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Key clinical point: Researchers used flow cytometry and genomic assessment to identify a shared DNMT3A mutation in a rare case of angioimmunoblastic T-cell lymphoma and myelodysplastic syndrome.
Major finding: DNMT3A N612Rfs*36 was identified as the common mutation for AITL and myeloid neoplasm using both cytogenetic analysis (karyotype), which showed deletion of the long arm of chromosome 20 in 14 of 20 metaphases and also fluorescent in situ hybridization (FISH), which showed the same deletion in 36.3% of cells.
Study details: The data come from a case report of a 75-year-old man with a history of lung adenocarcinoma who was diagnosed with angioimmunoblastic T-cell lymphoma (AITL) and concomitant myelodysplastic syndrome.
Disclosures: The study received no outside funding. Lead author Dr. Naganuma had no financial conflicts to disclose.
Source: Naganuma K et al. J Hematol. 2020 Nov 6. doi: 10.14740/jh760.
Key clinical point: Researchers used flow cytometry and genomic assessment to identify a shared DNMT3A mutation in a rare case of angioimmunoblastic T-cell lymphoma and myelodysplastic syndrome.
Major finding: DNMT3A N612Rfs*36 was identified as the common mutation for AITL and myeloid neoplasm using both cytogenetic analysis (karyotype), which showed deletion of the long arm of chromosome 20 in 14 of 20 metaphases and also fluorescent in situ hybridization (FISH), which showed the same deletion in 36.3% of cells.
Study details: The data come from a case report of a 75-year-old man with a history of lung adenocarcinoma who was diagnosed with angioimmunoblastic T-cell lymphoma (AITL) and concomitant myelodysplastic syndrome.
Disclosures: The study received no outside funding. Lead author Dr. Naganuma had no financial conflicts to disclose.
Source: Naganuma K et al. J Hematol. 2020 Nov 6. doi: 10.14740/jh760.
Key clinical point: Researchers used flow cytometry and genomic assessment to identify a shared DNMT3A mutation in a rare case of angioimmunoblastic T-cell lymphoma and myelodysplastic syndrome.
Major finding: DNMT3A N612Rfs*36 was identified as the common mutation for AITL and myeloid neoplasm using both cytogenetic analysis (karyotype), which showed deletion of the long arm of chromosome 20 in 14 of 20 metaphases and also fluorescent in situ hybridization (FISH), which showed the same deletion in 36.3% of cells.
Study details: The data come from a case report of a 75-year-old man with a history of lung adenocarcinoma who was diagnosed with angioimmunoblastic T-cell lymphoma (AITL) and concomitant myelodysplastic syndrome.
Disclosures: The study received no outside funding. Lead author Dr. Naganuma had no financial conflicts to disclose.
Source: Naganuma K et al. J Hematol. 2020 Nov 6. doi: 10.14740/jh760.