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Genomic oncology: moving beyond the tip of the iceberg
Historically, cancer has been diagnosed and treated on the basis of the tissue of origin. The promise of personalized therapy, matched more precisely to an individual’s tumor, was ushered in with the development of molecularly targeted therapies, based on a greater understanding of cancer as a genomic-driven disease. Here, we discuss some of the evolution of genomic oncology, the inherent complexities and challenges, and how novel clinical trial designs are among the strategies being developed to address them and shape the future of personalized medicine in cancer.
The evolution of genomic oncology
In the 15 years since the first map of the human genome emerged, genetics has become an integral part of medical practice worldwide.1 Oncology is no exception; the genetic origins of cancer were suspected more than a century ago and it is now well understood that most cancers are driven by genetic alterations that disrupt key cellular pathways involved in tumor survival and progression.2
In the 15 years since the first map of the human genome emerged, genetics has become an integral part of medical practice worldwide.1 Oncology is no exception; the genetic origins of cancer were suspected more than a century ago and it is now well understood that most cancers are driven by genetic alterations that disrupt key cellular pathways involved in tumor survival and progression.2
Click on the PDF icon at the top of this introduction to read the full article.
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Issue
The Journal of Community and Supportive Oncology - 13(8)
Page Number
300-306
Legacy Keywords
genomic oncology, personalized therapy, targeted therapies, next-generation sequencing, NGS, biologics, immunotherapy, BATTLE-2, I-SPY 2, NCI-MATCH, lungMAP
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Article PDF
Historically, cancer has been diagnosed and treated on the basis of the tissue of origin. The promise of personalized therapy, matched more precisely to an individual’s tumor, was ushered in with the development of molecularly targeted therapies, based on a greater understanding of cancer as a genomic-driven disease. Here, we discuss some of the evolution of genomic oncology, the inherent complexities and challenges, and how novel clinical trial designs are among the strategies being developed to address them and shape the future of personalized medicine in cancer.
The evolution of genomic oncology
In the 15 years since the first map of the human genome emerged, genetics has become an integral part of medical practice worldwide.1 Oncology is no exception; the genetic origins of cancer were suspected more than a century ago and it is now well understood that most cancers are driven by genetic alterations that disrupt key cellular pathways involved in tumor survival and progression.2
In the 15 years since the first map of the human genome emerged, genetics has become an integral part of medical practice worldwide.1 Oncology is no exception; the genetic origins of cancer were suspected more than a century ago and it is now well understood that most cancers are driven by genetic alterations that disrupt key cellular pathways involved in tumor survival and progression.2
Click on the PDF icon at the top of this introduction to read the full article.
Historically, cancer has been diagnosed and treated on the basis of the tissue of origin. The promise of personalized therapy, matched more precisely to an individual’s tumor, was ushered in with the development of molecularly targeted therapies, based on a greater understanding of cancer as a genomic-driven disease. Here, we discuss some of the evolution of genomic oncology, the inherent complexities and challenges, and how novel clinical trial designs are among the strategies being developed to address them and shape the future of personalized medicine in cancer.
The evolution of genomic oncology
In the 15 years since the first map of the human genome emerged, genetics has become an integral part of medical practice worldwide.1 Oncology is no exception; the genetic origins of cancer were suspected more than a century ago and it is now well understood that most cancers are driven by genetic alterations that disrupt key cellular pathways involved in tumor survival and progression.2
In the 15 years since the first map of the human genome emerged, genetics has become an integral part of medical practice worldwide.1 Oncology is no exception; the genetic origins of cancer were suspected more than a century ago and it is now well understood that most cancers are driven by genetic alterations that disrupt key cellular pathways involved in tumor survival and progression.2
Click on the PDF icon at the top of this introduction to read the full article.
Issue
The Journal of Community and Supportive Oncology - 13(8)
Issue
The Journal of Community and Supportive Oncology - 13(8)
Page Number
300-306
Page Number
300-306
Article Type
Display Headline
Genomic oncology: moving beyond the tip of the iceberg
Display Headline
Genomic oncology: moving beyond the tip of the iceberg
Legacy Keywords
genomic oncology, personalized therapy, targeted therapies, next-generation sequencing, NGS, biologics, immunotherapy, BATTLE-2, I-SPY 2, NCI-MATCH, lungMAP
Legacy Keywords
genomic oncology, personalized therapy, targeted therapies, next-generation sequencing, NGS, biologics, immunotherapy, BATTLE-2, I-SPY 2, NCI-MATCH, lungMAP
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JCSO 2015;13:300-306
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