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Angioedema risk jumps when switching HF meds
The risk for angioedema rises when switching from an ARB or ACE inhibitor to ARNI, observational data suggest.
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STS, new president apologize for predecessor’s speech amid Twitter backlash
A speech at the Society of Thoracic Surgeons’ annual meeting, delivered by its outgoing president, sparked outrage and dismay on social media and...
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Clarity on torsemide vs. furosemide in HF: TRANSFORM-HF published
A new meta-analysis of trials comparing TAVI to surgery for aortic valve stenosis highlights a high rate of potential bias in the trials.
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PCSK9 inhibitors for severe COVID? Pilot trial signals of benefit
“PCSK9 inhibition may represent a novel therapeutic pathway in addition to currently recommended therapeutic approaches for severe COVID-19.”
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One in four cardiologists worldwide report mental health issues
The mental health conditions were more common in women than in men and were closely linked to enduring hostile work environments and other strains...
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Bempedoic acid cuts CV risk in the statin-intolerant: CLEAR top-line results
In top-line results, high-risk patients with statin intolerance taking the lipid-lowering agent showed a significant decline in risk for CV events...
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EHR alerts to both doc and patient may boost statin prescribing
Electronic ‘nudges’ that promote new statin prescriptions seemed most effective when sent to patients as well as their primary care doctors in a...
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FDA tweaks Impella indications on basis of postapproval study
The updated indication tightens the description of eligible patients on the basis of postapproval study results but in line with premarket-study...
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FDA expands list of Getinge IABP system and component shortages
In a letter to providers, the agency added intra-aortic balloon pump systems to a list of Getinge IABP equipment currently in short supply due to...
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IRONMAN galvanizes case for IV iron repletion in heart failure
The trial missed its primary endpoint, but makes unique contributions; many see it as further evidence that the treatment helps iron-deficient...
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Be aware, mindfulness training can lower systolic BP: MB-BP
“This is exactly what we need: a well-done trial with a control group to show that it actually works,” said one expert, cautioning that it...
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Optimize HF meds rapidly and fully after hospital discharge: STRONG-HF
Outcomes were superior with a high-intensity up-titration strategy compared with usual care, but questions about implementation in practice remain...
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Dietary supplements hyped as LDL cholesterol lowering are a bust: SPORT
The list of supplements without effects on LDL in the placebo-controlled trial include commercial preparations of fish oil, cinnamon, garlic,...
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Avoid routine early ECMO in severe cardiogenic shock: ECMO-CS
Early ECMO in this setting is increasingly common, but it didn’t seem to improve outcomes in the trial, compared with a more conservative approach...
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No survival advantage for either torsemide or furosemide in HF: TRANSFORM-HF
One loop diuretic is the most widely used in heart failure, the other may have advantages in some situations, but there’s been no head-to-head...