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Researchers from Comenius University in Bratislava, Slovakia, have shown for the first time that fibrillin-1 (FBN-1) is overexpressed in testicular germ cell tumors (TGCTs). Their data suggest that progression of germ cell neoplasia in situ (GCNIS) to overt germ cell tumor is connected with decreased FBN-1 production. Fibrillin is a glycoprotein essential in forming the elastic fibers in connective tissue.
The researchers evaluated 350 tumor specimens and 85 adjacent nonneoplastic testicular tissues in 203 patients. They detected FBN-1 expression in 68 (97%) GCNIS, 21 (96%) yolk sac tumors, 85 (87%) seminomas, 78 (83%) embryonal carcinomas, 35 (71%) teratomas, 3 (18%) choriocarcinomas, and 1 (1%) nonneoplastic tissue. The highest FBN-1 positivity was found in GCNIS, with overexpression of FBN-1 in 77% of cases. The fact that the highest expression was observed in seminomas and the lowest in choriocarcinomas, the researchers say, suggests a reduction of FBN-1 expression with the process of differentiation.
Related: Is Chemotherapy a Good Choice for Neuroendocrine Tumors?
GCNIS represents the preinvasive stage of most TGCTs in adults. GCNIS cells are believed to be germ cells that have failed to mature normally, the researchers note. The appearance of FBN-1 expression in germ cells in the stage of GCNIS, they suggest, can be an early event in the process of malignant transformation.
Source:
Cierna Z, Mego M, Jurisica I, et al. BMC Cancer. 2016;16:597
doi: 10.1186/s12885-016-2644-z.
Researchers from Comenius University in Bratislava, Slovakia, have shown for the first time that fibrillin-1 (FBN-1) is overexpressed in testicular germ cell tumors (TGCTs). Their data suggest that progression of germ cell neoplasia in situ (GCNIS) to overt germ cell tumor is connected with decreased FBN-1 production. Fibrillin is a glycoprotein essential in forming the elastic fibers in connective tissue.
The researchers evaluated 350 tumor specimens and 85 adjacent nonneoplastic testicular tissues in 203 patients. They detected FBN-1 expression in 68 (97%) GCNIS, 21 (96%) yolk sac tumors, 85 (87%) seminomas, 78 (83%) embryonal carcinomas, 35 (71%) teratomas, 3 (18%) choriocarcinomas, and 1 (1%) nonneoplastic tissue. The highest FBN-1 positivity was found in GCNIS, with overexpression of FBN-1 in 77% of cases. The fact that the highest expression was observed in seminomas and the lowest in choriocarcinomas, the researchers say, suggests a reduction of FBN-1 expression with the process of differentiation.
Related: Is Chemotherapy a Good Choice for Neuroendocrine Tumors?
GCNIS represents the preinvasive stage of most TGCTs in adults. GCNIS cells are believed to be germ cells that have failed to mature normally, the researchers note. The appearance of FBN-1 expression in germ cells in the stage of GCNIS, they suggest, can be an early event in the process of malignant transformation.
Source:
Cierna Z, Mego M, Jurisica I, et al. BMC Cancer. 2016;16:597
doi: 10.1186/s12885-016-2644-z.
Researchers from Comenius University in Bratislava, Slovakia, have shown for the first time that fibrillin-1 (FBN-1) is overexpressed in testicular germ cell tumors (TGCTs). Their data suggest that progression of germ cell neoplasia in situ (GCNIS) to overt germ cell tumor is connected with decreased FBN-1 production. Fibrillin is a glycoprotein essential in forming the elastic fibers in connective tissue.
The researchers evaluated 350 tumor specimens and 85 adjacent nonneoplastic testicular tissues in 203 patients. They detected FBN-1 expression in 68 (97%) GCNIS, 21 (96%) yolk sac tumors, 85 (87%) seminomas, 78 (83%) embryonal carcinomas, 35 (71%) teratomas, 3 (18%) choriocarcinomas, and 1 (1%) nonneoplastic tissue. The highest FBN-1 positivity was found in GCNIS, with overexpression of FBN-1 in 77% of cases. The fact that the highest expression was observed in seminomas and the lowest in choriocarcinomas, the researchers say, suggests a reduction of FBN-1 expression with the process of differentiation.
Related: Is Chemotherapy a Good Choice for Neuroendocrine Tumors?
GCNIS represents the preinvasive stage of most TGCTs in adults. GCNIS cells are believed to be germ cells that have failed to mature normally, the researchers note. The appearance of FBN-1 expression in germ cells in the stage of GCNIS, they suggest, can be an early event in the process of malignant transformation.
Source:
Cierna Z, Mego M, Jurisica I, et al. BMC Cancer. 2016;16:597
doi: 10.1186/s12885-016-2644-z.