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Key clinical point: Treatment with nonsteroidal anti-inflammatory drugs (NSAID) worsened exocrine pancreatic insufficiency (EPI) in patients with primary osteoarthritis in gastrointestinal comorbidity with EPI. Moreover, the trophologic status of patients also deteriorated, indicating reduced nutrient uptake because of aggravation of EPI.
Major finding: Fecal a-elastase levels decreased, and the CO program score increased significantly after vs. before NSAID treatment, particularly in patients with chronic pancreatitis (all P < .05). Moreover, the levels of trophologic parameters (magnesium, calcium, iron, zinc, selenium, albumin, and vitamins A, E, and K) decreased significantly after NSAID treatment (all P < .05).
Study details: This study included 87 adult patients with primary osteoarthritis along with EPI (chronic pancreatitis, n = 30; chronic nonstone cholecystitis, functional diseases of the gallbladder, and biliary system, n = 28; chronic gastroduodenitis, n = 29) and 30 healthy controls.
Disclosures: This study was funded by the authors’ resources. The authors declared no conflict of interests.
Source: Halabitska IM et al. Fam Med Prim Care Rev. 2021;23(4), Oct 5. doi: 10.5114/fmpcr.2021.108207.
Key clinical point: Treatment with nonsteroidal anti-inflammatory drugs (NSAID) worsened exocrine pancreatic insufficiency (EPI) in patients with primary osteoarthritis in gastrointestinal comorbidity with EPI. Moreover, the trophologic status of patients also deteriorated, indicating reduced nutrient uptake because of aggravation of EPI.
Major finding: Fecal a-elastase levels decreased, and the CO program score increased significantly after vs. before NSAID treatment, particularly in patients with chronic pancreatitis (all P < .05). Moreover, the levels of trophologic parameters (magnesium, calcium, iron, zinc, selenium, albumin, and vitamins A, E, and K) decreased significantly after NSAID treatment (all P < .05).
Study details: This study included 87 adult patients with primary osteoarthritis along with EPI (chronic pancreatitis, n = 30; chronic nonstone cholecystitis, functional diseases of the gallbladder, and biliary system, n = 28; chronic gastroduodenitis, n = 29) and 30 healthy controls.
Disclosures: This study was funded by the authors’ resources. The authors declared no conflict of interests.
Source: Halabitska IM et al. Fam Med Prim Care Rev. 2021;23(4), Oct 5. doi: 10.5114/fmpcr.2021.108207.
Key clinical point: Treatment with nonsteroidal anti-inflammatory drugs (NSAID) worsened exocrine pancreatic insufficiency (EPI) in patients with primary osteoarthritis in gastrointestinal comorbidity with EPI. Moreover, the trophologic status of patients also deteriorated, indicating reduced nutrient uptake because of aggravation of EPI.
Major finding: Fecal a-elastase levels decreased, and the CO program score increased significantly after vs. before NSAID treatment, particularly in patients with chronic pancreatitis (all P < .05). Moreover, the levels of trophologic parameters (magnesium, calcium, iron, zinc, selenium, albumin, and vitamins A, E, and K) decreased significantly after NSAID treatment (all P < .05).
Study details: This study included 87 adult patients with primary osteoarthritis along with EPI (chronic pancreatitis, n = 30; chronic nonstone cholecystitis, functional diseases of the gallbladder, and biliary system, n = 28; chronic gastroduodenitis, n = 29) and 30 healthy controls.
Disclosures: This study was funded by the authors’ resources. The authors declared no conflict of interests.
Source: Halabitska IM et al. Fam Med Prim Care Rev. 2021;23(4), Oct 5. doi: 10.5114/fmpcr.2021.108207.