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Key clinical point: The sphere size is not an essential parameter for selecting effective pancreatin preparations for patients with exocrine pancreatic insufficiency (EPI).
Major finding: One study reported faster emptying of 2 mm pellets than a pancake meal in patients with pancreatic disease. Another study reported parallel emptying of liver pate and 1.5 mm pellets (range, 1.0-1.5 mm). One study reported no clear pattern in stomach emptying for pancreatin pellets of less than 1.2 mm. Emptying of pancreatin preparations with a particle size of up to 7 mm is also documented in the postprandial phase in healthy individuals.
Study details: Meta-analysis of 26 studies that evaluated gastric emptying of indigestible particles of different sizes in healthy volunteers or patients with EPI under fed conditions.
Disclosures: This meta-analysis was supported by Nordmark. The authors received consulting fees outside of this work.
Citation: Peterson K-U. J Gastrointestin Liver Dis. 2021 Mar 12. doi: 10.15403/jgld-2985.
Key clinical point: The sphere size is not an essential parameter for selecting effective pancreatin preparations for patients with exocrine pancreatic insufficiency (EPI).
Major finding: One study reported faster emptying of 2 mm pellets than a pancake meal in patients with pancreatic disease. Another study reported parallel emptying of liver pate and 1.5 mm pellets (range, 1.0-1.5 mm). One study reported no clear pattern in stomach emptying for pancreatin pellets of less than 1.2 mm. Emptying of pancreatin preparations with a particle size of up to 7 mm is also documented in the postprandial phase in healthy individuals.
Study details: Meta-analysis of 26 studies that evaluated gastric emptying of indigestible particles of different sizes in healthy volunteers or patients with EPI under fed conditions.
Disclosures: This meta-analysis was supported by Nordmark. The authors received consulting fees outside of this work.
Citation: Peterson K-U. J Gastrointestin Liver Dis. 2021 Mar 12. doi: 10.15403/jgld-2985.
Key clinical point: The sphere size is not an essential parameter for selecting effective pancreatin preparations for patients with exocrine pancreatic insufficiency (EPI).
Major finding: One study reported faster emptying of 2 mm pellets than a pancake meal in patients with pancreatic disease. Another study reported parallel emptying of liver pate and 1.5 mm pellets (range, 1.0-1.5 mm). One study reported no clear pattern in stomach emptying for pancreatin pellets of less than 1.2 mm. Emptying of pancreatin preparations with a particle size of up to 7 mm is also documented in the postprandial phase in healthy individuals.
Study details: Meta-analysis of 26 studies that evaluated gastric emptying of indigestible particles of different sizes in healthy volunteers or patients with EPI under fed conditions.
Disclosures: This meta-analysis was supported by Nordmark. The authors received consulting fees outside of this work.
Citation: Peterson K-U. J Gastrointestin Liver Dis. 2021 Mar 12. doi: 10.15403/jgld-2985.