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Regionalized trauma care boosts TBI survival

NAPLES, FLA. – A regional trauma system decreased hospital mortality for traumatic brain injury patients by 21% overall and by 26% for severe brain injuries, according to a partially retrospective study.

"Regionalization represents an additional step in attempting to improve outcomes for trauma patients. It can be defined as a tiered, integrated system that attempts to get the right patient to the right place at the right time," Dr. Michael L. Kelly said at the annual meeting of the Eastern Association for the Surgery of Trauma.

Dr. Michael L. Kelly

A few American studies and several more outside the United States have shown that regionalization decreases mortality in the general trauma population, but similar studies in traumatic brain injury (TBI) patients are scarce.

The Northern Ohio Trauma System (NOTS) was organized in 2010 and includes a transfer line to the Level I trauma center, a nontrauma hospital transfer protocol, a pilot scene triage protocol for emergency medical services, as well as the creation of a trauma-specific ICU in the level I center, explained Dr. Kelly, a sixth-year neurosurgery resident at the Cleveland Clinic, Ohio. The network includes the Level I MetroHealth Medical Center trauma center, two Level II trauma centers, and 12 nontrauma hospitals.

The three-tiered system mandates that TBI patients with a Glasgow Coma Scale (GCS) score of less than 12 and a traumatic mechanism, any penetrating head injury, or any open/depressed skull fracture, be sent to the Level I trauma center if they can be transferred within 15 minutes.

Patients with a GCS of 12-14 and a penetrating mechanism can be transferred to any trauma center, while those with lesser head injuries can remain at their hospital, unless their condition worsens.

For the study, Dr. Kelly and his coauthors analyzed data from 2008 through 2012 for 11,220 patients more than 14 years old with a TBI in the NOTS database, which was populated prospectively beginning in mid-2010.

Level I admissions increased significantly after NOTS by 10% for all TBIs (36% vs. 46%) and by 15% for severe TBIs with a head Abbreviated Injury Scale (AIS) score of 3 or more, he said. The percentage of patients who underwent transfers between NOTS institutions also increased significantly by 7% (7% vs. 14%) and 11% (10% vs. 21%), respectively.

Hospital mortality declined from 6.2% to 4.9% post-NOTS for all TBI patients (P = .005) and from 19% to 14% for the subset with severe TBI (P less than .0001). Mortality for trauma patients in general in Ohio has consistently hovered at 4% to 5% for the last decade, despite efforts to improve outcomes, including a 2002 law requiring the transfer of trauma patients to a validated trauma center, Dr. Kelly said.

In the post-NOTS period, craniotomies increased significantly for all TBIs (2% vs. 3%; P = .003) and for severe TBIs (6% vs. 8%; P = .02). The use of any neurosurgical procedure and hospital length of stay, however, remained constant for both groups in both time periods.

At baseline, the 6,713 post-NOTS patients were significantly older than the 4,507 pre-NOTS patients (55 years vs. 52 years) and less likely to be male (63% vs. 66%) or black (23% vs. 34%). GCS scores were similar (15 for both), as were Injury Severity Scores (14 for both) and the percentage of patients with a head AIS of 3 or more (34% post- vs. 32% pre-).

Multivariate regression analysis showed that the NOTS time period was an independent predictor of survival for all TBIs, with an odds ratio of 0.76, representing a 24% mortality reduction, and odds ratio of 0.72 for severe TBIs, representing a 28% mortality reduction.

Dr. Deborah Stein

"Of some importance, the multivariate model actually strengthened the effect of NOTS on mortality in our patient population," Dr. Kelly said.

Invited discussant Deborah Stein, medical director of neurotrauma critical care at the R Adams Cowley Shock Trauma Center at the University of Maryland Medical Center in Baltimore, described the study as an important contribution to the growing body of literature demonstrating that regionalization of care is associated with improved outcomes.

Dr. Stein went on to congratulate the NOTS members for participating in what was, at times, likely a contentious and difficult process: to bring a diverse group of hospitals to consensus about the best way to care for injured patients.

"Effecting change is difficult enough in a single division, department, or hospital," she remarked.

Following the formal presentation, audience members questioned whether the change in mortality was accomplished by simply shifting patients to nursing homes to die or whether it reflects a more aggressive surgical approach to TBI or improved critical care.

 

 

Dr. Kelly said that the creation of a trauma-specific ICU at MetroHealth, the uptick in transfers to the Level I trauma center, and the increased craniotomy rate all likely affected the outcome. Patient disposition data are still being analyzed, but hospice rates remained similar after NOTS was implemented, he said.

Dr. Kelly and his coauthors reported having no financial disclosures.

[email protected]

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For nearly 50 years, data has been accumulating regarding the effects of regionalized trauma systems on postinjury outcomes, and the verdict is clear: Having a system in place that is prepared to rapidly transport the severely injured to a trauma center provides the best opportunity to reduce morbidity and mortality in these patients. While this is true in a general sense, a penetrating injury to the torso is not the same as a TBI, with each requiring different resources and expertise for optimal management.

The group at Cleveland MetroHealth in Ohio sought to answer the question of whether or not regionalization of trauma services would demonstrate a benefit in patients with TBI. Reviewing 4 years' worth of data that coincided at its midpoint with the implementation of the Northern Ohio Trauma System (NOTS), the authors demonstrate a significant reduction in mortality in brain-injured patients, including a 28% reduction in patients with severe TBI on multivariate analysis.

Dr. Robert Winfield
While the mortality data is clearly impressive, the comments from the audience at EAST regarding the patients' functional outcomes are appropriate and timely; this is a weakness of most studies that utilize mortality as an endpoint, but it is perhaps an even more important consideration in a study of patients suffering TBI. Dr. Kelly has indicated that this is an area of active investigation for the group, and it will be eagerly anticipated. The authors' follow-up data will be of landmark importance if they are able to demonstrate that not only are lives of TBI patients saved through the regionalized delivery of trauma care, but that those patients are more likely to return home to their families, and are more capable of returning to work or school through earlier definitive and expert management.

In the end, the commendation from Dr. Stein regarding the ability of the NOTS group, which comprises three hospitals from two health systems, to coalesce into a highly functioning regional trauma system is prescient and reflective of an impressive achievement for the authors. It is a reminder that in a time of scarce resources and competition for health care dollars, maintaining a focus on patient care through a cooperative and collaborative approach will ultimately yield the best results for all involved.

Dr. Robert Winfield is an ACS Fellow and the chair of the ACS Resident and Associate Society, and assistant professor of trauma and acute and critical care surgery at Washington University, St. Louis.
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For nearly 50 years, data has been accumulating regarding the effects of regionalized trauma systems on postinjury outcomes, and the verdict is clear: Having a system in place that is prepared to rapidly transport the severely injured to a trauma center provides the best opportunity to reduce morbidity and mortality in these patients. While this is true in a general sense, a penetrating injury to the torso is not the same as a TBI, with each requiring different resources and expertise for optimal management.

The group at Cleveland MetroHealth in Ohio sought to answer the question of whether or not regionalization of trauma services would demonstrate a benefit in patients with TBI. Reviewing 4 years' worth of data that coincided at its midpoint with the implementation of the Northern Ohio Trauma System (NOTS), the authors demonstrate a significant reduction in mortality in brain-injured patients, including a 28% reduction in patients with severe TBI on multivariate analysis.

Dr. Robert Winfield
While the mortality data is clearly impressive, the comments from the audience at EAST regarding the patients' functional outcomes are appropriate and timely; this is a weakness of most studies that utilize mortality as an endpoint, but it is perhaps an even more important consideration in a study of patients suffering TBI. Dr. Kelly has indicated that this is an area of active investigation for the group, and it will be eagerly anticipated. The authors' follow-up data will be of landmark importance if they are able to demonstrate that not only are lives of TBI patients saved through the regionalized delivery of trauma care, but that those patients are more likely to return home to their families, and are more capable of returning to work or school through earlier definitive and expert management.

In the end, the commendation from Dr. Stein regarding the ability of the NOTS group, which comprises three hospitals from two health systems, to coalesce into a highly functioning regional trauma system is prescient and reflective of an impressive achievement for the authors. It is a reminder that in a time of scarce resources and competition for health care dollars, maintaining a focus on patient care through a cooperative and collaborative approach will ultimately yield the best results for all involved.

Dr. Robert Winfield is an ACS Fellow and the chair of the ACS Resident and Associate Society, and assistant professor of trauma and acute and critical care surgery at Washington University, St. Louis.
Body

For nearly 50 years, data has been accumulating regarding the effects of regionalized trauma systems on postinjury outcomes, and the verdict is clear: Having a system in place that is prepared to rapidly transport the severely injured to a trauma center provides the best opportunity to reduce morbidity and mortality in these patients. While this is true in a general sense, a penetrating injury to the torso is not the same as a TBI, with each requiring different resources and expertise for optimal management.

The group at Cleveland MetroHealth in Ohio sought to answer the question of whether or not regionalization of trauma services would demonstrate a benefit in patients with TBI. Reviewing 4 years' worth of data that coincided at its midpoint with the implementation of the Northern Ohio Trauma System (NOTS), the authors demonstrate a significant reduction in mortality in brain-injured patients, including a 28% reduction in patients with severe TBI on multivariate analysis.

Dr. Robert Winfield
While the mortality data is clearly impressive, the comments from the audience at EAST regarding the patients' functional outcomes are appropriate and timely; this is a weakness of most studies that utilize mortality as an endpoint, but it is perhaps an even more important consideration in a study of patients suffering TBI. Dr. Kelly has indicated that this is an area of active investigation for the group, and it will be eagerly anticipated. The authors' follow-up data will be of landmark importance if they are able to demonstrate that not only are lives of TBI patients saved through the regionalized delivery of trauma care, but that those patients are more likely to return home to their families, and are more capable of returning to work or school through earlier definitive and expert management.

In the end, the commendation from Dr. Stein regarding the ability of the NOTS group, which comprises three hospitals from two health systems, to coalesce into a highly functioning regional trauma system is prescient and reflective of an impressive achievement for the authors. It is a reminder that in a time of scarce resources and competition for health care dollars, maintaining a focus on patient care through a cooperative and collaborative approach will ultimately yield the best results for all involved.

Dr. Robert Winfield is an ACS Fellow and the chair of the ACS Resident and Associate Society, and assistant professor of trauma and acute and critical care surgery at Washington University, St. Louis.
Title
An impressive achievement
An impressive achievement

NAPLES, FLA. – A regional trauma system decreased hospital mortality for traumatic brain injury patients by 21% overall and by 26% for severe brain injuries, according to a partially retrospective study.

"Regionalization represents an additional step in attempting to improve outcomes for trauma patients. It can be defined as a tiered, integrated system that attempts to get the right patient to the right place at the right time," Dr. Michael L. Kelly said at the annual meeting of the Eastern Association for the Surgery of Trauma.

Dr. Michael L. Kelly

A few American studies and several more outside the United States have shown that regionalization decreases mortality in the general trauma population, but similar studies in traumatic brain injury (TBI) patients are scarce.

The Northern Ohio Trauma System (NOTS) was organized in 2010 and includes a transfer line to the Level I trauma center, a nontrauma hospital transfer protocol, a pilot scene triage protocol for emergency medical services, as well as the creation of a trauma-specific ICU in the level I center, explained Dr. Kelly, a sixth-year neurosurgery resident at the Cleveland Clinic, Ohio. The network includes the Level I MetroHealth Medical Center trauma center, two Level II trauma centers, and 12 nontrauma hospitals.

The three-tiered system mandates that TBI patients with a Glasgow Coma Scale (GCS) score of less than 12 and a traumatic mechanism, any penetrating head injury, or any open/depressed skull fracture, be sent to the Level I trauma center if they can be transferred within 15 minutes.

Patients with a GCS of 12-14 and a penetrating mechanism can be transferred to any trauma center, while those with lesser head injuries can remain at their hospital, unless their condition worsens.

For the study, Dr. Kelly and his coauthors analyzed data from 2008 through 2012 for 11,220 patients more than 14 years old with a TBI in the NOTS database, which was populated prospectively beginning in mid-2010.

Level I admissions increased significantly after NOTS by 10% for all TBIs (36% vs. 46%) and by 15% for severe TBIs with a head Abbreviated Injury Scale (AIS) score of 3 or more, he said. The percentage of patients who underwent transfers between NOTS institutions also increased significantly by 7% (7% vs. 14%) and 11% (10% vs. 21%), respectively.

Hospital mortality declined from 6.2% to 4.9% post-NOTS for all TBI patients (P = .005) and from 19% to 14% for the subset with severe TBI (P less than .0001). Mortality for trauma patients in general in Ohio has consistently hovered at 4% to 5% for the last decade, despite efforts to improve outcomes, including a 2002 law requiring the transfer of trauma patients to a validated trauma center, Dr. Kelly said.

In the post-NOTS period, craniotomies increased significantly for all TBIs (2% vs. 3%; P = .003) and for severe TBIs (6% vs. 8%; P = .02). The use of any neurosurgical procedure and hospital length of stay, however, remained constant for both groups in both time periods.

At baseline, the 6,713 post-NOTS patients were significantly older than the 4,507 pre-NOTS patients (55 years vs. 52 years) and less likely to be male (63% vs. 66%) or black (23% vs. 34%). GCS scores were similar (15 for both), as were Injury Severity Scores (14 for both) and the percentage of patients with a head AIS of 3 or more (34% post- vs. 32% pre-).

Multivariate regression analysis showed that the NOTS time period was an independent predictor of survival for all TBIs, with an odds ratio of 0.76, representing a 24% mortality reduction, and odds ratio of 0.72 for severe TBIs, representing a 28% mortality reduction.

Dr. Deborah Stein

"Of some importance, the multivariate model actually strengthened the effect of NOTS on mortality in our patient population," Dr. Kelly said.

Invited discussant Deborah Stein, medical director of neurotrauma critical care at the R Adams Cowley Shock Trauma Center at the University of Maryland Medical Center in Baltimore, described the study as an important contribution to the growing body of literature demonstrating that regionalization of care is associated with improved outcomes.

Dr. Stein went on to congratulate the NOTS members for participating in what was, at times, likely a contentious and difficult process: to bring a diverse group of hospitals to consensus about the best way to care for injured patients.

"Effecting change is difficult enough in a single division, department, or hospital," she remarked.

Following the formal presentation, audience members questioned whether the change in mortality was accomplished by simply shifting patients to nursing homes to die or whether it reflects a more aggressive surgical approach to TBI or improved critical care.

 

 

Dr. Kelly said that the creation of a trauma-specific ICU at MetroHealth, the uptick in transfers to the Level I trauma center, and the increased craniotomy rate all likely affected the outcome. Patient disposition data are still being analyzed, but hospice rates remained similar after NOTS was implemented, he said.

Dr. Kelly and his coauthors reported having no financial disclosures.

[email protected]

NAPLES, FLA. – A regional trauma system decreased hospital mortality for traumatic brain injury patients by 21% overall and by 26% for severe brain injuries, according to a partially retrospective study.

"Regionalization represents an additional step in attempting to improve outcomes for trauma patients. It can be defined as a tiered, integrated system that attempts to get the right patient to the right place at the right time," Dr. Michael L. Kelly said at the annual meeting of the Eastern Association for the Surgery of Trauma.

Dr. Michael L. Kelly

A few American studies and several more outside the United States have shown that regionalization decreases mortality in the general trauma population, but similar studies in traumatic brain injury (TBI) patients are scarce.

The Northern Ohio Trauma System (NOTS) was organized in 2010 and includes a transfer line to the Level I trauma center, a nontrauma hospital transfer protocol, a pilot scene triage protocol for emergency medical services, as well as the creation of a trauma-specific ICU in the level I center, explained Dr. Kelly, a sixth-year neurosurgery resident at the Cleveland Clinic, Ohio. The network includes the Level I MetroHealth Medical Center trauma center, two Level II trauma centers, and 12 nontrauma hospitals.

The three-tiered system mandates that TBI patients with a Glasgow Coma Scale (GCS) score of less than 12 and a traumatic mechanism, any penetrating head injury, or any open/depressed skull fracture, be sent to the Level I trauma center if they can be transferred within 15 minutes.

Patients with a GCS of 12-14 and a penetrating mechanism can be transferred to any trauma center, while those with lesser head injuries can remain at their hospital, unless their condition worsens.

For the study, Dr. Kelly and his coauthors analyzed data from 2008 through 2012 for 11,220 patients more than 14 years old with a TBI in the NOTS database, which was populated prospectively beginning in mid-2010.

Level I admissions increased significantly after NOTS by 10% for all TBIs (36% vs. 46%) and by 15% for severe TBIs with a head Abbreviated Injury Scale (AIS) score of 3 or more, he said. The percentage of patients who underwent transfers between NOTS institutions also increased significantly by 7% (7% vs. 14%) and 11% (10% vs. 21%), respectively.

Hospital mortality declined from 6.2% to 4.9% post-NOTS for all TBI patients (P = .005) and from 19% to 14% for the subset with severe TBI (P less than .0001). Mortality for trauma patients in general in Ohio has consistently hovered at 4% to 5% for the last decade, despite efforts to improve outcomes, including a 2002 law requiring the transfer of trauma patients to a validated trauma center, Dr. Kelly said.

In the post-NOTS period, craniotomies increased significantly for all TBIs (2% vs. 3%; P = .003) and for severe TBIs (6% vs. 8%; P = .02). The use of any neurosurgical procedure and hospital length of stay, however, remained constant for both groups in both time periods.

At baseline, the 6,713 post-NOTS patients were significantly older than the 4,507 pre-NOTS patients (55 years vs. 52 years) and less likely to be male (63% vs. 66%) or black (23% vs. 34%). GCS scores were similar (15 for both), as were Injury Severity Scores (14 for both) and the percentage of patients with a head AIS of 3 or more (34% post- vs. 32% pre-).

Multivariate regression analysis showed that the NOTS time period was an independent predictor of survival for all TBIs, with an odds ratio of 0.76, representing a 24% mortality reduction, and odds ratio of 0.72 for severe TBIs, representing a 28% mortality reduction.

Dr. Deborah Stein

"Of some importance, the multivariate model actually strengthened the effect of NOTS on mortality in our patient population," Dr. Kelly said.

Invited discussant Deborah Stein, medical director of neurotrauma critical care at the R Adams Cowley Shock Trauma Center at the University of Maryland Medical Center in Baltimore, described the study as an important contribution to the growing body of literature demonstrating that regionalization of care is associated with improved outcomes.

Dr. Stein went on to congratulate the NOTS members for participating in what was, at times, likely a contentious and difficult process: to bring a diverse group of hospitals to consensus about the best way to care for injured patients.

"Effecting change is difficult enough in a single division, department, or hospital," she remarked.

Following the formal presentation, audience members questioned whether the change in mortality was accomplished by simply shifting patients to nursing homes to die or whether it reflects a more aggressive surgical approach to TBI or improved critical care.

 

 

Dr. Kelly said that the creation of a trauma-specific ICU at MetroHealth, the uptick in transfers to the Level I trauma center, and the increased craniotomy rate all likely affected the outcome. Patient disposition data are still being analyzed, but hospice rates remained similar after NOTS was implemented, he said.

Dr. Kelly and his coauthors reported having no financial disclosures.

[email protected]

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Regionalized trauma care boosts TBI survival
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regional trauma system, hospital mortality, traumatic brain injury, severe brain injuries, regionalization, trauma, Dr. Michael L. Kelly
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regional trauma system, hospital mortality, traumatic brain injury, severe brain injuries, regionalization, trauma, Dr. Michael L. Kelly
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Major finding: Hospital mortality was 6.2% pre-NOTS vs. 4.9% post-NOTS for all TBIs (P = .005) and 19% vs. 14% for severe TBIs (P less than .001).

Data source: A partially retrospective analysis of 11,220 TBI trauma patients.

Disclosures: Dr. Kelly and his coauthors reported having no financial disclosures.