New Therapies for UGH

Upper gastrointestinal hemorrhage (UGH) is a common cause of acute admission for hospitalization.13 However, recent advances in our understanding of erosive disease (ED) and peptic ulcer disease (PUD), 2 of the most common etiologies of UGH, have led to effective strategies to reduce the risk of UGH. Successful implementation of these strategies, such as treatment of Helicobacter pylori (H. pylori) and the use of proton pump inhibitors (PPIs) and selective cyclooxygenase‐2 inhibitors (COX‐2s) in place of traditional nonselective nonsteroidal antiinflammatory drugs (NSAIDs), may be able to significantly reduce rates of UGH caused by ED and PUD.47

Prior to these preventive treatments, PUD and ED, both acid‐related disorders, were the most common causes of UGH requiring admission to the hospital, accounting for 62% and 14% of all UGHs, respectively.2 Given the widespread treatment of H. pylori and use of PPIs and COX‐2s, we might expect that the distribution of etiologies of UGH may have changed. However, there are limited data on the distribution of etiologies of UGH in the era of effective preventive therapy.8 If the distribution of etiologies causing patients to present with UGH has fundamentally changed with these new treatments, established strategies of managing acute UGH may need to be reevaluated. Given that well‐established guidelines exist and that many hospitals use a protocol‐driven management strategy to decide on the need for admission and/or intensive care unit (ICU) admission, changes in the distribution of etiologies since the widespread use of these new pharmacologic approaches may affect the appropriateness of these protocols.9, 10 For example, if the eradication of H. pylori has dramatically reduced the proportion of UGH caused by PUD, then risk stratification studies developed when PUD was far more common may need to be revisited. This would be particularly important if bleeding from PUD was of significantly different severity than bleeding from other causes.

While patients with H. pylori‐related UGH from PUD should be treated for H. pylori eradication, several important questions remain surrounding the use of newer therapeutics that may mitigate the risk of UGH in some patients. It is unclear what proportion of patients admitted with UGH in this new era developed bleeding despite using preventive therapy. These treatment failures are known to occur, but it is not well known how much of the burden of UGH today is due to this breakthrough bleeding.5, 6, 11, 12 Contrastingly, there are also patients who are admitted with UGH who are not on preventive treatment. Current guidelines suggest that high‐risk patients requiring NSAIDs be given COX‐2s or traditional NSAIDs with a PPI.1315 However, there is significant disagreement between these national guidelines about what constitutes a high‐risk profile.1315 For example, some guidelines recommend that elderly patients requiring NSAIDs should be on a PPI while others do not make that recommendation. Similarly, while prior UGH is a well‐recognized risk factor for future bleeding risk even without NSAIDs, current guidelines do not provide guidance toward the use of preventive therapy in these patients. If there are few patients who present with UGH related to acid disease that are not on a preventive therapy, then these unanswered questions or conflicts within current guidelines become less important. However, if a large portion of UGH is due to acid‐related disease in patients not on preventive therapy, then these unanswered questions may become important for future research.

In contrast to previous studies, the current study examines the distribution of etiologies of UGH in the era of widespread use of effective preventive therapy for ED and PUD in 2 U.S. academic medical centers. Prior studies were done before the advent of new therapeutics and did not compare different sites, which may be important.16, 17

PATIENTS AND METHODS

RESULTS

From the entire cohort of 12,091 admitted to the 2 inpatient medical services, 227 (1.9%) patients were identified as having UGH; 138 (61%) were from center 1, where 87% of patients were black and 89 (39%) were from center 2, where 89% of patients were white. Overall, the mean age was 59 years, 45% were female, and 41% were white (Table 1).

The most common etiologies of UGH were ED (44%), PUD (33%), and varices (17%) in the overall population. These same 3 etiologies were also the most common in both of the medical centers, although there were significant differences in the rates of etiologies between the 2 centers. ED was more common among subjects from center 1 (59%) than from center 2 (19%) (P < 0.001), while variceal bleeding was more common among subjects from center 2 (34%) than from center 1 (6.5%) (P = 0.009) (Table 2).

In multivariate logistic regression analyses, only age and site remained independent predictors of etiologies. Advancing age was associated with a higher risk of arteriovenous malformations (AVMs) with the odds of AVMs increasing 6% for every additional year of life (P = 0.007). Site was associated with both ED and variceal bleeding. Patients from center 1 were significantly more likely to have UGH caused by ED, with an OR = 7.10 (P < 0.001), compared to subjects from center 2. However, subjects from center 1 had a significantly lower OR (OR = 0.12) than those subjects at center 2 (P = 0.009) of having UGH caused by a variceal bleed (Table 2).

Risk factors for UGH were common among the patients, including use of aspirin (25.1%), NSAIDs (22.9%), COX‐2s (4.9%), or prior history of UGH (43%). Additionally, 6.6% of patients were taking both an NSAID and aspirin. Differences between the 2 sites were seen only in aspirin use, with 34.8% of patients in the center 1 population using aspirin compared to 10.1% in center 2 (P < 0.001) (Table 3).

Among the overall population, 68.7% of patients had identifiable risk factors (prior history of UGH or preadmission use of aspirin, NSAIDs, or COX‐2s). Of all subjects, 18.5% were on PPIs and 4.9% were taking COX‐2s while 21.1% of at risk subjects were on PPIs and 6.5% of these subjects were on a COX‐2.

Finally, we examined the effects of variations in preadmission medication use between the sites on the etiologies of UGH. None of the site‐based differences in etiologies could be explained by differences in preadmission medication patterns.

DISCUSSION

Despite the emergence of effective therapies for lowering the risk of ED and PUD, these remain the most common etiologies of UGH in our cohort of patients. In a dramatic change from historically reported patterns, ED was more common than PUD. In prior studies, PUD accounted for almost two‐thirds of all UGH.2 While some of the newer therapeutics such as PPIs and COX‐2s reduce the risk for acid‐related bleeding of all types, H. pylori eradication is effective primarily for PUD. Therefore, it may be that widespread testing and treatment of H. pylori have dramatically decreased rates of PUD. Unfortunately, this study does not allow us to directly evaluate the effect of H. pylori treatment on the changing epidemiology of UGH, as that would require a population‐based study.

While decreasing rates of PUD could explain a portion of the change in the distribution of etiologies, increasing rates of ED could also be playing a role. Prior studies have suggested that African Americans and the elderly are more susceptible to ED, particularly in the setting of NSAIDs and/or aspirin use, and less susceptible to cirrhosis.13, 16, 17, 2023 Our finding of a higher rate of ED and lower rates of cirrhosis in center 1 with a higher proportion of African Americans and greater aspirin use is consistent with these prior findings. However, in multivariate analyses, neither race nor preadmission medication use patterns explained the differences in etiologies seen. This suggests that some other factors must play a role in the differences between the 2 centers studied. These results emphasize the importance of local site characteristics in the interpretation and implementation of national guidelines and recommendations. This finding may be particularly important in diseases and clinical presentations that rely on protocol‐driven pathways, such as UGH. Current recommendations on implementing clinical pathways derived from national guidelines emphasize the fact that national development and local implementation optimization is probably the best approach for effective pathway utilization.24

It is important to understand why ED and PUD, for which we now have effective pharmacologic therapies, continue to account for such a large percentage of the burden of UGH. In this study, we found that a majority of subjects were known to have significant risk factors for UGH (aspirin use, NSAID use, COX‐2s, or prior UGH) and only 31% of the subjects could not have been identified as at‐risk prior to admission. PPIs or COX‐2s should not be used universally as preventive therapy, and they are not completely effective at preventing UGH in at‐risk patients. In this study, two‐thirds of patients with risk factors were not on preventive therapy, but almost one‐third of patients with risk factors had bleeding despite being on preventive therapy. A better understanding of why these treatment failures (bleeding despite preventive therapy) occur may be helpful in our future ability to prevent UGH. This study was not designed to determine if the two‐thirds of patients not taking preventive therapy were being treated consistent with established guidelines. However, current guidelines have significant variation in recommendations as to which patients are at high enough risk to warrant preventive therapy,1315 and there is no consensus as to which patients are at high enough risk to warrant preventive therapy. Our data suggest that additional studies will be required to determine the optimal recommendations for preventive therapy among at‐risk patients.

There are several limitations to this study. First, it only included 2 academic institutions. However, these institutions represented very different patient populations. Second, the study design is not a population‐based study. This limitation prevents us from addressing questions such as the effectiveness or cost‐effectiveness of interventions to prevent admission for UGH. Although we analyzed preadmission PPI or COX‐2 use in at‐risk patients as preventive therapy, we are unable to determine the actual intent of the physician in prescribing these drugs. Finally, although the mechanisms by which PPIs and COX‐2 affect the risk of UGH are fundamentally different and should not be considered equivalent choices, we chose to analyze either option as representing a preventive strategy in order to provide the most conservative estimate possible of preventive therapy utilization rates. However, our assumptions would generally overestimate the use of preventive therapy (as opposed to PPI use for symptom control), as we assumed all potentially preventive therapy was intended as such.

This study highlights several unanswered questions that may be important in the management of UGH. First, identifying factors that affect local patters of UGH may better inform local implementation of nationally developed guidelines. Second, a more complete understanding of the impact positive and negative risk factors for UGH have on specific patient populations may allow for a more consistent targeted approach to using preventive therapy in at‐risk patients.

Finally, and perhaps most importantly, is to determine if the change in distribution of etiologies is in fact related to a decline in bleeding related to PUD. In addition to this being a marker of the success of the H. pylori story, it may have important implications on our understanding of the acute management of UGH. If PUD is of a different severity than other common causes of UGH, such as ED, current risk stratification prediction models may need to be revalidated. For example, if UGH secondary to PUD results in greater morbidity and mortality than UGH secondary to ED, our current models identifying who requires ICU admission, urgent endoscopy, and other therapeutic interventions may result in overutilization of these resource intensive interventions. However, if larger studies do not confirm this decline in PUD it suggests the need for additional studies to identify why PUD remains so prevalent despite the major advances in treatment and prevention of PUD through H. pylori identification and eradication.

Upper gastrointestinal hemorrhage (UGH) is a common cause of acute admission for hospitalization.13 However, recent advances in our understanding of erosive disease (ED) and peptic ulcer disease (PUD), 2 of the most common etiologies of UGH, have led to effective strategies to reduce the risk of UGH. Successful implementation of these strategies, such as treatment of Helicobacter pylori (H. pylori) and the use of proton pump inhibitors (PPIs) and selective cyclooxygenase‐2 inhibitors (COX‐2s) in place of traditional nonselective nonsteroidal antiinflammatory drugs (NSAIDs), may be able to significantly reduce rates of UGH caused by ED and PUD.47

Prior to these preventive treatments, PUD and ED, both acid‐related disorders, were the most common causes of UGH requiring admission to the hospital, accounting for 62% and 14% of all UGHs, respectively.2 Given the widespread treatment of H. pylori and use of PPIs and COX‐2s, we might expect that the distribution of etiologies of UGH may have changed. However, there are limited data on the distribution of etiologies of UGH in the era of effective preventive therapy.8 If the distribution of etiologies causing patients to present with UGH has fundamentally changed with these new treatments, established strategies of managing acute UGH may need to be reevaluated. Given that well‐established guidelines exist and that many hospitals use a protocol‐driven management strategy to decide on the need for admission and/or intensive care unit (ICU) admission, changes in the distribution of etiologies since the widespread use of these new pharmacologic approaches may affect the appropriateness of these protocols.9, 10 For example, if the eradication of H. pylori has dramatically reduced the proportion of UGH caused by PUD, then risk stratification studies developed when PUD was far more common may need to be revisited. This would be particularly important if bleeding from PUD was of significantly different severity than bleeding from other causes.

While patients with H. pylori‐related UGH from PUD should be treated for H. pylori eradication, several important questions remain surrounding the use of newer therapeutics that may mitigate the risk of UGH in some patients. It is unclear what proportion of patients admitted with UGH in this new era developed bleeding despite using preventive therapy. These treatment failures are known to occur, but it is not well known how much of the burden of UGH today is due to this breakthrough bleeding.5, 6, 11, 12 Contrastingly, there are also patients who are admitted with UGH who are not on preventive treatment. Current guidelines suggest that high‐risk patients requiring NSAIDs be given COX‐2s or traditional NSAIDs with a PPI.1315 However, there is significant disagreement between these national guidelines about what constitutes a high‐risk profile.1315 For example, some guidelines recommend that elderly patients requiring NSAIDs should be on a PPI while others do not make that recommendation. Similarly, while prior UGH is a well‐recognized risk factor for future bleeding risk even without NSAIDs, current guidelines do not provide guidance toward the use of preventive therapy in these patients. If there are few patients who present with UGH related to acid disease that are not on a preventive therapy, then these unanswered questions or conflicts within current guidelines become less important. However, if a large portion of UGH is due to acid‐related disease in patients not on preventive therapy, then these unanswered questions may become important for future research.

In contrast to previous studies, the current study examines the distribution of etiologies of UGH in the era of widespread use of effective preventive therapy for ED and PUD in 2 U.S. academic medical centers. Prior studies were done before the advent of new therapeutics and did not compare different sites, which may be important.16, 17

PATIENTS AND METHODS

RESULTS

From the entire cohort of 12,091 admitted to the 2 inpatient medical services, 227 (1.9%) patients were identified as having UGH; 138 (61%) were from center 1, where 87% of patients were black and 89 (39%) were from center 2, where 89% of patients were white. Overall, the mean age was 59 years, 45% were female, and 41% were white (Table 1).

The most common etiologies of UGH were ED (44%), PUD (33%), and varices (17%) in the overall population. These same 3 etiologies were also the most common in both of the medical centers, although there were significant differences in the rates of etiologies between the 2 centers. ED was more common among subjects from center 1 (59%) than from center 2 (19%) (P < 0.001), while variceal bleeding was more common among subjects from center 2 (34%) than from center 1 (6.5%) (P = 0.009) (Table 2).

In multivariate logistic regression analyses, only age and site remained independent predictors of etiologies. Advancing age was associated with a higher risk of arteriovenous malformations (AVMs) with the odds of AVMs increasing 6% for every additional year of life (P = 0.007). Site was associated with both ED and variceal bleeding. Patients from center 1 were significantly more likely to have UGH caused by ED, with an OR = 7.10 (P < 0.001), compared to subjects from center 2. However, subjects from center 1 had a significantly lower OR (OR = 0.12) than those subjects at center 2 (P = 0.009) of having UGH caused by a variceal bleed (Table 2).

Risk factors for UGH were common among the patients, including use of aspirin (25.1%), NSAIDs (22.9%), COX‐2s (4.9%), or prior history of UGH (43%). Additionally, 6.6% of patients were taking both an NSAID and aspirin. Differences between the 2 sites were seen only in aspirin use, with 34.8% of patients in the center 1 population using aspirin compared to 10.1% in center 2 (P < 0.001) (Table 3).

Among the overall population, 68.7% of patients had identifiable risk factors (prior history of UGH or preadmission use of aspirin, NSAIDs, or COX‐2s). Of all subjects, 18.5% were on PPIs and 4.9% were taking COX‐2s while 21.1% of at risk subjects were on PPIs and 6.5% of these subjects were on a COX‐2.

Finally, we examined the effects of variations in preadmission medication use between the sites on the etiologies of UGH. None of the site‐based differences in etiologies could be explained by differences in preadmission medication patterns.

DISCUSSION

Despite the emergence of effective therapies for lowering the risk of ED and PUD, these remain the most common etiologies of UGH in our cohort of patients. In a dramatic change from historically reported patterns, ED was more common than PUD. In prior studies, PUD accounted for almost two‐thirds of all UGH.2 While some of the newer therapeutics such as PPIs and COX‐2s reduce the risk for acid‐related bleeding of all types, H. pylori eradication is effective primarily for PUD. Therefore, it may be that widespread testing and treatment of H. pylori have dramatically decreased rates of PUD. Unfortunately, this study does not allow us to directly evaluate the effect of H. pylori treatment on the changing epidemiology of UGH, as that would require a population‐based study.

While decreasing rates of PUD could explain a portion of the change in the distribution of etiologies, increasing rates of ED could also be playing a role. Prior studies have suggested that African Americans and the elderly are more susceptible to ED, particularly in the setting of NSAIDs and/or aspirin use, and less susceptible to cirrhosis.13, 16, 17, 2023 Our finding of a higher rate of ED and lower rates of cirrhosis in center 1 with a higher proportion of African Americans and greater aspirin use is consistent with these prior findings. However, in multivariate analyses, neither race nor preadmission medication use patterns explained the differences in etiologies seen. This suggests that some other factors must play a role in the differences between the 2 centers studied. These results emphasize the importance of local site characteristics in the interpretation and implementation of national guidelines and recommendations. This finding may be particularly important in diseases and clinical presentations that rely on protocol‐driven pathways, such as UGH. Current recommendations on implementing clinical pathways derived from national guidelines emphasize the fact that national development and local implementation optimization is probably the best approach for effective pathway utilization.24

It is important to understand why ED and PUD, for which we now have effective pharmacologic therapies, continue to account for such a large percentage of the burden of UGH. In this study, we found that a majority of subjects were known to have significant risk factors for UGH (aspirin use, NSAID use, COX‐2s, or prior UGH) and only 31% of the subjects could not have been identified as at‐risk prior to admission. PPIs or COX‐2s should not be used universally as preventive therapy, and they are not completely effective at preventing UGH in at‐risk patients. In this study, two‐thirds of patients with risk factors were not on preventive therapy, but almost one‐third of patients with risk factors had bleeding despite being on preventive therapy. A better understanding of why these treatment failures (bleeding despite preventive therapy) occur may be helpful in our future ability to prevent UGH. This study was not designed to determine if the two‐thirds of patients not taking preventive therapy were being treated consistent with established guidelines. However, current guidelines have significant variation in recommendations as to which patients are at high enough risk to warrant preventive therapy,1315 and there is no consensus as to which patients are at high enough risk to warrant preventive therapy. Our data suggest that additional studies will be required to determine the optimal recommendations for preventive therapy among at‐risk patients.

There are several limitations to this study. First, it only included 2 academic institutions. However, these institutions represented very different patient populations. Second, the study design is not a population‐based study. This limitation prevents us from addressing questions such as the effectiveness or cost‐effectiveness of interventions to prevent admission for UGH. Although we analyzed preadmission PPI or COX‐2 use in at‐risk patients as preventive therapy, we are unable to determine the actual intent of the physician in prescribing these drugs. Finally, although the mechanisms by which PPIs and COX‐2 affect the risk of UGH are fundamentally different and should not be considered equivalent choices, we chose to analyze either option as representing a preventive strategy in order to provide the most conservative estimate possible of preventive therapy utilization rates. However, our assumptions would generally overestimate the use of preventive therapy (as opposed to PPI use for symptom control), as we assumed all potentially preventive therapy was intended as such.

This study highlights several unanswered questions that may be important in the management of UGH. First, identifying factors that affect local patters of UGH may better inform local implementation of nationally developed guidelines. Second, a more complete understanding of the impact positive and negative risk factors for UGH have on specific patient populations may allow for a more consistent targeted approach to using preventive therapy in at‐risk patients.

Finally, and perhaps most importantly, is to determine if the change in distribution of etiologies is in fact related to a decline in bleeding related to PUD. In addition to this being a marker of the success of the H. pylori story, it may have important implications on our understanding of the acute management of UGH. If PUD is of a different severity than other common causes of UGH, such as ED, current risk stratification prediction models may need to be revalidated. For example, if UGH secondary to PUD results in greater morbidity and mortality than UGH secondary to ED, our current models identifying who requires ICU admission, urgent endoscopy, and other therapeutic interventions may result in overutilization of these resource intensive interventions. However, if larger studies do not confirm this decline in PUD it suggests the need for additional studies to identify why PUD remains so prevalent despite the major advances in treatment and prevention of PUD through H. pylori identification and eradication.

Upper gastrointestinal hemorrhage (UGH) is a common cause of acute admission for hospitalization.13 However, recent advances in our understanding of erosive disease (ED) and peptic ulcer disease (PUD), 2 of the most common etiologies of UGH, have led to effective strategies to reduce the risk of UGH. Successful implementation of these strategies, such as treatment of Helicobacter pylori (H. pylori) and the use of proton pump inhibitors (PPIs) and selective cyclooxygenase‐2 inhibitors (COX‐2s) in place of traditional nonselective nonsteroidal antiinflammatory drugs (NSAIDs), may be able to significantly reduce rates of UGH caused by ED and PUD.47

Prior to these preventive treatments, PUD and ED, both acid‐related disorders, were the most common causes of UGH requiring admission to the hospital, accounting for 62% and 14% of all UGHs, respectively.2 Given the widespread treatment of H. pylori and use of PPIs and COX‐2s, we might expect that the distribution of etiologies of UGH may have changed. However, there are limited data on the distribution of etiologies of UGH in the era of effective preventive therapy.8 If the distribution of etiologies causing patients to present with UGH has fundamentally changed with these new treatments, established strategies of managing acute UGH may need to be reevaluated. Given that well‐established guidelines exist and that many hospitals use a protocol‐driven management strategy to decide on the need for admission and/or intensive care unit (ICU) admission, changes in the distribution of etiologies since the widespread use of these new pharmacologic approaches may affect the appropriateness of these protocols.9, 10 For example, if the eradication of H. pylori has dramatically reduced the proportion of UGH caused by PUD, then risk stratification studies developed when PUD was far more common may need to be revisited. This would be particularly important if bleeding from PUD was of significantly different severity than bleeding from other causes.

While patients with H. pylori‐related UGH from PUD should be treated for H. pylori eradication, several important questions remain surrounding the use of newer therapeutics that may mitigate the risk of UGH in some patients. It is unclear what proportion of patients admitted with UGH in this new era developed bleeding despite using preventive therapy. These treatment failures are known to occur, but it is not well known how much of the burden of UGH today is due to this breakthrough bleeding.5, 6, 11, 12 Contrastingly, there are also patients who are admitted with UGH who are not on preventive treatment. Current guidelines suggest that high‐risk patients requiring NSAIDs be given COX‐2s or traditional NSAIDs with a PPI.1315 However, there is significant disagreement between these national guidelines about what constitutes a high‐risk profile.1315 For example, some guidelines recommend that elderly patients requiring NSAIDs should be on a PPI while others do not make that recommendation. Similarly, while prior UGH is a well‐recognized risk factor for future bleeding risk even without NSAIDs, current guidelines do not provide guidance toward the use of preventive therapy in these patients. If there are few patients who present with UGH related to acid disease that are not on a preventive therapy, then these unanswered questions or conflicts within current guidelines become less important. However, if a large portion of UGH is due to acid‐related disease in patients not on preventive therapy, then these unanswered questions may become important for future research.

In contrast to previous studies, the current study examines the distribution of etiologies of UGH in the era of widespread use of effective preventive therapy for ED and PUD in 2 U.S. academic medical centers. Prior studies were done before the advent of new therapeutics and did not compare different sites, which may be important.16, 17

PATIENTS AND METHODS

RESULTS

From the entire cohort of 12,091 admitted to the 2 inpatient medical services, 227 (1.9%) patients were identified as having UGH; 138 (61%) were from center 1, where 87% of patients were black and 89 (39%) were from center 2, where 89% of patients were white. Overall, the mean age was 59 years, 45% were female, and 41% were white (Table 1).

The most common etiologies of UGH were ED (44%), PUD (33%), and varices (17%) in the overall population. These same 3 etiologies were also the most common in both of the medical centers, although there were significant differences in the rates of etiologies between the 2 centers. ED was more common among subjects from center 1 (59%) than from center 2 (19%) (P < 0.001), while variceal bleeding was more common among subjects from center 2 (34%) than from center 1 (6.5%) (P = 0.009) (Table 2).

In multivariate logistic regression analyses, only age and site remained independent predictors of etiologies. Advancing age was associated with a higher risk of arteriovenous malformations (AVMs) with the odds of AVMs increasing 6% for every additional year of life (P = 0.007). Site was associated with both ED and variceal bleeding. Patients from center 1 were significantly more likely to have UGH caused by ED, with an OR = 7.10 (P < 0.001), compared to subjects from center 2. However, subjects from center 1 had a significantly lower OR (OR = 0.12) than those subjects at center 2 (P = 0.009) of having UGH caused by a variceal bleed (Table 2).

Risk factors for UGH were common among the patients, including use of aspirin (25.1%), NSAIDs (22.9%), COX‐2s (4.9%), or prior history of UGH (43%). Additionally, 6.6% of patients were taking both an NSAID and aspirin. Differences between the 2 sites were seen only in aspirin use, with 34.8% of patients in the center 1 population using aspirin compared to 10.1% in center 2 (P < 0.001) (Table 3).

Among the overall population, 68.7% of patients had identifiable risk factors (prior history of UGH or preadmission use of aspirin, NSAIDs, or COX‐2s). Of all subjects, 18.5% were on PPIs and 4.9% were taking COX‐2s while 21.1% of at risk subjects were on PPIs and 6.5% of these subjects were on a COX‐2.

Finally, we examined the effects of variations in preadmission medication use between the sites on the etiologies of UGH. None of the site‐based differences in etiologies could be explained by differences in preadmission medication patterns.

DISCUSSION

Despite the emergence of effective therapies for lowering the risk of ED and PUD, these remain the most common etiologies of UGH in our cohort of patients. In a dramatic change from historically reported patterns, ED was more common than PUD. In prior studies, PUD accounted for almost two‐thirds of all UGH.2 While some of the newer therapeutics such as PPIs and COX‐2s reduce the risk for acid‐related bleeding of all types, H. pylori eradication is effective primarily for PUD. Therefore, it may be that widespread testing and treatment of H. pylori have dramatically decreased rates of PUD. Unfortunately, this study does not allow us to directly evaluate the effect of H. pylori treatment on the changing epidemiology of UGH, as that would require a population‐based study.

While decreasing rates of PUD could explain a portion of the change in the distribution of etiologies, increasing rates of ED could also be playing a role. Prior studies have suggested that African Americans and the elderly are more susceptible to ED, particularly in the setting of NSAIDs and/or aspirin use, and less susceptible to cirrhosis.13, 16, 17, 2023 Our finding of a higher rate of ED and lower rates of cirrhosis in center 1 with a higher proportion of African Americans and greater aspirin use is consistent with these prior findings. However, in multivariate analyses, neither race nor preadmission medication use patterns explained the differences in etiologies seen. This suggests that some other factors must play a role in the differences between the 2 centers studied. These results emphasize the importance of local site characteristics in the interpretation and implementation of national guidelines and recommendations. This finding may be particularly important in diseases and clinical presentations that rely on protocol‐driven pathways, such as UGH. Current recommendations on implementing clinical pathways derived from national guidelines emphasize the fact that national development and local implementation optimization is probably the best approach for effective pathway utilization.24

It is important to understand why ED and PUD, for which we now have effective pharmacologic therapies, continue to account for such a large percentage of the burden of UGH. In this study, we found that a majority of subjects were known to have significant risk factors for UGH (aspirin use, NSAID use, COX‐2s, or prior UGH) and only 31% of the subjects could not have been identified as at‐risk prior to admission. PPIs or COX‐2s should not be used universally as preventive therapy, and they are not completely effective at preventing UGH in at‐risk patients. In this study, two‐thirds of patients with risk factors were not on preventive therapy, but almost one‐third of patients with risk factors had bleeding despite being on preventive therapy. A better understanding of why these treatment failures (bleeding despite preventive therapy) occur may be helpful in our future ability to prevent UGH. This study was not designed to determine if the two‐thirds of patients not taking preventive therapy were being treated consistent with established guidelines. However, current guidelines have significant variation in recommendations as to which patients are at high enough risk to warrant preventive therapy,1315 and there is no consensus as to which patients are at high enough risk to warrant preventive therapy. Our data suggest that additional studies will be required to determine the optimal recommendations for preventive therapy among at‐risk patients.

There are several limitations to this study. First, it only included 2 academic institutions. However, these institutions represented very different patient populations. Second, the study design is not a population‐based study. This limitation prevents us from addressing questions such as the effectiveness or cost‐effectiveness of interventions to prevent admission for UGH. Although we analyzed preadmission PPI or COX‐2 use in at‐risk patients as preventive therapy, we are unable to determine the actual intent of the physician in prescribing these drugs. Finally, although the mechanisms by which PPIs and COX‐2 affect the risk of UGH are fundamentally different and should not be considered equivalent choices, we chose to analyze either option as representing a preventive strategy in order to provide the most conservative estimate possible of preventive therapy utilization rates. However, our assumptions would generally overestimate the use of preventive therapy (as opposed to PPI use for symptom control), as we assumed all potentially preventive therapy was intended as such.

This study highlights several unanswered questions that may be important in the management of UGH. First, identifying factors that affect local patters of UGH may better inform local implementation of nationally developed guidelines. Second, a more complete understanding of the impact positive and negative risk factors for UGH have on specific patient populations may allow for a more consistent targeted approach to using preventive therapy in at‐risk patients.

Finally, and perhaps most importantly, is to determine if the change in distribution of etiologies is in fact related to a decline in bleeding related to PUD. In addition to this being a marker of the success of the H. pylori story, it may have important implications on our understanding of the acute management of UGH. If PUD is of a different severity than other common causes of UGH, such as ED, current risk stratification prediction models may need to be revalidated. For example, if UGH secondary to PUD results in greater morbidity and mortality than UGH secondary to ED, our current models identifying who requires ICU admission, urgent endoscopy, and other therapeutic interventions may result in overutilization of these resource intensive interventions. However, if larger studies do not confirm this decline in PUD it suggests the need for additional studies to identify why PUD remains so prevalent despite the major advances in treatment and prevention of PUD through H. pylori identification and eradication.