Adverse GERD Outcomes Rare After ALTE

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Adverse outcomes associated with gastroesophageal reflux disease are rare following an apparent life‐threatening event

Apparent life‐threatening events (ALTEs) are frightening for the parent/guardian and represent a challenge for the healthcare provider. ALTEs are defined as worrisome episodes of any combination of apnea, color change, change in muscle tone, choking or gagging.1 ALTEs account for 0.6% to 0.8% of emergency department (ED) visits for children <12 months old,2, 3 have an average length of stay (LOS) of 4.4 days and an average cost of $15,000 per hospitalization.4

Gastroesophageal reflux disease (GERD) is common in infancy11 and also is the most commonly (in 31%55% of ALTE cases) attributed cause of ALTE.2, 4, 5 It has been speculated that chemosensitivity to gastric acid results in laryngospasm, bronchospasm, and apnea. However, several small studies have failed to prove a causal link between reflux episodes and apnea.69 Furthermore, although consensus guidelines for GERD have been developed,14 the clinical use of testing for GERD remains highly variable. A study of infants discharged with an ALTE (n = 12,067) from 36 children's hospitals in the United States revealed extensive variability in the use of pH probes and upper gastrointestinal x‐ray series to diagnose GERD.4

The incidence of adverse outcomes associated with GERD after an ALTE remains unknown. It is also unknown whether an association exists between long‐term gastrointestinal (GI) outcomes and testing demonstrative of GERD or a diagnosis of GERD during hospitalization for ALTE. The primary objective of our study was to determine, in patients with an ALTE, the adverse outcomes associated with GERD (failure‐to‐thrive, aspiration pneumonia, and/or anti‐reflux surgery), the incidence of readmission for second ALTE, and death. Our secondary objective was to determine risk factors for adverse outcomes associated with GERD following an ALTE.

METHODS

Design

This was a retrospective cohort study. We reviewed electronic and paper medical charts of all infants <12 months of age admitted for ALTE between January 1, 1999 and December 31, 2003 to Primary Children's Medical Center in Salt Lake City, UT, which serves as the tertiary pediatric center for >1 million children and the primary facility for >270,000 children in Salt Lake County, UT.10 Primary Children's Medical Center is operated by a vertically integrated not‐for‐profit healthcare system (Intermountain Healthcare), which has 20 affiliated hospitals and EDs. The study was approved by the institutional review boards of the University of Utah and Intermountain Healthcare, and the privacy board of Intermountain Healthcare.

Participants

Patients were included if a computer search of ED chief complaint or hospital discharge diagnoses found one or more of the following keywords (or corresponding International Classification of Diseases, Ninth Revision [ICD‐9] codes if applicable): ALTE, altered mental status, apnea, breath‐holding spell, choking, GERD, hypotonia, lethargy, other convulsions, other neurologic diagnosis, other respiratory diagnosis, pallor, seizures, sleep apnea, stiff, syncope, and unresponsiveness. These diagnoses were chosen as potential proxy diagnoses or codes for possible ALTE, as ALTE did not have a corresponding ICD‐9 code at the time of this study.

Detailed review of the medical record included infants who were <12 months old at admission with a history consistent with ALTE, defined as an episode frightening to the observer with any combination of apnea, color change, change in muscle tone, choking, or gagging. Infants were excluded from the study if they had a previously documented underlying medical condition to explain the ALTE (such as a known seizure disorder) or had a clearly apparent diagnosis upon initial history and physical examination (such as bronchiolitis diagnosed in the emergency department) that would explain the event. Patients with unstable vital signs (eg, hypotension), trauma clearly apparent on admission, documented medication dosing error, or febrile seizure were also excluded. A complete list of exclusion criteria is found in Figure 1.

Figure 1
The ALTE cohort. Abbreviations: ALTE, apparent life‐threatening event; CNS, central nervous system; GERD, gastroesophageal reflux disease.

All hospital admissions, ED visits, and Pediatric GI clinic notes were reviewed for adverse outcomes associated with GERD, second ALTE admission, and death. The follow‐up time period included the original enrollment period (January 1, 1999 through December 31, 2003) through August 31, 2009.

Outcomes

Adverse outcomes associated with GERD were defined as aspiration pneumonia, failure‐to‐thrive (FTT; either admission or discharge diagnosis of FTT at another hospitalization, or follow‐up to gastroenterology clinic for FTT) and/or anti‐reflux surgery (Nissen fundoplication or gastrojejunal tube placement) as these are potential clinical consequences of having severe and uncontrolled GERD. We further collected readmission data for a second ALTE. Deaths and the attributed reasons were also collected.

Risk Factors

Potential risk factors for adverse outcomes associated with GERD (all during index hospitalization) included: age; prematurity; gender; previous event (as described by the parent, without previous ALTE hospitalization); primary discharge diagnosis of GERD; testing positive for reflux on index ALTE admission (upper GI x‐ray series, esophageal pH probe, swallow study, endoscopy, and/or consultation of pediatric gastroenterologist with results or assessments indicating gastroesophageal reflux); any anti‐reflux medication prescribed upon discharge; and LOS. We also considered diagnosis of neurologic impairment during follow‐up, which was defined as seizures or diagnosis of developmental delay from any etiology not recognized on index ALTE admission. We examined these risk factors as we postulated they might indicate higher risk for both ALTE and adverse outcomes associated with GERD, or might indicate a higher severity of initial event.

Analyses

Summary statistics were performed for adverse outcomes associated with GERD, readmission, and death. Univariate analyses were performed for risk factors using chi‐square tests for dichotomous predictors and Wilcoxon rank sum tests for nonparametric continuous predictors for any of the 3 adverse outcomes (FTT, aspiration pneumonia [AP], and/or anti‐reflux surgery) associated with GERD. All analyses were performed using SAS 9.13 (Carey, NC).

RESULTS

Eleven hundred forty‐eight infants with ALTE met inclusion criteria, from 187,903 patients meeting initial search criteria. Six hundred seventy‐one patients were excluded and 8 patients had missing charts. The study population of the 469‐patient cohort is shown in Figure 1.

Demographics are displayed in Table 1. The mean age was 65 days. One hundred three (22%) were premature. One hundred eighty‐nine patients (40%) had a primary discharge diagnosis of GERD; details of the diagnoses for the remaining patients are in Figure 1. Median length of follow‐up for the cohort was 7.8 years. The entire study period was 10.7 years.

Demographic, Clinical, and Hospitalization Characteristics of Patients by Discharge Diagnosis
 ALTE Cohort
N = 469
  • Abbreviations: ALTE, apparent life‐threatening event; GERD, gastroesophageal reflux disease; SD, standard deviation.

Female233 (49.7%)
Race 
Caucasian371 (79.1%)
Hispanic64 (13.6%)
Pacific Islander6 (1.3%)
Black4 (0.8%)
Other/unknown24 (5.1%)
Mean age in days (SD)65.2 (69.5)
Prematurity103 (22%)
Underwent testing for gastroesophageal reflux214 (45.6%)
Discharged on anti‐reflux medication238 (50.7%)
Previous event127 (27.1%)
Mean length of stay in days (SD)2.4 (2.4)
Later neurologic impairment (seizures or developmental delay)23 (4.9%)
Primary discharge diagnosis of GERD189 (40%)

Eighteen patients (3.8%) had an adverse outcome associated with GERD. Four (0.9%) had aspiration pneumonia, 9 (1.9%) had failure‐to‐thrive, and 7 (1.5%) had a Nissen fundoplication (no patients had a gastrojejunal tube placed). Five patients had a gastrostomy tube placed at the time of fundoplication. Two patients had more than 1 adverse GI outcome; 1 patient had aspiration pneumonia and another had failure‐to‐thrive prior to their Nissen fundoplications.

Fifty‐six patients (11.9%) were readmitted for a second ALTE. Median time from index ALTE to second ALTE admission was 16.5 days (interquartile range: Q1, 8Q3, 32). Two (0.4%) patients died. Both (occurring at 18 months and 5.5 years after the initial ALTE hospitalization) were related to the children first developing seizure disorders and severe developmental delay. Neither of the patients who died had an index discharge diagnoses of GERD.

There was no significance of the following variables in predicting adverse outcomes associated with GERD: age, prematurity, gender, previous event, testing positive for reflux, primary discharge diagnosis of GERD, or discharge on anti‐reflux medications (see Table 2). Patients with adverse outcomes associated with GERD had longer mean LOS on the index ALTE hospitalization (4.3 days vs 2.4 days; P = 0.03) and a higher rate of neurologic impairment diagnosed in follow‐up (16.7% vs 4.4%; P = 0.02) than patients without long‐term adverse GI outcomes. Patients with neurological impairment diagnosed in follow‐up were more likely to eventually develop an adverse outcome associated with GERD, compared to patients without neurological impairment (odds ratio 8.4; 95% confidence interval 1.1516.1).

Univariate Risk Factors of Long‐Term Adverse GI Outcomes
 AP, FTT, or SurgeryNo Long‐Term Adverse GI OutcomeP Value
N = 18N = 451
  • Abbreviations: ALTE, apparent life‐threatening event; AP, aspiration pneumonia; FTT, failure‐to‐thrive; GERD, gastroesophageal reflux disease; GI, gastrointestinal; SD, standard deviation.

Mean age in days (SD)51.9 (76.4)65.8 (69.3)0.27
Prematurity1 (5.6%)102 (22.6%)0.08
Male gender12 (66.7%)220 (48.8%)0.14
Previous ALTE‐like event (no hospitalization)8 (44.4%)119 (26.4%)0.09
Testing positive for reflux9 (50%)177 (39.3%)0.36
Discharge diagnosis GERD9 (50%)180 (39.9%)0.39
Discharged on anti‐reflux medication9 (50%)229 (50.7%)0.95
Mean length of stay in days (SD)4.3 (4.7)2.4 (2.3)0.03
Neurologic impairment diagnosed in follow‐up3 (16.7%)20 (4.4%)0.02

DISCUSSION

Our study had 2 main findings. First, infants admitted for an ALTE had a low percentage (3.8%) of adverse outcomes associated with GERD. Review of the literature provides little context to interpret this percentage. One study reports 9 per 100,000 of the general population <18 years of age having anti‐reflux surgery.24 The percentage of adverse outcomes associated with GERD converted to a rate in our study would likely reflect the bias of our center serving as a referral population for Utah and 5 surrounding states. Furthermore, there may be an additional bias of ALTE being a potential indication for anti‐reflux surgery for some clinicians, as well as confounding additional diagnoses (such as later neurologic impairment which might independently increase risk of study outcomes).

The second main finding of our study is that the development of neurologic impairment was predictive of developing adverse GI outcomes. As previous studies have shown that neurological impairment cannot be predicted during the initial ALTE hospitalization,14 adverse outcomes associated with GERD are similarly not predictable with current clinical approaches. Furthermore, the exact nature of the relationship between neurologic impairment and ALTEs remains unclear. While previous studies have described the increased prevalence of adverse neurological outcomes (such as seizures, developmental delay) in children who have had an ALTE, it is unclear what the precipitating reason for ALTE is in these infants (seizure, central apnea, GERD, etc).14

There is ongoing debate in the literature surrounding the optimal diagnosis of GERD in infants with ALTE. Recent guidelines state that investigations aimed to prove GERD causing an ALTE should include pH probe or impedance monitor testing, in combination with a sleep study, and discourages a GERD diagnosis based on upper GI‐series alone.14 Given the low use of pH probe and impedance monitoring at our institution during the study period (86% of the patients who had GI‐related testing had an upper GI‐series), we did not attempt to find the sensitivity or specificity of the different GI testing modalities for GERD in the setting of ALTE. The high use of upper‐GI series is not unique to our institutionone large study examining practice variation from 12,067 ALTE admissions in 36 children's hospitals, with 36.9% of infants (n = 4453) having a primary discharge diagnosis of gastroesophageal reflux, revealed that only 8.9% (SD 28%) received an esophageal pH probe, while 25.6% (SD 43.6%) had an upper GI‐series or swallow study.4

Given the difficulties in assigning a GERD diagnosis for ALTE infants, we focused on the long‐term adverse outcomes associated with GERD for the entire ALTE infant cohort. The 3 adverse outcomes we chose deserve some mention. Aspiration pneumonia is generally due to either primary aspiration (from dysfunctional swallowing) or secondary aspiration (from GERD). Failure‐to‐thrive can be due to ongoing GERD. Anti‐reflux surgery is often performed for severe GERD. While we believe that a prospective study with better diagnostic evaluations for GERD and apnea (such as pH probe or impedance monitor in combination with a sleep study) might help elucidate the unclear relationship between reflux episodes and ALTE, the low percentage of adverse outcomes associated with GERD after ALTE may suggest that such a study would be difficult both in terms of sample size and an unnecessary use of resources.

We also found that a high percentage (11.9%) of all patients had readmission for a second ALTE. This was substantially higher than the 2.5% readmission rate for second ALTE reported in a previous study of short‐term follow‐up (30 days).4 The number of readmissions in our study might be higher due to our comprehensive follow‐up, both in length of time and number of additional EDs and hospitals captured. Unfortunately, the retrospective nature of our study makes it difficult to determine if any interventions (prescription of anti‐reflux medication, education on reflux precautions) impacted the rate of readmission, as compliance was not measurable. Further studies should address why patients return with recurrent ALTE.

Interestingly, several potential risk factors did not predict long‐term adverse GI outcomes. For example, prematurity, a discharge diagnosis of GERD, or prescription of an anti‐reflux medication, were not associated with adverse GI outcomes. These findings support the concept that a diagnosis of GERD, at least as is commonly applied, is not meaningful in the setting of an ALTE. We did find associations with longer length of stay (LOS), and with eventual development of neurological impairment. Longer LOS might be a proxy for other subtle predictors that could influence adverse outcomes, such as requiring additional diagnostic tests prolonging hospitalization, or continued ALTEs while inpatient. The neurologic outcomes of patients with ALTE have been previously published, and the strong correlation between neurologic impairment and GERD has been well described.14, 25

There are several strengths of this study. This is the first study, to our knowledge, to look at adverse outcomes associated with GERD following ALTE, despite GERD being the most commonly attributed cause. The use of Intermountain Healthcare's electronic medical record system allowed for comprehensive tracking, over an extensive follow‐up period (median of 7.8 years), across 20 hospitals and EDs which care for the vast majority of pediatric patients in Utah. Finally, this large cohort of ALTE patients used clinical data from medical records and not only administrative data.

There are limitations of this study. This is a retrospective cohort study. Some of our study outcomes may be a result of pathophysiology other than GERD and, conversely, GERD may be a result of other issues (neurologic impairment). The small sample size and low percentage of the study outcomes make it possible that we did not detect true risk factors. Patients were lost to follow‐up if they moved or presented to a hospital not within the Intermountain Healthcare system. This study has slightly different patient numbers from 3 previously published studies for different outcomes on this cohort, as exclusion criteria for the different cohorts were different.14, 26, 27 Six patients had only their electronic medical record reviewed because the paper chart was missing.

IMPLICATIONS

The results of this study extend previous work of various outcomes regarding well‐appearing infants following an ALTE.14, 26, 27 In these studies, 3.9% and 3% were ultimately diagnosed with epilepsy and developmental delay, respectively; 1.4% were diagnosed with abusive head trauma; and 0.6% required otolaryngologic surgical intervention. In these previous studies, there were few predictors of these outcomes, with testing demonstrating largely normal results during the index ALTE admission.

Our study helps clinicians place the outcomes of aspiration pneumonia, failure‐to‐thrive, and anti‐reflux surgery into the context of these other studies when discharging infants from the hospital after an ALTE. Collectively, these studies provide clinicians with the information that, in the setting of a well‐appearing infant, few diagnostic tests in their ALTE patients will yield a definitive diagnosis. Ultimately, close follow‐up with further investigations if symptoms recur will be an important part of diagnosing the etiology of the ALTE in these infants.

We found that well‐appearing infants with ALTE, regardless of attributed cause, are at low risk for adverse outcomes associated with GERD. Only the eventual development of neurologic impairment or an increased length of stay during index ALTE hospitalization was found to be predictive of these outcomes.

Acknowledgements

The following individuals have made substantive intellectual contributions to this study: conception and design (G.Z., J.L.B., W.D.J., C.G.M., R.S.), acquisition of data (G.Z., J.L.B.), analysis (G.Z., RS) and interpretation of data (G.Z., J.L.B., W.D.J., C.G.M., R.S.). In addition, all listed authors have contributed to either drafting the article or revising it critically for important intellectual content. Finally, all listed authors have given final approval of this version submitted for publication. The authors also acknowledge Chelsea Welch for her assistance in data collection.

Disclosures: This study was presented in part at the national Pediatric Academic Societies meetings in Vancouver, Canada, May 2010 and in Denver, CO, May 2011. This study was supported by a National Institutes of Child Health and Human Development (NICHD) grant for Dr Srivastava (K23 HD052553), and a National Institute on Drug Abuse (NIDA) grant for Dr Bonkowsky (K08 DA24753). This research was supported in part by the Children's Health Research Center, University of Utah. There are no conflicts of interest.

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References
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Apparent life‐threatening events (ALTEs) are frightening for the parent/guardian and represent a challenge for the healthcare provider. ALTEs are defined as worrisome episodes of any combination of apnea, color change, change in muscle tone, choking or gagging.1 ALTEs account for 0.6% to 0.8% of emergency department (ED) visits for children <12 months old,2, 3 have an average length of stay (LOS) of 4.4 days and an average cost of $15,000 per hospitalization.4

Gastroesophageal reflux disease (GERD) is common in infancy11 and also is the most commonly (in 31%55% of ALTE cases) attributed cause of ALTE.2, 4, 5 It has been speculated that chemosensitivity to gastric acid results in laryngospasm, bronchospasm, and apnea. However, several small studies have failed to prove a causal link between reflux episodes and apnea.69 Furthermore, although consensus guidelines for GERD have been developed,14 the clinical use of testing for GERD remains highly variable. A study of infants discharged with an ALTE (n = 12,067) from 36 children's hospitals in the United States revealed extensive variability in the use of pH probes and upper gastrointestinal x‐ray series to diagnose GERD.4

The incidence of adverse outcomes associated with GERD after an ALTE remains unknown. It is also unknown whether an association exists between long‐term gastrointestinal (GI) outcomes and testing demonstrative of GERD or a diagnosis of GERD during hospitalization for ALTE. The primary objective of our study was to determine, in patients with an ALTE, the adverse outcomes associated with GERD (failure‐to‐thrive, aspiration pneumonia, and/or anti‐reflux surgery), the incidence of readmission for second ALTE, and death. Our secondary objective was to determine risk factors for adverse outcomes associated with GERD following an ALTE.

METHODS

Design

This was a retrospective cohort study. We reviewed electronic and paper medical charts of all infants <12 months of age admitted for ALTE between January 1, 1999 and December 31, 2003 to Primary Children's Medical Center in Salt Lake City, UT, which serves as the tertiary pediatric center for >1 million children and the primary facility for >270,000 children in Salt Lake County, UT.10 Primary Children's Medical Center is operated by a vertically integrated not‐for‐profit healthcare system (Intermountain Healthcare), which has 20 affiliated hospitals and EDs. The study was approved by the institutional review boards of the University of Utah and Intermountain Healthcare, and the privacy board of Intermountain Healthcare.

Participants

Patients were included if a computer search of ED chief complaint or hospital discharge diagnoses found one or more of the following keywords (or corresponding International Classification of Diseases, Ninth Revision [ICD‐9] codes if applicable): ALTE, altered mental status, apnea, breath‐holding spell, choking, GERD, hypotonia, lethargy, other convulsions, other neurologic diagnosis, other respiratory diagnosis, pallor, seizures, sleep apnea, stiff, syncope, and unresponsiveness. These diagnoses were chosen as potential proxy diagnoses or codes for possible ALTE, as ALTE did not have a corresponding ICD‐9 code at the time of this study.

Detailed review of the medical record included infants who were <12 months old at admission with a history consistent with ALTE, defined as an episode frightening to the observer with any combination of apnea, color change, change in muscle tone, choking, or gagging. Infants were excluded from the study if they had a previously documented underlying medical condition to explain the ALTE (such as a known seizure disorder) or had a clearly apparent diagnosis upon initial history and physical examination (such as bronchiolitis diagnosed in the emergency department) that would explain the event. Patients with unstable vital signs (eg, hypotension), trauma clearly apparent on admission, documented medication dosing error, or febrile seizure were also excluded. A complete list of exclusion criteria is found in Figure 1.

Figure 1
The ALTE cohort. Abbreviations: ALTE, apparent life‐threatening event; CNS, central nervous system; GERD, gastroesophageal reflux disease.

All hospital admissions, ED visits, and Pediatric GI clinic notes were reviewed for adverse outcomes associated with GERD, second ALTE admission, and death. The follow‐up time period included the original enrollment period (January 1, 1999 through December 31, 2003) through August 31, 2009.

Outcomes

Adverse outcomes associated with GERD were defined as aspiration pneumonia, failure‐to‐thrive (FTT; either admission or discharge diagnosis of FTT at another hospitalization, or follow‐up to gastroenterology clinic for FTT) and/or anti‐reflux surgery (Nissen fundoplication or gastrojejunal tube placement) as these are potential clinical consequences of having severe and uncontrolled GERD. We further collected readmission data for a second ALTE. Deaths and the attributed reasons were also collected.

Risk Factors

Potential risk factors for adverse outcomes associated with GERD (all during index hospitalization) included: age; prematurity; gender; previous event (as described by the parent, without previous ALTE hospitalization); primary discharge diagnosis of GERD; testing positive for reflux on index ALTE admission (upper GI x‐ray series, esophageal pH probe, swallow study, endoscopy, and/or consultation of pediatric gastroenterologist with results or assessments indicating gastroesophageal reflux); any anti‐reflux medication prescribed upon discharge; and LOS. We also considered diagnosis of neurologic impairment during follow‐up, which was defined as seizures or diagnosis of developmental delay from any etiology not recognized on index ALTE admission. We examined these risk factors as we postulated they might indicate higher risk for both ALTE and adverse outcomes associated with GERD, or might indicate a higher severity of initial event.

Analyses

Summary statistics were performed for adverse outcomes associated with GERD, readmission, and death. Univariate analyses were performed for risk factors using chi‐square tests for dichotomous predictors and Wilcoxon rank sum tests for nonparametric continuous predictors for any of the 3 adverse outcomes (FTT, aspiration pneumonia [AP], and/or anti‐reflux surgery) associated with GERD. All analyses were performed using SAS 9.13 (Carey, NC).

RESULTS

Eleven hundred forty‐eight infants with ALTE met inclusion criteria, from 187,903 patients meeting initial search criteria. Six hundred seventy‐one patients were excluded and 8 patients had missing charts. The study population of the 469‐patient cohort is shown in Figure 1.

Demographics are displayed in Table 1. The mean age was 65 days. One hundred three (22%) were premature. One hundred eighty‐nine patients (40%) had a primary discharge diagnosis of GERD; details of the diagnoses for the remaining patients are in Figure 1. Median length of follow‐up for the cohort was 7.8 years. The entire study period was 10.7 years.

Demographic, Clinical, and Hospitalization Characteristics of Patients by Discharge Diagnosis
 ALTE Cohort
N = 469
  • Abbreviations: ALTE, apparent life‐threatening event; GERD, gastroesophageal reflux disease; SD, standard deviation.

Female233 (49.7%)
Race 
Caucasian371 (79.1%)
Hispanic64 (13.6%)
Pacific Islander6 (1.3%)
Black4 (0.8%)
Other/unknown24 (5.1%)
Mean age in days (SD)65.2 (69.5)
Prematurity103 (22%)
Underwent testing for gastroesophageal reflux214 (45.6%)
Discharged on anti‐reflux medication238 (50.7%)
Previous event127 (27.1%)
Mean length of stay in days (SD)2.4 (2.4)
Later neurologic impairment (seizures or developmental delay)23 (4.9%)
Primary discharge diagnosis of GERD189 (40%)

Eighteen patients (3.8%) had an adverse outcome associated with GERD. Four (0.9%) had aspiration pneumonia, 9 (1.9%) had failure‐to‐thrive, and 7 (1.5%) had a Nissen fundoplication (no patients had a gastrojejunal tube placed). Five patients had a gastrostomy tube placed at the time of fundoplication. Two patients had more than 1 adverse GI outcome; 1 patient had aspiration pneumonia and another had failure‐to‐thrive prior to their Nissen fundoplications.

Fifty‐six patients (11.9%) were readmitted for a second ALTE. Median time from index ALTE to second ALTE admission was 16.5 days (interquartile range: Q1, 8Q3, 32). Two (0.4%) patients died. Both (occurring at 18 months and 5.5 years after the initial ALTE hospitalization) were related to the children first developing seizure disorders and severe developmental delay. Neither of the patients who died had an index discharge diagnoses of GERD.

There was no significance of the following variables in predicting adverse outcomes associated with GERD: age, prematurity, gender, previous event, testing positive for reflux, primary discharge diagnosis of GERD, or discharge on anti‐reflux medications (see Table 2). Patients with adverse outcomes associated with GERD had longer mean LOS on the index ALTE hospitalization (4.3 days vs 2.4 days; P = 0.03) and a higher rate of neurologic impairment diagnosed in follow‐up (16.7% vs 4.4%; P = 0.02) than patients without long‐term adverse GI outcomes. Patients with neurological impairment diagnosed in follow‐up were more likely to eventually develop an adverse outcome associated with GERD, compared to patients without neurological impairment (odds ratio 8.4; 95% confidence interval 1.1516.1).

Univariate Risk Factors of Long‐Term Adverse GI Outcomes
 AP, FTT, or SurgeryNo Long‐Term Adverse GI OutcomeP Value
N = 18N = 451
  • Abbreviations: ALTE, apparent life‐threatening event; AP, aspiration pneumonia; FTT, failure‐to‐thrive; GERD, gastroesophageal reflux disease; GI, gastrointestinal; SD, standard deviation.

Mean age in days (SD)51.9 (76.4)65.8 (69.3)0.27
Prematurity1 (5.6%)102 (22.6%)0.08
Male gender12 (66.7%)220 (48.8%)0.14
Previous ALTE‐like event (no hospitalization)8 (44.4%)119 (26.4%)0.09
Testing positive for reflux9 (50%)177 (39.3%)0.36
Discharge diagnosis GERD9 (50%)180 (39.9%)0.39
Discharged on anti‐reflux medication9 (50%)229 (50.7%)0.95
Mean length of stay in days (SD)4.3 (4.7)2.4 (2.3)0.03
Neurologic impairment diagnosed in follow‐up3 (16.7%)20 (4.4%)0.02

DISCUSSION

Our study had 2 main findings. First, infants admitted for an ALTE had a low percentage (3.8%) of adverse outcomes associated with GERD. Review of the literature provides little context to interpret this percentage. One study reports 9 per 100,000 of the general population <18 years of age having anti‐reflux surgery.24 The percentage of adverse outcomes associated with GERD converted to a rate in our study would likely reflect the bias of our center serving as a referral population for Utah and 5 surrounding states. Furthermore, there may be an additional bias of ALTE being a potential indication for anti‐reflux surgery for some clinicians, as well as confounding additional diagnoses (such as later neurologic impairment which might independently increase risk of study outcomes).

The second main finding of our study is that the development of neurologic impairment was predictive of developing adverse GI outcomes. As previous studies have shown that neurological impairment cannot be predicted during the initial ALTE hospitalization,14 adverse outcomes associated with GERD are similarly not predictable with current clinical approaches. Furthermore, the exact nature of the relationship between neurologic impairment and ALTEs remains unclear. While previous studies have described the increased prevalence of adverse neurological outcomes (such as seizures, developmental delay) in children who have had an ALTE, it is unclear what the precipitating reason for ALTE is in these infants (seizure, central apnea, GERD, etc).14

There is ongoing debate in the literature surrounding the optimal diagnosis of GERD in infants with ALTE. Recent guidelines state that investigations aimed to prove GERD causing an ALTE should include pH probe or impedance monitor testing, in combination with a sleep study, and discourages a GERD diagnosis based on upper GI‐series alone.14 Given the low use of pH probe and impedance monitoring at our institution during the study period (86% of the patients who had GI‐related testing had an upper GI‐series), we did not attempt to find the sensitivity or specificity of the different GI testing modalities for GERD in the setting of ALTE. The high use of upper‐GI series is not unique to our institutionone large study examining practice variation from 12,067 ALTE admissions in 36 children's hospitals, with 36.9% of infants (n = 4453) having a primary discharge diagnosis of gastroesophageal reflux, revealed that only 8.9% (SD 28%) received an esophageal pH probe, while 25.6% (SD 43.6%) had an upper GI‐series or swallow study.4

Given the difficulties in assigning a GERD diagnosis for ALTE infants, we focused on the long‐term adverse outcomes associated with GERD for the entire ALTE infant cohort. The 3 adverse outcomes we chose deserve some mention. Aspiration pneumonia is generally due to either primary aspiration (from dysfunctional swallowing) or secondary aspiration (from GERD). Failure‐to‐thrive can be due to ongoing GERD. Anti‐reflux surgery is often performed for severe GERD. While we believe that a prospective study with better diagnostic evaluations for GERD and apnea (such as pH probe or impedance monitor in combination with a sleep study) might help elucidate the unclear relationship between reflux episodes and ALTE, the low percentage of adverse outcomes associated with GERD after ALTE may suggest that such a study would be difficult both in terms of sample size and an unnecessary use of resources.

We also found that a high percentage (11.9%) of all patients had readmission for a second ALTE. This was substantially higher than the 2.5% readmission rate for second ALTE reported in a previous study of short‐term follow‐up (30 days).4 The number of readmissions in our study might be higher due to our comprehensive follow‐up, both in length of time and number of additional EDs and hospitals captured. Unfortunately, the retrospective nature of our study makes it difficult to determine if any interventions (prescription of anti‐reflux medication, education on reflux precautions) impacted the rate of readmission, as compliance was not measurable. Further studies should address why patients return with recurrent ALTE.

Interestingly, several potential risk factors did not predict long‐term adverse GI outcomes. For example, prematurity, a discharge diagnosis of GERD, or prescription of an anti‐reflux medication, were not associated with adverse GI outcomes. These findings support the concept that a diagnosis of GERD, at least as is commonly applied, is not meaningful in the setting of an ALTE. We did find associations with longer length of stay (LOS), and with eventual development of neurological impairment. Longer LOS might be a proxy for other subtle predictors that could influence adverse outcomes, such as requiring additional diagnostic tests prolonging hospitalization, or continued ALTEs while inpatient. The neurologic outcomes of patients with ALTE have been previously published, and the strong correlation between neurologic impairment and GERD has been well described.14, 25

There are several strengths of this study. This is the first study, to our knowledge, to look at adverse outcomes associated with GERD following ALTE, despite GERD being the most commonly attributed cause. The use of Intermountain Healthcare's electronic medical record system allowed for comprehensive tracking, over an extensive follow‐up period (median of 7.8 years), across 20 hospitals and EDs which care for the vast majority of pediatric patients in Utah. Finally, this large cohort of ALTE patients used clinical data from medical records and not only administrative data.

There are limitations of this study. This is a retrospective cohort study. Some of our study outcomes may be a result of pathophysiology other than GERD and, conversely, GERD may be a result of other issues (neurologic impairment). The small sample size and low percentage of the study outcomes make it possible that we did not detect true risk factors. Patients were lost to follow‐up if they moved or presented to a hospital not within the Intermountain Healthcare system. This study has slightly different patient numbers from 3 previously published studies for different outcomes on this cohort, as exclusion criteria for the different cohorts were different.14, 26, 27 Six patients had only their electronic medical record reviewed because the paper chart was missing.

IMPLICATIONS

The results of this study extend previous work of various outcomes regarding well‐appearing infants following an ALTE.14, 26, 27 In these studies, 3.9% and 3% were ultimately diagnosed with epilepsy and developmental delay, respectively; 1.4% were diagnosed with abusive head trauma; and 0.6% required otolaryngologic surgical intervention. In these previous studies, there were few predictors of these outcomes, with testing demonstrating largely normal results during the index ALTE admission.

Our study helps clinicians place the outcomes of aspiration pneumonia, failure‐to‐thrive, and anti‐reflux surgery into the context of these other studies when discharging infants from the hospital after an ALTE. Collectively, these studies provide clinicians with the information that, in the setting of a well‐appearing infant, few diagnostic tests in their ALTE patients will yield a definitive diagnosis. Ultimately, close follow‐up with further investigations if symptoms recur will be an important part of diagnosing the etiology of the ALTE in these infants.

We found that well‐appearing infants with ALTE, regardless of attributed cause, are at low risk for adverse outcomes associated with GERD. Only the eventual development of neurologic impairment or an increased length of stay during index ALTE hospitalization was found to be predictive of these outcomes.

Acknowledgements

The following individuals have made substantive intellectual contributions to this study: conception and design (G.Z., J.L.B., W.D.J., C.G.M., R.S.), acquisition of data (G.Z., J.L.B.), analysis (G.Z., RS) and interpretation of data (G.Z., J.L.B., W.D.J., C.G.M., R.S.). In addition, all listed authors have contributed to either drafting the article or revising it critically for important intellectual content. Finally, all listed authors have given final approval of this version submitted for publication. The authors also acknowledge Chelsea Welch for her assistance in data collection.

Disclosures: This study was presented in part at the national Pediatric Academic Societies meetings in Vancouver, Canada, May 2010 and in Denver, CO, May 2011. This study was supported by a National Institutes of Child Health and Human Development (NICHD) grant for Dr Srivastava (K23 HD052553), and a National Institute on Drug Abuse (NIDA) grant for Dr Bonkowsky (K08 DA24753). This research was supported in part by the Children's Health Research Center, University of Utah. There are no conflicts of interest.

Apparent life‐threatening events (ALTEs) are frightening for the parent/guardian and represent a challenge for the healthcare provider. ALTEs are defined as worrisome episodes of any combination of apnea, color change, change in muscle tone, choking or gagging.1 ALTEs account for 0.6% to 0.8% of emergency department (ED) visits for children <12 months old,2, 3 have an average length of stay (LOS) of 4.4 days and an average cost of $15,000 per hospitalization.4

Gastroesophageal reflux disease (GERD) is common in infancy11 and also is the most commonly (in 31%55% of ALTE cases) attributed cause of ALTE.2, 4, 5 It has been speculated that chemosensitivity to gastric acid results in laryngospasm, bronchospasm, and apnea. However, several small studies have failed to prove a causal link between reflux episodes and apnea.69 Furthermore, although consensus guidelines for GERD have been developed,14 the clinical use of testing for GERD remains highly variable. A study of infants discharged with an ALTE (n = 12,067) from 36 children's hospitals in the United States revealed extensive variability in the use of pH probes and upper gastrointestinal x‐ray series to diagnose GERD.4

The incidence of adverse outcomes associated with GERD after an ALTE remains unknown. It is also unknown whether an association exists between long‐term gastrointestinal (GI) outcomes and testing demonstrative of GERD or a diagnosis of GERD during hospitalization for ALTE. The primary objective of our study was to determine, in patients with an ALTE, the adverse outcomes associated with GERD (failure‐to‐thrive, aspiration pneumonia, and/or anti‐reflux surgery), the incidence of readmission for second ALTE, and death. Our secondary objective was to determine risk factors for adverse outcomes associated with GERD following an ALTE.

METHODS

Design

This was a retrospective cohort study. We reviewed electronic and paper medical charts of all infants <12 months of age admitted for ALTE between January 1, 1999 and December 31, 2003 to Primary Children's Medical Center in Salt Lake City, UT, which serves as the tertiary pediatric center for >1 million children and the primary facility for >270,000 children in Salt Lake County, UT.10 Primary Children's Medical Center is operated by a vertically integrated not‐for‐profit healthcare system (Intermountain Healthcare), which has 20 affiliated hospitals and EDs. The study was approved by the institutional review boards of the University of Utah and Intermountain Healthcare, and the privacy board of Intermountain Healthcare.

Participants

Patients were included if a computer search of ED chief complaint or hospital discharge diagnoses found one or more of the following keywords (or corresponding International Classification of Diseases, Ninth Revision [ICD‐9] codes if applicable): ALTE, altered mental status, apnea, breath‐holding spell, choking, GERD, hypotonia, lethargy, other convulsions, other neurologic diagnosis, other respiratory diagnosis, pallor, seizures, sleep apnea, stiff, syncope, and unresponsiveness. These diagnoses were chosen as potential proxy diagnoses or codes for possible ALTE, as ALTE did not have a corresponding ICD‐9 code at the time of this study.

Detailed review of the medical record included infants who were <12 months old at admission with a history consistent with ALTE, defined as an episode frightening to the observer with any combination of apnea, color change, change in muscle tone, choking, or gagging. Infants were excluded from the study if they had a previously documented underlying medical condition to explain the ALTE (such as a known seizure disorder) or had a clearly apparent diagnosis upon initial history and physical examination (such as bronchiolitis diagnosed in the emergency department) that would explain the event. Patients with unstable vital signs (eg, hypotension), trauma clearly apparent on admission, documented medication dosing error, or febrile seizure were also excluded. A complete list of exclusion criteria is found in Figure 1.

Figure 1
The ALTE cohort. Abbreviations: ALTE, apparent life‐threatening event; CNS, central nervous system; GERD, gastroesophageal reflux disease.

All hospital admissions, ED visits, and Pediatric GI clinic notes were reviewed for adverse outcomes associated with GERD, second ALTE admission, and death. The follow‐up time period included the original enrollment period (January 1, 1999 through December 31, 2003) through August 31, 2009.

Outcomes

Adverse outcomes associated with GERD were defined as aspiration pneumonia, failure‐to‐thrive (FTT; either admission or discharge diagnosis of FTT at another hospitalization, or follow‐up to gastroenterology clinic for FTT) and/or anti‐reflux surgery (Nissen fundoplication or gastrojejunal tube placement) as these are potential clinical consequences of having severe and uncontrolled GERD. We further collected readmission data for a second ALTE. Deaths and the attributed reasons were also collected.

Risk Factors

Potential risk factors for adverse outcomes associated with GERD (all during index hospitalization) included: age; prematurity; gender; previous event (as described by the parent, without previous ALTE hospitalization); primary discharge diagnosis of GERD; testing positive for reflux on index ALTE admission (upper GI x‐ray series, esophageal pH probe, swallow study, endoscopy, and/or consultation of pediatric gastroenterologist with results or assessments indicating gastroesophageal reflux); any anti‐reflux medication prescribed upon discharge; and LOS. We also considered diagnosis of neurologic impairment during follow‐up, which was defined as seizures or diagnosis of developmental delay from any etiology not recognized on index ALTE admission. We examined these risk factors as we postulated they might indicate higher risk for both ALTE and adverse outcomes associated with GERD, or might indicate a higher severity of initial event.

Analyses

Summary statistics were performed for adverse outcomes associated with GERD, readmission, and death. Univariate analyses were performed for risk factors using chi‐square tests for dichotomous predictors and Wilcoxon rank sum tests for nonparametric continuous predictors for any of the 3 adverse outcomes (FTT, aspiration pneumonia [AP], and/or anti‐reflux surgery) associated with GERD. All analyses were performed using SAS 9.13 (Carey, NC).

RESULTS

Eleven hundred forty‐eight infants with ALTE met inclusion criteria, from 187,903 patients meeting initial search criteria. Six hundred seventy‐one patients were excluded and 8 patients had missing charts. The study population of the 469‐patient cohort is shown in Figure 1.

Demographics are displayed in Table 1. The mean age was 65 days. One hundred three (22%) were premature. One hundred eighty‐nine patients (40%) had a primary discharge diagnosis of GERD; details of the diagnoses for the remaining patients are in Figure 1. Median length of follow‐up for the cohort was 7.8 years. The entire study period was 10.7 years.

Demographic, Clinical, and Hospitalization Characteristics of Patients by Discharge Diagnosis
 ALTE Cohort
N = 469
  • Abbreviations: ALTE, apparent life‐threatening event; GERD, gastroesophageal reflux disease; SD, standard deviation.

Female233 (49.7%)
Race 
Caucasian371 (79.1%)
Hispanic64 (13.6%)
Pacific Islander6 (1.3%)
Black4 (0.8%)
Other/unknown24 (5.1%)
Mean age in days (SD)65.2 (69.5)
Prematurity103 (22%)
Underwent testing for gastroesophageal reflux214 (45.6%)
Discharged on anti‐reflux medication238 (50.7%)
Previous event127 (27.1%)
Mean length of stay in days (SD)2.4 (2.4)
Later neurologic impairment (seizures or developmental delay)23 (4.9%)
Primary discharge diagnosis of GERD189 (40%)

Eighteen patients (3.8%) had an adverse outcome associated with GERD. Four (0.9%) had aspiration pneumonia, 9 (1.9%) had failure‐to‐thrive, and 7 (1.5%) had a Nissen fundoplication (no patients had a gastrojejunal tube placed). Five patients had a gastrostomy tube placed at the time of fundoplication. Two patients had more than 1 adverse GI outcome; 1 patient had aspiration pneumonia and another had failure‐to‐thrive prior to their Nissen fundoplications.

Fifty‐six patients (11.9%) were readmitted for a second ALTE. Median time from index ALTE to second ALTE admission was 16.5 days (interquartile range: Q1, 8Q3, 32). Two (0.4%) patients died. Both (occurring at 18 months and 5.5 years after the initial ALTE hospitalization) were related to the children first developing seizure disorders and severe developmental delay. Neither of the patients who died had an index discharge diagnoses of GERD.

There was no significance of the following variables in predicting adverse outcomes associated with GERD: age, prematurity, gender, previous event, testing positive for reflux, primary discharge diagnosis of GERD, or discharge on anti‐reflux medications (see Table 2). Patients with adverse outcomes associated with GERD had longer mean LOS on the index ALTE hospitalization (4.3 days vs 2.4 days; P = 0.03) and a higher rate of neurologic impairment diagnosed in follow‐up (16.7% vs 4.4%; P = 0.02) than patients without long‐term adverse GI outcomes. Patients with neurological impairment diagnosed in follow‐up were more likely to eventually develop an adverse outcome associated with GERD, compared to patients without neurological impairment (odds ratio 8.4; 95% confidence interval 1.1516.1).

Univariate Risk Factors of Long‐Term Adverse GI Outcomes
 AP, FTT, or SurgeryNo Long‐Term Adverse GI OutcomeP Value
N = 18N = 451
  • Abbreviations: ALTE, apparent life‐threatening event; AP, aspiration pneumonia; FTT, failure‐to‐thrive; GERD, gastroesophageal reflux disease; GI, gastrointestinal; SD, standard deviation.

Mean age in days (SD)51.9 (76.4)65.8 (69.3)0.27
Prematurity1 (5.6%)102 (22.6%)0.08
Male gender12 (66.7%)220 (48.8%)0.14
Previous ALTE‐like event (no hospitalization)8 (44.4%)119 (26.4%)0.09
Testing positive for reflux9 (50%)177 (39.3%)0.36
Discharge diagnosis GERD9 (50%)180 (39.9%)0.39
Discharged on anti‐reflux medication9 (50%)229 (50.7%)0.95
Mean length of stay in days (SD)4.3 (4.7)2.4 (2.3)0.03
Neurologic impairment diagnosed in follow‐up3 (16.7%)20 (4.4%)0.02

DISCUSSION

Our study had 2 main findings. First, infants admitted for an ALTE had a low percentage (3.8%) of adverse outcomes associated with GERD. Review of the literature provides little context to interpret this percentage. One study reports 9 per 100,000 of the general population <18 years of age having anti‐reflux surgery.24 The percentage of adverse outcomes associated with GERD converted to a rate in our study would likely reflect the bias of our center serving as a referral population for Utah and 5 surrounding states. Furthermore, there may be an additional bias of ALTE being a potential indication for anti‐reflux surgery for some clinicians, as well as confounding additional diagnoses (such as later neurologic impairment which might independently increase risk of study outcomes).

The second main finding of our study is that the development of neurologic impairment was predictive of developing adverse GI outcomes. As previous studies have shown that neurological impairment cannot be predicted during the initial ALTE hospitalization,14 adverse outcomes associated with GERD are similarly not predictable with current clinical approaches. Furthermore, the exact nature of the relationship between neurologic impairment and ALTEs remains unclear. While previous studies have described the increased prevalence of adverse neurological outcomes (such as seizures, developmental delay) in children who have had an ALTE, it is unclear what the precipitating reason for ALTE is in these infants (seizure, central apnea, GERD, etc).14

There is ongoing debate in the literature surrounding the optimal diagnosis of GERD in infants with ALTE. Recent guidelines state that investigations aimed to prove GERD causing an ALTE should include pH probe or impedance monitor testing, in combination with a sleep study, and discourages a GERD diagnosis based on upper GI‐series alone.14 Given the low use of pH probe and impedance monitoring at our institution during the study period (86% of the patients who had GI‐related testing had an upper GI‐series), we did not attempt to find the sensitivity or specificity of the different GI testing modalities for GERD in the setting of ALTE. The high use of upper‐GI series is not unique to our institutionone large study examining practice variation from 12,067 ALTE admissions in 36 children's hospitals, with 36.9% of infants (n = 4453) having a primary discharge diagnosis of gastroesophageal reflux, revealed that only 8.9% (SD 28%) received an esophageal pH probe, while 25.6% (SD 43.6%) had an upper GI‐series or swallow study.4

Given the difficulties in assigning a GERD diagnosis for ALTE infants, we focused on the long‐term adverse outcomes associated with GERD for the entire ALTE infant cohort. The 3 adverse outcomes we chose deserve some mention. Aspiration pneumonia is generally due to either primary aspiration (from dysfunctional swallowing) or secondary aspiration (from GERD). Failure‐to‐thrive can be due to ongoing GERD. Anti‐reflux surgery is often performed for severe GERD. While we believe that a prospective study with better diagnostic evaluations for GERD and apnea (such as pH probe or impedance monitor in combination with a sleep study) might help elucidate the unclear relationship between reflux episodes and ALTE, the low percentage of adverse outcomes associated with GERD after ALTE may suggest that such a study would be difficult both in terms of sample size and an unnecessary use of resources.

We also found that a high percentage (11.9%) of all patients had readmission for a second ALTE. This was substantially higher than the 2.5% readmission rate for second ALTE reported in a previous study of short‐term follow‐up (30 days).4 The number of readmissions in our study might be higher due to our comprehensive follow‐up, both in length of time and number of additional EDs and hospitals captured. Unfortunately, the retrospective nature of our study makes it difficult to determine if any interventions (prescription of anti‐reflux medication, education on reflux precautions) impacted the rate of readmission, as compliance was not measurable. Further studies should address why patients return with recurrent ALTE.

Interestingly, several potential risk factors did not predict long‐term adverse GI outcomes. For example, prematurity, a discharge diagnosis of GERD, or prescription of an anti‐reflux medication, were not associated with adverse GI outcomes. These findings support the concept that a diagnosis of GERD, at least as is commonly applied, is not meaningful in the setting of an ALTE. We did find associations with longer length of stay (LOS), and with eventual development of neurological impairment. Longer LOS might be a proxy for other subtle predictors that could influence adverse outcomes, such as requiring additional diagnostic tests prolonging hospitalization, or continued ALTEs while inpatient. The neurologic outcomes of patients with ALTE have been previously published, and the strong correlation between neurologic impairment and GERD has been well described.14, 25

There are several strengths of this study. This is the first study, to our knowledge, to look at adverse outcomes associated with GERD following ALTE, despite GERD being the most commonly attributed cause. The use of Intermountain Healthcare's electronic medical record system allowed for comprehensive tracking, over an extensive follow‐up period (median of 7.8 years), across 20 hospitals and EDs which care for the vast majority of pediatric patients in Utah. Finally, this large cohort of ALTE patients used clinical data from medical records and not only administrative data.

There are limitations of this study. This is a retrospective cohort study. Some of our study outcomes may be a result of pathophysiology other than GERD and, conversely, GERD may be a result of other issues (neurologic impairment). The small sample size and low percentage of the study outcomes make it possible that we did not detect true risk factors. Patients were lost to follow‐up if they moved or presented to a hospital not within the Intermountain Healthcare system. This study has slightly different patient numbers from 3 previously published studies for different outcomes on this cohort, as exclusion criteria for the different cohorts were different.14, 26, 27 Six patients had only their electronic medical record reviewed because the paper chart was missing.

IMPLICATIONS

The results of this study extend previous work of various outcomes regarding well‐appearing infants following an ALTE.14, 26, 27 In these studies, 3.9% and 3% were ultimately diagnosed with epilepsy and developmental delay, respectively; 1.4% were diagnosed with abusive head trauma; and 0.6% required otolaryngologic surgical intervention. In these previous studies, there were few predictors of these outcomes, with testing demonstrating largely normal results during the index ALTE admission.

Our study helps clinicians place the outcomes of aspiration pneumonia, failure‐to‐thrive, and anti‐reflux surgery into the context of these other studies when discharging infants from the hospital after an ALTE. Collectively, these studies provide clinicians with the information that, in the setting of a well‐appearing infant, few diagnostic tests in their ALTE patients will yield a definitive diagnosis. Ultimately, close follow‐up with further investigations if symptoms recur will be an important part of diagnosing the etiology of the ALTE in these infants.

We found that well‐appearing infants with ALTE, regardless of attributed cause, are at low risk for adverse outcomes associated with GERD. Only the eventual development of neurologic impairment or an increased length of stay during index ALTE hospitalization was found to be predictive of these outcomes.

Acknowledgements

The following individuals have made substantive intellectual contributions to this study: conception and design (G.Z., J.L.B., W.D.J., C.G.M., R.S.), acquisition of data (G.Z., J.L.B.), analysis (G.Z., RS) and interpretation of data (G.Z., J.L.B., W.D.J., C.G.M., R.S.). In addition, all listed authors have contributed to either drafting the article or revising it critically for important intellectual content. Finally, all listed authors have given final approval of this version submitted for publication. The authors also acknowledge Chelsea Welch for her assistance in data collection.

Disclosures: This study was presented in part at the national Pediatric Academic Societies meetings in Vancouver, Canada, May 2010 and in Denver, CO, May 2011. This study was supported by a National Institutes of Child Health and Human Development (NICHD) grant for Dr Srivastava (K23 HD052553), and a National Institute on Drug Abuse (NIDA) grant for Dr Bonkowsky (K08 DA24753). This research was supported in part by the Children's Health Research Center, University of Utah. There are no conflicts of interest.

References
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  2. McGovern MC,Smith MBH.Causes of apparent life threatening events in infants: a systematic review.Arch Dis Child.2004;89:10431048.
  3. Mitchell EA,Thompson JM.Parental reported apnea, admissions to hospital and sudden infant death syndrome.Acta Paediatr.2001;90(4):417422.
  4. Tieder JS,Cowan CA,Garrison MM,Christakis DA.Variation in inpatient resource utilization and management of apparent life‐threatening events.J Pediatr.2008;152(5):629635.
  5. Okada K,Miyako M,Honma S,Wakabayashi Y,Sugihara S,Osawa M.Discharge diagnoses in infants with apparent life‐threatening event.Pediatr Int.2003;45:560563.
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  14. Bonkowsky JL,Guenther E,Filloux FM,Srivastava R.Death, child abuse, and adverse neurological outcomes of infants after an apparent life‐threatening event.Pediatrics.2008;122:125131.
  15. Altman RL,Brand DA,Forman S, et al.Abusive head injury as a cause of apparent life‐threatening events in infancy.Arch Pediatr Adolesc Med.2003;157:10111015.
  16. Pitetti R,Whitman E,Zaylor A.Accidental and nonaccidental poisonings as a cause of apparent life‐threatening events in infants.Pediatrics.2008;122:e359e362.
  17. Brand DA,Altman RL,Purtill K,Edwards KS.Yield of diagnostic testing in infants who have had an apparent life‐threatening event.Pediatrics.2005;115:885893.
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  19. Johnston BT,Troshinsky MB,Castell JA,Castell DO.Comparison of barium radiology with esophageal pH monitoring in the diagnosis of gastroesophageal reflux disease.Am J Gastroenterol.1996;91(6):11811195.
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  22. Moore DJ,Tao BS,Lines DR, et al.Double‐blind placebo controlled trial of omeprazole in irritable infants with gastroesophageal reflux.J Pediatr.2003;143:219223.
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References
  1. Infantile apnea and home monitoring.NIH Consensus Statement 1986 Sep 29‐Oct 1.Pediatrics.1987;79(2):292299.
  2. McGovern MC,Smith MBH.Causes of apparent life threatening events in infants: a systematic review.Arch Dis Child.2004;89:10431048.
  3. Mitchell EA,Thompson JM.Parental reported apnea, admissions to hospital and sudden infant death syndrome.Acta Paediatr.2001;90(4):417422.
  4. Tieder JS,Cowan CA,Garrison MM,Christakis DA.Variation in inpatient resource utilization and management of apparent life‐threatening events.J Pediatr.2008;152(5):629635.
  5. Okada K,Miyako M,Honma S,Wakabayashi Y,Sugihara S,Osawa M.Discharge diagnoses in infants with apparent life‐threatening event.Pediatr Int.2003;45:560563.
  6. Kahn A,Rebuffat E,Sottiaux M,Dufour D,Cadranel S,Reiterer F.Lack of temporal relation between acid reflux in the proximal oesophagus and cardiorespiratory events in sleeping infants.Eur J Pediatr.1992;151(3):208212.
  7. Newman LJ,Russe J,Glassman MS, et al.Patterns of gastroesophageal reflux (GER) in patients with apparent life‐threatening events.J Pediatr Gastroenterol Nutr.1989;8(2):157160.
  8. Gorrotxategi P,Eizaquirre I,Saenz de Uqarte A, et al.Characteristics of continuous esophageal pH‐metering in infants with gastroesophageal reflux and apparent life‐threatening events.Eur J Pediatr Surg.1995;5(3);136138.
  9. DiFiore JM,Arko M,Whitehouse M,Kimball A,Martin RJ.Apnea is not prolonged by acid gastroesophageal reflux in preterm infants.Pediatrics.2005;116:10591063.
  10. Norlin C,Osborn LM.Organizational responses to managed care: issues for academic health centers and implications for pediatric programs.Pediatrics.1998;101(4):805811.
  11. Vandenplas Y,Rudolph CD,Di Lorenzo C, et al.Pediatric gastroesophageal reflux clinical practice guidelines: joint recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN) and the European Society for Pediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN).J Pediatr Gastroenterol Nutr.2009;49:498547.
  12. Campanozzi A,Boccia G,Pensabene L, et al.Prevalence and natural history of gastroesophageal reflux: pediatric prospective study.Pediatrics.2009;123(3):779783.
  13. Tolia V,Vandenplas Y.Systematic review: the estra‐oesophageal symptoms of gastro‐oesophageal reflux disease in children.Aliment Pharmacol Ther.2009;29:258272.
  14. Bonkowsky JL,Guenther E,Filloux FM,Srivastava R.Death, child abuse, and adverse neurological outcomes of infants after an apparent life‐threatening event.Pediatrics.2008;122:125131.
  15. Altman RL,Brand DA,Forman S, et al.Abusive head injury as a cause of apparent life‐threatening events in infancy.Arch Pediatr Adolesc Med.2003;157:10111015.
  16. Pitetti R,Whitman E,Zaylor A.Accidental and nonaccidental poisonings as a cause of apparent life‐threatening events in infants.Pediatrics.2008;122:e359e362.
  17. Brand DA,Altman RL,Purtill K,Edwards KS.Yield of diagnostic testing in infants who have had an apparent life‐threatening event.Pediatrics.2005;115:885893.
  18. Rudolph CD,Mazur LJ,Liptak GS, et al.Guidelines for evaluation and treatment of gastroesophageal reflux in infants and children: recommendations of the North American Society for Pediatric Gastroenterology and Nutrition.J Pediatr Gastroenterol Nutr.2001;32(suppl 2):S1S31.
  19. Johnston BT,Troshinsky MB,Castell JA,Castell DO.Comparison of barium radiology with esophageal pH monitoring in the diagnosis of gastroesophageal reflux disease.Am J Gastroenterol.1996;91(6):11811195.
  20. Chen MY,Ott DJ,Sinclair JW, et al.Gastroesophageal reflux disease: correlation of esophageal pH testing and radiographic finding.Radiology.1992;185:483486.
  21. Aksglaede K,Pedersen JB,Lange A, et al.Gastro‐esophageal reflux demonstrated by radiography in infants less than 1 year of age. Comparison with pH monitoring.Acta Radiol.2003;44:136138.
  22. Moore DJ,Tao BS,Lines DR, et al.Double‐blind placebo controlled trial of omeprazole in irritable infants with gastroesophageal reflux.J Pediatr.2003;143:219223.
  23. Heine RG,Jordan B,Lubitz L, et al.Clinical predictors of pathological gastro‐oesophageal reflux in infants with persistant distress.J Paediatr Child Health.2006;42:134139.
  24. Lasser MS,Laio JG,Burd RS.National trends in the use of anti‐reflux procedures for children.Pediatrics.2006;118:18281835.
  25. Sullivan PB,Lambert B,Rose M, et al.Prevalence and severity of feeding and nutritional problems in children with neurological impairment: Oxford feeding study.Dev Med Child Neurol.2000;42:674680.
  26. Guenther E,Powers A,Srivastava R.Abusive head trauma in children presenting with an apparent life‐threatening event.J Pediatr.2010;157(5):821825.
  27. Willis WM,Bonkowsky JL,Srivastava R.Usefulness of airway evaluation in children initially seen with apparent life‐threatening event.Arch Otolaryngol Head Neck Surg.2011;137(4):359362.
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Adverse outcomes associated with gastroesophageal reflux disease are rare following an apparent life‐threatening event
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Looks Aren’t Everything in Breast Reconstruction

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Looks Aren’t Everything in Breast Reconstruction
The surgeon-patient relationship can be critical to whether the procedure is perceived as successful.

Before-and-after photographs are the stock in trade of house painters, auto repair shops, and, yes, plastic and reconstructive surgeons. But a new study may make the last group pause, since it hints that far more is at play in breast cancer patients’ definition of “successful’’ breast reconstruction surgery than how their breasts appear.

The study from Liverpool, England (J Plast Reconstr Aesthet Surg (2012): doi:10.1016/j.bjps.2012.03.005) sidestepped traditional measures used to evaluate outcomes of aesthetic breast surgery and instead asked open-ended questions of survivors who had undergone reconstruction 1-8 years previously.

What the researchers discovered, not surprisingly, is that reconstruction patients are quite unlike cosmetic surgery patients in fundamental and important ways.

©Lilli Day/iStockphoto.com
When it comes to breast reconstruction, women and their surgeons have different definitions of what defines a "successful" procedure.

Of particular interest in the initial study cohort of 95 patients were 38 whose subjective evaluations of their surgical results completely contradicted objective ratings of cosmesis, the final appearance of the reconstructed breast(s) by surgeons and surgical nurses.

Incredibly, the association between women’s assessments and objective cosmesis ratings failed even to reach statistical significance.

In a structured data analysis of themes that arose in open-ended interviews with 27 of the survivors, the strongest link to women’s satisfaction with the procedure was the surgeon-patient relationship.

Next came the significance of reconstruction in what patients saw as the “completion of the cancer journey,” the authors wrote. “Patients who focused on this were positive about reconstruction that practitioners had rated negatively.”

A previous study asked patients about scarring, finding a correlation between scarring and dissatisfaction with reconstruction. But scarring wasn’t even a blip on the radar when, quoting from the Liverpool study, “we allowed patients to tell us what mattered to them rather than imposing our preconceptions.”

“It seems that surgeons and patients normally ‘talk different languages’; one technical and the other drawing more from relationships and patients’ sense of how normal they feel and appear and from their sense that reconstruction completes their cancer journey,” the investigators concluded. “In preoperative consultations, surgeons concentrate almost exclusively on the technical and cosmetic aspects of reconstruction: what can be achieved and what complications can occur.”

Of course, women who struggled with complications tended to factor that in to their assessments of their results, even if their final cosmetic outcome was considered by surgeons to be excellent.

Others were disappointed despite what seemed to surgeons to be  excellent cosmetic results because, as one said, “I was expecting to feel feminine again, but I don’t, I don’t at all.”

What is perhaps even more interesting is to eavesdrop on the comments of women whose surgeons judged their cosmetic result to be poor.

Said one, “I had a really good relationship with (the surgeon) and I just found it so reassuring to see her. That was part of the whole thing really. She was just so positive, and so, well, just understanding I think … I was really glad that I had chosen that form of reconstruction because I had this regular contact with her.”

Said another, who felt “normal” despite what her surgeon considered to be a poor result: “If I didn’t have it done, I wouldn’t have felt normal at all. It would always remind me of what had happened.”

A highly complex patient-surgeon dance occurs when breast surgery is performed for more than cosmetic reasons, the study found.

One woman, disappointed with the way her reconstructed breast fit in a bra, could not bring herself to voice her concern with the surgeon she credited with saving her life.

“It’s very difficult to come face to face with somebody who says, ‘You’ve had cancer but we can get rid of it,’ and does their best… without seeming ungrateful,” she said, tearfully.

The study concludes with a fascinating discussion about the potential clinical implications of the findings.

Considering the profound influence of the patient-surgeon relationship on these particular patients, the investigators offer a cautionary suggestion to avoid being overly effusive about the cosmetic result they may see. Patients, they explain, may not necessarily share their enthusiasm, if they continue to struggle with the sense that cancer has marred their bodies, their sense of self, or their security in relationships.

“Both patient and surgeon have invested physically and emotionally in the procedure and it is difficult for either to admit to the other that it was “not worth it,” they note.

Women, on the other hand, who appear to be disproportionately pleased with the result of surgery that objectively achieved a poor result may simply be expressing relief and gratitude. “Their apparent satisfaction,” they wrote, “should not excuse poor surgical practice.” Rather, routine assessments of reconstructive practice should be made by objective sources, not simply patient report.

 

 

On the other hand, in individual patients, the objective in reconstructive surgery is patient satisfaction, they suggest. An unhappy patient might spur a conscientious surgeon to keep trying, perhaps through repeated procedures, to achieve a better result – a strategy that could be inappropriate and pointless considering that in some cases, “the reason for disappointment with reconstruction include many that the surgeon cannot influence surgically.”

It all suggests that communication between surgeons and reconstruction candidates and patients needs to be deep and candidly honest, informed by the emotional, sexual, and existential meaning the surgery holds.

In a word, it’s complicated.

Betsy Bates Freed, Psych.D., is a clinical psychologist in Santa Barbara, Calif., and a medical journalist.

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The surgeon-patient relationship can be critical to whether the procedure is perceived as successful.
The surgeon-patient relationship can be critical to whether the procedure is perceived as successful.

Before-and-after photographs are the stock in trade of house painters, auto repair shops, and, yes, plastic and reconstructive surgeons. But a new study may make the last group pause, since it hints that far more is at play in breast cancer patients’ definition of “successful’’ breast reconstruction surgery than how their breasts appear.

The study from Liverpool, England (J Plast Reconstr Aesthet Surg (2012): doi:10.1016/j.bjps.2012.03.005) sidestepped traditional measures used to evaluate outcomes of aesthetic breast surgery and instead asked open-ended questions of survivors who had undergone reconstruction 1-8 years previously.

What the researchers discovered, not surprisingly, is that reconstruction patients are quite unlike cosmetic surgery patients in fundamental and important ways.

©Lilli Day/iStockphoto.com
When it comes to breast reconstruction, women and their surgeons have different definitions of what defines a "successful" procedure.

Of particular interest in the initial study cohort of 95 patients were 38 whose subjective evaluations of their surgical results completely contradicted objective ratings of cosmesis, the final appearance of the reconstructed breast(s) by surgeons and surgical nurses.

Incredibly, the association between women’s assessments and objective cosmesis ratings failed even to reach statistical significance.

In a structured data analysis of themes that arose in open-ended interviews with 27 of the survivors, the strongest link to women’s satisfaction with the procedure was the surgeon-patient relationship.

Next came the significance of reconstruction in what patients saw as the “completion of the cancer journey,” the authors wrote. “Patients who focused on this were positive about reconstruction that practitioners had rated negatively.”

A previous study asked patients about scarring, finding a correlation between scarring and dissatisfaction with reconstruction. But scarring wasn’t even a blip on the radar when, quoting from the Liverpool study, “we allowed patients to tell us what mattered to them rather than imposing our preconceptions.”

“It seems that surgeons and patients normally ‘talk different languages’; one technical and the other drawing more from relationships and patients’ sense of how normal they feel and appear and from their sense that reconstruction completes their cancer journey,” the investigators concluded. “In preoperative consultations, surgeons concentrate almost exclusively on the technical and cosmetic aspects of reconstruction: what can be achieved and what complications can occur.”

Of course, women who struggled with complications tended to factor that in to their assessments of their results, even if their final cosmetic outcome was considered by surgeons to be excellent.

Others were disappointed despite what seemed to surgeons to be  excellent cosmetic results because, as one said, “I was expecting to feel feminine again, but I don’t, I don’t at all.”

What is perhaps even more interesting is to eavesdrop on the comments of women whose surgeons judged their cosmetic result to be poor.

Said one, “I had a really good relationship with (the surgeon) and I just found it so reassuring to see her. That was part of the whole thing really. She was just so positive, and so, well, just understanding I think … I was really glad that I had chosen that form of reconstruction because I had this regular contact with her.”

Said another, who felt “normal” despite what her surgeon considered to be a poor result: “If I didn’t have it done, I wouldn’t have felt normal at all. It would always remind me of what had happened.”

A highly complex patient-surgeon dance occurs when breast surgery is performed for more than cosmetic reasons, the study found.

One woman, disappointed with the way her reconstructed breast fit in a bra, could not bring herself to voice her concern with the surgeon she credited with saving her life.

“It’s very difficult to come face to face with somebody who says, ‘You’ve had cancer but we can get rid of it,’ and does their best… without seeming ungrateful,” she said, tearfully.

The study concludes with a fascinating discussion about the potential clinical implications of the findings.

Considering the profound influence of the patient-surgeon relationship on these particular patients, the investigators offer a cautionary suggestion to avoid being overly effusive about the cosmetic result they may see. Patients, they explain, may not necessarily share their enthusiasm, if they continue to struggle with the sense that cancer has marred their bodies, their sense of self, or their security in relationships.

“Both patient and surgeon have invested physically and emotionally in the procedure and it is difficult for either to admit to the other that it was “not worth it,” they note.

Women, on the other hand, who appear to be disproportionately pleased with the result of surgery that objectively achieved a poor result may simply be expressing relief and gratitude. “Their apparent satisfaction,” they wrote, “should not excuse poor surgical practice.” Rather, routine assessments of reconstructive practice should be made by objective sources, not simply patient report.

 

 

On the other hand, in individual patients, the objective in reconstructive surgery is patient satisfaction, they suggest. An unhappy patient might spur a conscientious surgeon to keep trying, perhaps through repeated procedures, to achieve a better result – a strategy that could be inappropriate and pointless considering that in some cases, “the reason for disappointment with reconstruction include many that the surgeon cannot influence surgically.”

It all suggests that communication between surgeons and reconstruction candidates and patients needs to be deep and candidly honest, informed by the emotional, sexual, and existential meaning the surgery holds.

In a word, it’s complicated.

Betsy Bates Freed, Psych.D., is a clinical psychologist in Santa Barbara, Calif., and a medical journalist.

Before-and-after photographs are the stock in trade of house painters, auto repair shops, and, yes, plastic and reconstructive surgeons. But a new study may make the last group pause, since it hints that far more is at play in breast cancer patients’ definition of “successful’’ breast reconstruction surgery than how their breasts appear.

The study from Liverpool, England (J Plast Reconstr Aesthet Surg (2012): doi:10.1016/j.bjps.2012.03.005) sidestepped traditional measures used to evaluate outcomes of aesthetic breast surgery and instead asked open-ended questions of survivors who had undergone reconstruction 1-8 years previously.

What the researchers discovered, not surprisingly, is that reconstruction patients are quite unlike cosmetic surgery patients in fundamental and important ways.

©Lilli Day/iStockphoto.com
When it comes to breast reconstruction, women and their surgeons have different definitions of what defines a "successful" procedure.

Of particular interest in the initial study cohort of 95 patients were 38 whose subjective evaluations of their surgical results completely contradicted objective ratings of cosmesis, the final appearance of the reconstructed breast(s) by surgeons and surgical nurses.

Incredibly, the association between women’s assessments and objective cosmesis ratings failed even to reach statistical significance.

In a structured data analysis of themes that arose in open-ended interviews with 27 of the survivors, the strongest link to women’s satisfaction with the procedure was the surgeon-patient relationship.

Next came the significance of reconstruction in what patients saw as the “completion of the cancer journey,” the authors wrote. “Patients who focused on this were positive about reconstruction that practitioners had rated negatively.”

A previous study asked patients about scarring, finding a correlation between scarring and dissatisfaction with reconstruction. But scarring wasn’t even a blip on the radar when, quoting from the Liverpool study, “we allowed patients to tell us what mattered to them rather than imposing our preconceptions.”

“It seems that surgeons and patients normally ‘talk different languages’; one technical and the other drawing more from relationships and patients’ sense of how normal they feel and appear and from their sense that reconstruction completes their cancer journey,” the investigators concluded. “In preoperative consultations, surgeons concentrate almost exclusively on the technical and cosmetic aspects of reconstruction: what can be achieved and what complications can occur.”

Of course, women who struggled with complications tended to factor that in to their assessments of their results, even if their final cosmetic outcome was considered by surgeons to be excellent.

Others were disappointed despite what seemed to surgeons to be  excellent cosmetic results because, as one said, “I was expecting to feel feminine again, but I don’t, I don’t at all.”

What is perhaps even more interesting is to eavesdrop on the comments of women whose surgeons judged their cosmetic result to be poor.

Said one, “I had a really good relationship with (the surgeon) and I just found it so reassuring to see her. That was part of the whole thing really. She was just so positive, and so, well, just understanding I think … I was really glad that I had chosen that form of reconstruction because I had this regular contact with her.”

Said another, who felt “normal” despite what her surgeon considered to be a poor result: “If I didn’t have it done, I wouldn’t have felt normal at all. It would always remind me of what had happened.”

A highly complex patient-surgeon dance occurs when breast surgery is performed for more than cosmetic reasons, the study found.

One woman, disappointed with the way her reconstructed breast fit in a bra, could not bring herself to voice her concern with the surgeon she credited with saving her life.

“It’s very difficult to come face to face with somebody who says, ‘You’ve had cancer but we can get rid of it,’ and does their best… without seeming ungrateful,” she said, tearfully.

The study concludes with a fascinating discussion about the potential clinical implications of the findings.

Considering the profound influence of the patient-surgeon relationship on these particular patients, the investigators offer a cautionary suggestion to avoid being overly effusive about the cosmetic result they may see. Patients, they explain, may not necessarily share their enthusiasm, if they continue to struggle with the sense that cancer has marred their bodies, their sense of self, or their security in relationships.

“Both patient and surgeon have invested physically and emotionally in the procedure and it is difficult for either to admit to the other that it was “not worth it,” they note.

Women, on the other hand, who appear to be disproportionately pleased with the result of surgery that objectively achieved a poor result may simply be expressing relief and gratitude. “Their apparent satisfaction,” they wrote, “should not excuse poor surgical practice.” Rather, routine assessments of reconstructive practice should be made by objective sources, not simply patient report.

 

 

On the other hand, in individual patients, the objective in reconstructive surgery is patient satisfaction, they suggest. An unhappy patient might spur a conscientious surgeon to keep trying, perhaps through repeated procedures, to achieve a better result – a strategy that could be inappropriate and pointless considering that in some cases, “the reason for disappointment with reconstruction include many that the surgeon cannot influence surgically.”

It all suggests that communication between surgeons and reconstruction candidates and patients needs to be deep and candidly honest, informed by the emotional, sexual, and existential meaning the surgery holds.

In a word, it’s complicated.

Betsy Bates Freed, Psych.D., is a clinical psychologist in Santa Barbara, Calif., and a medical journalist.

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Exploring the Role of Modified-Release Doxycycline in Rosacea

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Exploring the Role of Modified-Release Doxycycline in Rosacea

A Journal Scan supplement to Skin & Allergy News®.  This supplement was sponsored by Galderma Laboratories, L.P. 

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  • Introduction - Exploring the Role of Modified-Release
  • Doxycycline in Rosacea
  • Comparing Antimicrobial and Anti-Inflammatory Doses of Oral Doxycycline in the Treatment of Rosacea
  • Impact of Antibiotic Resistance on Dermatologic Practice
  • The Effects of Modified-Release Doxycycline on Quality of Life
  • Combining Anti-Inflammatory–Dose Doxycycline With Topical Metronidazole

To view the supplement, click the image above.

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Brian Berman, MD, PhD
Voluntary Professor of Dermatology and Cutaneous Surgery
University of Miami, Miller School of Medicine
Co-Director
Center for Clinical and Cosmetic Research, Skin & Cancer Associates, LLP,
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Dr Berman has received funding for clinical grants from, is an investigator for, and is a consultant to, Galderma Laboratories, L.P.

Copyright © 2012 by Elsevier Inc.

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A Journal Scan supplement to Skin & Allergy News®.  This supplement was sponsored by Galderma Laboratories, L.P. 

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  • Introduction - Exploring the Role of Modified-Release
  • Doxycycline in Rosacea
  • Comparing Antimicrobial and Anti-Inflammatory Doses of Oral Doxycycline in the Treatment of Rosacea
  • Impact of Antibiotic Resistance on Dermatologic Practice
  • The Effects of Modified-Release Doxycycline on Quality of Life
  • Combining Anti-Inflammatory–Dose Doxycycline With Topical Metronidazole

To view the supplement, click the image above.

Faculty/Faculty Disclosure

Brian Berman, MD, PhD
Voluntary Professor of Dermatology and Cutaneous Surgery
University of Miami, Miller School of Medicine
Co-Director
Center for Clinical and Cosmetic Research, Skin & Cancer Associates, LLP,
Aventura, FL

Dr Berman has received funding for clinical grants from, is an investigator for, and is a consultant to, Galderma Laboratories, L.P.

Copyright © 2012 by Elsevier Inc.

A Journal Scan supplement to Skin & Allergy News®.  This supplement was sponsored by Galderma Laboratories, L.P. 

Topics

 

  • Introduction - Exploring the Role of Modified-Release
  • Doxycycline in Rosacea
  • Comparing Antimicrobial and Anti-Inflammatory Doses of Oral Doxycycline in the Treatment of Rosacea
  • Impact of Antibiotic Resistance on Dermatologic Practice
  • The Effects of Modified-Release Doxycycline on Quality of Life
  • Combining Anti-Inflammatory–Dose Doxycycline With Topical Metronidazole

To view the supplement, click the image above.

Faculty/Faculty Disclosure

Brian Berman, MD, PhD
Voluntary Professor of Dermatology and Cutaneous Surgery
University of Miami, Miller School of Medicine
Co-Director
Center for Clinical and Cosmetic Research, Skin & Cancer Associates, LLP,
Aventura, FL

Dr Berman has received funding for clinical grants from, is an investigator for, and is a consultant to, Galderma Laboratories, L.P.

Copyright © 2012 by Elsevier Inc.

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Exploring the Role of Modified-Release Doxycycline in Rosacea

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Exploring the Role of Modified-Release Doxycycline in Rosacea

 

A Journal Scan supplement to Family Practice News®.  This supplement was sponsored by Galderma Laboratories, L.P. 

Topics

 

  • Introduction - Exploring the Role of Modified-Release
  • Doxycycline in Rosacea
  • Comparing Antimicrobial and Anti-Inflammatory Doses of Oral Doxycycline in the Treatment of Rosacea
  • Impact of Antibiotic Resistance on Dermatologic Practice
  • The Effects of Modified-Release Doxycycline on Quality of Life
  • Combining Anti-Inflammatory–Dose Doxycycline With Topical Metronidazole

To view the supplement, click the image above.

Faculty/Faculty Disclosure

Brian Berman, MD, PhD
Voluntary Professor of Dermatology and Cutaneous Surgery
University of Miami, Miller School of Medicine Co-Director
Center for Clinical and Cosmetic Research, Skin & Cancer Associates, LLP, Aventura, FL

 

Dr Berman has received funding for clinical grants from, is an investigator for, and is a consultant to, Galderma Laboratories, L.P.

 

 

Copyright (c) 2012 by Elsevier Inc.

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A Journal Scan supplement to Family Practice News®.  This supplement was sponsored by Galderma Laboratories, L.P. 

Topics

 

  • Introduction - Exploring the Role of Modified-Release
  • Doxycycline in Rosacea
  • Comparing Antimicrobial and Anti-Inflammatory Doses of Oral Doxycycline in the Treatment of Rosacea
  • Impact of Antibiotic Resistance on Dermatologic Practice
  • The Effects of Modified-Release Doxycycline on Quality of Life
  • Combining Anti-Inflammatory–Dose Doxycycline With Topical Metronidazole

To view the supplement, click the image above.

Faculty/Faculty Disclosure

Brian Berman, MD, PhD
Voluntary Professor of Dermatology and Cutaneous Surgery
University of Miami, Miller School of Medicine Co-Director
Center for Clinical and Cosmetic Research, Skin & Cancer Associates, LLP, Aventura, FL

 

Dr Berman has received funding for clinical grants from, is an investigator for, and is a consultant to, Galderma Laboratories, L.P.

 

 

Copyright (c) 2012 by Elsevier Inc.

 

A Journal Scan supplement to Family Practice News®.  This supplement was sponsored by Galderma Laboratories, L.P. 

Topics

 

  • Introduction - Exploring the Role of Modified-Release
  • Doxycycline in Rosacea
  • Comparing Antimicrobial and Anti-Inflammatory Doses of Oral Doxycycline in the Treatment of Rosacea
  • Impact of Antibiotic Resistance on Dermatologic Practice
  • The Effects of Modified-Release Doxycycline on Quality of Life
  • Combining Anti-Inflammatory–Dose Doxycycline With Topical Metronidazole

To view the supplement, click the image above.

Faculty/Faculty Disclosure

Brian Berman, MD, PhD
Voluntary Professor of Dermatology and Cutaneous Surgery
University of Miami, Miller School of Medicine Co-Director
Center for Clinical and Cosmetic Research, Skin & Cancer Associates, LLP, Aventura, FL

 

Dr Berman has received funding for clinical grants from, is an investigator for, and is a consultant to, Galderma Laboratories, L.P.

 

 

Copyright (c) 2012 by Elsevier Inc.

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Military Teens Face Unique Mental Health Challenges

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"My Story: Blogs by Four Military Teens" is a book that gives voice to military teens by highlighting their feelings and experiences before, during, and after parental deployment. The four youths in "My Story" are fictional, but the stories are real in that the posts are a compilation of real life experiences of military kids.

"Adam" blogs, "My dad is one of the coolest, smartest, bravest men I’ve ever met, but sometimes I just can’t stand being around him. He’s a doctor – a surgeon – and is in the Air Force Reserves. He just returned from a second tour in Iraq, and he sure acts different. After his first tour, it took us some time to get caught up, but just when things got normal again, he got his orders to go back to Iraq. Now he’s finally home (for good?), but he just isn’t the same. He gets mad over the stupidest things and spends most of his time in his bedroom or in front of the computer.

Photo courtesy Michelle D. Sherman, Ph.D. and DeAnne M. Sherman, Ph.D.
    "My Story: Blogs by Four Military Teens"

"He’s still in ‘military mode,’ and orders us around way too much. He doesn’t joke around like before, and sometimes just hangs out in the garage by himself. We don’t talk much. I almost liked it better when he was gone. It was a lot quieter and less stressful around the house. Ashley, Lisa, and I just stay out of his way. Derrick is lucky – he’s leaving for college soon."

This book also provides support and education for military teens and preteens by honoring their unique joys and sacrifices, addressing their fears and hopes, and exploring how parental deployment affects their lives.

The book was written by Michelle D. Sherman, Ph.D., and her mother, DeAnne M. Sherman. Together, Dr. Sherman and her mother – a teacher – have written other books for teens, including "Finding My Way: A Teen’s Guide to Living with a Parent Who has Experienced Trauma" (Waco, Tex.: Seeds of Hope Publishers, 2005).

Dr. Sherman is a clinical psychologist at the Oklahoma City VA Medical Center, where she directs its Family Mental Health Program. She has dedicated her career to supporting families affected by mental illness and posttraumatic stress disorder, and has a special interest in the impact of parental mental illness and PTSD on youth.

"Think about the ... challenges facing our military teens," she writes in a guest post on the blog of an organization called Veterans Children. "Their parent(s) may be deployed once, twice, or even multiple times to a war zone. The parent may miss out on important events, such as prom, the school play, the state basketball tournament, and birthdays."

These young people are resilient, Dr. Sherman writes, but some are struggling with increased rates of anxiety, sleeping and behavioral problems, and the use of psychotropics.

"What does this tell us? ...They are affected by their parent’s deployment. We need to listen to them, provide resources, and make services available," writes Dr. Sherman, also is a clinical professor in the department of psychiatry and behavioral sciences at the University of Oklahoma Health Sciences Center and a research affiliate with the South Central Mental Illness Research, Education and Clinical Center (MIRECC).

    Michelle D. Sherman

In her work with veterans and families, Dr. Sherman has developed educational and support programs. Operation Enduring Families is a 5-session family education curriculum for Operation Enduring Freedom/Operation Iraqi Freedom (OEF/OIF) veterans/families, developed with Ursula B. Bowling, Psy.D., and Alan L. Doerman, Psy.D. This program is based on her S.A.F.E (Support and Family Education) program, an 18-session curriculum for those who care about someone with a mental illness/PTSD.

Dr. Sherman has developed an extensive resource list for OEF/OIF service members, and veterans and their families. (See box.) For a complete list, you can e-mail her at [email protected].

This column, "Families in Psychiatry," regularly appears in Clinical Psychiatry News, an Elsevier publication. Dr. Heru is an associate professor of psychiatry at the University of Colorado at Denver, Aurora. She has been a member of the Association of Family Psychiatrists since 2002 and currently serves as the organization’s treasurer. In addition, she is the coauthor of two books on working with families and is the author of numerous articles on this topic.

The following list of books and websites can be used to help military children of all ages cope with parental deployment:

Books

• "After the War Zone: A Practical Guide for Returning Troops and Their Families" (Cambridge, Mass.: Da Capo Press, 2008).

 

 

• "Back from the Front: Combat Trauma, Love, and the Family" (Brooklandville, Md.: Sidran Institute Press, 2007).

• "Courage After Fire: Coping Strategies for Returning Soldiers and Their Families" (Berkeley, Calif.: Ulysses Press, 2005).

• "I Miss You!: A Military Kid’s Book About Deployment" (Amherst, N.Y.: Prometheus Books, 2007).

• "Night Catch" (Jamestown, N.D.: Bubble Gum Press, 2005).

• "100 days and 99 nights" (New York: Little, Brown and Co. Books for Young Readers, 2008).

• "Sometimes We Were Brave" (Honesdale, Pa.: Boyds Mills Press, 2010).

• "The Fathers Are Coming Home" (New York: Margaret K. McElderry Books, 2010).

Websites

• "Courage to Care, Courage to Talk About War Injuries," developed by the Center for the Study of Traumatic Stress.

• "Military Child Bill of Rights."

National Military Family Association.

Operation Child Care.

Operation: Military Kids.

• Song and video: "The Price of Peace."

• Video (58 minutes): "Returning From the War Zone: A Guide for Families of Military Members," created by the National Center for PTSD.

Salute Our Services.

• SOAR (Student Online Achievement Resources).

Students at the Center: An Education Resource for Families, the Military, and Schools.

• "Talk, Listen, Connect: Deployments, Homecomings, Changes."

United Through Reading.

Veteran Parenting Toolkit, created by the Oklahoma City VA Family Mental Health Program.

• "Welcome Back Parenting: A Guide for Reconnecting Families After Military Deployment."

• DVD: "Young Children on the Homefront: Family Stories, Family, Strengths," developed by the nonprofit organization Zero to Three: National Center for Infants, Toddlers, and Families.

• "Operation: Military Kids."

• "Young Heroes: Military Deployment Through the Eyes of Youth."

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"My Story: Blogs by Four Military Teens" is a book that gives voice to military teens by highlighting their feelings and experiences before, during, and after parental deployment. The four youths in "My Story" are fictional, but the stories are real in that the posts are a compilation of real life experiences of military kids.

"Adam" blogs, "My dad is one of the coolest, smartest, bravest men I’ve ever met, but sometimes I just can’t stand being around him. He’s a doctor – a surgeon – and is in the Air Force Reserves. He just returned from a second tour in Iraq, and he sure acts different. After his first tour, it took us some time to get caught up, but just when things got normal again, he got his orders to go back to Iraq. Now he’s finally home (for good?), but he just isn’t the same. He gets mad over the stupidest things and spends most of his time in his bedroom or in front of the computer.

Photo courtesy Michelle D. Sherman, Ph.D. and DeAnne M. Sherman, Ph.D.
    "My Story: Blogs by Four Military Teens"

"He’s still in ‘military mode,’ and orders us around way too much. He doesn’t joke around like before, and sometimes just hangs out in the garage by himself. We don’t talk much. I almost liked it better when he was gone. It was a lot quieter and less stressful around the house. Ashley, Lisa, and I just stay out of his way. Derrick is lucky – he’s leaving for college soon."

This book also provides support and education for military teens and preteens by honoring their unique joys and sacrifices, addressing their fears and hopes, and exploring how parental deployment affects their lives.

The book was written by Michelle D. Sherman, Ph.D., and her mother, DeAnne M. Sherman. Together, Dr. Sherman and her mother – a teacher – have written other books for teens, including "Finding My Way: A Teen’s Guide to Living with a Parent Who has Experienced Trauma" (Waco, Tex.: Seeds of Hope Publishers, 2005).

Dr. Sherman is a clinical psychologist at the Oklahoma City VA Medical Center, where she directs its Family Mental Health Program. She has dedicated her career to supporting families affected by mental illness and posttraumatic stress disorder, and has a special interest in the impact of parental mental illness and PTSD on youth.

"Think about the ... challenges facing our military teens," she writes in a guest post on the blog of an organization called Veterans Children. "Their parent(s) may be deployed once, twice, or even multiple times to a war zone. The parent may miss out on important events, such as prom, the school play, the state basketball tournament, and birthdays."

These young people are resilient, Dr. Sherman writes, but some are struggling with increased rates of anxiety, sleeping and behavioral problems, and the use of psychotropics.

"What does this tell us? ...They are affected by their parent’s deployment. We need to listen to them, provide resources, and make services available," writes Dr. Sherman, also is a clinical professor in the department of psychiatry and behavioral sciences at the University of Oklahoma Health Sciences Center and a research affiliate with the South Central Mental Illness Research, Education and Clinical Center (MIRECC).

    Michelle D. Sherman

In her work with veterans and families, Dr. Sherman has developed educational and support programs. Operation Enduring Families is a 5-session family education curriculum for Operation Enduring Freedom/Operation Iraqi Freedom (OEF/OIF) veterans/families, developed with Ursula B. Bowling, Psy.D., and Alan L. Doerman, Psy.D. This program is based on her S.A.F.E (Support and Family Education) program, an 18-session curriculum for those who care about someone with a mental illness/PTSD.

Dr. Sherman has developed an extensive resource list for OEF/OIF service members, and veterans and their families. (See box.) For a complete list, you can e-mail her at [email protected].

This column, "Families in Psychiatry," regularly appears in Clinical Psychiatry News, an Elsevier publication. Dr. Heru is an associate professor of psychiatry at the University of Colorado at Denver, Aurora. She has been a member of the Association of Family Psychiatrists since 2002 and currently serves as the organization’s treasurer. In addition, she is the coauthor of two books on working with families and is the author of numerous articles on this topic.

The following list of books and websites can be used to help military children of all ages cope with parental deployment:

Books

• "After the War Zone: A Practical Guide for Returning Troops and Their Families" (Cambridge, Mass.: Da Capo Press, 2008).

 

 

• "Back from the Front: Combat Trauma, Love, and the Family" (Brooklandville, Md.: Sidran Institute Press, 2007).

• "Courage After Fire: Coping Strategies for Returning Soldiers and Their Families" (Berkeley, Calif.: Ulysses Press, 2005).

• "I Miss You!: A Military Kid’s Book About Deployment" (Amherst, N.Y.: Prometheus Books, 2007).

• "Night Catch" (Jamestown, N.D.: Bubble Gum Press, 2005).

• "100 days and 99 nights" (New York: Little, Brown and Co. Books for Young Readers, 2008).

• "Sometimes We Were Brave" (Honesdale, Pa.: Boyds Mills Press, 2010).

• "The Fathers Are Coming Home" (New York: Margaret K. McElderry Books, 2010).

Websites

• "Courage to Care, Courage to Talk About War Injuries," developed by the Center for the Study of Traumatic Stress.

• "Military Child Bill of Rights."

National Military Family Association.

Operation Child Care.

Operation: Military Kids.

• Song and video: "The Price of Peace."

• Video (58 minutes): "Returning From the War Zone: A Guide for Families of Military Members," created by the National Center for PTSD.

Salute Our Services.

• SOAR (Student Online Achievement Resources).

Students at the Center: An Education Resource for Families, the Military, and Schools.

• "Talk, Listen, Connect: Deployments, Homecomings, Changes."

United Through Reading.

Veteran Parenting Toolkit, created by the Oklahoma City VA Family Mental Health Program.

• "Welcome Back Parenting: A Guide for Reconnecting Families After Military Deployment."

• DVD: "Young Children on the Homefront: Family Stories, Family, Strengths," developed by the nonprofit organization Zero to Three: National Center for Infants, Toddlers, and Families.

• "Operation: Military Kids."

• "Young Heroes: Military Deployment Through the Eyes of Youth."

"My Story: Blogs by Four Military Teens" is a book that gives voice to military teens by highlighting their feelings and experiences before, during, and after parental deployment. The four youths in "My Story" are fictional, but the stories are real in that the posts are a compilation of real life experiences of military kids.

"Adam" blogs, "My dad is one of the coolest, smartest, bravest men I’ve ever met, but sometimes I just can’t stand being around him. He’s a doctor – a surgeon – and is in the Air Force Reserves. He just returned from a second tour in Iraq, and he sure acts different. After his first tour, it took us some time to get caught up, but just when things got normal again, he got his orders to go back to Iraq. Now he’s finally home (for good?), but he just isn’t the same. He gets mad over the stupidest things and spends most of his time in his bedroom or in front of the computer.

Photo courtesy Michelle D. Sherman, Ph.D. and DeAnne M. Sherman, Ph.D.
    "My Story: Blogs by Four Military Teens"

"He’s still in ‘military mode,’ and orders us around way too much. He doesn’t joke around like before, and sometimes just hangs out in the garage by himself. We don’t talk much. I almost liked it better when he was gone. It was a lot quieter and less stressful around the house. Ashley, Lisa, and I just stay out of his way. Derrick is lucky – he’s leaving for college soon."

This book also provides support and education for military teens and preteens by honoring their unique joys and sacrifices, addressing their fears and hopes, and exploring how parental deployment affects their lives.

The book was written by Michelle D. Sherman, Ph.D., and her mother, DeAnne M. Sherman. Together, Dr. Sherman and her mother – a teacher – have written other books for teens, including "Finding My Way: A Teen’s Guide to Living with a Parent Who has Experienced Trauma" (Waco, Tex.: Seeds of Hope Publishers, 2005).

Dr. Sherman is a clinical psychologist at the Oklahoma City VA Medical Center, where she directs its Family Mental Health Program. She has dedicated her career to supporting families affected by mental illness and posttraumatic stress disorder, and has a special interest in the impact of parental mental illness and PTSD on youth.

"Think about the ... challenges facing our military teens," she writes in a guest post on the blog of an organization called Veterans Children. "Their parent(s) may be deployed once, twice, or even multiple times to a war zone. The parent may miss out on important events, such as prom, the school play, the state basketball tournament, and birthdays."

These young people are resilient, Dr. Sherman writes, but some are struggling with increased rates of anxiety, sleeping and behavioral problems, and the use of psychotropics.

"What does this tell us? ...They are affected by their parent’s deployment. We need to listen to them, provide resources, and make services available," writes Dr. Sherman, also is a clinical professor in the department of psychiatry and behavioral sciences at the University of Oklahoma Health Sciences Center and a research affiliate with the South Central Mental Illness Research, Education and Clinical Center (MIRECC).

    Michelle D. Sherman

In her work with veterans and families, Dr. Sherman has developed educational and support programs. Operation Enduring Families is a 5-session family education curriculum for Operation Enduring Freedom/Operation Iraqi Freedom (OEF/OIF) veterans/families, developed with Ursula B. Bowling, Psy.D., and Alan L. Doerman, Psy.D. This program is based on her S.A.F.E (Support and Family Education) program, an 18-session curriculum for those who care about someone with a mental illness/PTSD.

Dr. Sherman has developed an extensive resource list for OEF/OIF service members, and veterans and their families. (See box.) For a complete list, you can e-mail her at [email protected].

This column, "Families in Psychiatry," regularly appears in Clinical Psychiatry News, an Elsevier publication. Dr. Heru is an associate professor of psychiatry at the University of Colorado at Denver, Aurora. She has been a member of the Association of Family Psychiatrists since 2002 and currently serves as the organization’s treasurer. In addition, she is the coauthor of two books on working with families and is the author of numerous articles on this topic.

The following list of books and websites can be used to help military children of all ages cope with parental deployment:

Books

• "After the War Zone: A Practical Guide for Returning Troops and Their Families" (Cambridge, Mass.: Da Capo Press, 2008).

 

 

• "Back from the Front: Combat Trauma, Love, and the Family" (Brooklandville, Md.: Sidran Institute Press, 2007).

• "Courage After Fire: Coping Strategies for Returning Soldiers and Their Families" (Berkeley, Calif.: Ulysses Press, 2005).

• "I Miss You!: A Military Kid’s Book About Deployment" (Amherst, N.Y.: Prometheus Books, 2007).

• "Night Catch" (Jamestown, N.D.: Bubble Gum Press, 2005).

• "100 days and 99 nights" (New York: Little, Brown and Co. Books for Young Readers, 2008).

• "Sometimes We Were Brave" (Honesdale, Pa.: Boyds Mills Press, 2010).

• "The Fathers Are Coming Home" (New York: Margaret K. McElderry Books, 2010).

Websites

• "Courage to Care, Courage to Talk About War Injuries," developed by the Center for the Study of Traumatic Stress.

• "Military Child Bill of Rights."

National Military Family Association.

Operation Child Care.

Operation: Military Kids.

• Song and video: "The Price of Peace."

• Video (58 minutes): "Returning From the War Zone: A Guide for Families of Military Members," created by the National Center for PTSD.

Salute Our Services.

• SOAR (Student Online Achievement Resources).

Students at the Center: An Education Resource for Families, the Military, and Schools.

• "Talk, Listen, Connect: Deployments, Homecomings, Changes."

United Through Reading.

Veteran Parenting Toolkit, created by the Oklahoma City VA Family Mental Health Program.

• "Welcome Back Parenting: A Guide for Reconnecting Families After Military Deployment."

• DVD: "Young Children on the Homefront: Family Stories, Family, Strengths," developed by the nonprofit organization Zero to Three: National Center for Infants, Toddlers, and Families.

• "Operation: Military Kids."

• "Young Heroes: Military Deployment Through the Eyes of Youth."

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Urgent Discharge: What's the Rush?

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Rehospitalization within 30 days of an initial acute coronary syndrome or heart failure event has now become a CMS quality measure that will affect overall hospital Medicare payments. It has been appreciated for some time that rehospitalization for these diagnoses has been unacceptably high.

A recent report indicates that a greater percentage of U.S. patients who experienced a STEMI are more likely to be rehospitalized within 30 days, compared with other Western countries (14.5% vs. 9.9%, respectively). That report (JAMA 2012;307:66-74) indicates that the increase is directly related to the shorter length of hospital stay in the United States. Among the 17 countries included in the report, the average duration was shortest in the United States (3 days) and longest in Germany (8 days). Predictors of readmission other than length of stay include the age of the patient and the presence of heart failure. The most interesting part of the story is how we arrived at this state of affairs.

For those of you who were not yet born or are too young to remember when Medicare was passed into law in 1965, I will give you a little history. And for those of you who were around at the time, I will provide a reminder.

As you undoubtedly know, Medicare, in addition to paying physicians’ fees also pays hospital costs. In the period between 1965 and 1983, using a payment system that was defined as "reasonable and allowable costs," Medicare payments to hospitals increased 10-fold, from $3 billion to $37 billion. In consequence, Congress passed a law in 1982 that created a prospective payment system for hospitals using diagnosis-related groups establishing a payment schedule for specific diagnoses, which included acute myocardial infarction and heart failure. With this schedule, hospitals were paid a fixed rate regardless of the number of procedures performed or duration of hospitalization. In order to minimize costs, hospitals accelerated discharges and shortened hospital length of stay. Emergency admissions resulted in urgent discharge.

In order to expedite the process of admission and discharge, hospitalists were hired to accelerate that process since practicing internists and cardiologists were not available to push the paperwork through fast enough to get the patients discharged quickly. Hospitals saw this additional layer of doctors caring for patients as financially profitable. As a result, hospital stays decreased markedly and payments to hospitals decreased by 52% from 1985 to 1990 and by an additional 37% between 1990 and 1995. Everyone seemed to be very happy with this, including the hospitals, Medicare, and doctors. As far as I know, patients were not consulted.

Cardiologists at that time were telling themselves how benign an acute MI is and began doing accelerated discharge after percutaneous coronary intervention. We prided ourselves on how patients could be discharged to home within 24-36 hours, but never actually reached the ultimate goal of a "drive-through PCI." The fact that patients with acute MI and heart failure were frequently readmitted was good business since each admission resulted in further Medicare payments both to the hospital and the doctors. Urging by some physicians to develop plans that could educate patients and develop discharge follow-up systems was met with incredulity by hospital administrators who saw readmission as a revenue source and discharge planning as costly.

It is important to emphasize that readmission not only reflects an important morbidity event, it also carries with it the potential for increased risk of mortality. In the report cited above, one-third of the deaths after hospitalization for a STEMI occurred within the same 30-day post-event period. The recent emphasis on decreasing door-to-balloon time, although effective in shortening that period, has had little effect on the mortality associated with an acute myocardial infarction. It is reasonable to assume that in placing a greater emphasis on insuring that patients are ready to leave the hospital, we can improve mortality and morbidity of both the ACS and heart failure patient. There really is no urgency to discharge patients other than improving the bottom line, and that imperative may no longer be relevant.

Dr. Goldstein, medical editor of Cardiology News, is professor of medicine at Wayne State University and division head emeritus of cardiovascular medicine at Henry Ford Hospital, both in Detroit. He is on data safety monitoring committees for the National Institutes of Health and several pharmaceutical companies.

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Rehospitalization within 30 days of an initial acute coronary syndrome or heart failure event has now become a CMS quality measure that will affect overall hospital Medicare payments. It has been appreciated for some time that rehospitalization for these diagnoses has been unacceptably high.

A recent report indicates that a greater percentage of U.S. patients who experienced a STEMI are more likely to be rehospitalized within 30 days, compared with other Western countries (14.5% vs. 9.9%, respectively). That report (JAMA 2012;307:66-74) indicates that the increase is directly related to the shorter length of hospital stay in the United States. Among the 17 countries included in the report, the average duration was shortest in the United States (3 days) and longest in Germany (8 days). Predictors of readmission other than length of stay include the age of the patient and the presence of heart failure. The most interesting part of the story is how we arrived at this state of affairs.

For those of you who were not yet born or are too young to remember when Medicare was passed into law in 1965, I will give you a little history. And for those of you who were around at the time, I will provide a reminder.

As you undoubtedly know, Medicare, in addition to paying physicians’ fees also pays hospital costs. In the period between 1965 and 1983, using a payment system that was defined as "reasonable and allowable costs," Medicare payments to hospitals increased 10-fold, from $3 billion to $37 billion. In consequence, Congress passed a law in 1982 that created a prospective payment system for hospitals using diagnosis-related groups establishing a payment schedule for specific diagnoses, which included acute myocardial infarction and heart failure. With this schedule, hospitals were paid a fixed rate regardless of the number of procedures performed or duration of hospitalization. In order to minimize costs, hospitals accelerated discharges and shortened hospital length of stay. Emergency admissions resulted in urgent discharge.

In order to expedite the process of admission and discharge, hospitalists were hired to accelerate that process since practicing internists and cardiologists were not available to push the paperwork through fast enough to get the patients discharged quickly. Hospitals saw this additional layer of doctors caring for patients as financially profitable. As a result, hospital stays decreased markedly and payments to hospitals decreased by 52% from 1985 to 1990 and by an additional 37% between 1990 and 1995. Everyone seemed to be very happy with this, including the hospitals, Medicare, and doctors. As far as I know, patients were not consulted.

Cardiologists at that time were telling themselves how benign an acute MI is and began doing accelerated discharge after percutaneous coronary intervention. We prided ourselves on how patients could be discharged to home within 24-36 hours, but never actually reached the ultimate goal of a "drive-through PCI." The fact that patients with acute MI and heart failure were frequently readmitted was good business since each admission resulted in further Medicare payments both to the hospital and the doctors. Urging by some physicians to develop plans that could educate patients and develop discharge follow-up systems was met with incredulity by hospital administrators who saw readmission as a revenue source and discharge planning as costly.

It is important to emphasize that readmission not only reflects an important morbidity event, it also carries with it the potential for increased risk of mortality. In the report cited above, one-third of the deaths after hospitalization for a STEMI occurred within the same 30-day post-event period. The recent emphasis on decreasing door-to-balloon time, although effective in shortening that period, has had little effect on the mortality associated with an acute myocardial infarction. It is reasonable to assume that in placing a greater emphasis on insuring that patients are ready to leave the hospital, we can improve mortality and morbidity of both the ACS and heart failure patient. There really is no urgency to discharge patients other than improving the bottom line, and that imperative may no longer be relevant.

Dr. Goldstein, medical editor of Cardiology News, is professor of medicine at Wayne State University and division head emeritus of cardiovascular medicine at Henry Ford Hospital, both in Detroit. He is on data safety monitoring committees for the National Institutes of Health and several pharmaceutical companies.

Rehospitalization within 30 days of an initial acute coronary syndrome or heart failure event has now become a CMS quality measure that will affect overall hospital Medicare payments. It has been appreciated for some time that rehospitalization for these diagnoses has been unacceptably high.

A recent report indicates that a greater percentage of U.S. patients who experienced a STEMI are more likely to be rehospitalized within 30 days, compared with other Western countries (14.5% vs. 9.9%, respectively). That report (JAMA 2012;307:66-74) indicates that the increase is directly related to the shorter length of hospital stay in the United States. Among the 17 countries included in the report, the average duration was shortest in the United States (3 days) and longest in Germany (8 days). Predictors of readmission other than length of stay include the age of the patient and the presence of heart failure. The most interesting part of the story is how we arrived at this state of affairs.

For those of you who were not yet born or are too young to remember when Medicare was passed into law in 1965, I will give you a little history. And for those of you who were around at the time, I will provide a reminder.

As you undoubtedly know, Medicare, in addition to paying physicians’ fees also pays hospital costs. In the period between 1965 and 1983, using a payment system that was defined as "reasonable and allowable costs," Medicare payments to hospitals increased 10-fold, from $3 billion to $37 billion. In consequence, Congress passed a law in 1982 that created a prospective payment system for hospitals using diagnosis-related groups establishing a payment schedule for specific diagnoses, which included acute myocardial infarction and heart failure. With this schedule, hospitals were paid a fixed rate regardless of the number of procedures performed or duration of hospitalization. In order to minimize costs, hospitals accelerated discharges and shortened hospital length of stay. Emergency admissions resulted in urgent discharge.

In order to expedite the process of admission and discharge, hospitalists were hired to accelerate that process since practicing internists and cardiologists were not available to push the paperwork through fast enough to get the patients discharged quickly. Hospitals saw this additional layer of doctors caring for patients as financially profitable. As a result, hospital stays decreased markedly and payments to hospitals decreased by 52% from 1985 to 1990 and by an additional 37% between 1990 and 1995. Everyone seemed to be very happy with this, including the hospitals, Medicare, and doctors. As far as I know, patients were not consulted.

Cardiologists at that time were telling themselves how benign an acute MI is and began doing accelerated discharge after percutaneous coronary intervention. We prided ourselves on how patients could be discharged to home within 24-36 hours, but never actually reached the ultimate goal of a "drive-through PCI." The fact that patients with acute MI and heart failure were frequently readmitted was good business since each admission resulted in further Medicare payments both to the hospital and the doctors. Urging by some physicians to develop plans that could educate patients and develop discharge follow-up systems was met with incredulity by hospital administrators who saw readmission as a revenue source and discharge planning as costly.

It is important to emphasize that readmission not only reflects an important morbidity event, it also carries with it the potential for increased risk of mortality. In the report cited above, one-third of the deaths after hospitalization for a STEMI occurred within the same 30-day post-event period. The recent emphasis on decreasing door-to-balloon time, although effective in shortening that period, has had little effect on the mortality associated with an acute myocardial infarction. It is reasonable to assume that in placing a greater emphasis on insuring that patients are ready to leave the hospital, we can improve mortality and morbidity of both the ACS and heart failure patient. There really is no urgency to discharge patients other than improving the bottom line, and that imperative may no longer be relevant.

Dr. Goldstein, medical editor of Cardiology News, is professor of medicine at Wayne State University and division head emeritus of cardiovascular medicine at Henry Ford Hospital, both in Detroit. He is on data safety monitoring committees for the National Institutes of Health and several pharmaceutical companies.

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When Veins Fail, Go to Bone

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NATIONAL HARBOR, MD. – When a child needs fluids or drugs but you can’t find a good vein, turn to bone.

Intraosseous (IO) access was pioneered during World War I, and it’s aged well – although peripheral IVs pushed it out of the limelight for several decades. But IO access remains the standard of care in emergency situations where IVs can’t be used, Dr. Angela Ellison said at a meeting sponsored by the American College of Emergency Physicians.

Dr. Angela Ellison

A 1988 review of 33 pediatric cardiac arrests showed that IO is the quickest way to go. Although a successful IO attempt took about 5 minutes, compared with 3 minutes for a peripheral IV, the success rate for an IO placement was much greater – 83% vs. 17%, said Dr. Ellison of the University of Pennsylvania, Philadelphia (Am. J. Emerg. Med. 1988;6:577-9).

"In difficult cases, the investigators recommended that IV attempts be very brief, and if unsuccessful, you should move on to IO right away," she said.

IO access works for children of all sizes, even newborns, she said, and in children with all kinds of emergencies, including shock, trauma, status epilepticus, and severe dehydration. IO access can be established by emergency medical technicians and nurses as well as physicians. With a preprocedural shot of lidocaine, IO catheters can easily be placed in conscious as well as unconscious patients.

For patients who need drugs urgently, IO is superior to IV; animal studies have shown that drugs reach the heart in 10-20 seconds, and there is no need to change the dose from a normal IV concentration.

Technical advances have made IO access easier, she added. "Over the past few decades, we’ve gotten a number of powered devices that have contributed to the rise of IO." Some can be placed in the sternum and others in long bones. Studies have shown that the complication rate is not increased when the needles are placed near a growth plate.

IO access is not for everyone or every bone, however. Contraindications include long bone fracture, vascular injury in the extremity, an overlying skin infection, a burn at the access site, 10 or more previous placements or attempts, and fragile bones (osteogenesis imperfecta or osteoporosis).

For the most part, however, IO access is very safe. Studies conducted in the late 1980s and early 1990s show an overall complication rate of less than 1%. Osteomyelitis occurred in 0.6%, and cellulitis or skin abscess developed in 0.7%. No evidence of bone deformity or growth arrest was seen in long-term follow-up studies.

Dr. Ellison had no financial conflicts.

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Intraosseous (IO) access, peripheral IVs, IVs can’t be used, Dr. Angela Ellison, American College of Emergency Physicians, pediatric cardiac arrests, shock, trauma, status epilepticus, severe dehydration, preprocedural shot of lidocaine, IO catheters, IO superior to IV, sternum, long bones, safety of IO
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NATIONAL HARBOR, MD. – When a child needs fluids or drugs but you can’t find a good vein, turn to bone.

Intraosseous (IO) access was pioneered during World War I, and it’s aged well – although peripheral IVs pushed it out of the limelight for several decades. But IO access remains the standard of care in emergency situations where IVs can’t be used, Dr. Angela Ellison said at a meeting sponsored by the American College of Emergency Physicians.

Dr. Angela Ellison

A 1988 review of 33 pediatric cardiac arrests showed that IO is the quickest way to go. Although a successful IO attempt took about 5 minutes, compared with 3 minutes for a peripheral IV, the success rate for an IO placement was much greater – 83% vs. 17%, said Dr. Ellison of the University of Pennsylvania, Philadelphia (Am. J. Emerg. Med. 1988;6:577-9).

"In difficult cases, the investigators recommended that IV attempts be very brief, and if unsuccessful, you should move on to IO right away," she said.

IO access works for children of all sizes, even newborns, she said, and in children with all kinds of emergencies, including shock, trauma, status epilepticus, and severe dehydration. IO access can be established by emergency medical technicians and nurses as well as physicians. With a preprocedural shot of lidocaine, IO catheters can easily be placed in conscious as well as unconscious patients.

For patients who need drugs urgently, IO is superior to IV; animal studies have shown that drugs reach the heart in 10-20 seconds, and there is no need to change the dose from a normal IV concentration.

Technical advances have made IO access easier, she added. "Over the past few decades, we’ve gotten a number of powered devices that have contributed to the rise of IO." Some can be placed in the sternum and others in long bones. Studies have shown that the complication rate is not increased when the needles are placed near a growth plate.

IO access is not for everyone or every bone, however. Contraindications include long bone fracture, vascular injury in the extremity, an overlying skin infection, a burn at the access site, 10 or more previous placements or attempts, and fragile bones (osteogenesis imperfecta or osteoporosis).

For the most part, however, IO access is very safe. Studies conducted in the late 1980s and early 1990s show an overall complication rate of less than 1%. Osteomyelitis occurred in 0.6%, and cellulitis or skin abscess developed in 0.7%. No evidence of bone deformity or growth arrest was seen in long-term follow-up studies.

Dr. Ellison had no financial conflicts.

NATIONAL HARBOR, MD. – When a child needs fluids or drugs but you can’t find a good vein, turn to bone.

Intraosseous (IO) access was pioneered during World War I, and it’s aged well – although peripheral IVs pushed it out of the limelight for several decades. But IO access remains the standard of care in emergency situations where IVs can’t be used, Dr. Angela Ellison said at a meeting sponsored by the American College of Emergency Physicians.

Dr. Angela Ellison

A 1988 review of 33 pediatric cardiac arrests showed that IO is the quickest way to go. Although a successful IO attempt took about 5 minutes, compared with 3 minutes for a peripheral IV, the success rate for an IO placement was much greater – 83% vs. 17%, said Dr. Ellison of the University of Pennsylvania, Philadelphia (Am. J. Emerg. Med. 1988;6:577-9).

"In difficult cases, the investigators recommended that IV attempts be very brief, and if unsuccessful, you should move on to IO right away," she said.

IO access works for children of all sizes, even newborns, she said, and in children with all kinds of emergencies, including shock, trauma, status epilepticus, and severe dehydration. IO access can be established by emergency medical technicians and nurses as well as physicians. With a preprocedural shot of lidocaine, IO catheters can easily be placed in conscious as well as unconscious patients.

For patients who need drugs urgently, IO is superior to IV; animal studies have shown that drugs reach the heart in 10-20 seconds, and there is no need to change the dose from a normal IV concentration.

Technical advances have made IO access easier, she added. "Over the past few decades, we’ve gotten a number of powered devices that have contributed to the rise of IO." Some can be placed in the sternum and others in long bones. Studies have shown that the complication rate is not increased when the needles are placed near a growth plate.

IO access is not for everyone or every bone, however. Contraindications include long bone fracture, vascular injury in the extremity, an overlying skin infection, a burn at the access site, 10 or more previous placements or attempts, and fragile bones (osteogenesis imperfecta or osteoporosis).

For the most part, however, IO access is very safe. Studies conducted in the late 1980s and early 1990s show an overall complication rate of less than 1%. Osteomyelitis occurred in 0.6%, and cellulitis or skin abscess developed in 0.7%. No evidence of bone deformity or growth arrest was seen in long-term follow-up studies.

Dr. Ellison had no financial conflicts.

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FROM A MEETING SPONSORED BY THE AMERICAN COLLEGE OF EMERGENCY PHYSICIANS

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Jeffrey Glasheen, New SHM Board Member, Committed to Raising Quality of Care

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Although based in an academic hospital program at the University of Colorado Denver, new SHM board member Jeffrey Glasheen, MD, SFHM, does not view himself as representative of only academic hospitalist groups on the board.

"I'd like to say I represent the constituency that cares about the quality, safety, and efficiency of healthcare delivery—and that includes every hospitalist,” says Dr. Glasheen, who has played major roles in developing SHM's Academic Hospitalist Academy and Academic Hospital Medicine Leadership Summit, and now chairs its Academic Committee.

Dr. Glasheen, who recently resigned as physician editor of the The Hospitalist is a senior deputy editor of the Journal of Hospital Medicine and was course director of HM12 in San Diego earlier this month. He intends to "push the envelope" for quality issues in his service on the board. "Quality is the best conceivable care you can provide, and clearly, where we are today is not there yet," he says.

Dr. Glasheen, who is committed to giving hospitalists the skills they need to elevate the quality of hospital care, says that starts with redesigning residency programs and medical school curriculums to teach quality improvement (QI). He believes that payment and healthcare reform will put hospitalists in a great position to serve as their hospitals' quality leaders, "but it's also going to take inspired leadership," he says. Hospitalists and hospitals need to make quality a major priority, which he recognizes is hard to do when groups are understaffed. As such, he hopes to find solutions to HM's pipeline issues—how to fill the hospitalist positions that will be needed in the future.

"I've been blessed in my situation [at my institution] to have an administration that's really supportive of hospital medicine," he says. "Our administration really gets the value equation, and we as hospitalists do, too. But as I travel around the country, I don't always see that."

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Although based in an academic hospital program at the University of Colorado Denver, new SHM board member Jeffrey Glasheen, MD, SFHM, does not view himself as representative of only academic hospitalist groups on the board.

"I'd like to say I represent the constituency that cares about the quality, safety, and efficiency of healthcare delivery—and that includes every hospitalist,” says Dr. Glasheen, who has played major roles in developing SHM's Academic Hospitalist Academy and Academic Hospital Medicine Leadership Summit, and now chairs its Academic Committee.

Dr. Glasheen, who recently resigned as physician editor of the The Hospitalist is a senior deputy editor of the Journal of Hospital Medicine and was course director of HM12 in San Diego earlier this month. He intends to "push the envelope" for quality issues in his service on the board. "Quality is the best conceivable care you can provide, and clearly, where we are today is not there yet," he says.

Dr. Glasheen, who is committed to giving hospitalists the skills they need to elevate the quality of hospital care, says that starts with redesigning residency programs and medical school curriculums to teach quality improvement (QI). He believes that payment and healthcare reform will put hospitalists in a great position to serve as their hospitals' quality leaders, "but it's also going to take inspired leadership," he says. Hospitalists and hospitals need to make quality a major priority, which he recognizes is hard to do when groups are understaffed. As such, he hopes to find solutions to HM's pipeline issues—how to fill the hospitalist positions that will be needed in the future.

"I've been blessed in my situation [at my institution] to have an administration that's really supportive of hospital medicine," he says. "Our administration really gets the value equation, and we as hospitalists do, too. But as I travel around the country, I don't always see that."

Although based in an academic hospital program at the University of Colorado Denver, new SHM board member Jeffrey Glasheen, MD, SFHM, does not view himself as representative of only academic hospitalist groups on the board.

"I'd like to say I represent the constituency that cares about the quality, safety, and efficiency of healthcare delivery—and that includes every hospitalist,” says Dr. Glasheen, who has played major roles in developing SHM's Academic Hospitalist Academy and Academic Hospital Medicine Leadership Summit, and now chairs its Academic Committee.

Dr. Glasheen, who recently resigned as physician editor of the The Hospitalist is a senior deputy editor of the Journal of Hospital Medicine and was course director of HM12 in San Diego earlier this month. He intends to "push the envelope" for quality issues in his service on the board. "Quality is the best conceivable care you can provide, and clearly, where we are today is not there yet," he says.

Dr. Glasheen, who is committed to giving hospitalists the skills they need to elevate the quality of hospital care, says that starts with redesigning residency programs and medical school curriculums to teach quality improvement (QI). He believes that payment and healthcare reform will put hospitalists in a great position to serve as their hospitals' quality leaders, "but it's also going to take inspired leadership," he says. Hospitalists and hospitals need to make quality a major priority, which he recognizes is hard to do when groups are understaffed. As such, he hopes to find solutions to HM's pipeline issues—how to fill the hospitalist positions that will be needed in the future.

"I've been blessed in my situation [at my institution] to have an administration that's really supportive of hospital medicine," he says. "Our administration really gets the value equation, and we as hospitalists do, too. But as I travel around the country, I don't always see that."

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HM Tool Designed to Pinpoint Program Strengths, Weaknesses

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The creators of the first measurement tool for hospitalist programs hope that it becomes a standardized gauge for HM practice performance.

The Greeno-Hawley Hospital Medicine Index, unveiled earlier this month by Cogent HMG, uses a 26-question survey to measure HM group performance in five categories: alignment, performance management, infrastructure, operational processes, and leadership and people. The score will offer HM leaders a perspective on where their group stands in comparison with other hospitalist programs.

"It's meant to be a snapshot in time," says Beth Hawley, MBA, FACHE, Cogent's chief customer experience officer, who helped develop the index with Ron Greeno, MD, MHM, the company's chief medical officer. It is intended to help programs pinpoint the areas on which they need to focus in order to improve their performance, she says.

The index will be formally demonstrated at the American College of Physician Executives meeting April 30 in San Francisco. It will be available online in May.

Hawley says that once programs begin using the index, Cogent can assimilate and review the data to determine whether the tool can serve as a predictive model. Until then, it can be a guidepost for practice improvement for HM leaders who have never before had comparative tools.

"People would sit there thinking they're doing a great job but they only know their little market or their hospital," she says, "and really don’t see the broad picture of where hospital medicine is going and what a hospital medicine program can do for a hospital."

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The creators of the first measurement tool for hospitalist programs hope that it becomes a standardized gauge for HM practice performance.

The Greeno-Hawley Hospital Medicine Index, unveiled earlier this month by Cogent HMG, uses a 26-question survey to measure HM group performance in five categories: alignment, performance management, infrastructure, operational processes, and leadership and people. The score will offer HM leaders a perspective on where their group stands in comparison with other hospitalist programs.

"It's meant to be a snapshot in time," says Beth Hawley, MBA, FACHE, Cogent's chief customer experience officer, who helped develop the index with Ron Greeno, MD, MHM, the company's chief medical officer. It is intended to help programs pinpoint the areas on which they need to focus in order to improve their performance, she says.

The index will be formally demonstrated at the American College of Physician Executives meeting April 30 in San Francisco. It will be available online in May.

Hawley says that once programs begin using the index, Cogent can assimilate and review the data to determine whether the tool can serve as a predictive model. Until then, it can be a guidepost for practice improvement for HM leaders who have never before had comparative tools.

"People would sit there thinking they're doing a great job but they only know their little market or their hospital," she says, "and really don’t see the broad picture of where hospital medicine is going and what a hospital medicine program can do for a hospital."

The creators of the first measurement tool for hospitalist programs hope that it becomes a standardized gauge for HM practice performance.

The Greeno-Hawley Hospital Medicine Index, unveiled earlier this month by Cogent HMG, uses a 26-question survey to measure HM group performance in five categories: alignment, performance management, infrastructure, operational processes, and leadership and people. The score will offer HM leaders a perspective on where their group stands in comparison with other hospitalist programs.

"It's meant to be a snapshot in time," says Beth Hawley, MBA, FACHE, Cogent's chief customer experience officer, who helped develop the index with Ron Greeno, MD, MHM, the company's chief medical officer. It is intended to help programs pinpoint the areas on which they need to focus in order to improve their performance, she says.

The index will be formally demonstrated at the American College of Physician Executives meeting April 30 in San Francisco. It will be available online in May.

Hawley says that once programs begin using the index, Cogent can assimilate and review the data to determine whether the tool can serve as a predictive model. Until then, it can be a guidepost for practice improvement for HM leaders who have never before had comparative tools.

"People would sit there thinking they're doing a great job but they only know their little market or their hospital," she says, "and really don’t see the broad picture of where hospital medicine is going and what a hospital medicine program can do for a hospital."

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Kids' Deadly Unintentional Injuries Drop 30%

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Fewer children died from unintentional injuries between 2000 and 2009, but death rates from suffocation and poisoning increased, according to a report from the Centers for Disease Control and Prevention.

The overall death rate from unintentional injuries among children dropped by nearly 30% during the 10-year period, according to an analysis of national mortality data. There were 9,143 childhood deaths from unintentional injuries in 2009, down from 12,441 in 2000. Yet, that’s about one child death per hour caused by unintentional injury, whether it’s a traffic crash, drowning, poisoning, or fire.

CDC/Amanda Mills
According to the Centers for Disease Control and Prevention, the rate of child deaths from unintentional injuries (such as traffic accidents, drowning, poisoning or fire) between 2000 and 2009 decreased by almost 30%.

"One child’s death is still one too many," said Ileana Arias, Ph.D., principal deputy director at CDC, in a news conference. "We know most of these events are predictable and preventable."

Traffic crashes were the leading cause of death among children and adolescents (4,564 deaths), followed by suffocation (1,160), drowning (983), poisoning (824), fire/burn (391), and falls (151), according to the report.

Despite a drop in most of the mechanisms, the authors noted the increase in poisoning and suffocation death rates.

There was a 91% increase in poisoning death rate among adolescents aged 15-19 years over the 10-year period. The authors attributed the rise to prescription drug overdoses. Painkillers seem to be replacing marijuana as a gateway drug, said Dr. Arias.

"Strategies to reduce the misuse of prescription drugs include appropriate prescribing, proper storage and disposal, discouraging medication sharing, and state-based prescription drug monitoring programs," the report’s authors wrote (MMWR 2012;61:1-7).

Also, unintentional infant suffocation rates increased 54% between 2000 and 2009. The increase "underscores the importance of safe sleeping environments as recommended by the American Academy of Pediatrics, which includes supine positioning, a firm sleep surface, room-sharing without bed-sharing, and avoiding loose bedding," the investigators noted.

There was nearly a 41% decrease in deaths from traffic crashes during the 10-year-period, which could be due to several factors, including improvements in seat belt use, child safety seat and booster seat use, licensing requirements, and vehicle design, according to the report.

Drowning deaths decreased 28%; deaths from fire/burn decreased 45%, and deaths from accidental falls dropped 19%.

Despite the declines, injury remains the leading cause of death among children in the United States. The nation also ranks worst among all high-income countries when it comes to injury deaths among 0 to 14-year-olds, according to the CDC report, which is the first of its kind to describe trends among 0 to 19-year-olds by mechanism and by state.

Unintentional injury rates varied widely among states, suggesting that "environment, exposure to hazards, and difference in public policy might play a role," the authors wrote. The variation also "demonstrated that it is possible to prevent these injuries," said Dr. Arias. Massachusetts had the lowest unintentional injury death rate (4/100,000), and Mississippi had the highest (25.1/100,000).

The report is based on analysis of national mortality data collected in the CDC’s National Vital Statistics Systems. 

The authors said the report has at least two limitations. First, the report is based on death certificate data, which are subject to misclassification errors. In addition, the report is limited to unintentional injury deaths and excludes nonfatal injuries. Thus, it underreports "the total burden from injury on the society and the medical care system."

CDC officials and their partners released the National Action Plan for Child Injury Prevention along with this report, hoping that the plan’s implementation "could result in significant reductions in needless deaths, injuries, and costs associated with injuries among children and adolescents in the United States."

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Fewer children died from unintentional injuries between 2000 and 2009, but death rates from suffocation and poisoning increased, according to a report from the Centers for Disease Control and Prevention.

The overall death rate from unintentional injuries among children dropped by nearly 30% during the 10-year period, according to an analysis of national mortality data. There were 9,143 childhood deaths from unintentional injuries in 2009, down from 12,441 in 2000. Yet, that’s about one child death per hour caused by unintentional injury, whether it’s a traffic crash, drowning, poisoning, or fire.

CDC/Amanda Mills
According to the Centers for Disease Control and Prevention, the rate of child deaths from unintentional injuries (such as traffic accidents, drowning, poisoning or fire) between 2000 and 2009 decreased by almost 30%.

"One child’s death is still one too many," said Ileana Arias, Ph.D., principal deputy director at CDC, in a news conference. "We know most of these events are predictable and preventable."

Traffic crashes were the leading cause of death among children and adolescents (4,564 deaths), followed by suffocation (1,160), drowning (983), poisoning (824), fire/burn (391), and falls (151), according to the report.

Despite a drop in most of the mechanisms, the authors noted the increase in poisoning and suffocation death rates.

There was a 91% increase in poisoning death rate among adolescents aged 15-19 years over the 10-year period. The authors attributed the rise to prescription drug overdoses. Painkillers seem to be replacing marijuana as a gateway drug, said Dr. Arias.

"Strategies to reduce the misuse of prescription drugs include appropriate prescribing, proper storage and disposal, discouraging medication sharing, and state-based prescription drug monitoring programs," the report’s authors wrote (MMWR 2012;61:1-7).

Also, unintentional infant suffocation rates increased 54% between 2000 and 2009. The increase "underscores the importance of safe sleeping environments as recommended by the American Academy of Pediatrics, which includes supine positioning, a firm sleep surface, room-sharing without bed-sharing, and avoiding loose bedding," the investigators noted.

There was nearly a 41% decrease in deaths from traffic crashes during the 10-year-period, which could be due to several factors, including improvements in seat belt use, child safety seat and booster seat use, licensing requirements, and vehicle design, according to the report.

Drowning deaths decreased 28%; deaths from fire/burn decreased 45%, and deaths from accidental falls dropped 19%.

Despite the declines, injury remains the leading cause of death among children in the United States. The nation also ranks worst among all high-income countries when it comes to injury deaths among 0 to 14-year-olds, according to the CDC report, which is the first of its kind to describe trends among 0 to 19-year-olds by mechanism and by state.

Unintentional injury rates varied widely among states, suggesting that "environment, exposure to hazards, and difference in public policy might play a role," the authors wrote. The variation also "demonstrated that it is possible to prevent these injuries," said Dr. Arias. Massachusetts had the lowest unintentional injury death rate (4/100,000), and Mississippi had the highest (25.1/100,000).

The report is based on analysis of national mortality data collected in the CDC’s National Vital Statistics Systems. 

The authors said the report has at least two limitations. First, the report is based on death certificate data, which are subject to misclassification errors. In addition, the report is limited to unintentional injury deaths and excludes nonfatal injuries. Thus, it underreports "the total burden from injury on the society and the medical care system."

CDC officials and their partners released the National Action Plan for Child Injury Prevention along with this report, hoping that the plan’s implementation "could result in significant reductions in needless deaths, injuries, and costs associated with injuries among children and adolescents in the United States."

Fewer children died from unintentional injuries between 2000 and 2009, but death rates from suffocation and poisoning increased, according to a report from the Centers for Disease Control and Prevention.

The overall death rate from unintentional injuries among children dropped by nearly 30% during the 10-year period, according to an analysis of national mortality data. There were 9,143 childhood deaths from unintentional injuries in 2009, down from 12,441 in 2000. Yet, that’s about one child death per hour caused by unintentional injury, whether it’s a traffic crash, drowning, poisoning, or fire.

CDC/Amanda Mills
According to the Centers for Disease Control and Prevention, the rate of child deaths from unintentional injuries (such as traffic accidents, drowning, poisoning or fire) between 2000 and 2009 decreased by almost 30%.

"One child’s death is still one too many," said Ileana Arias, Ph.D., principal deputy director at CDC, in a news conference. "We know most of these events are predictable and preventable."

Traffic crashes were the leading cause of death among children and adolescents (4,564 deaths), followed by suffocation (1,160), drowning (983), poisoning (824), fire/burn (391), and falls (151), according to the report.

Despite a drop in most of the mechanisms, the authors noted the increase in poisoning and suffocation death rates.

There was a 91% increase in poisoning death rate among adolescents aged 15-19 years over the 10-year period. The authors attributed the rise to prescription drug overdoses. Painkillers seem to be replacing marijuana as a gateway drug, said Dr. Arias.

"Strategies to reduce the misuse of prescription drugs include appropriate prescribing, proper storage and disposal, discouraging medication sharing, and state-based prescription drug monitoring programs," the report’s authors wrote (MMWR 2012;61:1-7).

Also, unintentional infant suffocation rates increased 54% between 2000 and 2009. The increase "underscores the importance of safe sleeping environments as recommended by the American Academy of Pediatrics, which includes supine positioning, a firm sleep surface, room-sharing without bed-sharing, and avoiding loose bedding," the investigators noted.

There was nearly a 41% decrease in deaths from traffic crashes during the 10-year-period, which could be due to several factors, including improvements in seat belt use, child safety seat and booster seat use, licensing requirements, and vehicle design, according to the report.

Drowning deaths decreased 28%; deaths from fire/burn decreased 45%, and deaths from accidental falls dropped 19%.

Despite the declines, injury remains the leading cause of death among children in the United States. The nation also ranks worst among all high-income countries when it comes to injury deaths among 0 to 14-year-olds, according to the CDC report, which is the first of its kind to describe trends among 0 to 19-year-olds by mechanism and by state.

Unintentional injury rates varied widely among states, suggesting that "environment, exposure to hazards, and difference in public policy might play a role," the authors wrote. The variation also "demonstrated that it is possible to prevent these injuries," said Dr. Arias. Massachusetts had the lowest unintentional injury death rate (4/100,000), and Mississippi had the highest (25.1/100,000).

The report is based on analysis of national mortality data collected in the CDC’s National Vital Statistics Systems. 

The authors said the report has at least two limitations. First, the report is based on death certificate data, which are subject to misclassification errors. In addition, the report is limited to unintentional injury deaths and excludes nonfatal injuries. Thus, it underreports "the total burden from injury on the society and the medical care system."

CDC officials and their partners released the National Action Plan for Child Injury Prevention along with this report, hoping that the plan’s implementation "could result in significant reductions in needless deaths, injuries, and costs associated with injuries among children and adolescents in the United States."

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FROM THE CENTERS FOR DISEASE CONTROL AND PREVENTION VITAL SIGNS REPORT

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Major Finding: The overall death rate from unintentional injuries among children dropped by nearly 30% during the 10-year period, but death rate from poisoning and suffocation increased in subgroups.

Data Source: Based on analysis of national mortality data collected in the CDC’s National Vital Statistics Systems.

Disclosures: None.