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Extended-release oxybutynin and tolterodine treat overactive bladder
PRACTICE RECOMMENDATIONS

Extended-release versions of oxybutynin and tolterodine are similarly effective and tolerable in the treatment of women with overactive bladder. No differences are seen in reduction of weekly episodes of urge incontinence and total incontinence after 3 months of treatment. Extended-release oxybutynin is more effective than extended-release tolterodine in promoting total dryness (no episodes of incontinence) after 12 weeks of treatment. Dry mouth is more common with oxybutynin; however, other side effects are similar.

 
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Diokno AC, Appell RA, Sand PK, et al. Prospective, randomized, double-blind study of the efficacy and tolerability of the extended-release formulations of oxybutynin and tolterodine for overactive bladder: results of the OPERA trial. Mayo Clin Proc 2003; 78:687–695.

Adrienne Z. Ables, PharmD
Spartanburg Family Medicine Residency Program, Spartanburg, SC. E-mail: [email protected].

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The Journal of Family Practice - 52(11)
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828-848
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Author and Disclosure Information

Diokno AC, Appell RA, Sand PK, et al. Prospective, randomized, double-blind study of the efficacy and tolerability of the extended-release formulations of oxybutynin and tolterodine for overactive bladder: results of the OPERA trial. Mayo Clin Proc 2003; 78:687–695.

Adrienne Z. Ables, PharmD
Spartanburg Family Medicine Residency Program, Spartanburg, SC. E-mail: [email protected].

Author and Disclosure Information

Diokno AC, Appell RA, Sand PK, et al. Prospective, randomized, double-blind study of the efficacy and tolerability of the extended-release formulations of oxybutynin and tolterodine for overactive bladder: results of the OPERA trial. Mayo Clin Proc 2003; 78:687–695.

Adrienne Z. Ables, PharmD
Spartanburg Family Medicine Residency Program, Spartanburg, SC. E-mail: [email protected].

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PRACTICE RECOMMENDATIONS

Extended-release versions of oxybutynin and tolterodine are similarly effective and tolerable in the treatment of women with overactive bladder. No differences are seen in reduction of weekly episodes of urge incontinence and total incontinence after 3 months of treatment. Extended-release oxybutynin is more effective than extended-release tolterodine in promoting total dryness (no episodes of incontinence) after 12 weeks of treatment. Dry mouth is more common with oxybutynin; however, other side effects are similar.

 
PRACTICE RECOMMENDATIONS

Extended-release versions of oxybutynin and tolterodine are similarly effective and tolerable in the treatment of women with overactive bladder. No differences are seen in reduction of weekly episodes of urge incontinence and total incontinence after 3 months of treatment. Extended-release oxybutynin is more effective than extended-release tolterodine in promoting total dryness (no episodes of incontinence) after 12 weeks of treatment. Dry mouth is more common with oxybutynin; however, other side effects are similar.

 
Issue
The Journal of Family Practice - 52(11)
Issue
The Journal of Family Practice - 52(11)
Page Number
828-848
Page Number
828-848
Publications
Publications
Topics
Article Type
Display Headline
Extended-release oxybutynin and tolterodine treat overactive bladder
Display Headline
Extended-release oxybutynin and tolterodine treat overactive bladder
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