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Key clinical point: Pyrotinib showed promising anti-tumor activity in first-, second-, and third- or later-line treatment settings along with a manageable safety profile in patients with human epidermal growth factor receptor 2-positive (HER2+) advanced breast cancer (BC).
Major finding: Median real-world progression-free survival (rwPFS) was 14.3 months (95% CI 13.3-15.2) for the total population. Median rwPFS was 17.8 months (95% CI 15.2-24.9) in the first-line treatment setting, 14.4 months (95% CI 12.9-15.3) in the second-line setting, and 9.3 months (95% CI 8.4-11.8) in the third- or later-line settings. Diarrhea (any grade) was the most common adverse event (73.4%).
Study details: This prospective observational study included 1129 patients with HER2+ advanced BC who received pyrotinib-based therapy in first- (n = 437), second- (n = 476), and third- or later-line (n = 216) settings.
Disclosures: This study was supported by Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences and Jiangsu Hengrui Pharmaceuticals Co., Ltd. The authors declared no conflicts of interest.
Source: Li Y et al. Real-world treatment patterns and outcomes of pyrotinib-based therapy in patients with HER2-positive advanced breast cancer (PRETTY): A nationwide, prospective, observational study. Int J Cancer. 2023 (Aug 6). doi: 10.1002/ijc.34676
Key clinical point: Pyrotinib showed promising anti-tumor activity in first-, second-, and third- or later-line treatment settings along with a manageable safety profile in patients with human epidermal growth factor receptor 2-positive (HER2+) advanced breast cancer (BC).
Major finding: Median real-world progression-free survival (rwPFS) was 14.3 months (95% CI 13.3-15.2) for the total population. Median rwPFS was 17.8 months (95% CI 15.2-24.9) in the first-line treatment setting, 14.4 months (95% CI 12.9-15.3) in the second-line setting, and 9.3 months (95% CI 8.4-11.8) in the third- or later-line settings. Diarrhea (any grade) was the most common adverse event (73.4%).
Study details: This prospective observational study included 1129 patients with HER2+ advanced BC who received pyrotinib-based therapy in first- (n = 437), second- (n = 476), and third- or later-line (n = 216) settings.
Disclosures: This study was supported by Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences and Jiangsu Hengrui Pharmaceuticals Co., Ltd. The authors declared no conflicts of interest.
Source: Li Y et al. Real-world treatment patterns and outcomes of pyrotinib-based therapy in patients with HER2-positive advanced breast cancer (PRETTY): A nationwide, prospective, observational study. Int J Cancer. 2023 (Aug 6). doi: 10.1002/ijc.34676
Key clinical point: Pyrotinib showed promising anti-tumor activity in first-, second-, and third- or later-line treatment settings along with a manageable safety profile in patients with human epidermal growth factor receptor 2-positive (HER2+) advanced breast cancer (BC).
Major finding: Median real-world progression-free survival (rwPFS) was 14.3 months (95% CI 13.3-15.2) for the total population. Median rwPFS was 17.8 months (95% CI 15.2-24.9) in the first-line treatment setting, 14.4 months (95% CI 12.9-15.3) in the second-line setting, and 9.3 months (95% CI 8.4-11.8) in the third- or later-line settings. Diarrhea (any grade) was the most common adverse event (73.4%).
Study details: This prospective observational study included 1129 patients with HER2+ advanced BC who received pyrotinib-based therapy in first- (n = 437), second- (n = 476), and third- or later-line (n = 216) settings.
Disclosures: This study was supported by Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences and Jiangsu Hengrui Pharmaceuticals Co., Ltd. The authors declared no conflicts of interest.
Source: Li Y et al. Real-world treatment patterns and outcomes of pyrotinib-based therapy in patients with HER2-positive advanced breast cancer (PRETTY): A nationwide, prospective, observational study. Int J Cancer. 2023 (Aug 6). doi: 10.1002/ijc.34676