SABCS 2013

SAN ANTONIO – Dr. William J. Gradishar, Betsy Bramsen Professor of Breast Oncology at Northwestern University Feinberg School of Medicine, Chicago; and Dr. Hope S. Rugo, Director, Breast Oncology and Clinical Trials Education at the UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, discuss the best to come from the San Antonio Breast Cancer Symposium, including:

• The ECOG, Turkish, and Indian trials that examine whether mastectomy results in better outcomes for the 10% of patients who present with de novo metastatic breast cancer and an intact primary tumor, as well as the accrual status of the U.S. trial examining this issue.

• The parameters of the NeoALTTO trial and the implications of dual targeting in early and preoperative HER2-positive breast cancer.

• Trials aiming to find less toxic regimens, and examining whether and when giving less – such as providing weekly paclitaxel for 12 weeks and a year of trastuzumab – is a better approach.

• Reports from a SWOG trial that will examine whether the numeric levels of circulating tumor cell markers can be used to make changes in therapy for patients with metastatic disease, and whether those changes can improve patients’ overall outcomes.

• Studies on novel agents in the neoadjuvant setting, including the CALGB 40603 trial of paclitaxel with and without bevacizumab and with and without carboplatin in patients with triple-negative disease. The findings may have implications for how newer agents are tested in patients with triple-negative disease.

Dr. Gradishar and Dr. Rugo also discuss reports on one of the arms of the I-SPY2 trial examining adaptive randomization of patients with MammaPrint high-risk disease to standard neoadjuvant chemotherapy vs. novel agents with paclitaxel, followed by anthracycline. The results represent the first oral presentation of data on the PARP inhibitor veliparib and carboplatin.

[email protected]

SAN ANTONIO – Dr. William J. Gradishar, Betsy Bramsen Professor of Breast Oncology at Northwestern University Feinberg School of Medicine, Chicago; and Dr. Hope S. Rugo, Director, Breast Oncology and Clinical Trials Education at the UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, discuss the best to come from the San Antonio Breast Cancer Symposium, including:

• The ECOG, Turkish, and Indian trials that examine whether mastectomy results in better outcomes for the 10% of patients who present with de novo metastatic breast cancer and an intact primary tumor, as well as the accrual status of the U.S. trial examining this issue.

• The parameters of the NeoALTTO trial and the implications of dual targeting in early and preoperative HER2-positive breast cancer.

• Trials aiming to find less toxic regimens, and examining whether and when giving less – such as providing weekly paclitaxel for 12 weeks and a year of trastuzumab – is a better approach.

• Reports from a SWOG trial that will examine whether the numeric levels of circulating tumor cell markers can be used to make changes in therapy for patients with metastatic disease, and whether those changes can improve patients’ overall outcomes.

• Studies on novel agents in the neoadjuvant setting, including the CALGB 40603 trial of paclitaxel with and without bevacizumab and with and without carboplatin in patients with triple-negative disease. The findings may have implications for how newer agents are tested in patients with triple-negative disease.

Dr. Gradishar and Dr. Rugo also discuss reports on one of the arms of the I-SPY2 trial examining adaptive randomization of patients with MammaPrint high-risk disease to standard neoadjuvant chemotherapy vs. novel agents with paclitaxel, followed by anthracycline. The results represent the first oral presentation of data on the PARP inhibitor veliparib and carboplatin.

[email protected]

SAN ANTONIO – Dr. William J. Gradishar, Betsy Bramsen Professor of Breast Oncology at Northwestern University Feinberg School of Medicine, Chicago; and Dr. Hope S. Rugo, Director, Breast Oncology and Clinical Trials Education at the UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, discuss the best to come from the San Antonio Breast Cancer Symposium, including:

• The ECOG, Turkish, and Indian trials that examine whether mastectomy results in better outcomes for the 10% of patients who present with de novo metastatic breast cancer and an intact primary tumor, as well as the accrual status of the U.S. trial examining this issue.

• The parameters of the NeoALTTO trial and the implications of dual targeting in early and preoperative HER2-positive breast cancer.

• Trials aiming to find less toxic regimens, and examining whether and when giving less – such as providing weekly paclitaxel for 12 weeks and a year of trastuzumab – is a better approach.

• Reports from a SWOG trial that will examine whether the numeric levels of circulating tumor cell markers can be used to make changes in therapy for patients with metastatic disease, and whether those changes can improve patients’ overall outcomes.

• Studies on novel agents in the neoadjuvant setting, including the CALGB 40603 trial of paclitaxel with and without bevacizumab and with and without carboplatin in patients with triple-negative disease. The findings may have implications for how newer agents are tested in patients with triple-negative disease.

Dr. Gradishar and Dr. Rugo also discuss reports on one of the arms of the I-SPY2 trial examining adaptive randomization of patients with MammaPrint high-risk disease to standard neoadjuvant chemotherapy vs. novel agents with paclitaxel, followed by anthracycline. The results represent the first oral presentation of data on the PARP inhibitor veliparib and carboplatin.

[email protected]

New results from the Neo ALTTO, I-SPY 2, and IBIS-II trials will head up our onsite coverage of the San Antonio Breast Cancer Symposium, to be held Dec. 10-14.

Survival follow-up analysis of the Neo ALTTO study (BIG 1-06)

Reports on new therapies in the neoadjuvant setting at SABCS will include the latest survival follow-up analysis from the Neo ALTTO (Neoadjuvant Lapatinib and/or Trastuzumab Treatment Optimization) study. The results examine the association between event-free survival and pathological complete response to neoadjuvant lapatinib, trastuzumab, or their combination in HER2-positive breast cancer.

To put the new findings in perspective, read our prior report on Neo ALTTO as well as a study that examined the effect of Neo ALTTO findings on treatment decisions.

Veliparib/carboplatin plus standard neoadjuvant therapy for high-risk breast cancer

First results from the I-SPY 2 trial will examine whether adding experimental agents to standard neoadjuvant medications increases the probability of pathologic complete response over standard neoadjuvant chemotherapy for specific biomarker signatures established at trial entry.

Anastrozole as preventive therapy in postmenopausal women at increased risk of breast cancer

First results of the IBIS-II (International Breast Cancer Intervention Study II) trial will examine the outcomes of women who were at high risk for breast cancer and given either anastrozole or placebo. Guidelines on preventive therapy, issued earlier this year by the U.S. Preventive Services Task Force, did not include recommendations regarding the aromatase inhibitor anastrozole, pending the data from the IBIS-II trial.

Look for your newsletters featuring these reports and our insightful video interviews with researchers who put the findings into perspective for your practice. Our next-best-thing-to-being-there coverage of SABCS begins on Dec. 10.

New results from the Neo ALTTO, I-SPY 2, and IBIS-II trials will head up our onsite coverage of the San Antonio Breast Cancer Symposium, to be held Dec. 10-14.

Survival follow-up analysis of the Neo ALTTO study (BIG 1-06)

Reports on new therapies in the neoadjuvant setting at SABCS will include the latest survival follow-up analysis from the Neo ALTTO (Neoadjuvant Lapatinib and/or Trastuzumab Treatment Optimization) study. The results examine the association between event-free survival and pathological complete response to neoadjuvant lapatinib, trastuzumab, or their combination in HER2-positive breast cancer.

To put the new findings in perspective, read our prior report on Neo ALTTO as well as a study that examined the effect of Neo ALTTO findings on treatment decisions.

Veliparib/carboplatin plus standard neoadjuvant therapy for high-risk breast cancer

First results from the I-SPY 2 trial will examine whether adding experimental agents to standard neoadjuvant medications increases the probability of pathologic complete response over standard neoadjuvant chemotherapy for specific biomarker signatures established at trial entry.

Anastrozole as preventive therapy in postmenopausal women at increased risk of breast cancer

First results of the IBIS-II (International Breast Cancer Intervention Study II) trial will examine the outcomes of women who were at high risk for breast cancer and given either anastrozole or placebo. Guidelines on preventive therapy, issued earlier this year by the U.S. Preventive Services Task Force, did not include recommendations regarding the aromatase inhibitor anastrozole, pending the data from the IBIS-II trial.

Look for your newsletters featuring these reports and our insightful video interviews with researchers who put the findings into perspective for your practice. Our next-best-thing-to-being-there coverage of SABCS begins on Dec. 10.

New results from the Neo ALTTO, I-SPY 2, and IBIS-II trials will head up our onsite coverage of the San Antonio Breast Cancer Symposium, to be held Dec. 10-14.

Survival follow-up analysis of the Neo ALTTO study (BIG 1-06)

Reports on new therapies in the neoadjuvant setting at SABCS will include the latest survival follow-up analysis from the Neo ALTTO (Neoadjuvant Lapatinib and/or Trastuzumab Treatment Optimization) study. The results examine the association between event-free survival and pathological complete response to neoadjuvant lapatinib, trastuzumab, or their combination in HER2-positive breast cancer.

To put the new findings in perspective, read our prior report on Neo ALTTO as well as a study that examined the effect of Neo ALTTO findings on treatment decisions.

Veliparib/carboplatin plus standard neoadjuvant therapy for high-risk breast cancer

First results from the I-SPY 2 trial will examine whether adding experimental agents to standard neoadjuvant medications increases the probability of pathologic complete response over standard neoadjuvant chemotherapy for specific biomarker signatures established at trial entry.

Anastrozole as preventive therapy in postmenopausal women at increased risk of breast cancer

First results of the IBIS-II (International Breast Cancer Intervention Study II) trial will examine the outcomes of women who were at high risk for breast cancer and given either anastrozole or placebo. Guidelines on preventive therapy, issued earlier this year by the U.S. Preventive Services Task Force, did not include recommendations regarding the aromatase inhibitor anastrozole, pending the data from the IBIS-II trial.

Look for your newsletters featuring these reports and our insightful video interviews with researchers who put the findings into perspective for your practice. Our next-best-thing-to-being-there coverage of SABCS begins on Dec. 10.