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Several single nucleotide polymorphisms were found to be significantly associated with salivary gland carcinoma in a genomewide association study, Li Xu, Ph.D., and associates at the University of Texas MD Anderson Cancer Center, Houston, reported online in Cancer.
The results of what they believe is the first such study conducted to identify common genetic variants associated with salivary gland carcinoma (SGC) need to be confirmed, but indicate that these single nucleotide polymorphisms (SNPs) could be further evaluated as possible screening tools for the rare cancer, they wrote (Cancer 2015 March 30 [doi:10.1002/cncr.29381]).
The study involved genotyping analyses of 309 cases of SGC in patients (mean age, 54 years) who had been treated at MD Anderson from September 2001 through February 2014; and 535 controls (mean age, 51 years), patients with no cancer.
Five SNPs were found to be associated with SGC risk. “The finding that the five novel SNPs associated with SGC risk are coding SNPs with functional potential, the finding that the genetic effects were considerable,” and the finding that the two SNPs with the strongest SGC risk were relatively rare among controls, “support that these five SNPs may be good candidate SNPs for SGC screening and prevention,” the authors concluded. “These findings support the existence of genetic heterogeneity between histological subtypes of SGC and provide a set of candidate SNPs and genes worthy of in-depth evaluation in future studies,” they added.
The small size of the study was among the limitations, and the results need to be confirmed in another study that also analyzes the function of the SNPs identified in the study, they noted.
In the United States, salivary gland carcinomas are rare, and account for about 0.3% of all malignancies, with an annual incidence of about 1 case per 100,000 people, Dr. Xu and associates said. A small proportion of SGCs are associated with high-dose ionizing radiation, the only well-documented environmental factor associated with the cancer, “suggesting a genetic role in the development of SGC,” they pointed out.
The authors had no disclosures. The study was partly supported by funds from the University of Texas MD Anderson Cancer Center, tge National Institutes of Health grants, and a Cancer Center Support grant.
Several single nucleotide polymorphisms were found to be significantly associated with salivary gland carcinoma in a genomewide association study, Li Xu, Ph.D., and associates at the University of Texas MD Anderson Cancer Center, Houston, reported online in Cancer.
The results of what they believe is the first such study conducted to identify common genetic variants associated with salivary gland carcinoma (SGC) need to be confirmed, but indicate that these single nucleotide polymorphisms (SNPs) could be further evaluated as possible screening tools for the rare cancer, they wrote (Cancer 2015 March 30 [doi:10.1002/cncr.29381]).
The study involved genotyping analyses of 309 cases of SGC in patients (mean age, 54 years) who had been treated at MD Anderson from September 2001 through February 2014; and 535 controls (mean age, 51 years), patients with no cancer.
Five SNPs were found to be associated with SGC risk. “The finding that the five novel SNPs associated with SGC risk are coding SNPs with functional potential, the finding that the genetic effects were considerable,” and the finding that the two SNPs with the strongest SGC risk were relatively rare among controls, “support that these five SNPs may be good candidate SNPs for SGC screening and prevention,” the authors concluded. “These findings support the existence of genetic heterogeneity between histological subtypes of SGC and provide a set of candidate SNPs and genes worthy of in-depth evaluation in future studies,” they added.
The small size of the study was among the limitations, and the results need to be confirmed in another study that also analyzes the function of the SNPs identified in the study, they noted.
In the United States, salivary gland carcinomas are rare, and account for about 0.3% of all malignancies, with an annual incidence of about 1 case per 100,000 people, Dr. Xu and associates said. A small proportion of SGCs are associated with high-dose ionizing radiation, the only well-documented environmental factor associated with the cancer, “suggesting a genetic role in the development of SGC,” they pointed out.
The authors had no disclosures. The study was partly supported by funds from the University of Texas MD Anderson Cancer Center, tge National Institutes of Health grants, and a Cancer Center Support grant.
Several single nucleotide polymorphisms were found to be significantly associated with salivary gland carcinoma in a genomewide association study, Li Xu, Ph.D., and associates at the University of Texas MD Anderson Cancer Center, Houston, reported online in Cancer.
The results of what they believe is the first such study conducted to identify common genetic variants associated with salivary gland carcinoma (SGC) need to be confirmed, but indicate that these single nucleotide polymorphisms (SNPs) could be further evaluated as possible screening tools for the rare cancer, they wrote (Cancer 2015 March 30 [doi:10.1002/cncr.29381]).
The study involved genotyping analyses of 309 cases of SGC in patients (mean age, 54 years) who had been treated at MD Anderson from September 2001 through February 2014; and 535 controls (mean age, 51 years), patients with no cancer.
Five SNPs were found to be associated with SGC risk. “The finding that the five novel SNPs associated with SGC risk are coding SNPs with functional potential, the finding that the genetic effects were considerable,” and the finding that the two SNPs with the strongest SGC risk were relatively rare among controls, “support that these five SNPs may be good candidate SNPs for SGC screening and prevention,” the authors concluded. “These findings support the existence of genetic heterogeneity between histological subtypes of SGC and provide a set of candidate SNPs and genes worthy of in-depth evaluation in future studies,” they added.
The small size of the study was among the limitations, and the results need to be confirmed in another study that also analyzes the function of the SNPs identified in the study, they noted.
In the United States, salivary gland carcinomas are rare, and account for about 0.3% of all malignancies, with an annual incidence of about 1 case per 100,000 people, Dr. Xu and associates said. A small proportion of SGCs are associated with high-dose ionizing radiation, the only well-documented environmental factor associated with the cancer, “suggesting a genetic role in the development of SGC,” they pointed out.
The authors had no disclosures. The study was partly supported by funds from the University of Texas MD Anderson Cancer Center, tge National Institutes of Health grants, and a Cancer Center Support grant.
Key clinical point: The identification of several gene variants associated with salivary gland carcinoma could eventually lead to screening tests for people at high risk for developing this rare cancer.
Major finding: Five different single nucleotide polymorphisms (SNPs) were significantly associated with salivary gland carcinomas.
Data source: A case-control genomewide association study looked for associations with salivary gland carcinomas, comparing results in 309 patients with salivary gland carcinoma and 535 controls with no cancer.
Disclosures: The authors had no disclosures. The study was partly supported by funds from the University of Texas MD Anderson Cancer Center, grants from the National Institutes of Health, and a Cancer Center Support grant.
