Article Type
Article
Changed
Fri, 05/02/2025 - 10:10
Display Headline

IBS: Mental Health Factors and Comorbidities

Author(s)
Lin Chang, MD
Laurie A. Keefer, PhD

Click to view more from Gastroenterology Data Trends 2025. 

References
  1. Staudacher HM, Black CJ, Teasdale SB, Mikocka-Walus A, Keefer L. Irritable bowel syndrome and mental health comorbidity - approach to multidisciplinary management. Nat Rev Gastroenterol Hepatol. 2023;20(9):582-596. doi:10.1038/s41575-023-00794-z
  2. Ballou S, Vasant DH, Guadagnoli L, et al. A primer for the gastroenterology provider on psychosocial assessment of patients with disorders of gut-brain interaction. Neurogastroenterol Motil. 2024;36(12):e14894. doi:10.1111/nmo.14894
  3. Keefer L, Ballou SK, Drossman DA, Ringstrom G, Elsenbruch S, Ljótsson B. A Rome Working Team Report on Brain-Gut Behavior Therapies for Disorders of Gut-Brain Interaction. Gastroenterology. 2022;162(1):300-315. doi:10.1053/j.gastro.2021.09.015
  4. Goodoory VC, Khasawneh M, Thakur ER, et al. Effect of Brain-Gut Behavioral Treatments on Abdominal Pain in Irritable Bowel Syndrome: Systematic Review and Network Meta-Analysis. Gastroenterology. 2024;167(5):934-943.e5. doi:10.1053/j.gastro.2024.05.010
  5. Chang L, Sultan S, Lembo A, Verne GN, Smalley W, Heidelbaugh JJ. AGA Clinical Practice Guideline on the Pharmacological Management of Irritable Bowel Syndrome With Constipation. Gastroenterology. 2022;163(1):118-136. doi:10.1053/j.gastro.2022.04.016
  6. Drossman DA, Tack J, Ford AC, Szigethy E, Törnblom H, Van Oudenhove L. Neuromodulators for Functional Gastrointestinal Disorders (Disorders of Gut-Brain Interaction): A Rome Foundation Working Team Report. Gastroenterology. 2018;154(4):1140-1171.e1. doi:10.1053/j.gastro.2017.11.279
  7. Hasan SS, Ballou S, Keefer L, Vasant DH. Improving access to gut-directed hypnotherapy for irritable bowel syndrome in the digital therapeutics’ era: Are mobile applications a “smart” solution? Neurogastroenterol Motil. 2023;35(4):e14554. doi:10.1111/nmo.14554
  8. Tarar ZI, Farooq U, Zafar Y, et al. Burden of anxiety and depression among hospitalized patients with irritable bowel syndrome: a nationwide analysis. Ir J Med Sci. 2023;192(5):2159-2166. doi:10.1007/s11845-022-03258-6
  9. Barbara G, Aziz I, Ballou S, et al. Rome Foundation Working Team Report on overlap in disorders of gut-brain interaction. Nat Rev Gastroenterol Hepatol. doi:10.1038/s41575-024-01033-9
  10. Thakur ER, Kunik M, Jarbrink-Sehgal ME, Lackner J, Dindo L, El-Serag H. Behavior Medicine Management of Irritable Bowel Syndrome: A Referral Toolkit for Gastroenterology Providers. 2018. Accessed February 19, 2025. https://www.mirecc.va.gov/VISN16/docs/ibs-referral-toolkit.pdf
  11. Irritable bowel syndrome (IBS). Johns Hopkins Medicine website. Accessed February 19, 2025. https://www.hopkinsmedicine.org/health/conditionsanddiseases/irritable-bowel-syndrome-ibs
  12. Burton-Murray H, Guadagnoli L, Kamp K, et al. Rome Foundation Working Team Report: Consensus Statement on the Design and Conduct of Behavioural Clinical Trials for Disorders of Gut-Brain Interaction. Aliment Pharmacol Ther. 2025;61(5):787-802. doi:10.1111/apt.18482
  13. Rome GastroPsych. Rome Foundation website. Accessed February 19, 2025. https://romegipsych.org/
  14. Scarlata K, Riehl M. Mind Your Gut: The Science-based, Whole-body Guide to Living Well with IBS. Hachette Book Group, 2025.
  15. IFFGD International Foundation for Gastrointestinal Disorders. IFFGD website. January 10, 2025. Accessed February 19, 2025. https://iffgd.org/
  16. GI Psychology: Mind Your Gut website. April 2, 2024. Accessed February 19, 2025. https://www.gipsychology.com/
  17. Drossman DA, Ruddy J. Gut Feelings: Disorders of the Gut-Brain Interaction (DGBI) and the Patient-Doctor Relationship. DrossmanCare Chapel Hill, 2020.
  18. Tuesday Night IBS website. Accessed February 19, 2025. https://www.tuesdaynightibs.com/
Author and Disclosure Information

Lin Chang, MD
Professor, David Geffen School of Medicine,
UCLA; Vice-Chief, Vatche and Tamar
Manoukian, Division of Digestive Diseases,
UCLA Digestive Diseases Center,
Los Angeles, California

Disclosures: Serve(d) as a director, officer, partner, employee, advisor,
consultant, or trustee for: Ardelyx; Alfasigma; Atmo; GLaxoSmithKline;
Food Marble; Vibrant; Nerva; Received research grant from: AnX Robotica;
Ironwood; Received income in an amount equal to or greater than $250
from: Alfasigma; Atmo; GLaxoSmithKline; Food Marble; Have stock options
in: Trellus Health; Food Marble; ModifyHealth

Laurie A. Keefer, PhD
Professor, Department of Medicine and
Psychiatry, Division of Gastroenterology, Icahn
School of Medicine at Mount Sinai; Gastro
Psychologist, Inflammatory Bowel Disease Center,
Mount Sinai Hospital, New York, New York

Disclosures: Serve(d) as a director, officer, partner, employee, advisor,
consultant, or trustee for: AbbVie; Pfizer; Eli Lilly; Reckitt Health; Johnson
and Johnson; Rome Foundation; Received research grant from: Ardelyx
Have a 5% or greater equity interest in: Trellus Health

Publications
GI and Hepatology News
Topics
IBD & Intestinal Disorders
Mental Health
Author(s)
Lin Chang, MD
Laurie A. Keefer, PhD
Author(s)
Lin Chang, MD
Laurie A. Keefer, PhD
Author and Disclosure Information

Lin Chang, MD
Professor, David Geffen School of Medicine,
UCLA; Vice-Chief, Vatche and Tamar
Manoukian, Division of Digestive Diseases,
UCLA Digestive Diseases Center,
Los Angeles, California

Disclosures: Serve(d) as a director, officer, partner, employee, advisor,
consultant, or trustee for: Ardelyx; Alfasigma; Atmo; GLaxoSmithKline;
Food Marble; Vibrant; Nerva; Received research grant from: AnX Robotica;
Ironwood; Received income in an amount equal to or greater than $250
from: Alfasigma; Atmo; GLaxoSmithKline; Food Marble; Have stock options
in: Trellus Health; Food Marble; ModifyHealth

Laurie A. Keefer, PhD
Professor, Department of Medicine and
Psychiatry, Division of Gastroenterology, Icahn
School of Medicine at Mount Sinai; Gastro
Psychologist, Inflammatory Bowel Disease Center,
Mount Sinai Hospital, New York, New York

Disclosures: Serve(d) as a director, officer, partner, employee, advisor,
consultant, or trustee for: AbbVie; Pfizer; Eli Lilly; Reckitt Health; Johnson
and Johnson; Rome Foundation; Received research grant from: Ardelyx
Have a 5% or greater equity interest in: Trellus Health

Author and Disclosure Information

Lin Chang, MD
Professor, David Geffen School of Medicine,
UCLA; Vice-Chief, Vatche and Tamar
Manoukian, Division of Digestive Diseases,
UCLA Digestive Diseases Center,
Los Angeles, California

Disclosures: Serve(d) as a director, officer, partner, employee, advisor,
consultant, or trustee for: Ardelyx; Alfasigma; Atmo; GLaxoSmithKline;
Food Marble; Vibrant; Nerva; Received research grant from: AnX Robotica;
Ironwood; Received income in an amount equal to or greater than $250
from: Alfasigma; Atmo; GLaxoSmithKline; Food Marble; Have stock options
in: Trellus Health; Food Marble; ModifyHealth

Laurie A. Keefer, PhD
Professor, Department of Medicine and
Psychiatry, Division of Gastroenterology, Icahn
School of Medicine at Mount Sinai; Gastro
Psychologist, Inflammatory Bowel Disease Center,
Mount Sinai Hospital, New York, New York

Disclosures: Serve(d) as a director, officer, partner, employee, advisor,
consultant, or trustee for: AbbVie; Pfizer; Eli Lilly; Reckitt Health; Johnson
and Johnson; Rome Foundation; Received research grant from: Ardelyx
Have a 5% or greater equity interest in: Trellus Health

Click to view more from Gastroenterology Data Trends 2025. 

Click to view more from Gastroenterology Data Trends 2025. 

References
  1. Staudacher HM, Black CJ, Teasdale SB, Mikocka-Walus A, Keefer L. Irritable bowel syndrome and mental health comorbidity - approach to multidisciplinary management. Nat Rev Gastroenterol Hepatol. 2023;20(9):582-596. doi:10.1038/s41575-023-00794-z
  2. Ballou S, Vasant DH, Guadagnoli L, et al. A primer for the gastroenterology provider on psychosocial assessment of patients with disorders of gut-brain interaction. Neurogastroenterol Motil. 2024;36(12):e14894. doi:10.1111/nmo.14894
  3. Keefer L, Ballou SK, Drossman DA, Ringstrom G, Elsenbruch S, Ljótsson B. A Rome Working Team Report on Brain-Gut Behavior Therapies for Disorders of Gut-Brain Interaction. Gastroenterology. 2022;162(1):300-315. doi:10.1053/j.gastro.2021.09.015
  4. Goodoory VC, Khasawneh M, Thakur ER, et al. Effect of Brain-Gut Behavioral Treatments on Abdominal Pain in Irritable Bowel Syndrome: Systematic Review and Network Meta-Analysis. Gastroenterology. 2024;167(5):934-943.e5. doi:10.1053/j.gastro.2024.05.010
  5. Chang L, Sultan S, Lembo A, Verne GN, Smalley W, Heidelbaugh JJ. AGA Clinical Practice Guideline on the Pharmacological Management of Irritable Bowel Syndrome With Constipation. Gastroenterology. 2022;163(1):118-136. doi:10.1053/j.gastro.2022.04.016
  6. Drossman DA, Tack J, Ford AC, Szigethy E, Törnblom H, Van Oudenhove L. Neuromodulators for Functional Gastrointestinal Disorders (Disorders of Gut-Brain Interaction): A Rome Foundation Working Team Report. Gastroenterology. 2018;154(4):1140-1171.e1. doi:10.1053/j.gastro.2017.11.279
  7. Hasan SS, Ballou S, Keefer L, Vasant DH. Improving access to gut-directed hypnotherapy for irritable bowel syndrome in the digital therapeutics’ era: Are mobile applications a “smart” solution? Neurogastroenterol Motil. 2023;35(4):e14554. doi:10.1111/nmo.14554
  8. Tarar ZI, Farooq U, Zafar Y, et al. Burden of anxiety and depression among hospitalized patients with irritable bowel syndrome: a nationwide analysis. Ir J Med Sci. 2023;192(5):2159-2166. doi:10.1007/s11845-022-03258-6
  9. Barbara G, Aziz I, Ballou S, et al. Rome Foundation Working Team Report on overlap in disorders of gut-brain interaction. Nat Rev Gastroenterol Hepatol. doi:10.1038/s41575-024-01033-9
  10. Thakur ER, Kunik M, Jarbrink-Sehgal ME, Lackner J, Dindo L, El-Serag H. Behavior Medicine Management of Irritable Bowel Syndrome: A Referral Toolkit for Gastroenterology Providers. 2018. Accessed February 19, 2025. https://www.mirecc.va.gov/VISN16/docs/ibs-referral-toolkit.pdf
  11. Irritable bowel syndrome (IBS). Johns Hopkins Medicine website. Accessed February 19, 2025. https://www.hopkinsmedicine.org/health/conditionsanddiseases/irritable-bowel-syndrome-ibs
  12. Burton-Murray H, Guadagnoli L, Kamp K, et al. Rome Foundation Working Team Report: Consensus Statement on the Design and Conduct of Behavioural Clinical Trials for Disorders of Gut-Brain Interaction. Aliment Pharmacol Ther. 2025;61(5):787-802. doi:10.1111/apt.18482
  13. Rome GastroPsych. Rome Foundation website. Accessed February 19, 2025. https://romegipsych.org/
  14. Scarlata K, Riehl M. Mind Your Gut: The Science-based, Whole-body Guide to Living Well with IBS. Hachette Book Group, 2025.
  15. IFFGD International Foundation for Gastrointestinal Disorders. IFFGD website. January 10, 2025. Accessed February 19, 2025. https://iffgd.org/
  16. GI Psychology: Mind Your Gut website. April 2, 2024. Accessed February 19, 2025. https://www.gipsychology.com/
  17. Drossman DA, Ruddy J. Gut Feelings: Disorders of the Gut-Brain Interaction (DGBI) and the Patient-Doctor Relationship. DrossmanCare Chapel Hill, 2020.
  18. Tuesday Night IBS website. Accessed February 19, 2025. https://www.tuesdaynightibs.com/
References
  1. Staudacher HM, Black CJ, Teasdale SB, Mikocka-Walus A, Keefer L. Irritable bowel syndrome and mental health comorbidity - approach to multidisciplinary management. Nat Rev Gastroenterol Hepatol. 2023;20(9):582-596. doi:10.1038/s41575-023-00794-z
  2. Ballou S, Vasant DH, Guadagnoli L, et al. A primer for the gastroenterology provider on psychosocial assessment of patients with disorders of gut-brain interaction. Neurogastroenterol Motil. 2024;36(12):e14894. doi:10.1111/nmo.14894
  3. Keefer L, Ballou SK, Drossman DA, Ringstrom G, Elsenbruch S, Ljótsson B. A Rome Working Team Report on Brain-Gut Behavior Therapies for Disorders of Gut-Brain Interaction. Gastroenterology. 2022;162(1):300-315. doi:10.1053/j.gastro.2021.09.015
  4. Goodoory VC, Khasawneh M, Thakur ER, et al. Effect of Brain-Gut Behavioral Treatments on Abdominal Pain in Irritable Bowel Syndrome: Systematic Review and Network Meta-Analysis. Gastroenterology. 2024;167(5):934-943.e5. doi:10.1053/j.gastro.2024.05.010
  5. Chang L, Sultan S, Lembo A, Verne GN, Smalley W, Heidelbaugh JJ. AGA Clinical Practice Guideline on the Pharmacological Management of Irritable Bowel Syndrome With Constipation. Gastroenterology. 2022;163(1):118-136. doi:10.1053/j.gastro.2022.04.016
  6. Drossman DA, Tack J, Ford AC, Szigethy E, Törnblom H, Van Oudenhove L. Neuromodulators for Functional Gastrointestinal Disorders (Disorders of Gut-Brain Interaction): A Rome Foundation Working Team Report. Gastroenterology. 2018;154(4):1140-1171.e1. doi:10.1053/j.gastro.2017.11.279
  7. Hasan SS, Ballou S, Keefer L, Vasant DH. Improving access to gut-directed hypnotherapy for irritable bowel syndrome in the digital therapeutics’ era: Are mobile applications a “smart” solution? Neurogastroenterol Motil. 2023;35(4):e14554. doi:10.1111/nmo.14554
  8. Tarar ZI, Farooq U, Zafar Y, et al. Burden of anxiety and depression among hospitalized patients with irritable bowel syndrome: a nationwide analysis. Ir J Med Sci. 2023;192(5):2159-2166. doi:10.1007/s11845-022-03258-6
  9. Barbara G, Aziz I, Ballou S, et al. Rome Foundation Working Team Report on overlap in disorders of gut-brain interaction. Nat Rev Gastroenterol Hepatol. doi:10.1038/s41575-024-01033-9
  10. Thakur ER, Kunik M, Jarbrink-Sehgal ME, Lackner J, Dindo L, El-Serag H. Behavior Medicine Management of Irritable Bowel Syndrome: A Referral Toolkit for Gastroenterology Providers. 2018. Accessed February 19, 2025. https://www.mirecc.va.gov/VISN16/docs/ibs-referral-toolkit.pdf
  11. Irritable bowel syndrome (IBS). Johns Hopkins Medicine website. Accessed February 19, 2025. https://www.hopkinsmedicine.org/health/conditionsanddiseases/irritable-bowel-syndrome-ibs
  12. Burton-Murray H, Guadagnoli L, Kamp K, et al. Rome Foundation Working Team Report: Consensus Statement on the Design and Conduct of Behavioural Clinical Trials for Disorders of Gut-Brain Interaction. Aliment Pharmacol Ther. 2025;61(5):787-802. doi:10.1111/apt.18482
  13. Rome GastroPsych. Rome Foundation website. Accessed February 19, 2025. https://romegipsych.org/
  14. Scarlata K, Riehl M. Mind Your Gut: The Science-based, Whole-body Guide to Living Well with IBS. Hachette Book Group, 2025.
  15. IFFGD International Foundation for Gastrointestinal Disorders. IFFGD website. January 10, 2025. Accessed February 19, 2025. https://iffgd.org/
  16. GI Psychology: Mind Your Gut website. April 2, 2024. Accessed February 19, 2025. https://www.gipsychology.com/
  17. Drossman DA, Ruddy J. Gut Feelings: Disorders of the Gut-Brain Interaction (DGBI) and the Patient-Doctor Relationship. DrossmanCare Chapel Hill, 2020.
  18. Tuesday Night IBS website. Accessed February 19, 2025. https://www.tuesdaynightibs.com/
Publications
GI and Hepatology News
Publications
GI and Hepatology News
Topics
IBD & Intestinal Disorders
Mental Health
Article Type
Article
Display Headline

IBS: Mental Health Factors and Comorbidities

Display Headline

IBS: Mental Health Factors and Comorbidities

Disallow All Ads
Content Gating
No Gating (article Unlocked/Free)
Alternative CME
Disqus Comments
Default
Eyebrow Default
SLIDESHOW
Gate On Date
Thu, 05/01/2025 - 15:49
Un-Gate On Date
Thu, 05/01/2025 - 15:49
Use ProPublica
CFC Schedule Remove Status
Thu, 05/01/2025 - 15:49
Hide sidebar & use full width
render the right sidebar.
Conference Recap Checkbox
Not Conference Recap
Clinical Edge
Display the Slideshow in this Article
Article Slideshow Optional Introduction

Irritable bowel syndrome (IBS), a disorder of gut-brain interaction, affects up to 10% of the global population.1 Psychological symptoms often are associated with IBS, increasing its burden and affecting quality of life.1-3 About one third of patients with IBS experience anxiety or depression.1 Multidisciplinary care, involving gastroenterologists, psychologists, and dietitians, is crucial to address both physical and emotional symptoms in patients with IBS.1

Effective clinical pathways vary by patient profile. Some patients may have maladaptive cognitive processes that affect coping with IBS (e.g., avoidance behaviors and symptom-related anxiety) but do not meet criteria for a psychiatric disorder.2 For these patients, referral to brain-gut behavior therapy (BGBT) is advised.2 BGBTs can include cognitive behavioral therapy (CBT), gut-directed hypnotherapy, and mindfulness-based interventions, among others.3 These approaches can improve not only mental health symptoms and symptom-related stress but also gastrointestinal (GI) symptoms.4 For patients with psychiatric illnesses, referrals to psychiatrists or psychologists specialized in the patient’s specific comorbid condition are recommended.2 It is also helpful for GI professionals to familiarize themselves with a few antidepressant medications for symptom-specific anxiety or mood symptoms when a psychiatrist is unavailable.5,6 Some antidepressants, called central neuromodulators, also improve IBS symptoms.5,6

Access to integrated IBS care remains a challenge. The number of GI psychologists is limited. Most digital applications aiming to bridge this gap have limitations, such as nonpersonalized approaches and problems with engagement.7 Other options to provide care for patients with IBS and psychological symptoms include support groups or nurse-led self-management programs, education, patient advocacy organizations, and placement of educational material in clinic waiting areas.3

Medscape Article
Display survey writer
Reuters content
Disable Inline Native ads
WebMD Article
survey writer start date
Thu, 05/01/2025 - 15:49
Slide Media