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Key clinical point: Rates of ipsilateral breast tumor recurrence (IBTR) were similar between partial breast irradiation (PBI) and whole breast irradiation (WBI). Acute skin toxicities were lower with PBI.
Major finding: The rate of IBTR at 5 years was not different between PBI (1.8%; 95% highest posterior density [HPD], 0.68%-3.2%) and WBI (1.7%; 95% HPD, 0.92%-2.4%). Rates of grade 2 or greater acute skin toxicity were lower with PBI (7.1%; 95% HPD, 0%-63.4%) vs. WBI (47.5%; 95% HPD, 0%-93.4%).
Study details: Meta-analysis of 7 randomized trials including 9,758 patients receiving either WBI (n=4,840) or PBI (n=4,918).
Disclosures: No funding source was identified. The lead author reported ties with Impedimed, PreludeDX, Varian Medical Systems, and Vision RT. Some other coinvestigators reported receiving grants or consultation fees from various pharmaceutical companies.
Source: Shah C et al. Ann Surg Oncol. 2021 Jan 3. doi: 10.1245/s10434-020-09447-w.
Key clinical point: Rates of ipsilateral breast tumor recurrence (IBTR) were similar between partial breast irradiation (PBI) and whole breast irradiation (WBI). Acute skin toxicities were lower with PBI.
Major finding: The rate of IBTR at 5 years was not different between PBI (1.8%; 95% highest posterior density [HPD], 0.68%-3.2%) and WBI (1.7%; 95% HPD, 0.92%-2.4%). Rates of grade 2 or greater acute skin toxicity were lower with PBI (7.1%; 95% HPD, 0%-63.4%) vs. WBI (47.5%; 95% HPD, 0%-93.4%).
Study details: Meta-analysis of 7 randomized trials including 9,758 patients receiving either WBI (n=4,840) or PBI (n=4,918).
Disclosures: No funding source was identified. The lead author reported ties with Impedimed, PreludeDX, Varian Medical Systems, and Vision RT. Some other coinvestigators reported receiving grants or consultation fees from various pharmaceutical companies.
Source: Shah C et al. Ann Surg Oncol. 2021 Jan 3. doi: 10.1245/s10434-020-09447-w.
Key clinical point: Rates of ipsilateral breast tumor recurrence (IBTR) were similar between partial breast irradiation (PBI) and whole breast irradiation (WBI). Acute skin toxicities were lower with PBI.
Major finding: The rate of IBTR at 5 years was not different between PBI (1.8%; 95% highest posterior density [HPD], 0.68%-3.2%) and WBI (1.7%; 95% HPD, 0.92%-2.4%). Rates of grade 2 or greater acute skin toxicity were lower with PBI (7.1%; 95% HPD, 0%-63.4%) vs. WBI (47.5%; 95% HPD, 0%-93.4%).
Study details: Meta-analysis of 7 randomized trials including 9,758 patients receiving either WBI (n=4,840) or PBI (n=4,918).
Disclosures: No funding source was identified. The lead author reported ties with Impedimed, PreludeDX, Varian Medical Systems, and Vision RT. Some other coinvestigators reported receiving grants or consultation fees from various pharmaceutical companies.
Source: Shah C et al. Ann Surg Oncol. 2021 Jan 3. doi: 10.1245/s10434-020-09447-w.