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Potential New Targeted Treatment for Chondrosarcoma
The gene BIRC5 is an “important player” in chondrosarcoma survival, say researchers from Leiden University, The Netherlands, and Athens University, Greece. They propose that targeting survivin, a protein encoded by BIRC5, could lead to a potential avenue for treating the tumor that accounts for 20% of all malignant bone cancers.
Chondrosarcomas are “intrinsically resistant” to chemo- and radiotherapy,” the researchers say, leaving surgery as the only curative option. So they aimed to identify genes that could be used in targeted drug treatment.
Related: Using a Multiplex of Biomarkers to Detect Prostate Cancer
They screened for 51 apoptosis-related genes. When the screening pinpointed survivin as essential for chondrosarcoma survival, the researchers used immunohistochemistry to analyze cytoplasmic survivin expression in 207 chondrosarcomas of different subtypes. Survivin is highly expressed, they found, in tumor tissue and cell lines of conventional as well as rare subtypes of chondrosarcoma.
Related: A Team Approach to Nonmelanotic Skin Cancer Procedures
The researchers also tested sensitivity to YM155 (a survivin-inhibiting compound) and found chondrosarcoma cells lines were highly sensitive. They say their findings suggest that YM155, which is already in phase I and II clinical trials for other tumors, could be readily applicable in clinical trials for chondrosarcoma patients. Although some larger phase II studies have not shown promising antitumor activity in diffuse large B-cell lymphoma, non-small cell lung cancer, melanoma, or prostate cancer, that doesn’t mean YM155 can’t help in chondrosarcoma patients, they say. Especially, they note, because in chondrosarcoma,YM155 does not induce apoptosis but blocks the cell cycle.
Related: Using a Multiplex of Biomarkers to Detect Prostate Cancer
In particular TP53 mutant cell lines were sensitive; thus, TP53 mutation may be a biomarker that can allow preselecting patients for treatment.
Source:
de Jong Y, van Oosterwijk JG, Kruisselbrink AB. Targeting survivin as a potential new treatment for chondrosarcoma of bone. Oncogenesis. 2016;5:e222.
doi: 10.1038/oncsis.2016.33.
The gene BIRC5 is an “important player” in chondrosarcoma survival, say researchers from Leiden University, The Netherlands, and Athens University, Greece. They propose that targeting survivin, a protein encoded by BIRC5, could lead to a potential avenue for treating the tumor that accounts for 20% of all malignant bone cancers.
Chondrosarcomas are “intrinsically resistant” to chemo- and radiotherapy,” the researchers say, leaving surgery as the only curative option. So they aimed to identify genes that could be used in targeted drug treatment.
Related: Using a Multiplex of Biomarkers to Detect Prostate Cancer
They screened for 51 apoptosis-related genes. When the screening pinpointed survivin as essential for chondrosarcoma survival, the researchers used immunohistochemistry to analyze cytoplasmic survivin expression in 207 chondrosarcomas of different subtypes. Survivin is highly expressed, they found, in tumor tissue and cell lines of conventional as well as rare subtypes of chondrosarcoma.
Related: A Team Approach to Nonmelanotic Skin Cancer Procedures
The researchers also tested sensitivity to YM155 (a survivin-inhibiting compound) and found chondrosarcoma cells lines were highly sensitive. They say their findings suggest that YM155, which is already in phase I and II clinical trials for other tumors, could be readily applicable in clinical trials for chondrosarcoma patients. Although some larger phase II studies have not shown promising antitumor activity in diffuse large B-cell lymphoma, non-small cell lung cancer, melanoma, or prostate cancer, that doesn’t mean YM155 can’t help in chondrosarcoma patients, they say. Especially, they note, because in chondrosarcoma,YM155 does not induce apoptosis but blocks the cell cycle.
Related: Using a Multiplex of Biomarkers to Detect Prostate Cancer
In particular TP53 mutant cell lines were sensitive; thus, TP53 mutation may be a biomarker that can allow preselecting patients for treatment.
Source:
de Jong Y, van Oosterwijk JG, Kruisselbrink AB. Targeting survivin as a potential new treatment for chondrosarcoma of bone. Oncogenesis. 2016;5:e222.
doi: 10.1038/oncsis.2016.33.
The gene BIRC5 is an “important player” in chondrosarcoma survival, say researchers from Leiden University, The Netherlands, and Athens University, Greece. They propose that targeting survivin, a protein encoded by BIRC5, could lead to a potential avenue for treating the tumor that accounts for 20% of all malignant bone cancers.
Chondrosarcomas are “intrinsically resistant” to chemo- and radiotherapy,” the researchers say, leaving surgery as the only curative option. So they aimed to identify genes that could be used in targeted drug treatment.
Related: Using a Multiplex of Biomarkers to Detect Prostate Cancer
They screened for 51 apoptosis-related genes. When the screening pinpointed survivin as essential for chondrosarcoma survival, the researchers used immunohistochemistry to analyze cytoplasmic survivin expression in 207 chondrosarcomas of different subtypes. Survivin is highly expressed, they found, in tumor tissue and cell lines of conventional as well as rare subtypes of chondrosarcoma.
Related: A Team Approach to Nonmelanotic Skin Cancer Procedures
The researchers also tested sensitivity to YM155 (a survivin-inhibiting compound) and found chondrosarcoma cells lines were highly sensitive. They say their findings suggest that YM155, which is already in phase I and II clinical trials for other tumors, could be readily applicable in clinical trials for chondrosarcoma patients. Although some larger phase II studies have not shown promising antitumor activity in diffuse large B-cell lymphoma, non-small cell lung cancer, melanoma, or prostate cancer, that doesn’t mean YM155 can’t help in chondrosarcoma patients, they say. Especially, they note, because in chondrosarcoma,YM155 does not induce apoptosis but blocks the cell cycle.
Related: Using a Multiplex of Biomarkers to Detect Prostate Cancer
In particular TP53 mutant cell lines were sensitive; thus, TP53 mutation may be a biomarker that can allow preselecting patients for treatment.
Source:
de Jong Y, van Oosterwijk JG, Kruisselbrink AB. Targeting survivin as a potential new treatment for chondrosarcoma of bone. Oncogenesis. 2016;5:e222.
doi: 10.1038/oncsis.2016.33.
A Deadly Problem Among American Indians
Despite efforts to change the results, the American Indian infant mortality rate is still nearly twice that of the nation. The Great Plains area—South Dakota, North Dakota, Iowa, and Nebraska—is particularly hard-hit. There, babies are 2 to 3 times more likely than white babies to die within their first year. A recent article in Native Health News Alliance (NHNA)provides some background.
In South Dakota, American Indian babies accounted for 23 of 73 infant deaths reported in 2014, according to the South Dakota Department of Health, quoted in NHNA. In fact, between 2013 and 2014, although the number dropped of white babies dying, the number rose slightly for American Indians. Usually the postneonatal period (starting on day 28) marks the end of the “danger zone,” when the risk of infant death tends to go down. But for American Indian babies in South Dakota, the rate jumps from 4.2 per 1,000 births to 7.9.
In the NHNA article, Carol Iron Rope Herrera, who teaches parents about Lakota birthing and child-rearing traditions, says the Lakota tradition considers all babies sacred. She believes infant death in American Indian communities reflects lifestyle changes: “a shift in the cultural and spiritual ways of Native people.”
Linda Littlefield, manager of the Northern Plains Healthy Start program, agrees about lifestyle issues, specifically citing smoking. The NHNA article cites a report by the Northern Plains Tribal Epidemiology Center that found that between 2008 and 2012, > 30% of American Indian women in the Great Plains reported using tobacco during pregnancy.
Many American Indian traditions and beliefs support infant health and well-being, according to Christy Hacker, director of Maternal and Child Health programs for the Great Plains Tribal Chairmen’s Health Board, quoted in the NHNA article. Healthy Start communities often incorporate Lakota traditions about life and the sacredness of babies at powwows and other ceremonies.
But Hacker believes it is also important to encourage and support good care for women. According to research by the CDC and Northern Plains Tribal Epidemiology Center, only half of American Indian mothers in the Great Plains began prenatal care within the first trimester. “If mothers can take care of themselves,” Hacker says, “they can take care of the baby when it’s born.”
Despite efforts to change the results, the American Indian infant mortality rate is still nearly twice that of the nation. The Great Plains area—South Dakota, North Dakota, Iowa, and Nebraska—is particularly hard-hit. There, babies are 2 to 3 times more likely than white babies to die within their first year. A recent article in Native Health News Alliance (NHNA)provides some background.
In South Dakota, American Indian babies accounted for 23 of 73 infant deaths reported in 2014, according to the South Dakota Department of Health, quoted in NHNA. In fact, between 2013 and 2014, although the number dropped of white babies dying, the number rose slightly for American Indians. Usually the postneonatal period (starting on day 28) marks the end of the “danger zone,” when the risk of infant death tends to go down. But for American Indian babies in South Dakota, the rate jumps from 4.2 per 1,000 births to 7.9.
In the NHNA article, Carol Iron Rope Herrera, who teaches parents about Lakota birthing and child-rearing traditions, says the Lakota tradition considers all babies sacred. She believes infant death in American Indian communities reflects lifestyle changes: “a shift in the cultural and spiritual ways of Native people.”
Linda Littlefield, manager of the Northern Plains Healthy Start program, agrees about lifestyle issues, specifically citing smoking. The NHNA article cites a report by the Northern Plains Tribal Epidemiology Center that found that between 2008 and 2012, > 30% of American Indian women in the Great Plains reported using tobacco during pregnancy.
Many American Indian traditions and beliefs support infant health and well-being, according to Christy Hacker, director of Maternal and Child Health programs for the Great Plains Tribal Chairmen’s Health Board, quoted in the NHNA article. Healthy Start communities often incorporate Lakota traditions about life and the sacredness of babies at powwows and other ceremonies.
But Hacker believes it is also important to encourage and support good care for women. According to research by the CDC and Northern Plains Tribal Epidemiology Center, only half of American Indian mothers in the Great Plains began prenatal care within the first trimester. “If mothers can take care of themselves,” Hacker says, “they can take care of the baby when it’s born.”
Despite efforts to change the results, the American Indian infant mortality rate is still nearly twice that of the nation. The Great Plains area—South Dakota, North Dakota, Iowa, and Nebraska—is particularly hard-hit. There, babies are 2 to 3 times more likely than white babies to die within their first year. A recent article in Native Health News Alliance (NHNA)provides some background.
In South Dakota, American Indian babies accounted for 23 of 73 infant deaths reported in 2014, according to the South Dakota Department of Health, quoted in NHNA. In fact, between 2013 and 2014, although the number dropped of white babies dying, the number rose slightly for American Indians. Usually the postneonatal period (starting on day 28) marks the end of the “danger zone,” when the risk of infant death tends to go down. But for American Indian babies in South Dakota, the rate jumps from 4.2 per 1,000 births to 7.9.
In the NHNA article, Carol Iron Rope Herrera, who teaches parents about Lakota birthing and child-rearing traditions, says the Lakota tradition considers all babies sacred. She believes infant death in American Indian communities reflects lifestyle changes: “a shift in the cultural and spiritual ways of Native people.”
Linda Littlefield, manager of the Northern Plains Healthy Start program, agrees about lifestyle issues, specifically citing smoking. The NHNA article cites a report by the Northern Plains Tribal Epidemiology Center that found that between 2008 and 2012, > 30% of American Indian women in the Great Plains reported using tobacco during pregnancy.
Many American Indian traditions and beliefs support infant health and well-being, according to Christy Hacker, director of Maternal and Child Health programs for the Great Plains Tribal Chairmen’s Health Board, quoted in the NHNA article. Healthy Start communities often incorporate Lakota traditions about life and the sacredness of babies at powwows and other ceremonies.
But Hacker believes it is also important to encourage and support good care for women. According to research by the CDC and Northern Plains Tribal Epidemiology Center, only half of American Indian mothers in the Great Plains began prenatal care within the first trimester. “If mothers can take care of themselves,” Hacker says, “they can take care of the baby when it’s born.”
Contest Aims to Redesign Medical Bills
It’s a common complaint: “I can’t understand my medical bill!” Now, HHS is giving health care organizations, designers, developers, and others a chance to change that.
The “A Bill You Can Understand” challenge, sponsored by AARP, is intended to “help patients understand their medical bills and the financial aspect of health.” The concept was born of research that included responses from a survey of more than 300 patients and their families and one-on-one interviews with patients, families, and representatives from health systems, insurance companies, and integrated systems. In the patient survey 61% of patients rated their medical bills as “confusing” or “very confusing.”
The challenge is offering 2 awards of $5,000 each: one to the innovator who designs the easiest-to-understand bill and the other to the innovator who designs the best approach to improve the medical billing system—focusing on what the patient sees and does throughout the process.
The competition is open for submissions until August 10, 2016. Winners will be announced in September. Submissions to the challenge will be judged based on understandability, creativity, and how well they address the challenge criteria. For more information, visit www.abillyoucanunderstand.com.
It’s a common complaint: “I can’t understand my medical bill!” Now, HHS is giving health care organizations, designers, developers, and others a chance to change that.
The “A Bill You Can Understand” challenge, sponsored by AARP, is intended to “help patients understand their medical bills and the financial aspect of health.” The concept was born of research that included responses from a survey of more than 300 patients and their families and one-on-one interviews with patients, families, and representatives from health systems, insurance companies, and integrated systems. In the patient survey 61% of patients rated their medical bills as “confusing” or “very confusing.”
The challenge is offering 2 awards of $5,000 each: one to the innovator who designs the easiest-to-understand bill and the other to the innovator who designs the best approach to improve the medical billing system—focusing on what the patient sees and does throughout the process.
The competition is open for submissions until August 10, 2016. Winners will be announced in September. Submissions to the challenge will be judged based on understandability, creativity, and how well they address the challenge criteria. For more information, visit www.abillyoucanunderstand.com.
It’s a common complaint: “I can’t understand my medical bill!” Now, HHS is giving health care organizations, designers, developers, and others a chance to change that.
The “A Bill You Can Understand” challenge, sponsored by AARP, is intended to “help patients understand their medical bills and the financial aspect of health.” The concept was born of research that included responses from a survey of more than 300 patients and their families and one-on-one interviews with patients, families, and representatives from health systems, insurance companies, and integrated systems. In the patient survey 61% of patients rated their medical bills as “confusing” or “very confusing.”
The challenge is offering 2 awards of $5,000 each: one to the innovator who designs the easiest-to-understand bill and the other to the innovator who designs the best approach to improve the medical billing system—focusing on what the patient sees and does throughout the process.
The competition is open for submissions until August 10, 2016. Winners will be announced in September. Submissions to the challenge will be judged based on understandability, creativity, and how well they address the challenge criteria. For more information, visit www.abillyoucanunderstand.com.
Update on Sexual Assault in the Military
Reports of sexual assault among military personnel are still at high levels, according to the DoD’s 12th Annual Report on Sexual Assault in the Military, covering October 2014 through September 2015.
The department received 6,083 reports for 2015 involving service members—only a 1% drop from 6,131 in 2014. Climate survey results also showed that about 16,000 service members intervened in situations they believed to have a risk of sexual assault, the DoD says.
Some of the data on sexual assaults come from 459 participants in 58 focus group sessions, part of an alternating cycle of surveys and focus groups conducted in support of the annual report.
Research has “consistently shown that sexual assault is most likely to occur in environments where there are unhealthy social factors,” the report says. Those factors include gender discrimination, sexual harassment, and other problems that “degrade or devalue individuals and their contributions in the workplace.” In cases of 657 formal complaints concerning sexual harassment, 74% of substantiated incidents occurred on duty. Nearly all complainants were enlisted. The largest single group of complainants by both gender and pay grade was females in pay grades E1-E4. Forty percent of substantiated offenders were in pay grades E5-E6; 96% were men.
About one-third of victims said the perpetrator sexually harassed them prior to the assault. Most survey respondents said they knew their alleged offenders; 57% said the alleged offender was someone they considered a friend or acquaintance.
“Our efforts are having an impact, but there are still many hurdles to overcome,” said Army Major General Camille Nichols, director of the DoD Sexual Assault Prevention and Response (SAPR) Office. Reporting is essential, she said. In fact, encouraging greater reporting is 1 of 5 key SAPR program elements. The DoD also took “significant action” to advance sexual assault prevention, improve response to male sexual assault victims, combat retaliation associated with sexual assault, and track accountability of sexual assault cases.
The DoD also is tracking the overall experience of investigation and justice. In a survey of assault victims, 77% said they would recommend others to report, and 80% who interacted with the Special Victims’ Counsel Program were satisfied with the experience.
The full report is available at www.sapr.mil/index.php/annual-reports.
Reports of sexual assault among military personnel are still at high levels, according to the DoD’s 12th Annual Report on Sexual Assault in the Military, covering October 2014 through September 2015.
The department received 6,083 reports for 2015 involving service members—only a 1% drop from 6,131 in 2014. Climate survey results also showed that about 16,000 service members intervened in situations they believed to have a risk of sexual assault, the DoD says.
Some of the data on sexual assaults come from 459 participants in 58 focus group sessions, part of an alternating cycle of surveys and focus groups conducted in support of the annual report.
Research has “consistently shown that sexual assault is most likely to occur in environments where there are unhealthy social factors,” the report says. Those factors include gender discrimination, sexual harassment, and other problems that “degrade or devalue individuals and their contributions in the workplace.” In cases of 657 formal complaints concerning sexual harassment, 74% of substantiated incidents occurred on duty. Nearly all complainants were enlisted. The largest single group of complainants by both gender and pay grade was females in pay grades E1-E4. Forty percent of substantiated offenders were in pay grades E5-E6; 96% were men.
About one-third of victims said the perpetrator sexually harassed them prior to the assault. Most survey respondents said they knew their alleged offenders; 57% said the alleged offender was someone they considered a friend or acquaintance.
“Our efforts are having an impact, but there are still many hurdles to overcome,” said Army Major General Camille Nichols, director of the DoD Sexual Assault Prevention and Response (SAPR) Office. Reporting is essential, she said. In fact, encouraging greater reporting is 1 of 5 key SAPR program elements. The DoD also took “significant action” to advance sexual assault prevention, improve response to male sexual assault victims, combat retaliation associated with sexual assault, and track accountability of sexual assault cases.
The DoD also is tracking the overall experience of investigation and justice. In a survey of assault victims, 77% said they would recommend others to report, and 80% who interacted with the Special Victims’ Counsel Program were satisfied with the experience.
The full report is available at www.sapr.mil/index.php/annual-reports.
Reports of sexual assault among military personnel are still at high levels, according to the DoD’s 12th Annual Report on Sexual Assault in the Military, covering October 2014 through September 2015.
The department received 6,083 reports for 2015 involving service members—only a 1% drop from 6,131 in 2014. Climate survey results also showed that about 16,000 service members intervened in situations they believed to have a risk of sexual assault, the DoD says.
Some of the data on sexual assaults come from 459 participants in 58 focus group sessions, part of an alternating cycle of surveys and focus groups conducted in support of the annual report.
Research has “consistently shown that sexual assault is most likely to occur in environments where there are unhealthy social factors,” the report says. Those factors include gender discrimination, sexual harassment, and other problems that “degrade or devalue individuals and their contributions in the workplace.” In cases of 657 formal complaints concerning sexual harassment, 74% of substantiated incidents occurred on duty. Nearly all complainants were enlisted. The largest single group of complainants by both gender and pay grade was females in pay grades E1-E4. Forty percent of substantiated offenders were in pay grades E5-E6; 96% were men.
About one-third of victims said the perpetrator sexually harassed them prior to the assault. Most survey respondents said they knew their alleged offenders; 57% said the alleged offender was someone they considered a friend or acquaintance.
“Our efforts are having an impact, but there are still many hurdles to overcome,” said Army Major General Camille Nichols, director of the DoD Sexual Assault Prevention and Response (SAPR) Office. Reporting is essential, she said. In fact, encouraging greater reporting is 1 of 5 key SAPR program elements. The DoD also took “significant action” to advance sexual assault prevention, improve response to male sexual assault victims, combat retaliation associated with sexual assault, and track accountability of sexual assault cases.
The DoD also is tracking the overall experience of investigation and justice. In a survey of assault victims, 77% said they would recommend others to report, and 80% who interacted with the Special Victims’ Counsel Program were satisfied with the experience.
The full report is available at www.sapr.mil/index.php/annual-reports.
A Better Way to Remove Chemical Contamination
Disrobing and wiping skin with a paper towel or dry wipe seems simple—but doing both removes nearly 100% of chemical contamination, say researchers in an HHS-sponsored study.
The study, at University of Hertfordshire in the United Kingdom, looked at various approaches to mass patient decontamination after chemical exposure: using various water temperatures, adding soap, and having patients disrobe before showering. They found disrobing took care of up to 90% of chemical contamination; wiping exposed skin removed another 9%. Finally, showering and drying off with a towel or cloth brought contamination levels down to 99.9%.
National recommendations emphasize the importance of having people disrobe and then use low-pressure water. But the researchers say in actual practice, people were not always required to disrobe, and high-pressure water from fire engines was used to shower the clothed patients. Their study revealed that showering in contaminated clothing actually washes chemicals through to the skin, increasing contamination.
“Every minute counts in protecting health after chemical exposure,” said Acting Director Richard J. Hatchett, MD, of the Biomedical Advanced Research and Development Authority. “This study provides critical scientific evidence of effective actions emergency responders and community partners should consider in their emergency plan.”
Disrobing and wiping skin with a paper towel or dry wipe seems simple—but doing both removes nearly 100% of chemical contamination, say researchers in an HHS-sponsored study.
The study, at University of Hertfordshire in the United Kingdom, looked at various approaches to mass patient decontamination after chemical exposure: using various water temperatures, adding soap, and having patients disrobe before showering. They found disrobing took care of up to 90% of chemical contamination; wiping exposed skin removed another 9%. Finally, showering and drying off with a towel or cloth brought contamination levels down to 99.9%.
National recommendations emphasize the importance of having people disrobe and then use low-pressure water. But the researchers say in actual practice, people were not always required to disrobe, and high-pressure water from fire engines was used to shower the clothed patients. Their study revealed that showering in contaminated clothing actually washes chemicals through to the skin, increasing contamination.
“Every minute counts in protecting health after chemical exposure,” said Acting Director Richard J. Hatchett, MD, of the Biomedical Advanced Research and Development Authority. “This study provides critical scientific evidence of effective actions emergency responders and community partners should consider in their emergency plan.”
Disrobing and wiping skin with a paper towel or dry wipe seems simple—but doing both removes nearly 100% of chemical contamination, say researchers in an HHS-sponsored study.
The study, at University of Hertfordshire in the United Kingdom, looked at various approaches to mass patient decontamination after chemical exposure: using various water temperatures, adding soap, and having patients disrobe before showering. They found disrobing took care of up to 90% of chemical contamination; wiping exposed skin removed another 9%. Finally, showering and drying off with a towel or cloth brought contamination levels down to 99.9%.
National recommendations emphasize the importance of having people disrobe and then use low-pressure water. But the researchers say in actual practice, people were not always required to disrobe, and high-pressure water from fire engines was used to shower the clothed patients. Their study revealed that showering in contaminated clothing actually washes chemicals through to the skin, increasing contamination.
“Every minute counts in protecting health after chemical exposure,” said Acting Director Richard J. Hatchett, MD, of the Biomedical Advanced Research and Development Authority. “This study provides critical scientific evidence of effective actions emergency responders and community partners should consider in their emergency plan.”
Diagnosing Anthrax in Minutes
A simple point-of-care finger prick test to diagnose anthrax infection is moving into the final stages of development. Unlike current tests, which can take days for lab analysis, this one shows results within minutes. Immediate response is crucial in cases of anthrax exposure. Untreated, inhaled anthrax can be deadly within days.
The test is being developed by SRI International (Menlo Park, CA) under an 18-month, $2.5 million agreement with HHS’s Biomedical Advanced Research and Development Authority . Based partly on a similar version developed at the CDC, the SRI test uses blood samples on small cartridges. After 15 minutes, the cartridge is placed in a palm-sized reader, which displays results. The convenient size, says HHS, makes it ideally suited for bedside use or by first responders.
A simple point-of-care finger prick test to diagnose anthrax infection is moving into the final stages of development. Unlike current tests, which can take days for lab analysis, this one shows results within minutes. Immediate response is crucial in cases of anthrax exposure. Untreated, inhaled anthrax can be deadly within days.
The test is being developed by SRI International (Menlo Park, CA) under an 18-month, $2.5 million agreement with HHS’s Biomedical Advanced Research and Development Authority . Based partly on a similar version developed at the CDC, the SRI test uses blood samples on small cartridges. After 15 minutes, the cartridge is placed in a palm-sized reader, which displays results. The convenient size, says HHS, makes it ideally suited for bedside use or by first responders.
A simple point-of-care finger prick test to diagnose anthrax infection is moving into the final stages of development. Unlike current tests, which can take days for lab analysis, this one shows results within minutes. Immediate response is crucial in cases of anthrax exposure. Untreated, inhaled anthrax can be deadly within days.
The test is being developed by SRI International (Menlo Park, CA) under an 18-month, $2.5 million agreement with HHS’s Biomedical Advanced Research and Development Authority . Based partly on a similar version developed at the CDC, the SRI test uses blood samples on small cartridges. After 15 minutes, the cartridge is placed in a palm-sized reader, which displays results. The convenient size, says HHS, makes it ideally suited for bedside use or by first responders.
Exercise Lowers Risk of Some Cancers
Here’s one more reason to take a break and exercise: A recent study links leisure-time physical activities with a lower risk of developing 13 different types of cancer. The international team of investigators pooled data from 12 prospective U.S. and European cohorts with self-reported physical activity that included more than 1.4 million participants and 186,932 cases of cancer. The greatest risk reductions were for esophageal adenocarcinoma, liver cancer, cancer of the gastric cardia, kidney cancer, and myeloid leukemia. Previous research has examined the links between physical activity and cancer risk and shown reduced risks for colon, breast, and endometrial cancers, but these studies have been underpowered to make the connection with other forms of cancer.
Related: IBD and the Risk of Oral Cancer
“Leisure-time physical activity is known to reduce risks of heart disease and risk of death from all causes, and our study demonstrates that it is also associated with lower risks of many types of cancer,” said Steven C. Moore, PhD, MPH, an investigator at the National Cancer Institute. “Furthermore, our results support that these associations are broadly generalizable to different populations, including people who are overweight or obese, or those with a history of smoking. Health care professionals counseling inactive adults should promote physical activity as a component of a healthy lifestyle and cancer prevention.”
For 13 cancers, increased levels of leisure-time physical activity were associated with lower risk: esophageal adenocarcinoma (hazard ratio [HR] 0.58, 95%; confidence interval [CI] 0.37-0.89); liver (HR 0.73, 95% CI 0.55-0.98); lung (HR 0.74, 95% CI 0.71-0.77); kidney (HR 0.77, 95% CI 0.70-0.85); gastric cardia (HR 0.78, 95% CI 0.64-0.95); endometrial (HR 0.79, 95% CI 0.68-0.92); myeloid leukemia (HR 0.80, 95% CI 0.70-0.92); myeloma (HR 0.83, 95% CI 0.72-0.95); colon (HR 0.84, 95% CI 0.77-0.91); head and neck (HR 0.85, 95% CI 0.78-0.93); rectal (HR 0.87, 95% CI 0.80-0.95); bladder (HR 0.87, 95% CI 0.82-0.92); and breast (HR 0.90, 95% CI 0.87-0.93). Conversely, leisure-time physical activity increased the risks of malignant melanoma (HR 1.27, 95% CI 1.16-1.40) and prostate cancer (HR 1.05, 95% CI 1.03-1.08).
Related: Sexual Orientation and Cancer Risk
According to the authors, the associations were similar between patients who were overweight/obese and those who were normal weight. They also noted that smoking status modified the association with lung cancer but not other smoking-related cancers.
The amount of exercise was important for some of the cancers. The risk of developing 7 of the cancer types was at least 20% lower for the most active participants (90th percentile of activity) compared with the least active participants (10th percentile of activity).
A number of physical activity mechanisms can affect cancer risk. It has been hypothesized that cancer growth could be initiated or abetted by 3 metabolic pathways that also are affected by exercise: sex steroids (estrogens and androgens); insulin and insulin-like growth factors; and proteins involved with both insulin metabolism and inflammation. Additionally, several non-hormonal mechanisms have been hypothesized to link physical activity to cancer risk, including inflammation, immune function, oxidative stress, and, for colon cancer, a reduction in time that it takes for waste to pass through the gastrointestinal tract.
Related: Alcohol Intake Increases Cancer Risk
“For years, we’ve had substantial evidence supporting a role for physical activity in three leading cancers: colon, breast, and endometrial cancers, which together account for nearly one in four cancers in the United States,” said another study author, Alpa V. Patel, PhD, a cancer epidemiologist at the American Cancer Society. “This study linking physical activity to 10 additional cancers shows its impact may be even more relevant, and that physical activity has far reaching value for cancer prevention.”
Source:
Increased physical activity associated with lower risk of 13 types of cancer [press release]. Bethesda, MD: National Institutes of Health; May 16, 2016.
Here’s one more reason to take a break and exercise: A recent study links leisure-time physical activities with a lower risk of developing 13 different types of cancer. The international team of investigators pooled data from 12 prospective U.S. and European cohorts with self-reported physical activity that included more than 1.4 million participants and 186,932 cases of cancer. The greatest risk reductions were for esophageal adenocarcinoma, liver cancer, cancer of the gastric cardia, kidney cancer, and myeloid leukemia. Previous research has examined the links between physical activity and cancer risk and shown reduced risks for colon, breast, and endometrial cancers, but these studies have been underpowered to make the connection with other forms of cancer.
Related: IBD and the Risk of Oral Cancer
“Leisure-time physical activity is known to reduce risks of heart disease and risk of death from all causes, and our study demonstrates that it is also associated with lower risks of many types of cancer,” said Steven C. Moore, PhD, MPH, an investigator at the National Cancer Institute. “Furthermore, our results support that these associations are broadly generalizable to different populations, including people who are overweight or obese, or those with a history of smoking. Health care professionals counseling inactive adults should promote physical activity as a component of a healthy lifestyle and cancer prevention.”
For 13 cancers, increased levels of leisure-time physical activity were associated with lower risk: esophageal adenocarcinoma (hazard ratio [HR] 0.58, 95%; confidence interval [CI] 0.37-0.89); liver (HR 0.73, 95% CI 0.55-0.98); lung (HR 0.74, 95% CI 0.71-0.77); kidney (HR 0.77, 95% CI 0.70-0.85); gastric cardia (HR 0.78, 95% CI 0.64-0.95); endometrial (HR 0.79, 95% CI 0.68-0.92); myeloid leukemia (HR 0.80, 95% CI 0.70-0.92); myeloma (HR 0.83, 95% CI 0.72-0.95); colon (HR 0.84, 95% CI 0.77-0.91); head and neck (HR 0.85, 95% CI 0.78-0.93); rectal (HR 0.87, 95% CI 0.80-0.95); bladder (HR 0.87, 95% CI 0.82-0.92); and breast (HR 0.90, 95% CI 0.87-0.93). Conversely, leisure-time physical activity increased the risks of malignant melanoma (HR 1.27, 95% CI 1.16-1.40) and prostate cancer (HR 1.05, 95% CI 1.03-1.08).
Related: Sexual Orientation and Cancer Risk
According to the authors, the associations were similar between patients who were overweight/obese and those who were normal weight. They also noted that smoking status modified the association with lung cancer but not other smoking-related cancers.
The amount of exercise was important for some of the cancers. The risk of developing 7 of the cancer types was at least 20% lower for the most active participants (90th percentile of activity) compared with the least active participants (10th percentile of activity).
A number of physical activity mechanisms can affect cancer risk. It has been hypothesized that cancer growth could be initiated or abetted by 3 metabolic pathways that also are affected by exercise: sex steroids (estrogens and androgens); insulin and insulin-like growth factors; and proteins involved with both insulin metabolism and inflammation. Additionally, several non-hormonal mechanisms have been hypothesized to link physical activity to cancer risk, including inflammation, immune function, oxidative stress, and, for colon cancer, a reduction in time that it takes for waste to pass through the gastrointestinal tract.
Related: Alcohol Intake Increases Cancer Risk
“For years, we’ve had substantial evidence supporting a role for physical activity in three leading cancers: colon, breast, and endometrial cancers, which together account for nearly one in four cancers in the United States,” said another study author, Alpa V. Patel, PhD, a cancer epidemiologist at the American Cancer Society. “This study linking physical activity to 10 additional cancers shows its impact may be even more relevant, and that physical activity has far reaching value for cancer prevention.”
Source:
Increased physical activity associated with lower risk of 13 types of cancer [press release]. Bethesda, MD: National Institutes of Health; May 16, 2016.
Here’s one more reason to take a break and exercise: A recent study links leisure-time physical activities with a lower risk of developing 13 different types of cancer. The international team of investigators pooled data from 12 prospective U.S. and European cohorts with self-reported physical activity that included more than 1.4 million participants and 186,932 cases of cancer. The greatest risk reductions were for esophageal adenocarcinoma, liver cancer, cancer of the gastric cardia, kidney cancer, and myeloid leukemia. Previous research has examined the links between physical activity and cancer risk and shown reduced risks for colon, breast, and endometrial cancers, but these studies have been underpowered to make the connection with other forms of cancer.
Related: IBD and the Risk of Oral Cancer
“Leisure-time physical activity is known to reduce risks of heart disease and risk of death from all causes, and our study demonstrates that it is also associated with lower risks of many types of cancer,” said Steven C. Moore, PhD, MPH, an investigator at the National Cancer Institute. “Furthermore, our results support that these associations are broadly generalizable to different populations, including people who are overweight or obese, or those with a history of smoking. Health care professionals counseling inactive adults should promote physical activity as a component of a healthy lifestyle and cancer prevention.”
For 13 cancers, increased levels of leisure-time physical activity were associated with lower risk: esophageal adenocarcinoma (hazard ratio [HR] 0.58, 95%; confidence interval [CI] 0.37-0.89); liver (HR 0.73, 95% CI 0.55-0.98); lung (HR 0.74, 95% CI 0.71-0.77); kidney (HR 0.77, 95% CI 0.70-0.85); gastric cardia (HR 0.78, 95% CI 0.64-0.95); endometrial (HR 0.79, 95% CI 0.68-0.92); myeloid leukemia (HR 0.80, 95% CI 0.70-0.92); myeloma (HR 0.83, 95% CI 0.72-0.95); colon (HR 0.84, 95% CI 0.77-0.91); head and neck (HR 0.85, 95% CI 0.78-0.93); rectal (HR 0.87, 95% CI 0.80-0.95); bladder (HR 0.87, 95% CI 0.82-0.92); and breast (HR 0.90, 95% CI 0.87-0.93). Conversely, leisure-time physical activity increased the risks of malignant melanoma (HR 1.27, 95% CI 1.16-1.40) and prostate cancer (HR 1.05, 95% CI 1.03-1.08).
Related: Sexual Orientation and Cancer Risk
According to the authors, the associations were similar between patients who were overweight/obese and those who were normal weight. They also noted that smoking status modified the association with lung cancer but not other smoking-related cancers.
The amount of exercise was important for some of the cancers. The risk of developing 7 of the cancer types was at least 20% lower for the most active participants (90th percentile of activity) compared with the least active participants (10th percentile of activity).
A number of physical activity mechanisms can affect cancer risk. It has been hypothesized that cancer growth could be initiated or abetted by 3 metabolic pathways that also are affected by exercise: sex steroids (estrogens and androgens); insulin and insulin-like growth factors; and proteins involved with both insulin metabolism and inflammation. Additionally, several non-hormonal mechanisms have been hypothesized to link physical activity to cancer risk, including inflammation, immune function, oxidative stress, and, for colon cancer, a reduction in time that it takes for waste to pass through the gastrointestinal tract.
Related: Alcohol Intake Increases Cancer Risk
“For years, we’ve had substantial evidence supporting a role for physical activity in three leading cancers: colon, breast, and endometrial cancers, which together account for nearly one in four cancers in the United States,” said another study author, Alpa V. Patel, PhD, a cancer epidemiologist at the American Cancer Society. “This study linking physical activity to 10 additional cancers shows its impact may be even more relevant, and that physical activity has far reaching value for cancer prevention.”
Source:
Increased physical activity associated with lower risk of 13 types of cancer [press release]. Bethesda, MD: National Institutes of Health; May 16, 2016.
CDC Media Campaign Helps Americans Quit Smoking
Three years ago, the CDC launched “Tips From Former Smokers,” the first federally funded anti-smoking paid media campaign. The ads included striking real-life stories of smokers’ struggles with smoking-related health issues, such as cancer, gum disease, premature birth, and stroke. Since its launch, the campaign has helped at least 400,000 smokers quit according to CDC Director Tom Frieden, MD, MPH. An estimated 104,000 Americans quit smoking for good as a result of the 2014 campaign alone.
The 2014 campaign aired in 2 phases from February to April and July to September. In a survey, about 80% of U.S. adult cigarette smokers said they had seen at least 1 television ad from phase 2 of the campaign.
Tips is “extremely cost-effective and a best buy, saving both lives and money,” said Frieden. “With a year-round campaign we could save even more lives and money.”
As effective as the campaign is, it’s up against a tough antagonist that refuses to surrender. Corinne Graffunder, DrPH, director of the CDC’s Office on Smoking and Health added, “The money spent in 1 year on ‘Tips’ is less than the amount the tobacco industry spends on advertising and promotion in just 3 days.”
Moreover, young people are, in a sense, cannon fodder. “We know that 90% of all adult smokers first try cigarettes as teens,” Graffunder said. According to the CDC’s 2015 National Youth Tobacco Survey, overall tobacco use among middle- and high school students has not changed since 2011; 4.7 million were current users of a tobacco product in 2015. E-cigarettes are now the most commonly used tobacco product by adolescents, the CDC found, and its use continues to climb.
Three years ago, the CDC launched “Tips From Former Smokers,” the first federally funded anti-smoking paid media campaign. The ads included striking real-life stories of smokers’ struggles with smoking-related health issues, such as cancer, gum disease, premature birth, and stroke. Since its launch, the campaign has helped at least 400,000 smokers quit according to CDC Director Tom Frieden, MD, MPH. An estimated 104,000 Americans quit smoking for good as a result of the 2014 campaign alone.
The 2014 campaign aired in 2 phases from February to April and July to September. In a survey, about 80% of U.S. adult cigarette smokers said they had seen at least 1 television ad from phase 2 of the campaign.
Tips is “extremely cost-effective and a best buy, saving both lives and money,” said Frieden. “With a year-round campaign we could save even more lives and money.”
As effective as the campaign is, it’s up against a tough antagonist that refuses to surrender. Corinne Graffunder, DrPH, director of the CDC’s Office on Smoking and Health added, “The money spent in 1 year on ‘Tips’ is less than the amount the tobacco industry spends on advertising and promotion in just 3 days.”
Moreover, young people are, in a sense, cannon fodder. “We know that 90% of all adult smokers first try cigarettes as teens,” Graffunder said. According to the CDC’s 2015 National Youth Tobacco Survey, overall tobacco use among middle- and high school students has not changed since 2011; 4.7 million were current users of a tobacco product in 2015. E-cigarettes are now the most commonly used tobacco product by adolescents, the CDC found, and its use continues to climb.
Three years ago, the CDC launched “Tips From Former Smokers,” the first federally funded anti-smoking paid media campaign. The ads included striking real-life stories of smokers’ struggles with smoking-related health issues, such as cancer, gum disease, premature birth, and stroke. Since its launch, the campaign has helped at least 400,000 smokers quit according to CDC Director Tom Frieden, MD, MPH. An estimated 104,000 Americans quit smoking for good as a result of the 2014 campaign alone.
The 2014 campaign aired in 2 phases from February to April and July to September. In a survey, about 80% of U.S. adult cigarette smokers said they had seen at least 1 television ad from phase 2 of the campaign.
Tips is “extremely cost-effective and a best buy, saving both lives and money,” said Frieden. “With a year-round campaign we could save even more lives and money.”
As effective as the campaign is, it’s up against a tough antagonist that refuses to surrender. Corinne Graffunder, DrPH, director of the CDC’s Office on Smoking and Health added, “The money spent in 1 year on ‘Tips’ is less than the amount the tobacco industry spends on advertising and promotion in just 3 days.”
Moreover, young people are, in a sense, cannon fodder. “We know that 90% of all adult smokers first try cigarettes as teens,” Graffunder said. According to the CDC’s 2015 National Youth Tobacco Survey, overall tobacco use among middle- and high school students has not changed since 2011; 4.7 million were current users of a tobacco product in 2015. E-cigarettes are now the most commonly used tobacco product by adolescents, the CDC found, and its use continues to climb.
Thanks to IHS Funding Program, “Sustained Achievements” in Diabetes Prevention
American Indian and Alaska Native people have among the highest rates of diabetes in the country. The IHS Special Diabetes Program for Indians (SDPI) has supported and encouraged innovative interventions across the country to prevent and reduce diabetes, which the IHS says have “changed the diabetes landscape across the Indian health system.”
This year, SDPI is awarding approximately $137 million to 301 Tribes, Tribal organizations, Urban Indian organizations, and IHS facilities for programs to prevent and treat diabetes in American Indians and Alaska Natives (AI/ANs).
Based on local needs and priorities, the grant programs have increased access to diabetes services and helped improve key outcomes, the IHS says. For example, between 1997 and 2010 access to diabetes clinics rose from 31% to 71%, access to registered dietitians rose from 37% to 77%, and access to culturally tailored diabetes education programs from 36% to 99%.
Similarly, in the 13 years the program has been in existence, its results have seen “sustained achievements” in diabetes outcomes, such as declines in blood sugar and cholesterol levels. Between 1995 and 2006, the incident rate of end-stage renal disease in AI/AN people with diabetes fell by 27.7%—more than in any other racial or ethnic group.
American Indian and Alaska Native people have among the highest rates of diabetes in the country. The IHS Special Diabetes Program for Indians (SDPI) has supported and encouraged innovative interventions across the country to prevent and reduce diabetes, which the IHS says have “changed the diabetes landscape across the Indian health system.”
This year, SDPI is awarding approximately $137 million to 301 Tribes, Tribal organizations, Urban Indian organizations, and IHS facilities for programs to prevent and treat diabetes in American Indians and Alaska Natives (AI/ANs).
Based on local needs and priorities, the grant programs have increased access to diabetes services and helped improve key outcomes, the IHS says. For example, between 1997 and 2010 access to diabetes clinics rose from 31% to 71%, access to registered dietitians rose from 37% to 77%, and access to culturally tailored diabetes education programs from 36% to 99%.
Similarly, in the 13 years the program has been in existence, its results have seen “sustained achievements” in diabetes outcomes, such as declines in blood sugar and cholesterol levels. Between 1995 and 2006, the incident rate of end-stage renal disease in AI/AN people with diabetes fell by 27.7%—more than in any other racial or ethnic group.
American Indian and Alaska Native people have among the highest rates of diabetes in the country. The IHS Special Diabetes Program for Indians (SDPI) has supported and encouraged innovative interventions across the country to prevent and reduce diabetes, which the IHS says have “changed the diabetes landscape across the Indian health system.”
This year, SDPI is awarding approximately $137 million to 301 Tribes, Tribal organizations, Urban Indian organizations, and IHS facilities for programs to prevent and treat diabetes in American Indians and Alaska Natives (AI/ANs).
Based on local needs and priorities, the grant programs have increased access to diabetes services and helped improve key outcomes, the IHS says. For example, between 1997 and 2010 access to diabetes clinics rose from 31% to 71%, access to registered dietitians rose from 37% to 77%, and access to culturally tailored diabetes education programs from 36% to 99%.
Similarly, in the 13 years the program has been in existence, its results have seen “sustained achievements” in diabetes outcomes, such as declines in blood sugar and cholesterol levels. Between 1995 and 2006, the incident rate of end-stage renal disease in AI/AN people with diabetes fell by 27.7%—more than in any other racial or ethnic group.
Death Rates for Brain Cancer Trend Downward
Brain cancer rates have declined slightly in recent years, according to the Annual Report to the Nation on the Status of Cancer, 1975-2012, which tracks trends in cancer incidence and deaths in the U.S.
Between 2003 and 2012, brain cancer was 1 of 7 common cancers for which incidence rates dropped among men. Death rates remained stable among men during that time for melanoma and cancers of the bladder, brain, oral cavity, and pharynx. Between 2003 and 2012, brain cancer ranked 11th of the top 17 cancers for whites, 15th for blacks, 13th for Asian/Pacific Islanders (API), 14th for American Indian/Alaska Natives (AI/AN), and 13th for Hispanics.
Related: Major Cancer Death Rates Are Down
When data from 1975 through 2012 were factored in, the long-term trend was a general decline in cancer deaths for adults. Overall, cancer deaths for both sexes decreased by 1.5% per year between 2003 and 2012. For men in all ethnic and racial groups, rates of brain cancer also trended downward. The annual percent change was 4.4% between 1975 and 1977; -0.4% between 1977 and 1982, 1.3% between 1982 and 1991, -1.0% between 1991 and 2007, and 0.7% between 2007 and 2012.
Among women, death rates declined slightly overall but remained stable for brain cancer. Between 2003 and 2012, brain cancer ranked 9th among the top 17 cancers for whites, 15th for blacks, 12th for API, 14th for AI/AN, and 12th for Hispanics.
Related: Predicting Tongue Cancer Recurrence
The annual updates are the joint production of The American Cancer Society, the CDC, National Cancer Institute, and the North American Association of Central Cancer Registries. This is the 18th year the report has been published.
Source:
Ryerson AB, Eheman CR, Altekruse SF, et al. Cancer. 2016;122(9):1312-137.
doi: 10.1002/cncr.29936.
Brain cancer rates have declined slightly in recent years, according to the Annual Report to the Nation on the Status of Cancer, 1975-2012, which tracks trends in cancer incidence and deaths in the U.S.
Between 2003 and 2012, brain cancer was 1 of 7 common cancers for which incidence rates dropped among men. Death rates remained stable among men during that time for melanoma and cancers of the bladder, brain, oral cavity, and pharynx. Between 2003 and 2012, brain cancer ranked 11th of the top 17 cancers for whites, 15th for blacks, 13th for Asian/Pacific Islanders (API), 14th for American Indian/Alaska Natives (AI/AN), and 13th for Hispanics.
Related: Major Cancer Death Rates Are Down
When data from 1975 through 2012 were factored in, the long-term trend was a general decline in cancer deaths for adults. Overall, cancer deaths for both sexes decreased by 1.5% per year between 2003 and 2012. For men in all ethnic and racial groups, rates of brain cancer also trended downward. The annual percent change was 4.4% between 1975 and 1977; -0.4% between 1977 and 1982, 1.3% between 1982 and 1991, -1.0% between 1991 and 2007, and 0.7% between 2007 and 2012.
Among women, death rates declined slightly overall but remained stable for brain cancer. Between 2003 and 2012, brain cancer ranked 9th among the top 17 cancers for whites, 15th for blacks, 12th for API, 14th for AI/AN, and 12th for Hispanics.
Related: Predicting Tongue Cancer Recurrence
The annual updates are the joint production of The American Cancer Society, the CDC, National Cancer Institute, and the North American Association of Central Cancer Registries. This is the 18th year the report has been published.
Source:
Ryerson AB, Eheman CR, Altekruse SF, et al. Cancer. 2016;122(9):1312-137.
doi: 10.1002/cncr.29936.
Brain cancer rates have declined slightly in recent years, according to the Annual Report to the Nation on the Status of Cancer, 1975-2012, which tracks trends in cancer incidence and deaths in the U.S.
Between 2003 and 2012, brain cancer was 1 of 7 common cancers for which incidence rates dropped among men. Death rates remained stable among men during that time for melanoma and cancers of the bladder, brain, oral cavity, and pharynx. Between 2003 and 2012, brain cancer ranked 11th of the top 17 cancers for whites, 15th for blacks, 13th for Asian/Pacific Islanders (API), 14th for American Indian/Alaska Natives (AI/AN), and 13th for Hispanics.
Related: Major Cancer Death Rates Are Down
When data from 1975 through 2012 were factored in, the long-term trend was a general decline in cancer deaths for adults. Overall, cancer deaths for both sexes decreased by 1.5% per year between 2003 and 2012. For men in all ethnic and racial groups, rates of brain cancer also trended downward. The annual percent change was 4.4% between 1975 and 1977; -0.4% between 1977 and 1982, 1.3% between 1982 and 1991, -1.0% between 1991 and 2007, and 0.7% between 2007 and 2012.
Among women, death rates declined slightly overall but remained stable for brain cancer. Between 2003 and 2012, brain cancer ranked 9th among the top 17 cancers for whites, 15th for blacks, 12th for API, 14th for AI/AN, and 12th for Hispanics.
Related: Predicting Tongue Cancer Recurrence
The annual updates are the joint production of The American Cancer Society, the CDC, National Cancer Institute, and the North American Association of Central Cancer Registries. This is the 18th year the report has been published.
Source:
Ryerson AB, Eheman CR, Altekruse SF, et al. Cancer. 2016;122(9):1312-137.
doi: 10.1002/cncr.29936.