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Key clinical point: Adolescent oral contraceptive use was associated with a significant increase in risk of major depressive disorder in young adulthood; the results may help inform choices for contraceptive methods.
Major finding: Use of oral contraceptives at age 16-19 years was significantly associated with an episode of major depressive disorder at age 20-25 years (odds ratio 1.41, P < .001). The association was slightly higher among young women with no previous history of major depressive disorder.
Study details: The data come from a prospective cohort study of 725 women who participated in the Tracking Adolescents’ Individual Lives (TRAILS) study in Denmark. Use of OCs at ages 16-19 years was assessed as a predictor of major depressive disorder at ages 20-25 years based on the Diagnostic and Statistical Manual of Mental Disorders-IV oriented Lifetime Depression Assessment Self-Report and the Composite International Diagnostic Interview.
Disclosures: The larger TRAILS study was supported by Netherlands Organization for Scientific Research NWO, the Dutch Ministry of Justice, the European Science Foundation, the European Research Council, Biobanking and Biomolecular Resources Research Infrastructure, the Gratama Foundation, the Jan Dekker Foundation, the participating universities, and Accare Centre for Child and Adolescent Psychiatry. This specific study was also supported by the Feodor Lynen Research Fellowship from the Alexander von Humboldt-Foundation and a Canadian Institutes of Health Research Project Grant awarded to study authors. The researchers had no financial conflicts to disclose.
Source: Anderl C et al. J Child Psychol Psychiatry. 2021 Jul 12. doi: 10.1111/jcpp.13476.
Key clinical point: Adolescent oral contraceptive use was associated with a significant increase in risk of major depressive disorder in young adulthood; the results may help inform choices for contraceptive methods.
Major finding: Use of oral contraceptives at age 16-19 years was significantly associated with an episode of major depressive disorder at age 20-25 years (odds ratio 1.41, P < .001). The association was slightly higher among young women with no previous history of major depressive disorder.
Study details: The data come from a prospective cohort study of 725 women who participated in the Tracking Adolescents’ Individual Lives (TRAILS) study in Denmark. Use of OCs at ages 16-19 years was assessed as a predictor of major depressive disorder at ages 20-25 years based on the Diagnostic and Statistical Manual of Mental Disorders-IV oriented Lifetime Depression Assessment Self-Report and the Composite International Diagnostic Interview.
Disclosures: The larger TRAILS study was supported by Netherlands Organization for Scientific Research NWO, the Dutch Ministry of Justice, the European Science Foundation, the European Research Council, Biobanking and Biomolecular Resources Research Infrastructure, the Gratama Foundation, the Jan Dekker Foundation, the participating universities, and Accare Centre for Child and Adolescent Psychiatry. This specific study was also supported by the Feodor Lynen Research Fellowship from the Alexander von Humboldt-Foundation and a Canadian Institutes of Health Research Project Grant awarded to study authors. The researchers had no financial conflicts to disclose.
Source: Anderl C et al. J Child Psychol Psychiatry. 2021 Jul 12. doi: 10.1111/jcpp.13476.
Key clinical point: Adolescent oral contraceptive use was associated with a significant increase in risk of major depressive disorder in young adulthood; the results may help inform choices for contraceptive methods.
Major finding: Use of oral contraceptives at age 16-19 years was significantly associated with an episode of major depressive disorder at age 20-25 years (odds ratio 1.41, P < .001). The association was slightly higher among young women with no previous history of major depressive disorder.
Study details: The data come from a prospective cohort study of 725 women who participated in the Tracking Adolescents’ Individual Lives (TRAILS) study in Denmark. Use of OCs at ages 16-19 years was assessed as a predictor of major depressive disorder at ages 20-25 years based on the Diagnostic and Statistical Manual of Mental Disorders-IV oriented Lifetime Depression Assessment Self-Report and the Composite International Diagnostic Interview.
Disclosures: The larger TRAILS study was supported by Netherlands Organization for Scientific Research NWO, the Dutch Ministry of Justice, the European Science Foundation, the European Research Council, Biobanking and Biomolecular Resources Research Infrastructure, the Gratama Foundation, the Jan Dekker Foundation, the participating universities, and Accare Centre for Child and Adolescent Psychiatry. This specific study was also supported by the Feodor Lynen Research Fellowship from the Alexander von Humboldt-Foundation and a Canadian Institutes of Health Research Project Grant awarded to study authors. The researchers had no financial conflicts to disclose.
Source: Anderl C et al. J Child Psychol Psychiatry. 2021 Jul 12. doi: 10.1111/jcpp.13476.