Unique MRI Findings in Juvenile Myoclonic Epilepsy

The cortical regions of the brains of patients with juvenile myoclonic epilepsy (JME) are more likely to be disassociated from subcortical structures, according to a recent study that compared the MRI readings of JME patients to those of normal children. 

• Investigators from the University of Wisconsin School of Medicine compared 21 children with JME to 22 healthy controls over a 2 year period.
• Normal children had modular cortical development and network integration between cortical and subcortical regions.
• Patients with epilepsy had a less modular cortical network that was disassociated from subcortical structures.
• Children with JME were also found to have weaker modules or communities, as indicated by higher clustering and lower modularity indices.

Garcia-Ramos C, Dabbs K, Lin JJ, et al. Progressive dissociation of cortical and subcortical network development in children with new‐onset juvenile myoclonic epilepsy [Published online ahead of print Oct 3, 2018]. Epilepsia.  https://doi.org/10.1111/epi.14560

The cortical regions of the brains of patients with juvenile myoclonic epilepsy (JME) are more likely to be disassociated from subcortical structures, according to a recent study that compared the MRI readings of JME patients to those of normal children. 

• Investigators from the University of Wisconsin School of Medicine compared 21 children with JME to 22 healthy controls over a 2 year period.
• Normal children had modular cortical development and network integration between cortical and subcortical regions.
• Patients with epilepsy had a less modular cortical network that was disassociated from subcortical structures.
• Children with JME were also found to have weaker modules or communities, as indicated by higher clustering and lower modularity indices.

Garcia-Ramos C, Dabbs K, Lin JJ, et al. Progressive dissociation of cortical and subcortical network development in children with new‐onset juvenile myoclonic epilepsy [Published online ahead of print Oct 3, 2018]. Epilepsia.  https://doi.org/10.1111/epi.14560

The cortical regions of the brains of patients with juvenile myoclonic epilepsy (JME) are more likely to be disassociated from subcortical structures, according to a recent study that compared the MRI readings of JME patients to those of normal children. 

• Investigators from the University of Wisconsin School of Medicine compared 21 children with JME to 22 healthy controls over a 2 year period.
• Normal children had modular cortical development and network integration between cortical and subcortical regions.
• Patients with epilepsy had a less modular cortical network that was disassociated from subcortical structures.
• Children with JME were also found to have weaker modules or communities, as indicated by higher clustering and lower modularity indices.

Garcia-Ramos C, Dabbs K, Lin JJ, et al. Progressive dissociation of cortical and subcortical network development in children with new‐onset juvenile myoclonic epilepsy [Published online ahead of print Oct 3, 2018]. Epilepsia.  https://doi.org/10.1111/epi.14560