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Amoxicillin-clavulanate ineffective for suspected acute sinusitis
PRACTICE RECOMMENDATIONS

Amoxicillin-clavulanate was no more effective than placebo in quickly relieving symptoms in patients diagnosed clinically with acute sinusitis in a general practice setting. It was, however, much more likely to cause diarrhea. Because most patients will improve spontaneously, antibiotics should be reserved for patients with prolonged symptoms. An inexpensive, narrow-spectrum drug such as amoxicillin is a good initial choice.

 
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Practice Recommendations from Key Studies

Bucher HC, Tschudi P, Young J, et al. Effect of amoxicillin-clavulanate in clinically diagnosed acute rhinosinusitis: a placebo-controlled, double-blind, randomized trial in general practice. Arch Intern Med 2003; 163:1793–1798.

Eric A. Jackson, PharmD
Department of Family Medicine, University of Connecticut School of Medicine and Saint Francis Hospital and Medical Center, Hartford. E-mail: [email protected].

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The Journal of Family Practice - 52(12)
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919-941
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Practice Recommendations from Key Studies

Bucher HC, Tschudi P, Young J, et al. Effect of amoxicillin-clavulanate in clinically diagnosed acute rhinosinusitis: a placebo-controlled, double-blind, randomized trial in general practice. Arch Intern Med 2003; 163:1793–1798.

Eric A. Jackson, PharmD
Department of Family Medicine, University of Connecticut School of Medicine and Saint Francis Hospital and Medical Center, Hartford. E-mail: [email protected].

Author and Disclosure Information

Practice Recommendations from Key Studies

Bucher HC, Tschudi P, Young J, et al. Effect of amoxicillin-clavulanate in clinically diagnosed acute rhinosinusitis: a placebo-controlled, double-blind, randomized trial in general practice. Arch Intern Med 2003; 163:1793–1798.

Eric A. Jackson, PharmD
Department of Family Medicine, University of Connecticut School of Medicine and Saint Francis Hospital and Medical Center, Hartford. E-mail: [email protected].

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PRACTICE RECOMMENDATIONS

Amoxicillin-clavulanate was no more effective than placebo in quickly relieving symptoms in patients diagnosed clinically with acute sinusitis in a general practice setting. It was, however, much more likely to cause diarrhea. Because most patients will improve spontaneously, antibiotics should be reserved for patients with prolonged symptoms. An inexpensive, narrow-spectrum drug such as amoxicillin is a good initial choice.

 
PRACTICE RECOMMENDATIONS

Amoxicillin-clavulanate was no more effective than placebo in quickly relieving symptoms in patients diagnosed clinically with acute sinusitis in a general practice setting. It was, however, much more likely to cause diarrhea. Because most patients will improve spontaneously, antibiotics should be reserved for patients with prolonged symptoms. An inexpensive, narrow-spectrum drug such as amoxicillin is a good initial choice.

 
Issue
The Journal of Family Practice - 52(12)
Issue
The Journal of Family Practice - 52(12)
Page Number
919-941
Page Number
919-941
Publications
Publications
Topics
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Amoxicillin-clavulanate ineffective for suspected acute sinusitis
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Amoxicillin-clavulanate ineffective for suspected acute sinusitis
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