the 100-gram, 3-hour oral glucose tolerance test.

Overall, 20.9% of the women had a positive GCT (plasma glucose at least 140 mg/dL). Approximately 4% had GDM based on the National Diabetes Data Group (NDDG) criteria, and 7% had GDM based on the Carpenter and Coustan (C&C) criteria.

After adjusting for age, the investigators found that 10% of the Korean women had GDM based on the C&C criteria, followed by 9.8% of Chinese women and 8.3% among Filipino women. The prevalence was lowest among African Americans (3.3%) and Caucasians (4.2%).

Based on the NDDG criteria, Puerto Rican women had the highest age-adjusted prevalence of GDM (7.4%), but this was barely higher than the average when C&C criteria were applied. However, Korean, Filipino, and Chinese women had the next highest prevalences of GDM, at 6.4%, 5.8%, and 5.6%, respectively, based on the NDDG criteria. Again, Caucasians and African Americans had the lowest prevalence of GDM, at 2.5% and 2.2%, respectively.

The study included women aged 13-39 years who gave birth in Hawaii between 1995 and 2003. The Asian population was divided into five subgroups: Korean, Chinese, Japanese, Vietnamese, and Filipino. Additional groups included Samoan, Puerto Rican, Native Hawaiian, Caucasian, African American, Native American, other Hispanic, and other Pacific Islander.

The results suggest that the risks for developing GDM may vary greatly depending on specific ethnic background.

“These findings point to the need for further research along several avenues, such as maternal-child outcome differences and perhaps ethnic-specific guidelines for GDM diagnosis,” the researchers said.

Disclosures: The study was funded by the American Diabetes Association. Coauthor Dr. Teresa A. Hillier was funded by a 1-year ADA-European Association for the Study of Diabetes Trans-Atlantic Fellowship.

Using two sets of criteria, investigators found a high prevalence of GDM in Asian women.

Source ©Thye Aun Ngo/Fotolia.com

Women of Korean, Chinese, and Filipino descent are more than twice as likely to develop gestational diabetes as Caucasian or African American women, according to a data analysis of more than 16,000 pregnant women in Hawaii published in the Ethnicity and Disease journal.

Gestational diabetes occurs in 4%-8% of all pregnant women, wrote Kathryn L. Pedula and her colleagues. Data from a pair of recent U.S. studies suggested that Asians have a higher prevalence of gestational diabetes mellitus (GDM) than do other ethnicities, but differences among subcategories of Asian populations have not been well studied.

Ms. Pedula and her associates at the Center for Health Research, Kaiser Permanente Northwest in Portland, Ore., reviewed 10 years' worth of data from 22,110 pregnancies in 16,757 women. Hawaii was chosen for the study because of its ethnically diverse population, the researchers said (Ethn. Dis. 2009;19:414-9).

A total of 353 women had pre-existing diabetes. The remaining women underwent screening for GDM between 24 and 28 weeks of pregnancy, using the 50-gram, 1-hour glucose challenge test (GCT). Women with plasma glucose levels greater than 200 mg/dL on the GCT were deemed to have GDM and were not tested further. The remaining women with a GCT value greater than 140 mg/dL underwent the 100-gram, 3-hour oral glucose tolerance test.

Overall, 20.9% of the women had a positive GCT (plasma glucose at least 140 mg/dL). Approximately 4% had GDM based on the National Diabetes Data Group (NDDG) criteria, and 7% had GDM based on the Carpenter and Coustan (C&C) criteria.

After adjusting for age, the investigators found that 10% of the Korean women had GDM based on the C&C criteria, followed by 9.8% of Chinese women and 8.3% among Filipino women. The prevalence was lowest among African Americans (3.3%) and Caucasians (4.2%).

Based on the NDDG criteria, Puerto Rican women had the highest age-adjusted prevalence of GDM (7.4%), but this was barely higher than the average when C&C criteria were applied. However, Korean, Filipino, and Chinese women had the next highest prevalences of GDM, at 6.4%, 5.8%, and 5.6%, respectively, based on the NDDG criteria. Again, Caucasians and African Americans had the lowest prevalence of GDM, at 2.5% and 2.2%, respectively.

The study included women aged 13-39 years who gave birth in Hawaii between 1995 and 2003. The Asian population was divided into five subgroups: Korean, Chinese, Japanese, Vietnamese, and Filipino. Additional groups included Samoan, Puerto Rican, Native Hawaiian, Caucasian, African American, Native American, other Hispanic, and other Pacific Islander.

The results suggest that the risks for developing GDM may vary greatly depending on specific ethnic background.

“These findings point to the need for further research along several avenues, such as maternal-child outcome differences and perhaps ethnic-specific guidelines for GDM diagnosis,” the researchers said.

Disclosures: The study was funded by the American Diabetes Association. Coauthor Dr. Teresa A. Hillier was funded by a 1-year ADA-European Association for the Study of Diabetes Trans-Atlantic Fellowship.

Using two sets of criteria, investigators found a high prevalence of GDM in Asian women.

Source ©Thye Aun Ngo/Fotolia.com

Disclosures: The study was funded by the American Diabetes Association. Coauthor Dr. Teresa A. Hillier was funded by a 1-year ADA-European Association for the Study of Diabetes Trans-Atlantic Fellowship.

Women of Korean, Chinese, and Filipino descent are more than twice as likely to develop gestational diabetes as Caucasian or African American women, according to a data analysis of more than 16,000 pregnant women in Hawaii.

Gestational diabetes occurs in 4%-8% of all pregnant women, wrote Kathryn L. Pedula and her colleagues. Data from a pair of recent U.S. studies suggested that Asians have a higher prevalence of gestational diabetes mellitus (GDM) than do other ethnicities, but differences among subcategories of Asian populations have not been well studied.

Ms. Pedula and her associates at the Center for Health Research, Kaiser Permanente Northwest in Portland, Ore., reviewed 10 years' worth of data from 22,110 pregnancies in 16,757 women. Hawaii was chosen for the study because of its ethnically diverse population (Ethn. Dis. 2009;19:414-9).

A total of 353 women had pre-existing diabetes. The remaining women underwent screening for GDM between 24 and 28 weeks of pregnancy, using the 50-gram, 1-hour glucose challenge test (GCT). Women with plasma glucose levels greater than 200 mg/dL on the GCT were deemed to have GDM and were not tested further. The remaining women with a GCT value greater than 140 mg/dL underwent the 100-gram, 3-hour oral glucose tolerance test.

Overall, 20.9% of the women had a positive GCT (plasma glucose at least 140 mg/dL). Approximately 4% had GDM based on the National Diabetes Data Group (NDDG) criteria, and 7% had GDM based on the Carpenter and Coustan (C&C) criteria.

After adjusting for age, the investigators found that 10% of the Korean women had GDM based on the C&C criteria, followed by 9.8% of Chinese women and 8.3% among Filipino women. The prevalence was lowest among African Americans (3.3%) and Caucasians (4.2%).

Based on the NDDG criteria, Puerto Rican women had the highest age-adjusted prevalence of GDM (7.4%), but this was barely higher than the average when C&C criteria were applied. However, Korean, Filipino, and Chinese women had the next highest prevalences of GDM, at 6.4%, 5.8%, and 5.6%, respectively, based on the NDDG criteria. Again, Caucasians and African Americans had the lowest prevalence of GDM, at 2.5% and 2.2%, respectively.

The study included women aged 13-39 years who gave birth in Hawaii between 1995 and 2003. The Asian population was divided into five subgroups: Korean, Chinese, Japanese, Vietnamese, and Filipino. Additional groups included Samoan, Puerto Rican, Native Hawaiian, Caucasian, African American, Native American, other Hispanic, and other Pacific Islander.

The results suggest that the risks for developing GDM may vary greatly depending on specific ethnic background. “These findings point to the need for further research along several avenues, such as maternal-child outcome differences and perhaps ethnic-specific guidelines for GDM diagnosis,” the researchers said.

Chinese women had a high gestational diabetes prevalence at 5.6%.

Source ©Thye Aun Ngo/Fotolia.com

Disclosures: The study was funded by the American Diabetes Association. Coauthor Dr. Teresa A. Hillier was funded by a 1-year ADA-European Association for the Study of Diabetes Trans-Atlantic Fellowship.

Women of Korean, Chinese, and Filipino descent are more than twice as likely to develop gestational diabetes as Caucasian or African American women, according to a data analysis of more than 16,000 pregnant women in Hawaii.

Gestational diabetes occurs in 4%-8% of all pregnant women, wrote Kathryn L. Pedula and her colleagues. Data from a pair of recent U.S. studies suggested that Asians have a higher prevalence of gestational diabetes mellitus (GDM) than do other ethnicities, but differences among subcategories of Asian populations have not been well studied.

Ms. Pedula and her associates at the Center for Health Research, Kaiser Permanente Northwest in Portland, Ore., reviewed 10 years' worth of data from 22,110 pregnancies in 16,757 women. Hawaii was chosen for the study because of its ethnically diverse population (Ethn. Dis. 2009;19:414-9).

A total of 353 women had pre-existing diabetes. The remaining women underwent screening for GDM between 24 and 28 weeks of pregnancy, using the 50-gram, 1-hour glucose challenge test (GCT). Women with plasma glucose levels greater than 200 mg/dL on the GCT were deemed to have GDM and were not tested further. The remaining women with a GCT value greater than 140 mg/dL underwent the 100-gram, 3-hour oral glucose tolerance test.

Overall, 20.9% of the women had a positive GCT (plasma glucose at least 140 mg/dL). Approximately 4% had GDM based on the National Diabetes Data Group (NDDG) criteria, and 7% had GDM based on the Carpenter and Coustan (C&C) criteria.

After adjusting for age, the investigators found that 10% of the Korean women had GDM based on the C&C criteria, followed by 9.8% of Chinese women and 8.3% among Filipino women. The prevalence was lowest among African Americans (3.3%) and Caucasians (4.2%).

Based on the NDDG criteria, Puerto Rican women had the highest age-adjusted prevalence of GDM (7.4%), but this was barely higher than the average when C&C criteria were applied. However, Korean, Filipino, and Chinese women had the next highest prevalences of GDM, at 6.4%, 5.8%, and 5.6%, respectively, based on the NDDG criteria. Again, Caucasians and African Americans had the lowest prevalence of GDM, at 2.5% and 2.2%, respectively.

The study included women aged 13-39 years who gave birth in Hawaii between 1995 and 2003. The Asian population was divided into five subgroups: Korean, Chinese, Japanese, Vietnamese, and Filipino. Additional groups included Samoan, Puerto Rican, Native Hawaiian, Caucasian, African American, Native American, other Hispanic, and other Pacific Islander.

The results suggest that the risks for developing GDM may vary greatly depending on specific ethnic background. “These findings point to the need for further research along several avenues, such as maternal-child outcome differences and perhaps ethnic-specific guidelines for GDM diagnosis,” the researchers said.

Chinese women had a high gestational diabetes prevalence at 5.6%.

Source ©Thye Aun Ngo/Fotolia.com

Disclosures: The study was funded by the American Diabetes Association. Coauthor Dr. Teresa A. Hillier was funded by a 1-year ADA-European Association for the Study of Diabetes Trans-Atlantic Fellowship.

Women of Korean, Chinese, and Filipino descent are more than twice as likely to develop gestational diabetes as Caucasian or African American women, according to a data analysis of more than 16,000 pregnant women in Hawaii.

Gestational diabetes occurs in 4%-8% of all pregnant women, wrote Kathryn L. Pedula and her colleagues. Data from a pair of recent U.S. studies suggested that Asians have a higher prevalence of gestational diabetes mellitus (GDM) than do other ethnicities, but differences among subcategories of Asian populations have not been well studied.

Ms. Pedula and her associates at the Center for Health Research, Kaiser Permanente Northwest in Portland, Ore., reviewed 10 years' worth of data from 22,110 pregnancies in 16,757 women. Hawaii was chosen for the study because of its ethnically diverse population (Ethn. Dis. 2009;19:414-9).

A total of 353 women had pre-existing diabetes. The remaining women underwent screening for GDM between 24 and 28 weeks of pregnancy, using the 50-gram, 1-hour glucose challenge test (GCT). Women with plasma glucose levels greater than 200 mg/dL on the GCT were deemed to have GDM and were not tested further. The remaining women with a GCT value greater than 140 mg/dL underwent the 100-gram, 3-hour oral glucose tolerance test.

Overall, 20.9% of the women had a positive GCT (plasma glucose at least 140 mg/dL). Approximately 4% had GDM based on the National Diabetes Data Group (NDDG) criteria, and 7% had GDM based on the Carpenter and Coustan (C&C) criteria.

After adjusting for age, the investigators found that 10% of the Korean women had GDM based on the C&C criteria, followed by 9.8% of Chinese women and 8.3% among Filipino women. The prevalence was lowest among African Americans (3.3%) and Caucasians (4.2%).

Based on the NDDG criteria, Puerto Rican women had the highest age-adjusted prevalence of GDM (7.4%), but this was barely higher than the average when C&C criteria were applied. However, Korean, Filipino, and Chinese women had the next highest prevalences of GDM, at 6.4%, 5.8%, and 5.6%, respectively, based on the NDDG criteria. Again, Caucasians and African Americans had the lowest prevalence of GDM, at 2.5% and 2.2%, respectively.

The study included women aged 13-39 years who gave birth in Hawaii between 1995 and 2003. The Asian population was divided into five subgroups: Korean, Chinese, Japanese, Vietnamese, and Filipino. Additional groups included Samoan, Puerto Rican, Native Hawaiian, Caucasian, African American, Native American, other Hispanic, and other Pacific Islander.

The results suggest that the risks for developing GDM may vary greatly depending on specific ethnic background. “These findings point to the need for further research along several avenues, such as maternal-child outcome differences and perhaps ethnic-specific guidelines for GDM diagnosis,” the researchers said.

Chinese women had a high gestational diabetes prevalence at 5.6%.

Source ©Thye Aun Ngo/Fotolia.com

WASHINGTON — Obese women are less likely to be screened for osteoporosis than are normal- or overweight women, according to findings from a study of more than 140,000 women included in an integrated health care plan database.

Previous studies have shown mixed results on the disparity in preventive health care for obese patients, compared with normal-weight patients, said Kristi Reynolds, Ph.D., of Kaiser Permanente in Pasadena, Calif., and her colleagues.

“It is largely unknown whether obesity is associated with the quality of care for osteoporosis, which is both preventable and treatable but is often undiagnosed and untreated,” the researchers said. Physicians may be less inclined to screen obese women for osteoporosis because body weight is associated with higher bone density, they noted.

Data from 146,975 health care provider visits between July 1, 2007, and June 30, 2008, were reviewed.

The average age of the women was 73 years; 35% were normal weight; 35% were overweight; and 19%, 7%, and 4% fell into obesity categories I, II, and III, respectively. Normal-weight body mass index (BMI) was defined as 18.5-24.9 kg/m

About 67% of the women had undergone bone mineral density testing within 4 years of the study, which was the criteria by which participants could be considered “screened.” Only 52% of women with a BMI of 40 kg/m

After controlling for age, race, and income, the odds ratio of osteoporosis screening for overweight women was 0.99, while the odds ratios for women in obese classes I, II, and III groups were 0.90, 0.77, and 0.60, respectively. The findings were presented in a poster at the the annual meeting of the Obesity Society.

The results suggest that many overweight and obese women aren't screened for osteoporosis. However, more research is needed to examine the health outcomes of screened versus unscreened women, and the factors that influence providers to screen women according to BMI, the researchers said.

The researchers are employees of Kaiser Permanente. They reported having no financial conflicts of interest.

WASHINGTON — Obese women are less likely to be screened for osteoporosis than are normal- or overweight women, according to findings from a study of more than 140,000 women included in an integrated health care plan database.

Previous studies have shown mixed results on the disparity in preventive health care for obese patients, compared with normal-weight patients, said Kristi Reynolds, Ph.D., of Kaiser Permanente in Pasadena, Calif., and her colleagues.

“It is largely unknown whether obesity is associated with the quality of care for osteoporosis, which is both preventable and treatable but is often undiagnosed and untreated,” the researchers said. Physicians may be less inclined to screen obese women for osteoporosis because body weight is associated with higher bone density, they noted.

Data from 146,975 health care provider visits between July 1, 2007, and June 30, 2008, were reviewed.

The average age of the women was 73 years; 35% were normal weight; 35% were overweight; and 19%, 7%, and 4% fell into obesity categories I, II, and III, respectively. Normal-weight body mass index (BMI) was defined as 18.5-24.9 kg/m

About 67% of the women had undergone bone mineral density testing within 4 years of the study, which was the criteria by which participants could be considered “screened.” Only 52% of women with a BMI of 40 kg/m

After controlling for age, race, and income, the odds ratio of osteoporosis screening for overweight women was 0.99, while the odds ratios for women in obese classes I, II, and III groups were 0.90, 0.77, and 0.60, respectively. The findings were presented in a poster at the the annual meeting of the Obesity Society.

The results suggest that many overweight and obese women aren't screened for osteoporosis. However, more research is needed to examine the health outcomes of screened versus unscreened women, and the factors that influence providers to screen women according to BMI, the researchers said.

The researchers are employees of Kaiser Permanente. They reported having no financial conflicts of interest.

WASHINGTON — Obese women are less likely to be screened for osteoporosis than are normal- or overweight women, according to findings from a study of more than 140,000 women included in an integrated health care plan database.

Previous studies have shown mixed results on the disparity in preventive health care for obese patients, compared with normal-weight patients, said Kristi Reynolds, Ph.D., of Kaiser Permanente in Pasadena, Calif., and her colleagues.

“It is largely unknown whether obesity is associated with the quality of care for osteoporosis, which is both preventable and treatable but is often undiagnosed and untreated,” the researchers said. Physicians may be less inclined to screen obese women for osteoporosis because body weight is associated with higher bone density, they noted.

Data from 146,975 health care provider visits between July 1, 2007, and June 30, 2008, were reviewed.

The average age of the women was 73 years; 35% were normal weight; 35% were overweight; and 19%, 7%, and 4% fell into obesity categories I, II, and III, respectively. Normal-weight body mass index (BMI) was defined as 18.5-24.9 kg/m

About 67% of the women had undergone bone mineral density testing within 4 years of the study, which was the criteria by which participants could be considered “screened.” Only 52% of women with a BMI of 40 kg/m

After controlling for age, race, and income, the odds ratio of osteoporosis screening for overweight women was 0.99, while the odds ratios for women in obese classes I, II, and III groups were 0.90, 0.77, and 0.60, respectively. The findings were presented in a poster at the the annual meeting of the Obesity Society.

The results suggest that many overweight and obese women aren't screened for osteoporosis. However, more research is needed to examine the health outcomes of screened versus unscreened women, and the factors that influence providers to screen women according to BMI, the researchers said.

The researchers are employees of Kaiser Permanente. They reported having no financial conflicts of interest.

Approximately 1% of 8-year-old children in the United States meet criteria for an autism spectrum disorder, based on results of a nationwide study of 8-year-olds conducted in 2006.

“No single factor explains the change in prevalence,” said Catherine Rice, Ph.D., of the National Center on Birth Defects and Developmental Disabilities. Dr. Rice presented the study results in a telebriefing.

The study included health and education records from 11 communities throughout the United States participating in the Autism and Developmental Disabilities Network (ADDM). The project was funded by the Centers for Disease Control and Prevention. Dr. Rice and her colleagues at the CDC focused on 8-year-olds because most children with autism spectrum disorder (ASD) have been identified by this age. A team of clinicians reviewed the records to confirm ASD diagnoses and identified 2,757 children who met criteria for ASD (MMWR 2009;58[SS-10]:1–24).

The prevalence of ASD among 8-year-olds increased by an average of 57% between 2002 and 2006, based on data from 10 reporting communities that participated in the study in both years. This increase might be attributable to improved diagnostic techniques, but “a true increase in the risk for children to develop ASD symptoms cannot be ruled out,” the researchers said.

Increases in ASD occurred across sex, ethnicity, and cognitive function, but the most consistent pattern was the increase in ASD among boys, Dr. Rice said. Overall, the prevalence of ASD was 1 in 70 boys and 1 in 315 girls, which amounts to a four to five times higher prevalence in boys, compared with girls.

Dr. Rice advised all primary care physicians who suspect ASD in a child to refer the child for further diagnostic evaluation or intervention.

The researchers did not conduct in-person evaluations of each child, and the results were limited by variations in record keeping. The study was not designed to evaluate causes of ASD, but the findings suggest that more research is needed to determine how genetic and environmental factors interact to cause ASD spectrum symptoms, the researchers wrote.

Approximately 1% of 8-year-old children in the United States meet criteria for an autism spectrum disorder, based on results of a nationwide study of 8-year-olds conducted in 2006.

“No single factor explains the change in prevalence,” said Catherine Rice, Ph.D., of the National Center on Birth Defects and Developmental Disabilities. Dr. Rice presented the study results in a telebriefing.

The study included health and education records from 11 communities throughout the United States participating in the Autism and Developmental Disabilities Network (ADDM). The project was funded by the Centers for Disease Control and Prevention. Dr. Rice and her colleagues at the CDC focused on 8-year-olds because most children with autism spectrum disorder (ASD) have been identified by this age. A team of clinicians reviewed the records to confirm ASD diagnoses and identified 2,757 children who met criteria for ASD (MMWR 2009;58[SS-10]:1–24).

The prevalence of ASD among 8-year-olds increased by an average of 57% between 2002 and 2006, based on data from 10 reporting communities that participated in the study in both years. This increase might be attributable to improved diagnostic techniques, but “a true increase in the risk for children to develop ASD symptoms cannot be ruled out,” the researchers said.

Increases in ASD occurred across sex, ethnicity, and cognitive function, but the most consistent pattern was the increase in ASD among boys, Dr. Rice said. Overall, the prevalence of ASD was 1 in 70 boys and 1 in 315 girls, which amounts to a four to five times higher prevalence in boys, compared with girls.

Dr. Rice advised all primary care physicians who suspect ASD in a child to refer the child for further diagnostic evaluation or intervention.

The researchers did not conduct in-person evaluations of each child, and the results were limited by variations in record keeping. The study was not designed to evaluate causes of ASD, but the findings suggest that more research is needed to determine how genetic and environmental factors interact to cause ASD spectrum symptoms, the researchers wrote.

Approximately 1% of 8-year-old children in the United States meet criteria for an autism spectrum disorder, based on results of a nationwide study of 8-year-olds conducted in 2006.

“No single factor explains the change in prevalence,” said Catherine Rice, Ph.D., of the National Center on Birth Defects and Developmental Disabilities. Dr. Rice presented the study results in a telebriefing.

The study included health and education records from 11 communities throughout the United States participating in the Autism and Developmental Disabilities Network (ADDM). The project was funded by the Centers for Disease Control and Prevention. Dr. Rice and her colleagues at the CDC focused on 8-year-olds because most children with autism spectrum disorder (ASD) have been identified by this age. A team of clinicians reviewed the records to confirm ASD diagnoses and identified 2,757 children who met criteria for ASD (MMWR 2009;58[SS-10]:1–24).

The prevalence of ASD among 8-year-olds increased by an average of 57% between 2002 and 2006, based on data from 10 reporting communities that participated in the study in both years. This increase might be attributable to improved diagnostic techniques, but “a true increase in the risk for children to develop ASD symptoms cannot be ruled out,” the researchers said.

Increases in ASD occurred across sex, ethnicity, and cognitive function, but the most consistent pattern was the increase in ASD among boys, Dr. Rice said. Overall, the prevalence of ASD was 1 in 70 boys and 1 in 315 girls, which amounts to a four to five times higher prevalence in boys, compared with girls.

Dr. Rice advised all primary care physicians who suspect ASD in a child to refer the child for further diagnostic evaluation or intervention.

The researchers did not conduct in-person evaluations of each child, and the results were limited by variations in record keeping. The study was not designed to evaluate causes of ASD, but the findings suggest that more research is needed to determine how genetic and environmental factors interact to cause ASD spectrum symptoms, the researchers wrote.

The pandemic influenza A(H1N1) virus does not appear to spread among an infected person's household contacts as easily as viruses in past pandemics, according to an analysis of data collected in the United States.

Simon Cauchemez, Ph.D., of Imperial College, London, and colleagues reviewed information on the H1N1 infection in 216 households; in total, the virus was transmitted from 216 index patients to 600 household contacts. The median age of the index patient was 15 years, and each household had two to six members. Data were collected by the Centers for Disease Control and Prevention.

Overall, 78 (13%) of the 600 household contacts developed acute respiratory illness and 60 (10%) developed an influenzalike illness.

In 156 households (72%), no household contacts developed acute respiratory illness. In 46 households (21%), one household contact developed acute respiratory illness, and in 14 households (6%), more than one contact developed acute respiratory illness. These secondary cases were not systematically confirmed as H1N1 illness (N. Engl. J. Med. 2009;361:2619–27).

In the secondary cases of possible H1N1 influenza, household contacts who were aged 18 years and younger were about twice as likely to develop either acute respiratory illness or flulike illness, compared with household contacts aged 19 years and older. The median age of the household contacts was 26 years, but the median age of contacts with acute respiratory illness was 16.5 years and the median age of contacts with flulike illness was 14.5 years.

The average time between the onset of illness in an index patient and the onset of illness in one of his or her household contacts was 2.6 days.

The estimates of transmissibility in households were lower than those seen in previous pandemics, but they were similar to transmissibility data from the early phase of the H1N1 pandemic in Mexico. No specific symptom was associated with increased transmission of illness, and the findings showed no link between increased transmission of illness and the index patient's age, the researchers noted.

The findings were limited by several factors, including a lack of data about antiviral therapy in household contacts.

Dr. Cauchemez has received consulting fees from Sanofi Pasteur. The study was supported in part by grants from several organizations including the Medical Research Council and the Bill and Melinda Gates Foundation.

The pandemic influenza A(H1N1) virus does not appear to spread among an infected person's household contacts as easily as viruses in past pandemics, according to an analysis of data collected in the United States.

Simon Cauchemez, Ph.D., of Imperial College, London, and colleagues reviewed information on the H1N1 infection in 216 households; in total, the virus was transmitted from 216 index patients to 600 household contacts. The median age of the index patient was 15 years, and each household had two to six members. Data were collected by the Centers for Disease Control and Prevention.

Overall, 78 (13%) of the 600 household contacts developed acute respiratory illness and 60 (10%) developed an influenzalike illness.

In 156 households (72%), no household contacts developed acute respiratory illness. In 46 households (21%), one household contact developed acute respiratory illness, and in 14 households (6%), more than one contact developed acute respiratory illness. These secondary cases were not systematically confirmed as H1N1 illness (N. Engl. J. Med. 2009;361:2619–27).

In the secondary cases of possible H1N1 influenza, household contacts who were aged 18 years and younger were about twice as likely to develop either acute respiratory illness or flulike illness, compared with household contacts aged 19 years and older. The median age of the household contacts was 26 years, but the median age of contacts with acute respiratory illness was 16.5 years and the median age of contacts with flulike illness was 14.5 years.

The average time between the onset of illness in an index patient and the onset of illness in one of his or her household contacts was 2.6 days.

The estimates of transmissibility in households were lower than those seen in previous pandemics, but they were similar to transmissibility data from the early phase of the H1N1 pandemic in Mexico. No specific symptom was associated with increased transmission of illness, and the findings showed no link between increased transmission of illness and the index patient's age, the researchers noted.

The findings were limited by several factors, including a lack of data about antiviral therapy in household contacts.

Dr. Cauchemez has received consulting fees from Sanofi Pasteur. The study was supported in part by grants from several organizations including the Medical Research Council and the Bill and Melinda Gates Foundation.

The pandemic influenza A(H1N1) virus does not appear to spread among an infected person's household contacts as easily as viruses in past pandemics, according to an analysis of data collected in the United States.

Simon Cauchemez, Ph.D., of Imperial College, London, and colleagues reviewed information on the H1N1 infection in 216 households; in total, the virus was transmitted from 216 index patients to 600 household contacts. The median age of the index patient was 15 years, and each household had two to six members. Data were collected by the Centers for Disease Control and Prevention.

Overall, 78 (13%) of the 600 household contacts developed acute respiratory illness and 60 (10%) developed an influenzalike illness.

In 156 households (72%), no household contacts developed acute respiratory illness. In 46 households (21%), one household contact developed acute respiratory illness, and in 14 households (6%), more than one contact developed acute respiratory illness. These secondary cases were not systematically confirmed as H1N1 illness (N. Engl. J. Med. 2009;361:2619–27).

In the secondary cases of possible H1N1 influenza, household contacts who were aged 18 years and younger were about twice as likely to develop either acute respiratory illness or flulike illness, compared with household contacts aged 19 years and older. The median age of the household contacts was 26 years, but the median age of contacts with acute respiratory illness was 16.5 years and the median age of contacts with flulike illness was 14.5 years.

The average time between the onset of illness in an index patient and the onset of illness in one of his or her household contacts was 2.6 days.

The estimates of transmissibility in households were lower than those seen in previous pandemics, but they were similar to transmissibility data from the early phase of the H1N1 pandemic in Mexico. No specific symptom was associated with increased transmission of illness, and the findings showed no link between increased transmission of illness and the index patient's age, the researchers noted.

The findings were limited by several factors, including a lack of data about antiviral therapy in household contacts.

Dr. Cauchemez has received consulting fees from Sanofi Pasteur. The study was supported in part by grants from several organizations including the Medical Research Council and the Bill and Melinda Gates Foundation.

BOSTON — Initial serum lactate measurements are not reliable predictors of major injuries in children with severe blunt trauma, based on data from a prospective study of 200 children in a university pediatric emergency department.

Serum lactate levels are often used to measure tissue hypoperfusion in adult sepsis patients and in trauma patients who don't show signs of shock. “Elevated blood lactate reflects anaerobic metabolism due to hypoperfusion,” Dr. Antonio E. Muniz said at the annual meeting of the American Academy of Emergency Physicians.

Dr. Muniz of the University of Texas Health Sciences Center at Houston reviewed serum lactate levels in children aged 2–18 who had suffered blunt trauma. Serum lactate levels were elevated in 56 (28%) of the children. For predicting the 102 major injuries, the sensitivity of elevated lactate was 47% and the specificity was 86%, suggesting that initial levels of serum lactate are not helpful, he noted. The positive predictive value was 71%, and the negative predictive value was 68%.

Extremity fractures accounted for about 25% of the major injuries. Other types of major injuries included facial fracture, pelvic fracture, liver laceration, and spleen laceration. Most of the blunt trauma injuries were caused by motor vehicle accidents (152 children), followed by being hit by a car (24 children), falls (12 children), bicycle accidents (8 children), and gunshot wounds (4 children).

Data from other studies suggest that measuring serum lactate at later intervals after blunt trauma might be useful for assessing injuries, Dr. Muniz noted. He had no financial conflicts to disclose.

BOSTON — Initial serum lactate measurements are not reliable predictors of major injuries in children with severe blunt trauma, based on data from a prospective study of 200 children in a university pediatric emergency department.

Serum lactate levels are often used to measure tissue hypoperfusion in adult sepsis patients and in trauma patients who don't show signs of shock. “Elevated blood lactate reflects anaerobic metabolism due to hypoperfusion,” Dr. Antonio E. Muniz said at the annual meeting of the American Academy of Emergency Physicians.

Dr. Muniz of the University of Texas Health Sciences Center at Houston reviewed serum lactate levels in children aged 2–18 who had suffered blunt trauma. Serum lactate levels were elevated in 56 (28%) of the children. For predicting the 102 major injuries, the sensitivity of elevated lactate was 47% and the specificity was 86%, suggesting that initial levels of serum lactate are not helpful, he noted. The positive predictive value was 71%, and the negative predictive value was 68%.

Extremity fractures accounted for about 25% of the major injuries. Other types of major injuries included facial fracture, pelvic fracture, liver laceration, and spleen laceration. Most of the blunt trauma injuries were caused by motor vehicle accidents (152 children), followed by being hit by a car (24 children), falls (12 children), bicycle accidents (8 children), and gunshot wounds (4 children).

Data from other studies suggest that measuring serum lactate at later intervals after blunt trauma might be useful for assessing injuries, Dr. Muniz noted. He had no financial conflicts to disclose.

BOSTON — Initial serum lactate measurements are not reliable predictors of major injuries in children with severe blunt trauma, based on data from a prospective study of 200 children in a university pediatric emergency department.

Serum lactate levels are often used to measure tissue hypoperfusion in adult sepsis patients and in trauma patients who don't show signs of shock. “Elevated blood lactate reflects anaerobic metabolism due to hypoperfusion,” Dr. Antonio E. Muniz said at the annual meeting of the American Academy of Emergency Physicians.

Dr. Muniz of the University of Texas Health Sciences Center at Houston reviewed serum lactate levels in children aged 2–18 who had suffered blunt trauma. Serum lactate levels were elevated in 56 (28%) of the children. For predicting the 102 major injuries, the sensitivity of elevated lactate was 47% and the specificity was 86%, suggesting that initial levels of serum lactate are not helpful, he noted. The positive predictive value was 71%, and the negative predictive value was 68%.

Extremity fractures accounted for about 25% of the major injuries. Other types of major injuries included facial fracture, pelvic fracture, liver laceration, and spleen laceration. Most of the blunt trauma injuries were caused by motor vehicle accidents (152 children), followed by being hit by a car (24 children), falls (12 children), bicycle accidents (8 children), and gunshot wounds (4 children).

Data from other studies suggest that measuring serum lactate at later intervals after blunt trauma might be useful for assessing injuries, Dr. Muniz noted. He had no financial conflicts to disclose.