Are diuretics helpful in acute renal failure?

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Are diuretics helpful in acute renal failure?
PRACTICE RECOMMENDATIONS

Although widely used to treat acute renal failure, diuretics may actually be harmful.

The results of this observational study demonstrated a higher risk of death and nonrecovery of renal function when diuretics were initiated during the first week of hospitalization. It didn’t matter whether a single or combination diuretic was used.

A randomized controlled trial would better answer this question by minimizing the inherent flaws in an observational study. Although this study doesn’t conclusively prove that diuretics cause poorer outcomes, it certainly raises the possibility and should prompt us to think twice before initiating diuretic therapy for acute renal failure.

 
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Practice Recommendations from Key Studies

Mehta LM, Pascual MT, Soroko S, Chertow GM. Diuretics, mortality, and nonrecovery of renal function in acute renal failure. JAMA 2002; 288:2547–2553.

Lawrence Dybedock, MD
Kevin Kane, MD, MSPH
Department of Family & Community Medicine, University of Missouri Columbia

[email protected]

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The Journal of Family Practice - 52(3)
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183-200
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Practice Recommendations from Key Studies

Mehta LM, Pascual MT, Soroko S, Chertow GM. Diuretics, mortality, and nonrecovery of renal function in acute renal failure. JAMA 2002; 288:2547–2553.

Lawrence Dybedock, MD
Kevin Kane, MD, MSPH
Department of Family & Community Medicine, University of Missouri Columbia

[email protected]

Author and Disclosure Information

Practice Recommendations from Key Studies

Mehta LM, Pascual MT, Soroko S, Chertow GM. Diuretics, mortality, and nonrecovery of renal function in acute renal failure. JAMA 2002; 288:2547–2553.

Lawrence Dybedock, MD
Kevin Kane, MD, MSPH
Department of Family & Community Medicine, University of Missouri Columbia

[email protected]

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PRACTICE RECOMMENDATIONS

Although widely used to treat acute renal failure, diuretics may actually be harmful.

The results of this observational study demonstrated a higher risk of death and nonrecovery of renal function when diuretics were initiated during the first week of hospitalization. It didn’t matter whether a single or combination diuretic was used.

A randomized controlled trial would better answer this question by minimizing the inherent flaws in an observational study. Although this study doesn’t conclusively prove that diuretics cause poorer outcomes, it certainly raises the possibility and should prompt us to think twice before initiating diuretic therapy for acute renal failure.

 
PRACTICE RECOMMENDATIONS

Although widely used to treat acute renal failure, diuretics may actually be harmful.

The results of this observational study demonstrated a higher risk of death and nonrecovery of renal function when diuretics were initiated during the first week of hospitalization. It didn’t matter whether a single or combination diuretic was used.

A randomized controlled trial would better answer this question by minimizing the inherent flaws in an observational study. Although this study doesn’t conclusively prove that diuretics cause poorer outcomes, it certainly raises the possibility and should prompt us to think twice before initiating diuretic therapy for acute renal failure.

 
Issue
The Journal of Family Practice - 52(3)
Issue
The Journal of Family Practice - 52(3)
Page Number
183-200
Page Number
183-200
Publications
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Topics
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Are diuretics helpful in acute renal failure?
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Are diuretics helpful in acute renal failure?
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