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Key clinical point: RHOA expression level is associated with clinical features, including Union for International Cancer Control (UICC) stage progression and poorly differentiated status, in patients with gastric cancer.
Major finding: High/positive RHOA expression was significantly associated with UICC stage progression (III-IV vs I-II: odds ratio [OR] 1.37; P = .02) and poorly differentiated status (poorly differentiated vs well/moderately differentiated: OR,1.65; P = .02).
Study details: This was a meta-analysis of 10 retrospective case-control studies including 1389 patients with gastric cancer, of which 735 were RHOA positive and 654 were RHOA negative.
Disclosures: This study was sponsored by the Basic Science Research Program, through the National Research Foundation of Korea, funded by the Ministry of Education, and the Gachon University Gil Medical Center. The authors declared no conflicts of interest.
Source: Nam S et al. RHOA protein expression correlates with clinical features in gastric cancer: A systematic review and meta-analysis. BMC Cancer. 2022; 22(1):798 (Jul 19). Doi: 10.1186/s12885-022-09904-7
Key clinical point: RHOA expression level is associated with clinical features, including Union for International Cancer Control (UICC) stage progression and poorly differentiated status, in patients with gastric cancer.
Major finding: High/positive RHOA expression was significantly associated with UICC stage progression (III-IV vs I-II: odds ratio [OR] 1.37; P = .02) and poorly differentiated status (poorly differentiated vs well/moderately differentiated: OR,1.65; P = .02).
Study details: This was a meta-analysis of 10 retrospective case-control studies including 1389 patients with gastric cancer, of which 735 were RHOA positive and 654 were RHOA negative.
Disclosures: This study was sponsored by the Basic Science Research Program, through the National Research Foundation of Korea, funded by the Ministry of Education, and the Gachon University Gil Medical Center. The authors declared no conflicts of interest.
Source: Nam S et al. RHOA protein expression correlates with clinical features in gastric cancer: A systematic review and meta-analysis. BMC Cancer. 2022; 22(1):798 (Jul 19). Doi: 10.1186/s12885-022-09904-7
Key clinical point: RHOA expression level is associated with clinical features, including Union for International Cancer Control (UICC) stage progression and poorly differentiated status, in patients with gastric cancer.
Major finding: High/positive RHOA expression was significantly associated with UICC stage progression (III-IV vs I-II: odds ratio [OR] 1.37; P = .02) and poorly differentiated status (poorly differentiated vs well/moderately differentiated: OR,1.65; P = .02).
Study details: This was a meta-analysis of 10 retrospective case-control studies including 1389 patients with gastric cancer, of which 735 were RHOA positive and 654 were RHOA negative.
Disclosures: This study was sponsored by the Basic Science Research Program, through the National Research Foundation of Korea, funded by the Ministry of Education, and the Gachon University Gil Medical Center. The authors declared no conflicts of interest.
Source: Nam S et al. RHOA protein expression correlates with clinical features in gastric cancer: A systematic review and meta-analysis. BMC Cancer. 2022; 22(1):798 (Jul 19). Doi: 10.1186/s12885-022-09904-7