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Adult Photosensitivity Disorders
Review the PDF of the fact sheet on adult photosensitivity disorders with board-relevant, easy-to-review material. This month's fact sheet will review important disorders in the adult population where photosensitivity is a major feature.
Practice Questions
1. A 50-year-old woman with a history of alcoholism and new-onset diarrhea developed a painful, scaly, erythematous, and hyperpigmented eruption on the photoexposed areas on the chest and hands. A similar presentation can occur in patients on which medications?
a. azathioprine
b. fluorouracil
c. pyrazinamide
d. A and C only
e. all of the above
2. A college student presents with a streaky blistering rash on the arms and legs. He is on summer vacation and recently started a side job of mowing lawns. This phototoxic eruption requires which light spectrum?
a. 200–290 nm
b. 290–315 nm
c. 315–400 nm
d. 400–700 nm
e. none of the above
3. A middle-aged man with psoriasis complains of new onset of redness of the hands and face that occurs within hours of going outside. The patient may be taking which medications?
a. doxepin
b. NSAIDS
c. tar shampoo
d. terbinafine
e. A, B, and C
f. B, C, and D
4. A patient with metastatic melanoma was just started on vemurafenib. Which side effect is most likely to occur from this medication?
a. cough
b. myalgia
c. panniculitis
d. photosensitivity
e. squamous cell carcinoma
5. A 30-year-old black woman reports an itchy, flesh-colored, bumpy rash on the extensor forearms that appears 24 hours after sun exposure. There was no prior exposure to systemic or topical photoallergens. Which of the following is false regarding this condition?
a. classified as a type IV hypersensitivity reaction
b. condition improves with subsequent exposures (hardening)
c. histology is characterized by mucin deposition
d. rash is generally nonscarring
e. similar reaction localized to the helices may occur in adolescent boys
Answers to practice questions provided on next page
Practice Question Answers
1. A 50-year-old woman with a history of alcoholism and new-onset diarrhea developed a painful, scaly, erythematous, and hyperpigmented eruption on the photoexposed areas on the chest and hands. A similar presentation can occur in patients on which medications?
a. azathioprine
b. fluorouracil
c. pyrazinamide
d. A and C only
e. all of the above
2. A college student presents with a streaky blistering rash on the arms and legs. He is on summer vacation and recently started a side job of mowing lawns. This phototoxic eruption requires which light spectrum?
a. 200–290 nm
b. 290–315 nm
c. 315–400 nm
d. 400–700 nm
e. none of the above
3. A middle-aged man with psoriasis complains of new onset of redness of the hands and face that occurs within hours of going outside. The patient may be taking which medications?
a. doxepin
b. NSAIDS
c. tar shampoo
d. terbinafine
e. A, B, and C
f. B, C, and D
4. A patient with metastatic melanoma was just started on vemurafenib. Which side effect is most likely to occur from this medication?
a. cough
b. myalgia
c. panniculitis
d. photosensitivity
e. squamous cell carcinoma
5. A 30-year-old black woman reports an itchy, flesh-colored, bumpy rash on the extensor forearms that appears 24 hours after sun exposure. There was no prior exposure to systemic or topical photoallergens. Which of the following is false regarding this condition?
a. classified as a type IV hypersensitivity reaction
b. condition improves with subsequent exposures (hardening)
c. histology is characterized by mucin deposition
d. rash is generally nonscarring
e. similar reaction localized to the helices may occur in adolescent boys
Review the PDF of the fact sheet on adult photosensitivity disorders with board-relevant, easy-to-review material. This month's fact sheet will review important disorders in the adult population where photosensitivity is a major feature.
Practice Questions
1. A 50-year-old woman with a history of alcoholism and new-onset diarrhea developed a painful, scaly, erythematous, and hyperpigmented eruption on the photoexposed areas on the chest and hands. A similar presentation can occur in patients on which medications?
a. azathioprine
b. fluorouracil
c. pyrazinamide
d. A and C only
e. all of the above
2. A college student presents with a streaky blistering rash on the arms and legs. He is on summer vacation and recently started a side job of mowing lawns. This phototoxic eruption requires which light spectrum?
a. 200–290 nm
b. 290–315 nm
c. 315–400 nm
d. 400–700 nm
e. none of the above
3. A middle-aged man with psoriasis complains of new onset of redness of the hands and face that occurs within hours of going outside. The patient may be taking which medications?
a. doxepin
b. NSAIDS
c. tar shampoo
d. terbinafine
e. A, B, and C
f. B, C, and D
4. A patient with metastatic melanoma was just started on vemurafenib. Which side effect is most likely to occur from this medication?
a. cough
b. myalgia
c. panniculitis
d. photosensitivity
e. squamous cell carcinoma
5. A 30-year-old black woman reports an itchy, flesh-colored, bumpy rash on the extensor forearms that appears 24 hours after sun exposure. There was no prior exposure to systemic or topical photoallergens. Which of the following is false regarding this condition?
a. classified as a type IV hypersensitivity reaction
b. condition improves with subsequent exposures (hardening)
c. histology is characterized by mucin deposition
d. rash is generally nonscarring
e. similar reaction localized to the helices may occur in adolescent boys
Answers to practice questions provided on next page
Practice Question Answers
1. A 50-year-old woman with a history of alcoholism and new-onset diarrhea developed a painful, scaly, erythematous, and hyperpigmented eruption on the photoexposed areas on the chest and hands. A similar presentation can occur in patients on which medications?
a. azathioprine
b. fluorouracil
c. pyrazinamide
d. A and C only
e. all of the above
2. A college student presents with a streaky blistering rash on the arms and legs. He is on summer vacation and recently started a side job of mowing lawns. This phototoxic eruption requires which light spectrum?
a. 200–290 nm
b. 290–315 nm
c. 315–400 nm
d. 400–700 nm
e. none of the above
3. A middle-aged man with psoriasis complains of new onset of redness of the hands and face that occurs within hours of going outside. The patient may be taking which medications?
a. doxepin
b. NSAIDS
c. tar shampoo
d. terbinafine
e. A, B, and C
f. B, C, and D
4. A patient with metastatic melanoma was just started on vemurafenib. Which side effect is most likely to occur from this medication?
a. cough
b. myalgia
c. panniculitis
d. photosensitivity
e. squamous cell carcinoma
5. A 30-year-old black woman reports an itchy, flesh-colored, bumpy rash on the extensor forearms that appears 24 hours after sun exposure. There was no prior exposure to systemic or topical photoallergens. Which of the following is false regarding this condition?
a. classified as a type IV hypersensitivity reaction
b. condition improves with subsequent exposures (hardening)
c. histology is characterized by mucin deposition
d. rash is generally nonscarring
e. similar reaction localized to the helices may occur in adolescent boys
Review the PDF of the fact sheet on adult photosensitivity disorders with board-relevant, easy-to-review material. This month's fact sheet will review important disorders in the adult population where photosensitivity is a major feature.
Practice Questions
1. A 50-year-old woman with a history of alcoholism and new-onset diarrhea developed a painful, scaly, erythematous, and hyperpigmented eruption on the photoexposed areas on the chest and hands. A similar presentation can occur in patients on which medications?
a. azathioprine
b. fluorouracil
c. pyrazinamide
d. A and C only
e. all of the above
2. A college student presents with a streaky blistering rash on the arms and legs. He is on summer vacation and recently started a side job of mowing lawns. This phototoxic eruption requires which light spectrum?
a. 200–290 nm
b. 290–315 nm
c. 315–400 nm
d. 400–700 nm
e. none of the above
3. A middle-aged man with psoriasis complains of new onset of redness of the hands and face that occurs within hours of going outside. The patient may be taking which medications?
a. doxepin
b. NSAIDS
c. tar shampoo
d. terbinafine
e. A, B, and C
f. B, C, and D
4. A patient with metastatic melanoma was just started on vemurafenib. Which side effect is most likely to occur from this medication?
a. cough
b. myalgia
c. panniculitis
d. photosensitivity
e. squamous cell carcinoma
5. A 30-year-old black woman reports an itchy, flesh-colored, bumpy rash on the extensor forearms that appears 24 hours after sun exposure. There was no prior exposure to systemic or topical photoallergens. Which of the following is false regarding this condition?
a. classified as a type IV hypersensitivity reaction
b. condition improves with subsequent exposures (hardening)
c. histology is characterized by mucin deposition
d. rash is generally nonscarring
e. similar reaction localized to the helices may occur in adolescent boys
Answers to practice questions provided on next page
Practice Question Answers
1. A 50-year-old woman with a history of alcoholism and new-onset diarrhea developed a painful, scaly, erythematous, and hyperpigmented eruption on the photoexposed areas on the chest and hands. A similar presentation can occur in patients on which medications?
a. azathioprine
b. fluorouracil
c. pyrazinamide
d. A and C only
e. all of the above
2. A college student presents with a streaky blistering rash on the arms and legs. He is on summer vacation and recently started a side job of mowing lawns. This phototoxic eruption requires which light spectrum?
a. 200–290 nm
b. 290–315 nm
c. 315–400 nm
d. 400–700 nm
e. none of the above
3. A middle-aged man with psoriasis complains of new onset of redness of the hands and face that occurs within hours of going outside. The patient may be taking which medications?
a. doxepin
b. NSAIDS
c. tar shampoo
d. terbinafine
e. A, B, and C
f. B, C, and D
4. A patient with metastatic melanoma was just started on vemurafenib. Which side effect is most likely to occur from this medication?
a. cough
b. myalgia
c. panniculitis
d. photosensitivity
e. squamous cell carcinoma
5. A 30-year-old black woman reports an itchy, flesh-colored, bumpy rash on the extensor forearms that appears 24 hours after sun exposure. There was no prior exposure to systemic or topical photoallergens. Which of the following is false regarding this condition?
a. classified as a type IV hypersensitivity reaction
b. condition improves with subsequent exposures (hardening)
c. histology is characterized by mucin deposition
d. rash is generally nonscarring
e. similar reaction localized to the helices may occur in adolescent boys
Pediatric Photosensitivity Disorders
Review the PDF of the fact sheet on pediatric photosensitivity disorders with board-relevant, easy-to-review material. This month's fact sheet will review important disorders in the pediatric population where photosensitivity is a major feature
Practice Questions
1. Which photosensitivity disorder is characterized by decreased immunoglobulin-mediated immunity?
a. Bloom syndrome
b. Cockayne syndrome
c. hydroa vacciniforme
d. Kindler syndrome
e. poikiloderma congenitale
2. Which of the following is an inappropriate treatment for a young Mexican girl with cheilitis and treatment-resistant chronic pruritic crusted papules and scars on both sun-exposed and nonexposed sites?
a. oral isotretinoin
b. oral prednisone
c. oral thalidomide
d. topical calcineurin inhibitors
e. topical corticosteroids
3. Which gene is mutated in a patient with a history of congenital acral blistering and then gradual onset of cutaneous atrophy and fragility, oral lesions, and photosensitivity?
a. DHCR7
b. KIND1
c. RECQL4
d. SLC6A19
e. XPD
4. Which photosensitivity disorder is associated with an increased risk for osteosarcoma?
a. actinic prurigo
b. Rothmund-Thomson syndrome
c. Smith-Lemli-Opitz syndrome
d. trichothiodystrophy
e. xeroderma pigmentosum
5. All of the following are features seen in De Sanctis-Cacchione syndrome except:
a. ataxia
b. basal ganglion calcification
c. deafness
d. hypogonadism
e. short stature
Answers to practice questions provided on next page
Practice Question Answers
1. Which photosensitivity disorder is characterized by decreased immunoglobulin-mediated immunity?
a. Bloom syndrome
b. Cockayne syndrome
c. hydroa vacciniforme
d. Kindler syndrome
e. poikiloderma congenitale
2. Which of the following is an inappropriate treatment for a young Mexican girl with cheilitis and treatment-resistant chronic pruritic crusted papules and scars on both sun-exposed and nonexposed sites?
a. oral isotretinoin
b. oral prednisone
c. oral thalidomide
d. topical calcineurin inhibitors
e. topical corticosteroids
3. Which gene is mutated in a patient with a history of congenital acral blistering and then gradual onset of cutaneous atrophy and fragility, oral lesions, and photosensitivity?
a. DHCR7
b. KIND1
c. RECQL4
d. SLC6A19
e. XPD
4. Which photosensitivity disorder is associated with an increased risk for osteosarcoma?
a. actinic prurigo
b. Rothmund-Thomson syndrome
c. Smith-Lemli-Opitz syndrome
d. trichothiodystrophy
e. xeroderma pigmentosum
5. All of the following are features seen in De Sanctis-Cacchione syndrome except:
a. ataxia
b. basal ganglion calcification
c. deafness
d. hypogonadism
e. short stature
Review the PDF of the fact sheet on pediatric photosensitivity disorders with board-relevant, easy-to-review material. This month's fact sheet will review important disorders in the pediatric population where photosensitivity is a major feature
Practice Questions
1. Which photosensitivity disorder is characterized by decreased immunoglobulin-mediated immunity?
a. Bloom syndrome
b. Cockayne syndrome
c. hydroa vacciniforme
d. Kindler syndrome
e. poikiloderma congenitale
2. Which of the following is an inappropriate treatment for a young Mexican girl with cheilitis and treatment-resistant chronic pruritic crusted papules and scars on both sun-exposed and nonexposed sites?
a. oral isotretinoin
b. oral prednisone
c. oral thalidomide
d. topical calcineurin inhibitors
e. topical corticosteroids
3. Which gene is mutated in a patient with a history of congenital acral blistering and then gradual onset of cutaneous atrophy and fragility, oral lesions, and photosensitivity?
a. DHCR7
b. KIND1
c. RECQL4
d. SLC6A19
e. XPD
4. Which photosensitivity disorder is associated with an increased risk for osteosarcoma?
a. actinic prurigo
b. Rothmund-Thomson syndrome
c. Smith-Lemli-Opitz syndrome
d. trichothiodystrophy
e. xeroderma pigmentosum
5. All of the following are features seen in De Sanctis-Cacchione syndrome except:
a. ataxia
b. basal ganglion calcification
c. deafness
d. hypogonadism
e. short stature
Answers to practice questions provided on next page
Practice Question Answers
1. Which photosensitivity disorder is characterized by decreased immunoglobulin-mediated immunity?
a. Bloom syndrome
b. Cockayne syndrome
c. hydroa vacciniforme
d. Kindler syndrome
e. poikiloderma congenitale
2. Which of the following is an inappropriate treatment for a young Mexican girl with cheilitis and treatment-resistant chronic pruritic crusted papules and scars on both sun-exposed and nonexposed sites?
a. oral isotretinoin
b. oral prednisone
c. oral thalidomide
d. topical calcineurin inhibitors
e. topical corticosteroids
3. Which gene is mutated in a patient with a history of congenital acral blistering and then gradual onset of cutaneous atrophy and fragility, oral lesions, and photosensitivity?
a. DHCR7
b. KIND1
c. RECQL4
d. SLC6A19
e. XPD
4. Which photosensitivity disorder is associated with an increased risk for osteosarcoma?
a. actinic prurigo
b. Rothmund-Thomson syndrome
c. Smith-Lemli-Opitz syndrome
d. trichothiodystrophy
e. xeroderma pigmentosum
5. All of the following are features seen in De Sanctis-Cacchione syndrome except:
a. ataxia
b. basal ganglion calcification
c. deafness
d. hypogonadism
e. short stature
Review the PDF of the fact sheet on pediatric photosensitivity disorders with board-relevant, easy-to-review material. This month's fact sheet will review important disorders in the pediatric population where photosensitivity is a major feature
Practice Questions
1. Which photosensitivity disorder is characterized by decreased immunoglobulin-mediated immunity?
a. Bloom syndrome
b. Cockayne syndrome
c. hydroa vacciniforme
d. Kindler syndrome
e. poikiloderma congenitale
2. Which of the following is an inappropriate treatment for a young Mexican girl with cheilitis and treatment-resistant chronic pruritic crusted papules and scars on both sun-exposed and nonexposed sites?
a. oral isotretinoin
b. oral prednisone
c. oral thalidomide
d. topical calcineurin inhibitors
e. topical corticosteroids
3. Which gene is mutated in a patient with a history of congenital acral blistering and then gradual onset of cutaneous atrophy and fragility, oral lesions, and photosensitivity?
a. DHCR7
b. KIND1
c. RECQL4
d. SLC6A19
e. XPD
4. Which photosensitivity disorder is associated with an increased risk for osteosarcoma?
a. actinic prurigo
b. Rothmund-Thomson syndrome
c. Smith-Lemli-Opitz syndrome
d. trichothiodystrophy
e. xeroderma pigmentosum
5. All of the following are features seen in De Sanctis-Cacchione syndrome except:
a. ataxia
b. basal ganglion calcification
c. deafness
d. hypogonadism
e. short stature
Answers to practice questions provided on next page
Practice Question Answers
1. Which photosensitivity disorder is characterized by decreased immunoglobulin-mediated immunity?
a. Bloom syndrome
b. Cockayne syndrome
c. hydroa vacciniforme
d. Kindler syndrome
e. poikiloderma congenitale
2. Which of the following is an inappropriate treatment for a young Mexican girl with cheilitis and treatment-resistant chronic pruritic crusted papules and scars on both sun-exposed and nonexposed sites?
a. oral isotretinoin
b. oral prednisone
c. oral thalidomide
d. topical calcineurin inhibitors
e. topical corticosteroids
3. Which gene is mutated in a patient with a history of congenital acral blistering and then gradual onset of cutaneous atrophy and fragility, oral lesions, and photosensitivity?
a. DHCR7
b. KIND1
c. RECQL4
d. SLC6A19
e. XPD
4. Which photosensitivity disorder is associated with an increased risk for osteosarcoma?
a. actinic prurigo
b. Rothmund-Thomson syndrome
c. Smith-Lemli-Opitz syndrome
d. trichothiodystrophy
e. xeroderma pigmentosum
5. All of the following are features seen in De Sanctis-Cacchione syndrome except:
a. ataxia
b. basal ganglion calcification
c. deafness
d. hypogonadism
e. short stature