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Dietary supplements hyped as LDL cholesterol lowering are a bust: SPORT
The list of supplements without effects on LDL in the placebo-controlled trial include commercial preparations of fish oil, cinnamon, garlic,...
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Avoid routine early ECMO in severe cardiogenic shock: ECMO-CS
Early ECMO in this setting is increasingly common, but it didn’t seem to improve outcomes in the trial, compared with a more conservative approach...
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No survival advantage for either torsemide or furosemide in HF: TRANSFORM-HF
One loop diuretic is the most widely used in heart failure, the other may have advantages in some situations, but there’s been no head-to-head...
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AHA 2022 to recapture in-person vibe but preserve global reach
Planners see the meeting’s Chicago return as a hybrid after 2 years relegated to cyberspace as a chance for first impressions on some just...
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FDA OKs Medtronic lead for left bundle branch pacing
A lead already approved for stimulating the His bundle is now also indicated for LBB pacing, another prominent form of conduction system pacing....
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Trial of early intensive meds at HF discharge halted for benefit: STRONG-HF
Topline results point to significant clinical benefit from a strategy featuring early initiation and rapid uptitration of meds for patients...
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FDA approves self-administered, SubQ furosemide preparation
The preparation of the common loop diuretic is said to provide “intravenous-equivalent” dosing for outpatients with heart failure and volume...
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Dapagliflozin DELIVERs regardless of systolic pressure in HFpEF
The finding may alleviate long-standing concerns that starting modestly diuretic SGLT2 inhibitors in patients with heart failure might present a...
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Salt pills for patients with acute decompensated heart failure?
It may seem counterintuitive, but a new trial testing extra sodium intake in patients receiving high-dose intravenous diuretics for acute HF...
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Add PCSK9 inhibitor to high-intensity statin at primary PCI, proposes sham-controlled EPIC-STEMI
The powerful LDL cholesterol–lowering agents aren’t being used to their fullest potential, but giving them early to STEMI patients along with high...
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Legacy of neutral renal denervation trial recast by long-term outcomes: SYMPLICITY HTN-3
Although interest in renal denervation in hypertension fell off after disappointing results from the 2014 trial, a new, longer-term analysis...
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PASCAL for MV repair noninferior to MitraClip in CLASP IID; FDA took notice
A newly FDA-approved transcatheter mitral valve repair system and another one widely used for years were similarly safe and effective in an...
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Ultrasonic renal denervation passes 2-month test in uncontrolled HTN: RADIANCE II
No ill effects were seen in the sham-controlled trial of patients with uncontrolled mild to moderate hypertension. The approach led to significant...
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Heparin pretreatment may safely open arteries before STEMI cath
The “early reperfusion” associated with IRA patency at angiography “could have long-term benefit due to smaller infarct size.”
News
No invasive strategy benefit at 5 years in ISCHEMIA-CKD extension study
The trial speaks to the lofty high-risk status of patients with CAD. ‘You’re seeing in a group of patients, with largely preserved EF but advanced...