miRNAs Play a Role in Bone Health in HIV Patients

In this review, Fabiola E. Del Carpio-Cano and colleagues, from Temple University School of Medicine, Philadelphia, discuss micro-ribonucleic acid (miRNA) in human immunodeficiency virus (HIV)-induced osteoporosis, including basic concepts of bone biology and current research on the role of miRNAs in bone development. 

“Increased life expectancy and the need for long-term antiretroviral therapy have brought new challenges to the clinical management of HIV-infected individuals,” the authors explained in a study published online ahead of print October 27, 2013 in the Journal of Osteoporosis. “The prevalence of osteoporosis and fractures is increased in HIV-infected patients; thus optimal strategies for risk management and treatment in this group of patients need to be redefined.”

Del Carpio-Cano and colleagues discuss bone biology, including the 2 distinct phases of bone formation, homeostatic bone remodeling, the role of transforming growth factor-β and bone morphogenic proteins (BMPs) in bone formation, and Runx2. In addition, the authors review pathophysiology of osteoporosis, biology and function of miRNA, the regulatory role of miRNA in bone biology, as well as HIV and bone biology. 

“Prevention of bone loss is an important component of HIV care as the HIV population grows older,” the authors concluded. “Understanding the mechanisms by which HIV infection affects bone biology leading to osteoporosis is crucial to delineate potential adjuvant treatment.” 

Del Carpio-Cano FE, Dela Cadena RA, Sawaya BE. HIV and Bone Disease: A Perspective of the Role of microRNAs in Bone Biology upon HIV Infection. J Osteoporos. 2013. [Epub ahead of print]

In this review, Fabiola E. Del Carpio-Cano and colleagues, from Temple University School of Medicine, Philadelphia, discuss micro-ribonucleic acid (miRNA) in human immunodeficiency virus (HIV)-induced osteoporosis, including basic concepts of bone biology and current research on the role of miRNAs in bone development. 

“Increased life expectancy and the need for long-term antiretroviral therapy have brought new challenges to the clinical management of HIV-infected individuals,” the authors explained in a study published online ahead of print October 27, 2013 in the Journal of Osteoporosis. “The prevalence of osteoporosis and fractures is increased in HIV-infected patients; thus optimal strategies for risk management and treatment in this group of patients need to be redefined.”

Del Carpio-Cano and colleagues discuss bone biology, including the 2 distinct phases of bone formation, homeostatic bone remodeling, the role of transforming growth factor-β and bone morphogenic proteins (BMPs) in bone formation, and Runx2. In addition, the authors review pathophysiology of osteoporosis, biology and function of miRNA, the regulatory role of miRNA in bone biology, as well as HIV and bone biology. 

“Prevention of bone loss is an important component of HIV care as the HIV population grows older,” the authors concluded. “Understanding the mechanisms by which HIV infection affects bone biology leading to osteoporosis is crucial to delineate potential adjuvant treatment.” 

Del Carpio-Cano FE, Dela Cadena RA, Sawaya BE. HIV and Bone Disease: A Perspective of the Role of microRNAs in Bone Biology upon HIV Infection. J Osteoporos. 2013. [Epub ahead of print]

In this review, Fabiola E. Del Carpio-Cano and colleagues, from Temple University School of Medicine, Philadelphia, discuss micro-ribonucleic acid (miRNA) in human immunodeficiency virus (HIV)-induced osteoporosis, including basic concepts of bone biology and current research on the role of miRNAs in bone development. 

“Increased life expectancy and the need for long-term antiretroviral therapy have brought new challenges to the clinical management of HIV-infected individuals,” the authors explained in a study published online ahead of print October 27, 2013 in the Journal of Osteoporosis. “The prevalence of osteoporosis and fractures is increased in HIV-infected patients; thus optimal strategies for risk management and treatment in this group of patients need to be redefined.”

Del Carpio-Cano and colleagues discuss bone biology, including the 2 distinct phases of bone formation, homeostatic bone remodeling, the role of transforming growth factor-β and bone morphogenic proteins (BMPs) in bone formation, and Runx2. In addition, the authors review pathophysiology of osteoporosis, biology and function of miRNA, the regulatory role of miRNA in bone biology, as well as HIV and bone biology. 

“Prevention of bone loss is an important component of HIV care as the HIV population grows older,” the authors concluded. “Understanding the mechanisms by which HIV infection affects bone biology leading to osteoporosis is crucial to delineate potential adjuvant treatment.” 

Del Carpio-Cano FE, Dela Cadena RA, Sawaya BE. HIV and Bone Disease: A Perspective of the Role of microRNAs in Bone Biology upon HIV Infection. J Osteoporos. 2013. [Epub ahead of print]