Development of EPI differs with type of bariatric surgery

Key clinical point: The development of exocrine pancreatic insufficiency (EPI) varied with the type of restrictive or malabsorptive bariatric surgery, i.e., sleeve gastrectomy (SG), Roux-en-Y gastric bypass (RYGB), or biliopancreatic diversion with duodenal switch (BPD/DS).

Major finding: Six-hour ¹³C-cumulative recovery rate was significantly reduced (all P less than .001) in patients who underwent BPD/DS (25.6±13.5%) vs those who underwent RYGB (44.0±9.6%) or SG (47.6±9.3%) and the control group of patients who did not undergo bariatric surgery (45.0±6.1%). EPI was present in 78.8% of patients after BPD/DS, 8.3% of patients after RYGB, and 4.3% of patients after SG (P < .01).

Study details: This was a prospective study that assessed pancreatic function using a ¹³C-mixed triglyceride breath test in 95 adult patients who underwent bariatric surgery (RYGB, n=36; BPD/DS, n=36; SG, n=23) and 10 patients with obesity who formed the control group.

Disclosures: No source of funding was identified. JE Dominguez-Munoz received personal fees from Abbott Pharmaceuticals, AbbVie, and Viatris. Other authors declared no conflict of interests.

Source: Uribarri-Gonzalez L et al. Surg Obes Relat Dis. 2021 Jul 6. doi: 10.1016/j.soard.2021.06.019.

Key clinical point: The development of exocrine pancreatic insufficiency (EPI) varied with the type of restrictive or malabsorptive bariatric surgery, i.e., sleeve gastrectomy (SG), Roux-en-Y gastric bypass (RYGB), or biliopancreatic diversion with duodenal switch (BPD/DS).

Major finding: Six-hour ¹³C-cumulative recovery rate was significantly reduced (all P less than .001) in patients who underwent BPD/DS (25.6±13.5%) vs those who underwent RYGB (44.0±9.6%) or SG (47.6±9.3%) and the control group of patients who did not undergo bariatric surgery (45.0±6.1%). EPI was present in 78.8% of patients after BPD/DS, 8.3% of patients after RYGB, and 4.3% of patients after SG (P < .01).

Study details: This was a prospective study that assessed pancreatic function using a ¹³C-mixed triglyceride breath test in 95 adult patients who underwent bariatric surgery (RYGB, n=36; BPD/DS, n=36; SG, n=23) and 10 patients with obesity who formed the control group.

Disclosures: No source of funding was identified. JE Dominguez-Munoz received personal fees from Abbott Pharmaceuticals, AbbVie, and Viatris. Other authors declared no conflict of interests.

Source: Uribarri-Gonzalez L et al. Surg Obes Relat Dis. 2021 Jul 6. doi: 10.1016/j.soard.2021.06.019.

Key clinical point: The development of exocrine pancreatic insufficiency (EPI) varied with the type of restrictive or malabsorptive bariatric surgery, i.e., sleeve gastrectomy (SG), Roux-en-Y gastric bypass (RYGB), or biliopancreatic diversion with duodenal switch (BPD/DS).

Major finding: Six-hour ¹³C-cumulative recovery rate was significantly reduced (all P less than .001) in patients who underwent BPD/DS (25.6±13.5%) vs those who underwent RYGB (44.0±9.6%) or SG (47.6±9.3%) and the control group of patients who did not undergo bariatric surgery (45.0±6.1%). EPI was present in 78.8% of patients after BPD/DS, 8.3% of patients after RYGB, and 4.3% of patients after SG (P < .01).

Study details: This was a prospective study that assessed pancreatic function using a ¹³C-mixed triglyceride breath test in 95 adult patients who underwent bariatric surgery (RYGB, n=36; BPD/DS, n=36; SG, n=23) and 10 patients with obesity who formed the control group.

Disclosures: No source of funding was identified. JE Dominguez-Munoz received personal fees from Abbott Pharmaceuticals, AbbVie, and Viatris. Other authors declared no conflict of interests.

Source: Uribarri-Gonzalez L et al. Surg Obes Relat Dis. 2021 Jul 6. doi: 10.1016/j.soard.2021.06.019.