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Insidious progress

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I love Dr. Nasrallah’s editorials, but none more so than his commentary in the June issue, “A skeptical view of ‘progress’ in psychiatry” (From the Editor, Current Psychiatry, June 2011, p. 18-19), in which he deftly highlights factors hindering the advancement of our profession. Clearly, his arguments come from the heart and speak directly to many psychiatrists’ concerns about what is happening in clinical settings.

I believe managed care has contributed to the proliferation of irrational polypharmacy. This is a consequence of clinicians who find themselves under unrealistic time pressures and cost constraints to come up with an expedient, “magical” treatment for acute hospitalized patients.

In reference to the comments about the phrase “behavioral health,” I have always objected to the pejorative term “providers” to refer to physicians. The designation “behavioral health providers” lumps psychiatrists and all other workers in the mental health field under the same umbrella, blurring the roles and identities of the different professions. Insurance companies further dismiss our psychiatric follow-ups as “medication management,” which ignores the broader, more specialized nature of our work with patients for the purpose of slashing fees. We often take these terms for granted, accepting them as nothing more than semantics or corporate jargon, but they are not so innocuous. We all should be aware of how these labels limit psychiatric practice and allow us to be subjugated by parties with financial motives.

On behalf of all of us who see the insidious side of the so-called progress being made in psychiatry, thank you for this insightful, well organized, and well written editorial.

Radwan F. Haykal, MD
Clinical Professor of Psychiatry
University of Tennessee Health Science Center
Memphis, TN

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I love Dr. Nasrallah’s editorials, but none more so than his commentary in the June issue, “A skeptical view of ‘progress’ in psychiatry” (From the Editor, Current Psychiatry, June 2011, p. 18-19), in which he deftly highlights factors hindering the advancement of our profession. Clearly, his arguments come from the heart and speak directly to many psychiatrists’ concerns about what is happening in clinical settings.

I believe managed care has contributed to the proliferation of irrational polypharmacy. This is a consequence of clinicians who find themselves under unrealistic time pressures and cost constraints to come up with an expedient, “magical” treatment for acute hospitalized patients.

In reference to the comments about the phrase “behavioral health,” I have always objected to the pejorative term “providers” to refer to physicians. The designation “behavioral health providers” lumps psychiatrists and all other workers in the mental health field under the same umbrella, blurring the roles and identities of the different professions. Insurance companies further dismiss our psychiatric follow-ups as “medication management,” which ignores the broader, more specialized nature of our work with patients for the purpose of slashing fees. We often take these terms for granted, accepting them as nothing more than semantics or corporate jargon, but they are not so innocuous. We all should be aware of how these labels limit psychiatric practice and allow us to be subjugated by parties with financial motives.

On behalf of all of us who see the insidious side of the so-called progress being made in psychiatry, thank you for this insightful, well organized, and well written editorial.

Radwan F. Haykal, MD
Clinical Professor of Psychiatry
University of Tennessee Health Science Center
Memphis, TN

I love Dr. Nasrallah’s editorials, but none more so than his commentary in the June issue, “A skeptical view of ‘progress’ in psychiatry” (From the Editor, Current Psychiatry, June 2011, p. 18-19), in which he deftly highlights factors hindering the advancement of our profession. Clearly, his arguments come from the heart and speak directly to many psychiatrists’ concerns about what is happening in clinical settings.

I believe managed care has contributed to the proliferation of irrational polypharmacy. This is a consequence of clinicians who find themselves under unrealistic time pressures and cost constraints to come up with an expedient, “magical” treatment for acute hospitalized patients.

In reference to the comments about the phrase “behavioral health,” I have always objected to the pejorative term “providers” to refer to physicians. The designation “behavioral health providers” lumps psychiatrists and all other workers in the mental health field under the same umbrella, blurring the roles and identities of the different professions. Insurance companies further dismiss our psychiatric follow-ups as “medication management,” which ignores the broader, more specialized nature of our work with patients for the purpose of slashing fees. We often take these terms for granted, accepting them as nothing more than semantics or corporate jargon, but they are not so innocuous. We all should be aware of how these labels limit psychiatric practice and allow us to be subjugated by parties with financial motives.

On behalf of all of us who see the insidious side of the so-called progress being made in psychiatry, thank you for this insightful, well organized, and well written editorial.

Radwan F. Haykal, MD
Clinical Professor of Psychiatry
University of Tennessee Health Science Center
Memphis, TN

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Managed care woes

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Regarding Dr. Nasrallah’s insightful editorial (“A skeptical view of ‘progress’ in psychiatry,” From the Editor, Current Psychiatry, June 2011, p. 18-19): Since the late 1980s and early 1990s, the Employment Retirement Income Security Act, has enabled managed “care” to exist, with failed attempts to repeal or limit the act. Managed “care” has worked hard to change our language, such as “primary care physician” instead of physician or doctor and “behavioral health” instead of psychiatric or mental health care. These changes minimize our importance, influence, and reimbursements as well as the medications and treatments we use. When it was obvious what was happening, we abdicated our responsibility and control to the kind of people Dr. Nasrallah described.

There will be more cuts on reimbursements and limits on us unless we say “no.” We are not allowed to organize, physicians in Congress have not helped, and our elected professional organization leaders have little influence. We can give in and accept the “inevitable,” but the Hippocratic Oath seems to preclude such irresponsibility. We can refuse to treat anyone, except in emergencies, unless we choose to do so in good conscience. We need to change and the law has to change. The people who control our health care are evil, immoral, and venal; why should they be dictating care?

Gerald A. Shubs, MD
Butler Behavioral Health Services
Hamilton, OH

Dr. Nasrallah responds

Thanks to all my colleagues who took the time to read and express their views, to agree or to challenge the tenets in my editorial that lamented the lack of progress in certain practice aspects of psychiatry. Current Psychiatry is a marketplace of updates, ideas, suggestions, critiques, and rebuttals. It is interesting psychiatrists who have worked for a long time with seriously mentally ill patients in hospitals or the community seem to feel the pain of the lack of steady progress and/or the slippage in some areas, while those who identify with the managed care model of care see things differently— ie, managed care is, in fact, progress.

We psychiatrists evaluate and treat patients in very diverse settings and perceive things through different prisms, which is why we have disparate views. No one has a monopoly on the truth, but we all have important common ground: we all share an intense loyalty to our suffering patients, and we all share pride in our noble profession regardless of its ups or downs. We know in our hearts psychiatry remains indispensable for the well-being of all citizens. Pass it on…

Henry A. Nasrallah, MD
Editor-in-Chief

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Regarding Dr. Nasrallah’s insightful editorial (“A skeptical view of ‘progress’ in psychiatry,” From the Editor, Current Psychiatry, June 2011, p. 18-19): Since the late 1980s and early 1990s, the Employment Retirement Income Security Act, has enabled managed “care” to exist, with failed attempts to repeal or limit the act. Managed “care” has worked hard to change our language, such as “primary care physician” instead of physician or doctor and “behavioral health” instead of psychiatric or mental health care. These changes minimize our importance, influence, and reimbursements as well as the medications and treatments we use. When it was obvious what was happening, we abdicated our responsibility and control to the kind of people Dr. Nasrallah described.

There will be more cuts on reimbursements and limits on us unless we say “no.” We are not allowed to organize, physicians in Congress have not helped, and our elected professional organization leaders have little influence. We can give in and accept the “inevitable,” but the Hippocratic Oath seems to preclude such irresponsibility. We can refuse to treat anyone, except in emergencies, unless we choose to do so in good conscience. We need to change and the law has to change. The people who control our health care are evil, immoral, and venal; why should they be dictating care?

Gerald A. Shubs, MD
Butler Behavioral Health Services
Hamilton, OH

Dr. Nasrallah responds

Thanks to all my colleagues who took the time to read and express their views, to agree or to challenge the tenets in my editorial that lamented the lack of progress in certain practice aspects of psychiatry. Current Psychiatry is a marketplace of updates, ideas, suggestions, critiques, and rebuttals. It is interesting psychiatrists who have worked for a long time with seriously mentally ill patients in hospitals or the community seem to feel the pain of the lack of steady progress and/or the slippage in some areas, while those who identify with the managed care model of care see things differently— ie, managed care is, in fact, progress.

We psychiatrists evaluate and treat patients in very diverse settings and perceive things through different prisms, which is why we have disparate views. No one has a monopoly on the truth, but we all have important common ground: we all share an intense loyalty to our suffering patients, and we all share pride in our noble profession regardless of its ups or downs. We know in our hearts psychiatry remains indispensable for the well-being of all citizens. Pass it on…

Henry A. Nasrallah, MD
Editor-in-Chief

Regarding Dr. Nasrallah’s insightful editorial (“A skeptical view of ‘progress’ in psychiatry,” From the Editor, Current Psychiatry, June 2011, p. 18-19): Since the late 1980s and early 1990s, the Employment Retirement Income Security Act, has enabled managed “care” to exist, with failed attempts to repeal or limit the act. Managed “care” has worked hard to change our language, such as “primary care physician” instead of physician or doctor and “behavioral health” instead of psychiatric or mental health care. These changes minimize our importance, influence, and reimbursements as well as the medications and treatments we use. When it was obvious what was happening, we abdicated our responsibility and control to the kind of people Dr. Nasrallah described.

There will be more cuts on reimbursements and limits on us unless we say “no.” We are not allowed to organize, physicians in Congress have not helped, and our elected professional organization leaders have little influence. We can give in and accept the “inevitable,” but the Hippocratic Oath seems to preclude such irresponsibility. We can refuse to treat anyone, except in emergencies, unless we choose to do so in good conscience. We need to change and the law has to change. The people who control our health care are evil, immoral, and venal; why should they be dictating care?

Gerald A. Shubs, MD
Butler Behavioral Health Services
Hamilton, OH

Dr. Nasrallah responds

Thanks to all my colleagues who took the time to read and express their views, to agree or to challenge the tenets in my editorial that lamented the lack of progress in certain practice aspects of psychiatry. Current Psychiatry is a marketplace of updates, ideas, suggestions, critiques, and rebuttals. It is interesting psychiatrists who have worked for a long time with seriously mentally ill patients in hospitals or the community seem to feel the pain of the lack of steady progress and/or the slippage in some areas, while those who identify with the managed care model of care see things differently— ie, managed care is, in fact, progress.

We psychiatrists evaluate and treat patients in very diverse settings and perceive things through different prisms, which is why we have disparate views. No one has a monopoly on the truth, but we all have important common ground: we all share an intense loyalty to our suffering patients, and we all share pride in our noble profession regardless of its ups or downs. We know in our hearts psychiatry remains indispensable for the well-being of all citizens. Pass it on…

Henry A. Nasrallah, MD
Editor-in-Chief

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Focus on change

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Dr. Nasrallah’s editorial (“A skeptical view of ‘progress’ in psychiatry,” From the Editor, Current Psychiatry, June 2011, p. 18-19) is intriguing because it summarized concerns I have seen frequently expressed in publications catering to psychiatrists. Since the advent of managed care, these kinds of “poor psychiatry” articles have appeared regularly.

Instead of bemoaning the lack of “progress” in psychiatry, perhaps Dr. Nasrallah would have been better served by focusing on change and its inevitability. I found it ridiculous he contrasted the “asylum era” with current practices in order to focus on length of stay. At that time, the mentally ill were—except for well-intentioned attempts at “cure” via “milieu therapy”—warehoused for years, if not lifetimes, under filthy conditions.

Dr. Nasrallah then segues into the expected attacks upon insurance companies, lack of parity, and drastically shortened lengths of stay. It is obvious 3 to 4 days of acute care generally is not sufficient for serious psychiatric conditions. As an experienced managed care and independent reviewer, I can assure Dr. Nasrallah such strict criteria sets are the minority. What about psychiatrists who keep patients until their insurance runs out or let relatively benign patients languish because they did not call attention to themselves and kept a bed filled? Contrary to Dr. Nasrallah’s assertion, judges and lawyers do not tell us how to practice medicine; they are part of a necessary system of checks and balances that, in a highly imperfect world, help prevent inappropriate or abusive practices by incompetent, uninvested, or morally deficient physicians, of which there are plenty.

Dr. Nasrallah should be aware terms such as “behavioral health” are largely the result of efforts to destigmatize mental illness, leading society to coin more politically correct and palatable terms for just about everything.

At no point does Dr. Nasrallah even hint at offering solutions. For example, psychiatrists have done next to nothing to educate the public about their profession. Meanwhile, a substantial number of prominent psychiatrists are more than happy to accept steak dinners and honoraria from drug companies, along with going out and speaking at free CME events, in order to oh-so-subtly hawk a medication that just happens to be manufactured by the company paying for the “free lunch.”

Forget about judges and lawyers “telling us how to practice.” What about “Big Pharma” manipulating us and advertising on television, urging viewers to “talk to their doctor” about medication X? Dr. Nasrallah is preaching to the choir here. What we need is less breast-beating and more constructive action.

Edward W. Darell, MD
Psychiatrist, Private Practice
New York, NY

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Dr. Nasrallah’s editorial (“A skeptical view of ‘progress’ in psychiatry,” From the Editor, Current Psychiatry, June 2011, p. 18-19) is intriguing because it summarized concerns I have seen frequently expressed in publications catering to psychiatrists. Since the advent of managed care, these kinds of “poor psychiatry” articles have appeared regularly.

Instead of bemoaning the lack of “progress” in psychiatry, perhaps Dr. Nasrallah would have been better served by focusing on change and its inevitability. I found it ridiculous he contrasted the “asylum era” with current practices in order to focus on length of stay. At that time, the mentally ill were—except for well-intentioned attempts at “cure” via “milieu therapy”—warehoused for years, if not lifetimes, under filthy conditions.

Dr. Nasrallah then segues into the expected attacks upon insurance companies, lack of parity, and drastically shortened lengths of stay. It is obvious 3 to 4 days of acute care generally is not sufficient for serious psychiatric conditions. As an experienced managed care and independent reviewer, I can assure Dr. Nasrallah such strict criteria sets are the minority. What about psychiatrists who keep patients until their insurance runs out or let relatively benign patients languish because they did not call attention to themselves and kept a bed filled? Contrary to Dr. Nasrallah’s assertion, judges and lawyers do not tell us how to practice medicine; they are part of a necessary system of checks and balances that, in a highly imperfect world, help prevent inappropriate or abusive practices by incompetent, uninvested, or morally deficient physicians, of which there are plenty.

Dr. Nasrallah should be aware terms such as “behavioral health” are largely the result of efforts to destigmatize mental illness, leading society to coin more politically correct and palatable terms for just about everything.

At no point does Dr. Nasrallah even hint at offering solutions. For example, psychiatrists have done next to nothing to educate the public about their profession. Meanwhile, a substantial number of prominent psychiatrists are more than happy to accept steak dinners and honoraria from drug companies, along with going out and speaking at free CME events, in order to oh-so-subtly hawk a medication that just happens to be manufactured by the company paying for the “free lunch.”

Forget about judges and lawyers “telling us how to practice.” What about “Big Pharma” manipulating us and advertising on television, urging viewers to “talk to their doctor” about medication X? Dr. Nasrallah is preaching to the choir here. What we need is less breast-beating and more constructive action.

Edward W. Darell, MD
Psychiatrist, Private Practice
New York, NY

Dr. Nasrallah’s editorial (“A skeptical view of ‘progress’ in psychiatry,” From the Editor, Current Psychiatry, June 2011, p. 18-19) is intriguing because it summarized concerns I have seen frequently expressed in publications catering to psychiatrists. Since the advent of managed care, these kinds of “poor psychiatry” articles have appeared regularly.

Instead of bemoaning the lack of “progress” in psychiatry, perhaps Dr. Nasrallah would have been better served by focusing on change and its inevitability. I found it ridiculous he contrasted the “asylum era” with current practices in order to focus on length of stay. At that time, the mentally ill were—except for well-intentioned attempts at “cure” via “milieu therapy”—warehoused for years, if not lifetimes, under filthy conditions.

Dr. Nasrallah then segues into the expected attacks upon insurance companies, lack of parity, and drastically shortened lengths of stay. It is obvious 3 to 4 days of acute care generally is not sufficient for serious psychiatric conditions. As an experienced managed care and independent reviewer, I can assure Dr. Nasrallah such strict criteria sets are the minority. What about psychiatrists who keep patients until their insurance runs out or let relatively benign patients languish because they did not call attention to themselves and kept a bed filled? Contrary to Dr. Nasrallah’s assertion, judges and lawyers do not tell us how to practice medicine; they are part of a necessary system of checks and balances that, in a highly imperfect world, help prevent inappropriate or abusive practices by incompetent, uninvested, or morally deficient physicians, of which there are plenty.

Dr. Nasrallah should be aware terms such as “behavioral health” are largely the result of efforts to destigmatize mental illness, leading society to coin more politically correct and palatable terms for just about everything.

At no point does Dr. Nasrallah even hint at offering solutions. For example, psychiatrists have done next to nothing to educate the public about their profession. Meanwhile, a substantial number of prominent psychiatrists are more than happy to accept steak dinners and honoraria from drug companies, along with going out and speaking at free CME events, in order to oh-so-subtly hawk a medication that just happens to be manufactured by the company paying for the “free lunch.”

Forget about judges and lawyers “telling us how to practice.” What about “Big Pharma” manipulating us and advertising on television, urging viewers to “talk to their doctor” about medication X? Dr. Nasrallah is preaching to the choir here. What we need is less breast-beating and more constructive action.

Edward W. Darell, MD
Psychiatrist, Private Practice
New York, NY

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Missed progress

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I, too, am concerned with the lack of recent progress in psychiatry. Nevertheless, Dr. Nasrallah is missing some of the progress he downplays (“A skeptical view of ‘progress’ in psychiatry,” From the Editor, Current Psychiatry, June 2011, p. 18-19). For instance, the discovery of chlorpromazine brought about concomitant serious side effects and homelessness, but many patients gained a life in society, which allowed some to become peer specialists, helping others with mental illness. Sure, insurance hassles for state hospitalization did not exist and hospitalization stays today often are much too short, but 40 years ago, state mental hospitals were so-called “snake pits” of overcrowding with excrement on the floor, and precious little treatment. Yes, in psychiatry we have more legal constraints, but in part this is a reflection of past coercive and unneeded hospitalizations.

I agree funding reductions have broken public mental health systems, but psychiatrists generally have preferred private practice with mentally healthier patients and sat quietly while other disciplines took over psychotherapies. I also don’t like the term “behavioral health,” but behavior can be measured, and we have precious few ways to measure progress and outcomes in psychiatry. Maybe pharmaceutical companies are abandoning drug development because they have been unsuccessful in developing novel medications in the last few decades, instead benefitting from serendipitous discoveries such as chlorpromazine. We may need new approaches to biologic treatments to progress any further, but this should not be surprising, given how difficult it is to access and study the brain

Steven Moffic, MD
Professor of Psychiatry
Medical College of Wisconsin
Milwaukee, WI

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I, too, am concerned with the lack of recent progress in psychiatry. Nevertheless, Dr. Nasrallah is missing some of the progress he downplays (“A skeptical view of ‘progress’ in psychiatry,” From the Editor, Current Psychiatry, June 2011, p. 18-19). For instance, the discovery of chlorpromazine brought about concomitant serious side effects and homelessness, but many patients gained a life in society, which allowed some to become peer specialists, helping others with mental illness. Sure, insurance hassles for state hospitalization did not exist and hospitalization stays today often are much too short, but 40 years ago, state mental hospitals were so-called “snake pits” of overcrowding with excrement on the floor, and precious little treatment. Yes, in psychiatry we have more legal constraints, but in part this is a reflection of past coercive and unneeded hospitalizations.

I agree funding reductions have broken public mental health systems, but psychiatrists generally have preferred private practice with mentally healthier patients and sat quietly while other disciplines took over psychotherapies. I also don’t like the term “behavioral health,” but behavior can be measured, and we have precious few ways to measure progress and outcomes in psychiatry. Maybe pharmaceutical companies are abandoning drug development because they have been unsuccessful in developing novel medications in the last few decades, instead benefitting from serendipitous discoveries such as chlorpromazine. We may need new approaches to biologic treatments to progress any further, but this should not be surprising, given how difficult it is to access and study the brain

Steven Moffic, MD
Professor of Psychiatry
Medical College of Wisconsin
Milwaukee, WI

I, too, am concerned with the lack of recent progress in psychiatry. Nevertheless, Dr. Nasrallah is missing some of the progress he downplays (“A skeptical view of ‘progress’ in psychiatry,” From the Editor, Current Psychiatry, June 2011, p. 18-19). For instance, the discovery of chlorpromazine brought about concomitant serious side effects and homelessness, but many patients gained a life in society, which allowed some to become peer specialists, helping others with mental illness. Sure, insurance hassles for state hospitalization did not exist and hospitalization stays today often are much too short, but 40 years ago, state mental hospitals were so-called “snake pits” of overcrowding with excrement on the floor, and precious little treatment. Yes, in psychiatry we have more legal constraints, but in part this is a reflection of past coercive and unneeded hospitalizations.

I agree funding reductions have broken public mental health systems, but psychiatrists generally have preferred private practice with mentally healthier patients and sat quietly while other disciplines took over psychotherapies. I also don’t like the term “behavioral health,” but behavior can be measured, and we have precious few ways to measure progress and outcomes in psychiatry. Maybe pharmaceutical companies are abandoning drug development because they have been unsuccessful in developing novel medications in the last few decades, instead benefitting from serendipitous discoveries such as chlorpromazine. We may need new approaches to biologic treatments to progress any further, but this should not be surprising, given how difficult it is to access and study the brain

Steven Moffic, MD
Professor of Psychiatry
Medical College of Wisconsin
Milwaukee, WI

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‘Progress’ in psychiatry

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I have practiced community mental health in Fayetteville, NC for 12 years and have observed every point Dr. Nasrallah made in “A skeptical view of ‘progress’ in psychiatry” (From the Editor, Current Psychiatry, June 2011, p. 18-19). As psychiatrists, we share a great deal of the blame. We handed over leadership of community mental health centers to social workers and allowed ourselves to be “carved out” of community hospitals. State hospitals are dysfunctional at best.

Dr. Nasrallah is correct in asking who is the “genius” behind these decisions. Many new psychiatric practices are based on family practice models of herding 60 to 80 patients per day. I’m not sure I will even recognize the practice of psychiatry in 10 to 20 years. Perhaps with obstinate rigor we can restore what we’ve lost.

Mark Chandler, MD
Medical Director
Cumberland County Mental Health Center
Fayetteville, NC

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I have practiced community mental health in Fayetteville, NC for 12 years and have observed every point Dr. Nasrallah made in “A skeptical view of ‘progress’ in psychiatry” (From the Editor, Current Psychiatry, June 2011, p. 18-19). As psychiatrists, we share a great deal of the blame. We handed over leadership of community mental health centers to social workers and allowed ourselves to be “carved out” of community hospitals. State hospitals are dysfunctional at best.

Dr. Nasrallah is correct in asking who is the “genius” behind these decisions. Many new psychiatric practices are based on family practice models of herding 60 to 80 patients per day. I’m not sure I will even recognize the practice of psychiatry in 10 to 20 years. Perhaps with obstinate rigor we can restore what we’ve lost.

Mark Chandler, MD
Medical Director
Cumberland County Mental Health Center
Fayetteville, NC

I have practiced community mental health in Fayetteville, NC for 12 years and have observed every point Dr. Nasrallah made in “A skeptical view of ‘progress’ in psychiatry” (From the Editor, Current Psychiatry, June 2011, p. 18-19). As psychiatrists, we share a great deal of the blame. We handed over leadership of community mental health centers to social workers and allowed ourselves to be “carved out” of community hospitals. State hospitals are dysfunctional at best.

Dr. Nasrallah is correct in asking who is the “genius” behind these decisions. Many new psychiatric practices are based on family practice models of herding 60 to 80 patients per day. I’m not sure I will even recognize the practice of psychiatry in 10 to 20 years. Perhaps with obstinate rigor we can restore what we’ve lost.

Mark Chandler, MD
Medical Director
Cumberland County Mental Health Center
Fayetteville, NC

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‘Progress’ in psychiatry

I have practiced community mental health in Fayetteville, NC for 12 years and have observed every point Dr. Nasrallah made in “A skeptical view of ‘progress’ in psychiatry” (From the Editor, Current Psychiatry, June 2011, p. 18-19). As psychiatrists, we share a great deal of the blame. We handed over leadership of community mental health centers to social workers and allowed ourselves to be “carved out” of community hospitals. State hospitals are dysfunctional at best.

Dr. Nasrallah is correct in asking who is the “genius” behind these decisions. Many new psychiatric practices are based on family practice models of herding 60 to 80 patients per day. I’m not sure I will even recognize the practice of psychiatry in 10 to 20 years. Perhaps with obstinate rigor we can restore what we’ve lost.

Mark Chandler, MD
Medical Director
Cumberland County Mental Health Center
Fayetteville, NC

Missed progress

I, too, am concerned with the lack of recent progress in psychiatry. Nevertheless, Dr. Nasrallah is missing some of the progress he downplays (“A skeptical view of ‘progress’ in psychiatry,” From the Editor, Current Psychiatry, June 2011, p. 18-19). For instance, the discovery of chlorpromazine brought about concomitant serious side effects and homelessness, but many patients gained a life in society, which allowed some to become peer specialists, helping others with mental illness. Sure, insurance hassles for state hospitalization did not exist and hospitalization stays today often are much too short, but 40 years ago, state mental hospitals were so-called “snake pits” of overcrowding with excrement on the floor, and precious little treatment. Yes, in psychiatry we have more legal constraints, but in part this is a reflection of past coercive and unneeded hospitalizations.

I agree funding reductions have broken public mental health systems, but psychiatrists generally have preferred private practice with mentally healthier patients and sat quietly while other disciplines took over psychotherapies. I also don’t like the term “behavioral health,” but behavior can be measured, and we have precious few ways to measure progress and outcomes in psychiatry. Maybe pharmaceutical companies are abandoning drug development because they have been unsuccessful in developing novel medications in the last few decades, instead benefitting from serendipitous discoveries such as chlorpromazine. We may need new approaches to biologic treatments to progress any further, but this should not be surprising, given how difficult it is to access and study the brain

Steven Moffic, MD
Professor of Psychiatry
Medical College of Wisconsin
Milwaukee, WI

Focus on change

Dr. Nasrallah’s editorial (“A skeptical view of ‘progress’ in psychiatry,” From the Editor, Current Psychiatry, June 2011, p. 18-19) is intriguing because it summarized concerns I have seen frequently expressed in publications catering to psychiatrists. Since the advent of managed care, these kinds of “poor psychiatry” articles have appeared regularly.

Instead of bemoaning the lack of “progress” in psychiatry, perhaps Dr. Nasrallah would have been better served by focusing on change and its inevitability. I found it ridiculous he contrasted the “asylum era” with current practices in order to focus on length of stay. At that time, the mentally ill were—except for well-intentioned attempts at “cure” via “milieu therapy”—warehoused for years, if not lifetimes, under filthy conditions.

Dr. Nasrallah then segues into the expected attacks upon insurance companies, lack of parity, and drastically shortened lengths of stay. It is obvious 3 to 4 days of acute care generally is not sufficient for serious psychiatric conditions. As an experienced managed care and independent reviewer, I can assure Dr. Nasrallah such strict criteria sets are the minority. What about psychiatrists who keep patients until their insurance runs out or let relatively benign patients languish because they did not call attention to themselves and kept a bed filled? Contrary to Dr. Nasrallah’s assertion, judges and lawyers do not tell us how to practice medicine; they are part of a necessary system of checks and balances that, in a highly imperfect world, help prevent inappropriate or abusive practices by incompetent, uninvested, or morally deficient physicians, of which there are plenty.

Dr. Nasrallah should be aware terms such as “behavioral health” are largely the result of efforts to destigmatize mental illness, leading society to coin more politically correct and palatable terms for just about everything.

At no point does Dr. Nasrallah even hint at offering solutions. For example, psychiatrists have done next to nothing to educate the public about their profession. Meanwhile, a substantial number of prominent psychiatrists are more than happy to accept steak dinners and honoraria from drug companies, along with going out and speaking at free CME events, in order to oh-so-subtly hawk a medication that just happens to be manufactured by the company paying for the “free lunch.”

 

 

Forget about judges and lawyers “telling us how to practice.” What about “Big Pharma” manipulating us and advertising on television, urging viewers to “talk to their doctor” about medication X? Dr. Nasrallah is preaching to the choir here. What we need is less breast-beating and more constructive action.

Edward W. Darell, MD
Psychiatrist, Private Practice
New York, NY

Managed care woes

Regarding Dr. Nasrallah’s insightful editorial (“A skeptical view of ‘progress’ in psychiatry,” From the Editor, Current Psychiatry, June 2011, p. 18-19): Since the late 1980s and early 1990s, the Employment Retirement Income Security Act, has enabled managed “care” to exist, with failed attempts to repeal or limit the act. Managed “care” has worked hard to change our language, such as “primary care physician” instead of physician or doctor and “behavioral health” instead of psychiatric or mental health care. These changes minimize our importance, influence, and reimbursements as well as the medications and treatments we use. When it was obvious what was happening, we abdicated our responsibility and control to the kind of people Dr. Nasrallah described.

There will be more cuts on reimbursements and limits on us unless we say “no.” We are not allowed to organize, physicians in Congress have not helped, and our elected professional organization leaders have little influence. We can give in and accept the “inevitable,” but the Hippocratic Oath seems to preclude such irresponsibility. We can refuse to treat anyone, except in emergencies, unless we choose to do so in good conscience. We need to change and the law has to change. The people who control our health care are evil, immoral, and venal; why should they be dictating care?

Gerald A. Shubs, MD
Butler Behavioral Health Services
Hamilton, OH

Insidious progress

I love Dr. Nasrallah’s editorials, but none more so than his commentary in the June issue, “A skeptical view of ‘progress’ in psychiatry” (From the Editor, Current Psychiatry, June 2011, p. 18-19), in which he deftly highlights factors hindering the advancement of our profession. Clearly, his arguments come from the heart and speak directly to many psychiatrists’ concerns about what is happening in clinical settings.

I believe managed care has contributed to the proliferation of irrational polypharmacy. This is a consequence of clinicians who find themselves under unrealistic time pressures and cost constraints to come up with an expedient, “magical” treatment for acute hospitalized patients.

In reference to the comments about the phrase “behavioral health,” I have always objected to the pejorative term “providers” to refer to physicians. The designation “behavioral health providers” lumps psychiatrists and all other workers in the mental health field under the same umbrella, blurring the roles and identities of the different professions. Insurance companies further dismiss our psychiatric follow-ups as “medication management,” which ignores the broader, more specialized nature of our work with patients for the purpose of slashing fees. We often take these terms for granted, accepting them as nothing more than semantics or corporate jargon, but they are not so innocuous. We all should be aware of how these labels limit psychiatric practice and allow us to be subjugated by parties with financial motives.

On behalf of all of us who see the insidious side of the so-called progress being made in psychiatry, thank you for this insightful, well organized, and well written editorial.

Radwan F. Haykal, MD
Clinical Professor of Psychiatry
University of Tennessee Health Science Center
Memphis, TN

To tell the truth

I loved Dr. Nasrallah’s editorial in the June 2011 issue (“A skeptical view of ‘progress’ in psychiatry,” Current Psychiatry, June 2011, p. 18-19). It’s calling a spade a spade. This should be published as an op-ed piece in the New York Times or another national newspaper so the public can see the reality of the situation.

Royal Kiehl, MD
Psychiatrist, Private Practice
Anchorage, AK

Dr. Nasrallah responds

Thanks to all my colleagues who took the time to read and express their views, to agree or to challenge the tenets in my editorial that lamented the lack of progress in certain practice aspects of psychiatry. Current Psychiatry is a marketplace of updates, ideas, suggestions, critiques, and rebuttals. It is interesting psychiatrists who have worked for a long time with seriously mentally ill patients in hospitals or the community seem to feel the pain of the lack of steady progress and/or the slippage in some areas, while those who identify with the managed care model of care see things differently— ie, managed care is, in fact, progress.

We psychiatrists evaluate and treat patients in very diverse settings and perceive things through different prisms, which is why we have disparate views. No one has a monopoly on the truth, but we all have important common ground: we all share an intense loyalty to our suffering patients, and we all share pride in our noble profession regardless of its ups or downs. We know in our hearts psychiatry remains indispensable for the well-being of all citizens. Pass it on…

 

 

Henry A. Nasrallah, MD
Editor-in-Chief

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‘Progress’ in psychiatry

I have practiced community mental health in Fayetteville, NC for 12 years and have observed every point Dr. Nasrallah made in “A skeptical view of ‘progress’ in psychiatry” (From the Editor, Current Psychiatry, June 2011, p. 18-19). As psychiatrists, we share a great deal of the blame. We handed over leadership of community mental health centers to social workers and allowed ourselves to be “carved out” of community hospitals. State hospitals are dysfunctional at best.

Dr. Nasrallah is correct in asking who is the “genius” behind these decisions. Many new psychiatric practices are based on family practice models of herding 60 to 80 patients per day. I’m not sure I will even recognize the practice of psychiatry in 10 to 20 years. Perhaps with obstinate rigor we can restore what we’ve lost.

Mark Chandler, MD
Medical Director
Cumberland County Mental Health Center
Fayetteville, NC

Missed progress

I, too, am concerned with the lack of recent progress in psychiatry. Nevertheless, Dr. Nasrallah is missing some of the progress he downplays (“A skeptical view of ‘progress’ in psychiatry,” From the Editor, Current Psychiatry, June 2011, p. 18-19). For instance, the discovery of chlorpromazine brought about concomitant serious side effects and homelessness, but many patients gained a life in society, which allowed some to become peer specialists, helping others with mental illness. Sure, insurance hassles for state hospitalization did not exist and hospitalization stays today often are much too short, but 40 years ago, state mental hospitals were so-called “snake pits” of overcrowding with excrement on the floor, and precious little treatment. Yes, in psychiatry we have more legal constraints, but in part this is a reflection of past coercive and unneeded hospitalizations.

I agree funding reductions have broken public mental health systems, but psychiatrists generally have preferred private practice with mentally healthier patients and sat quietly while other disciplines took over psychotherapies. I also don’t like the term “behavioral health,” but behavior can be measured, and we have precious few ways to measure progress and outcomes in psychiatry. Maybe pharmaceutical companies are abandoning drug development because they have been unsuccessful in developing novel medications in the last few decades, instead benefitting from serendipitous discoveries such as chlorpromazine. We may need new approaches to biologic treatments to progress any further, but this should not be surprising, given how difficult it is to access and study the brain

Steven Moffic, MD
Professor of Psychiatry
Medical College of Wisconsin
Milwaukee, WI

Focus on change

Dr. Nasrallah’s editorial (“A skeptical view of ‘progress’ in psychiatry,” From the Editor, Current Psychiatry, June 2011, p. 18-19) is intriguing because it summarized concerns I have seen frequently expressed in publications catering to psychiatrists. Since the advent of managed care, these kinds of “poor psychiatry” articles have appeared regularly.

Instead of bemoaning the lack of “progress” in psychiatry, perhaps Dr. Nasrallah would have been better served by focusing on change and its inevitability. I found it ridiculous he contrasted the “asylum era” with current practices in order to focus on length of stay. At that time, the mentally ill were—except for well-intentioned attempts at “cure” via “milieu therapy”—warehoused for years, if not lifetimes, under filthy conditions.

Dr. Nasrallah then segues into the expected attacks upon insurance companies, lack of parity, and drastically shortened lengths of stay. It is obvious 3 to 4 days of acute care generally is not sufficient for serious psychiatric conditions. As an experienced managed care and independent reviewer, I can assure Dr. Nasrallah such strict criteria sets are the minority. What about psychiatrists who keep patients until their insurance runs out or let relatively benign patients languish because they did not call attention to themselves and kept a bed filled? Contrary to Dr. Nasrallah’s assertion, judges and lawyers do not tell us how to practice medicine; they are part of a necessary system of checks and balances that, in a highly imperfect world, help prevent inappropriate or abusive practices by incompetent, uninvested, or morally deficient physicians, of which there are plenty.

Dr. Nasrallah should be aware terms such as “behavioral health” are largely the result of efforts to destigmatize mental illness, leading society to coin more politically correct and palatable terms for just about everything.

At no point does Dr. Nasrallah even hint at offering solutions. For example, psychiatrists have done next to nothing to educate the public about their profession. Meanwhile, a substantial number of prominent psychiatrists are more than happy to accept steak dinners and honoraria from drug companies, along with going out and speaking at free CME events, in order to oh-so-subtly hawk a medication that just happens to be manufactured by the company paying for the “free lunch.”

 

 

Forget about judges and lawyers “telling us how to practice.” What about “Big Pharma” manipulating us and advertising on television, urging viewers to “talk to their doctor” about medication X? Dr. Nasrallah is preaching to the choir here. What we need is less breast-beating and more constructive action.

Edward W. Darell, MD
Psychiatrist, Private Practice
New York, NY

Managed care woes

Regarding Dr. Nasrallah’s insightful editorial (“A skeptical view of ‘progress’ in psychiatry,” From the Editor, Current Psychiatry, June 2011, p. 18-19): Since the late 1980s and early 1990s, the Employment Retirement Income Security Act, has enabled managed “care” to exist, with failed attempts to repeal or limit the act. Managed “care” has worked hard to change our language, such as “primary care physician” instead of physician or doctor and “behavioral health” instead of psychiatric or mental health care. These changes minimize our importance, influence, and reimbursements as well as the medications and treatments we use. When it was obvious what was happening, we abdicated our responsibility and control to the kind of people Dr. Nasrallah described.

There will be more cuts on reimbursements and limits on us unless we say “no.” We are not allowed to organize, physicians in Congress have not helped, and our elected professional organization leaders have little influence. We can give in and accept the “inevitable,” but the Hippocratic Oath seems to preclude such irresponsibility. We can refuse to treat anyone, except in emergencies, unless we choose to do so in good conscience. We need to change and the law has to change. The people who control our health care are evil, immoral, and venal; why should they be dictating care?

Gerald A. Shubs, MD
Butler Behavioral Health Services
Hamilton, OH

Insidious progress

I love Dr. Nasrallah’s editorials, but none more so than his commentary in the June issue, “A skeptical view of ‘progress’ in psychiatry” (From the Editor, Current Psychiatry, June 2011, p. 18-19), in which he deftly highlights factors hindering the advancement of our profession. Clearly, his arguments come from the heart and speak directly to many psychiatrists’ concerns about what is happening in clinical settings.

I believe managed care has contributed to the proliferation of irrational polypharmacy. This is a consequence of clinicians who find themselves under unrealistic time pressures and cost constraints to come up with an expedient, “magical” treatment for acute hospitalized patients.

In reference to the comments about the phrase “behavioral health,” I have always objected to the pejorative term “providers” to refer to physicians. The designation “behavioral health providers” lumps psychiatrists and all other workers in the mental health field under the same umbrella, blurring the roles and identities of the different professions. Insurance companies further dismiss our psychiatric follow-ups as “medication management,” which ignores the broader, more specialized nature of our work with patients for the purpose of slashing fees. We often take these terms for granted, accepting them as nothing more than semantics or corporate jargon, but they are not so innocuous. We all should be aware of how these labels limit psychiatric practice and allow us to be subjugated by parties with financial motives.

On behalf of all of us who see the insidious side of the so-called progress being made in psychiatry, thank you for this insightful, well organized, and well written editorial.

Radwan F. Haykal, MD
Clinical Professor of Psychiatry
University of Tennessee Health Science Center
Memphis, TN

To tell the truth

I loved Dr. Nasrallah’s editorial in the June 2011 issue (“A skeptical view of ‘progress’ in psychiatry,” Current Psychiatry, June 2011, p. 18-19). It’s calling a spade a spade. This should be published as an op-ed piece in the New York Times or another national newspaper so the public can see the reality of the situation.

Royal Kiehl, MD
Psychiatrist, Private Practice
Anchorage, AK

Dr. Nasrallah responds

Thanks to all my colleagues who took the time to read and express their views, to agree or to challenge the tenets in my editorial that lamented the lack of progress in certain practice aspects of psychiatry. Current Psychiatry is a marketplace of updates, ideas, suggestions, critiques, and rebuttals. It is interesting psychiatrists who have worked for a long time with seriously mentally ill patients in hospitals or the community seem to feel the pain of the lack of steady progress and/or the slippage in some areas, while those who identify with the managed care model of care see things differently— ie, managed care is, in fact, progress.

We psychiatrists evaluate and treat patients in very diverse settings and perceive things through different prisms, which is why we have disparate views. No one has a monopoly on the truth, but we all have important common ground: we all share an intense loyalty to our suffering patients, and we all share pride in our noble profession regardless of its ups or downs. We know in our hearts psychiatry remains indispensable for the well-being of all citizens. Pass it on…

 

 

Henry A. Nasrallah, MD
Editor-in-Chief

Discuss this article at www.facebook.com/CurrentPsychiatry

‘Progress’ in psychiatry

I have practiced community mental health in Fayetteville, NC for 12 years and have observed every point Dr. Nasrallah made in “A skeptical view of ‘progress’ in psychiatry” (From the Editor, Current Psychiatry, June 2011, p. 18-19). As psychiatrists, we share a great deal of the blame. We handed over leadership of community mental health centers to social workers and allowed ourselves to be “carved out” of community hospitals. State hospitals are dysfunctional at best.

Dr. Nasrallah is correct in asking who is the “genius” behind these decisions. Many new psychiatric practices are based on family practice models of herding 60 to 80 patients per day. I’m not sure I will even recognize the practice of psychiatry in 10 to 20 years. Perhaps with obstinate rigor we can restore what we’ve lost.

Mark Chandler, MD
Medical Director
Cumberland County Mental Health Center
Fayetteville, NC

Missed progress

I, too, am concerned with the lack of recent progress in psychiatry. Nevertheless, Dr. Nasrallah is missing some of the progress he downplays (“A skeptical view of ‘progress’ in psychiatry,” From the Editor, Current Psychiatry, June 2011, p. 18-19). For instance, the discovery of chlorpromazine brought about concomitant serious side effects and homelessness, but many patients gained a life in society, which allowed some to become peer specialists, helping others with mental illness. Sure, insurance hassles for state hospitalization did not exist and hospitalization stays today often are much too short, but 40 years ago, state mental hospitals were so-called “snake pits” of overcrowding with excrement on the floor, and precious little treatment. Yes, in psychiatry we have more legal constraints, but in part this is a reflection of past coercive and unneeded hospitalizations.

I agree funding reductions have broken public mental health systems, but psychiatrists generally have preferred private practice with mentally healthier patients and sat quietly while other disciplines took over psychotherapies. I also don’t like the term “behavioral health,” but behavior can be measured, and we have precious few ways to measure progress and outcomes in psychiatry. Maybe pharmaceutical companies are abandoning drug development because they have been unsuccessful in developing novel medications in the last few decades, instead benefitting from serendipitous discoveries such as chlorpromazine. We may need new approaches to biologic treatments to progress any further, but this should not be surprising, given how difficult it is to access and study the brain

Steven Moffic, MD
Professor of Psychiatry
Medical College of Wisconsin
Milwaukee, WI

Focus on change

Dr. Nasrallah’s editorial (“A skeptical view of ‘progress’ in psychiatry,” From the Editor, Current Psychiatry, June 2011, p. 18-19) is intriguing because it summarized concerns I have seen frequently expressed in publications catering to psychiatrists. Since the advent of managed care, these kinds of “poor psychiatry” articles have appeared regularly.

Instead of bemoaning the lack of “progress” in psychiatry, perhaps Dr. Nasrallah would have been better served by focusing on change and its inevitability. I found it ridiculous he contrasted the “asylum era” with current practices in order to focus on length of stay. At that time, the mentally ill were—except for well-intentioned attempts at “cure” via “milieu therapy”—warehoused for years, if not lifetimes, under filthy conditions.

Dr. Nasrallah then segues into the expected attacks upon insurance companies, lack of parity, and drastically shortened lengths of stay. It is obvious 3 to 4 days of acute care generally is not sufficient for serious psychiatric conditions. As an experienced managed care and independent reviewer, I can assure Dr. Nasrallah such strict criteria sets are the minority. What about psychiatrists who keep patients until their insurance runs out or let relatively benign patients languish because they did not call attention to themselves and kept a bed filled? Contrary to Dr. Nasrallah’s assertion, judges and lawyers do not tell us how to practice medicine; they are part of a necessary system of checks and balances that, in a highly imperfect world, help prevent inappropriate or abusive practices by incompetent, uninvested, or morally deficient physicians, of which there are plenty.

Dr. Nasrallah should be aware terms such as “behavioral health” are largely the result of efforts to destigmatize mental illness, leading society to coin more politically correct and palatable terms for just about everything.

At no point does Dr. Nasrallah even hint at offering solutions. For example, psychiatrists have done next to nothing to educate the public about their profession. Meanwhile, a substantial number of prominent psychiatrists are more than happy to accept steak dinners and honoraria from drug companies, along with going out and speaking at free CME events, in order to oh-so-subtly hawk a medication that just happens to be manufactured by the company paying for the “free lunch.”

 

 

Forget about judges and lawyers “telling us how to practice.” What about “Big Pharma” manipulating us and advertising on television, urging viewers to “talk to their doctor” about medication X? Dr. Nasrallah is preaching to the choir here. What we need is less breast-beating and more constructive action.

Edward W. Darell, MD
Psychiatrist, Private Practice
New York, NY

Managed care woes

Regarding Dr. Nasrallah’s insightful editorial (“A skeptical view of ‘progress’ in psychiatry,” From the Editor, Current Psychiatry, June 2011, p. 18-19): Since the late 1980s and early 1990s, the Employment Retirement Income Security Act, has enabled managed “care” to exist, with failed attempts to repeal or limit the act. Managed “care” has worked hard to change our language, such as “primary care physician” instead of physician or doctor and “behavioral health” instead of psychiatric or mental health care. These changes minimize our importance, influence, and reimbursements as well as the medications and treatments we use. When it was obvious what was happening, we abdicated our responsibility and control to the kind of people Dr. Nasrallah described.

There will be more cuts on reimbursements and limits on us unless we say “no.” We are not allowed to organize, physicians in Congress have not helped, and our elected professional organization leaders have little influence. We can give in and accept the “inevitable,” but the Hippocratic Oath seems to preclude such irresponsibility. We can refuse to treat anyone, except in emergencies, unless we choose to do so in good conscience. We need to change and the law has to change. The people who control our health care are evil, immoral, and venal; why should they be dictating care?

Gerald A. Shubs, MD
Butler Behavioral Health Services
Hamilton, OH

Insidious progress

I love Dr. Nasrallah’s editorials, but none more so than his commentary in the June issue, “A skeptical view of ‘progress’ in psychiatry” (From the Editor, Current Psychiatry, June 2011, p. 18-19), in which he deftly highlights factors hindering the advancement of our profession. Clearly, his arguments come from the heart and speak directly to many psychiatrists’ concerns about what is happening in clinical settings.

I believe managed care has contributed to the proliferation of irrational polypharmacy. This is a consequence of clinicians who find themselves under unrealistic time pressures and cost constraints to come up with an expedient, “magical” treatment for acute hospitalized patients.

In reference to the comments about the phrase “behavioral health,” I have always objected to the pejorative term “providers” to refer to physicians. The designation “behavioral health providers” lumps psychiatrists and all other workers in the mental health field under the same umbrella, blurring the roles and identities of the different professions. Insurance companies further dismiss our psychiatric follow-ups as “medication management,” which ignores the broader, more specialized nature of our work with patients for the purpose of slashing fees. We often take these terms for granted, accepting them as nothing more than semantics or corporate jargon, but they are not so innocuous. We all should be aware of how these labels limit psychiatric practice and allow us to be subjugated by parties with financial motives.

On behalf of all of us who see the insidious side of the so-called progress being made in psychiatry, thank you for this insightful, well organized, and well written editorial.

Radwan F. Haykal, MD
Clinical Professor of Psychiatry
University of Tennessee Health Science Center
Memphis, TN

To tell the truth

I loved Dr. Nasrallah’s editorial in the June 2011 issue (“A skeptical view of ‘progress’ in psychiatry,” Current Psychiatry, June 2011, p. 18-19). It’s calling a spade a spade. This should be published as an op-ed piece in the New York Times or another national newspaper so the public can see the reality of the situation.

Royal Kiehl, MD
Psychiatrist, Private Practice
Anchorage, AK

Dr. Nasrallah responds

Thanks to all my colleagues who took the time to read and express their views, to agree or to challenge the tenets in my editorial that lamented the lack of progress in certain practice aspects of psychiatry. Current Psychiatry is a marketplace of updates, ideas, suggestions, critiques, and rebuttals. It is interesting psychiatrists who have worked for a long time with seriously mentally ill patients in hospitals or the community seem to feel the pain of the lack of steady progress and/or the slippage in some areas, while those who identify with the managed care model of care see things differently— ie, managed care is, in fact, progress.

We psychiatrists evaluate and treat patients in very diverse settings and perceive things through different prisms, which is why we have disparate views. No one has a monopoly on the truth, but we all have important common ground: we all share an intense loyalty to our suffering patients, and we all share pride in our noble profession regardless of its ups or downs. We know in our hearts psychiatry remains indispensable for the well-being of all citizens. Pass it on…

 

 

Henry A. Nasrallah, MD
Editor-in-Chief

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A psychiatric approach to vasovagal syncope

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Vasovagal syncope—also called neurocardiogenic syncope—is a brief loss of consciousness caused by a sudden drop in heart rate and blood pressure usually diagnosed and treated by a cardiologist. Psychiatrists rarely are consulted in such cases, but evidence suggests these patients often have comorbid psychiatric disorders.1 Psychiatrists can aid cardiologists in treating patients troubled by recurring episodes of vasovagal syncope.

Similar to panic disorder, vasovagal syncope can occur following a trigger or without any warning. After an initial event, vasovagal syncope episodes may never occur again, may occur occasionally, or may be frequent. Cardiologists use Holter monitoring, echocardiography, laboratory testing, stress testing, tilt table monitoring, and other methods to rule out cardiac causes of syncope. For patients whom a cardiac or neurologic cause cannot be determined, there is no recommended treatment, although beta blockers commonly are used.2

I suggest a protocol that includes psychiatric evaluation, pharmacotherapy, cognitive-behavioral therapy (CBT), and patient education.

Psychiatric evaluation. Because psychiatric disorders often accompany vasovagal syncope, patients should undergo a thorough psychiatric evaluation, and any comorbid psychiatric disorders should be addressed according to current treatment guidelines.

Pharmacotherapy. Because serotonin (5-HT) may play a key role in blood pressure regulation and vasovagal syncope,2 a selective serotonin reuptake inhibitor (SSRI) may be an option. Evidence suggests paroxetine and sertraline may help prevent vasovagal syncope, and other SSRIs may share this benefit.3 In 1 nonrandomized trial of 74 patients with a history of vasovagal syncope, amitriptyline prevented recurrent episodes.4 In a small trial, sublingual lorazepam, 2 to 4 mg, prevented vasovagal attacks in patients undergoing a procedure that previously triggered syncope.5

CBT can help patients identify and modify thoughts that trigger syncope. In a small case series, CBT led to significant reductions in syncopal episodes.6 Educate patients about environmental triggers of vasovagal events they can avoid, such as dehydration, hot rooms, long periods of standing, and emotional events. Patients who have known triggers that usually cannot be avoided, such as the sight of blood and other conditioned responses, may be helped by behavioral therapies such as systematic desensitization. Patients with known body triggers may be able to take prophylactic medication—for example, patients who are known to faint when nauseous may be able to take prochlorperazine to prevent a syncopal episode.

Patient education. Patients who experience presyncopal symptoms such as lightheadedness, visual dimming, nausea, and weakness should be instructed to lie down on the floor with their legs up at the first sign of an impending episode. If sitting, they can put their head between their knees. Progressive relaxation should be avoided. Patients might be able to block an episode by crossing their legs and tensing their muscles.7

Disclosure

Dr. LaFerney reports no financial relationship with any company whose products are mentioned in this article or with manufacturers of competing products.

References

1. Leftheriotis D, Michopoulos I, Flevari P, et al. Minor psychiatric disorders and syncope: the role of psychopathology in the expression of vasovagal reflex. Psychother Psychosom. 2008;77(6):372-376.

2. White CM, Tsikouris JP. A review of pathophysiology and therapy of patients with vasovagal syncope. Pharmacotherapy. 2000;20(2):158-165.

3. Stone KJ, Viera AJ, Parman CL. Off-label applications for SSRIs. Am Fam Physician. 2003;68(3):498-504.

4. Baris Kaya E, Abali G, Aytemir K, et al. Preliminary observations on the effect of amitriptyline treatment in preventing syncope recurrence in patients with vasovagel syncope. Ann Noninvasive Electrocardiol. 2007;12(2):153-157.

5. James JJ, Wilson AR, Evans AJ, et al. The use of a short-acting benzodiazepine to reduce the risk of syncopal episodes during upright stereotactic breast biopsy. Clin Radiol. 2005;60(3):394-396.

6. Newton JL, Kenny RA, Baker CR. Cognitive behavioural therapy as a potential treatment for vasovagal/neurocardiogenic syncope—a pilot study. Europace. 2003;5(3):299-301.

7. Krediet CT, van Dijk N, Linzer M, et al. Management of vasovagal syncope: controlling or aborting faints by leg crossing and muscle tensing. Circulation. 2002;106(13):1684-1689.

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Vasovagal syncope—also called neurocardiogenic syncope—is a brief loss of consciousness caused by a sudden drop in heart rate and blood pressure usually diagnosed and treated by a cardiologist. Psychiatrists rarely are consulted in such cases, but evidence suggests these patients often have comorbid psychiatric disorders.1 Psychiatrists can aid cardiologists in treating patients troubled by recurring episodes of vasovagal syncope.

Similar to panic disorder, vasovagal syncope can occur following a trigger or without any warning. After an initial event, vasovagal syncope episodes may never occur again, may occur occasionally, or may be frequent. Cardiologists use Holter monitoring, echocardiography, laboratory testing, stress testing, tilt table monitoring, and other methods to rule out cardiac causes of syncope. For patients whom a cardiac or neurologic cause cannot be determined, there is no recommended treatment, although beta blockers commonly are used.2

I suggest a protocol that includes psychiatric evaluation, pharmacotherapy, cognitive-behavioral therapy (CBT), and patient education.

Psychiatric evaluation. Because psychiatric disorders often accompany vasovagal syncope, patients should undergo a thorough psychiatric evaluation, and any comorbid psychiatric disorders should be addressed according to current treatment guidelines.

Pharmacotherapy. Because serotonin (5-HT) may play a key role in blood pressure regulation and vasovagal syncope,2 a selective serotonin reuptake inhibitor (SSRI) may be an option. Evidence suggests paroxetine and sertraline may help prevent vasovagal syncope, and other SSRIs may share this benefit.3 In 1 nonrandomized trial of 74 patients with a history of vasovagal syncope, amitriptyline prevented recurrent episodes.4 In a small trial, sublingual lorazepam, 2 to 4 mg, prevented vasovagal attacks in patients undergoing a procedure that previously triggered syncope.5

CBT can help patients identify and modify thoughts that trigger syncope. In a small case series, CBT led to significant reductions in syncopal episodes.6 Educate patients about environmental triggers of vasovagal events they can avoid, such as dehydration, hot rooms, long periods of standing, and emotional events. Patients who have known triggers that usually cannot be avoided, such as the sight of blood and other conditioned responses, may be helped by behavioral therapies such as systematic desensitization. Patients with known body triggers may be able to take prophylactic medication—for example, patients who are known to faint when nauseous may be able to take prochlorperazine to prevent a syncopal episode.

Patient education. Patients who experience presyncopal symptoms such as lightheadedness, visual dimming, nausea, and weakness should be instructed to lie down on the floor with their legs up at the first sign of an impending episode. If sitting, they can put their head between their knees. Progressive relaxation should be avoided. Patients might be able to block an episode by crossing their legs and tensing their muscles.7

Disclosure

Dr. LaFerney reports no financial relationship with any company whose products are mentioned in this article or with manufacturers of competing products.

Discuss this article at www.facebook.com/CurrentPsychiatry

Vasovagal syncope—also called neurocardiogenic syncope—is a brief loss of consciousness caused by a sudden drop in heart rate and blood pressure usually diagnosed and treated by a cardiologist. Psychiatrists rarely are consulted in such cases, but evidence suggests these patients often have comorbid psychiatric disorders.1 Psychiatrists can aid cardiologists in treating patients troubled by recurring episodes of vasovagal syncope.

Similar to panic disorder, vasovagal syncope can occur following a trigger or without any warning. After an initial event, vasovagal syncope episodes may never occur again, may occur occasionally, or may be frequent. Cardiologists use Holter monitoring, echocardiography, laboratory testing, stress testing, tilt table monitoring, and other methods to rule out cardiac causes of syncope. For patients whom a cardiac or neurologic cause cannot be determined, there is no recommended treatment, although beta blockers commonly are used.2

I suggest a protocol that includes psychiatric evaluation, pharmacotherapy, cognitive-behavioral therapy (CBT), and patient education.

Psychiatric evaluation. Because psychiatric disorders often accompany vasovagal syncope, patients should undergo a thorough psychiatric evaluation, and any comorbid psychiatric disorders should be addressed according to current treatment guidelines.

Pharmacotherapy. Because serotonin (5-HT) may play a key role in blood pressure regulation and vasovagal syncope,2 a selective serotonin reuptake inhibitor (SSRI) may be an option. Evidence suggests paroxetine and sertraline may help prevent vasovagal syncope, and other SSRIs may share this benefit.3 In 1 nonrandomized trial of 74 patients with a history of vasovagal syncope, amitriptyline prevented recurrent episodes.4 In a small trial, sublingual lorazepam, 2 to 4 mg, prevented vasovagal attacks in patients undergoing a procedure that previously triggered syncope.5

CBT can help patients identify and modify thoughts that trigger syncope. In a small case series, CBT led to significant reductions in syncopal episodes.6 Educate patients about environmental triggers of vasovagal events they can avoid, such as dehydration, hot rooms, long periods of standing, and emotional events. Patients who have known triggers that usually cannot be avoided, such as the sight of blood and other conditioned responses, may be helped by behavioral therapies such as systematic desensitization. Patients with known body triggers may be able to take prophylactic medication—for example, patients who are known to faint when nauseous may be able to take prochlorperazine to prevent a syncopal episode.

Patient education. Patients who experience presyncopal symptoms such as lightheadedness, visual dimming, nausea, and weakness should be instructed to lie down on the floor with their legs up at the first sign of an impending episode. If sitting, they can put their head between their knees. Progressive relaxation should be avoided. Patients might be able to block an episode by crossing their legs and tensing their muscles.7

Disclosure

Dr. LaFerney reports no financial relationship with any company whose products are mentioned in this article or with manufacturers of competing products.

References

1. Leftheriotis D, Michopoulos I, Flevari P, et al. Minor psychiatric disorders and syncope: the role of psychopathology in the expression of vasovagal reflex. Psychother Psychosom. 2008;77(6):372-376.

2. White CM, Tsikouris JP. A review of pathophysiology and therapy of patients with vasovagal syncope. Pharmacotherapy. 2000;20(2):158-165.

3. Stone KJ, Viera AJ, Parman CL. Off-label applications for SSRIs. Am Fam Physician. 2003;68(3):498-504.

4. Baris Kaya E, Abali G, Aytemir K, et al. Preliminary observations on the effect of amitriptyline treatment in preventing syncope recurrence in patients with vasovagel syncope. Ann Noninvasive Electrocardiol. 2007;12(2):153-157.

5. James JJ, Wilson AR, Evans AJ, et al. The use of a short-acting benzodiazepine to reduce the risk of syncopal episodes during upright stereotactic breast biopsy. Clin Radiol. 2005;60(3):394-396.

6. Newton JL, Kenny RA, Baker CR. Cognitive behavioural therapy as a potential treatment for vasovagal/neurocardiogenic syncope—a pilot study. Europace. 2003;5(3):299-301.

7. Krediet CT, van Dijk N, Linzer M, et al. Management of vasovagal syncope: controlling or aborting faints by leg crossing and muscle tensing. Circulation. 2002;106(13):1684-1689.

References

1. Leftheriotis D, Michopoulos I, Flevari P, et al. Minor psychiatric disorders and syncope: the role of psychopathology in the expression of vasovagal reflex. Psychother Psychosom. 2008;77(6):372-376.

2. White CM, Tsikouris JP. A review of pathophysiology and therapy of patients with vasovagal syncope. Pharmacotherapy. 2000;20(2):158-165.

3. Stone KJ, Viera AJ, Parman CL. Off-label applications for SSRIs. Am Fam Physician. 2003;68(3):498-504.

4. Baris Kaya E, Abali G, Aytemir K, et al. Preliminary observations on the effect of amitriptyline treatment in preventing syncope recurrence in patients with vasovagel syncope. Ann Noninvasive Electrocardiol. 2007;12(2):153-157.

5. James JJ, Wilson AR, Evans AJ, et al. The use of a short-acting benzodiazepine to reduce the risk of syncopal episodes during upright stereotactic breast biopsy. Clin Radiol. 2005;60(3):394-396.

6. Newton JL, Kenny RA, Baker CR. Cognitive behavioural therapy as a potential treatment for vasovagal/neurocardiogenic syncope—a pilot study. Europace. 2003;5(3):299-301.

7. Krediet CT, van Dijk N, Linzer M, et al. Management of vasovagal syncope: controlling or aborting faints by leg crossing and muscle tensing. Circulation. 2002;106(13):1684-1689.

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Managing boundaries when your patients are your neighbors

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Psychiatrists—especially residents—often prefer to reside close to the hospitals in which they train and work. Training programs in urban settings may offer their residents housing either attached to the hospital or immediately adjacent to it.

Psychiatry residents often discover their most ill patients also prefer to live close to the hospital. They become acquainted with their neighbors on the streets and in the emergency room. As a consequence, new residents must learn how to maintain appropriate boundaries in these situations.

Patients as neighbors

Chronic psychiatric patients are likely to utilize the services of the closest hospital. Individuals with severe mental illness seem especially prone to move to and live in areas near a hospital. For example, a study of VA patients with schizophrenia, bipolar disorder, and depression found those with schizophrenia and bipolar disorder were more likely to move closer to their health care providers.1 Also, many hospitals and training programs are located in inner-city areas, where individuals with severe mental illness are known to cluster.2-4

Managing boundaries

When encountering their chronically mentally ill patients on the street, psychiatric residents could have a host of reactions—ranging from becoming over-involved in their patients’ lives to completely avoiding them—that could cause them and their patients significant distress. The literature on boundary management in these situations is immense, and conclusions often are nebulous. Most authors suggest if a psychiatrist encounters a patient outside of the office, he or she should follow the patient’s lead while trying to avoid discussing the patient’s problems in public.5

It is important for residency training programs to educate residents on how to manage these professional boundaries. Residents should seek out support from their training department when they encounter these difficult situations.

Disclosure

The authors report no financial relationship with any company whose products are mentioned in this article or with manufacturers of competing products.

References

1. McCarthy JF, Valenstein M, Blow FC. Residential mobility among patients in the VA health system: associations with psychiatric morbidity geographic accessibility, and continuity of care. Adm Policy Ment Health. 2007;34(5):448-455.

2. DeVerteuil G, Hinds A, Lix L, et al. Mental health and the city: intra-urban mobility among individuals with schizophrenia. Health Place. 2007;13(2):310-323.

3. Almog M, Curtis S, Copeland A, et al. Geographical variation in acute psychiatric admissions within New York City 1990-2000: growing inequalities in service use? Soc Sci Med. 2004;59(2):361-376.

4. Silver E, Mulvey EP, Swanson JW. Neighborhood structural characteristic and mental disorder: Faris and Dunham revisited. Soc Sci Med. 2002;55(8):1457-1470.

5. MacKinnon RA, Michels R, Buckley PJ. The psychiatric interview in clinical practice. 2nd ed. Arlington VA: American Psychiatric Publishing Inc.; 2006.

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Psychiatrists—especially residents—often prefer to reside close to the hospitals in which they train and work. Training programs in urban settings may offer their residents housing either attached to the hospital or immediately adjacent to it.

Psychiatry residents often discover their most ill patients also prefer to live close to the hospital. They become acquainted with their neighbors on the streets and in the emergency room. As a consequence, new residents must learn how to maintain appropriate boundaries in these situations.

Patients as neighbors

Chronic psychiatric patients are likely to utilize the services of the closest hospital. Individuals with severe mental illness seem especially prone to move to and live in areas near a hospital. For example, a study of VA patients with schizophrenia, bipolar disorder, and depression found those with schizophrenia and bipolar disorder were more likely to move closer to their health care providers.1 Also, many hospitals and training programs are located in inner-city areas, where individuals with severe mental illness are known to cluster.2-4

Managing boundaries

When encountering their chronically mentally ill patients on the street, psychiatric residents could have a host of reactions—ranging from becoming over-involved in their patients’ lives to completely avoiding them—that could cause them and their patients significant distress. The literature on boundary management in these situations is immense, and conclusions often are nebulous. Most authors suggest if a psychiatrist encounters a patient outside of the office, he or she should follow the patient’s lead while trying to avoid discussing the patient’s problems in public.5

It is important for residency training programs to educate residents on how to manage these professional boundaries. Residents should seek out support from their training department when they encounter these difficult situations.

Disclosure

The authors report no financial relationship with any company whose products are mentioned in this article or with manufacturers of competing products.

Discuss this article at www.facebook.com/CurrentPsychiatry

Psychiatrists—especially residents—often prefer to reside close to the hospitals in which they train and work. Training programs in urban settings may offer their residents housing either attached to the hospital or immediately adjacent to it.

Psychiatry residents often discover their most ill patients also prefer to live close to the hospital. They become acquainted with their neighbors on the streets and in the emergency room. As a consequence, new residents must learn how to maintain appropriate boundaries in these situations.

Patients as neighbors

Chronic psychiatric patients are likely to utilize the services of the closest hospital. Individuals with severe mental illness seem especially prone to move to and live in areas near a hospital. For example, a study of VA patients with schizophrenia, bipolar disorder, and depression found those with schizophrenia and bipolar disorder were more likely to move closer to their health care providers.1 Also, many hospitals and training programs are located in inner-city areas, where individuals with severe mental illness are known to cluster.2-4

Managing boundaries

When encountering their chronically mentally ill patients on the street, psychiatric residents could have a host of reactions—ranging from becoming over-involved in their patients’ lives to completely avoiding them—that could cause them and their patients significant distress. The literature on boundary management in these situations is immense, and conclusions often are nebulous. Most authors suggest if a psychiatrist encounters a patient outside of the office, he or she should follow the patient’s lead while trying to avoid discussing the patient’s problems in public.5

It is important for residency training programs to educate residents on how to manage these professional boundaries. Residents should seek out support from their training department when they encounter these difficult situations.

Disclosure

The authors report no financial relationship with any company whose products are mentioned in this article or with manufacturers of competing products.

References

1. McCarthy JF, Valenstein M, Blow FC. Residential mobility among patients in the VA health system: associations with psychiatric morbidity geographic accessibility, and continuity of care. Adm Policy Ment Health. 2007;34(5):448-455.

2. DeVerteuil G, Hinds A, Lix L, et al. Mental health and the city: intra-urban mobility among individuals with schizophrenia. Health Place. 2007;13(2):310-323.

3. Almog M, Curtis S, Copeland A, et al. Geographical variation in acute psychiatric admissions within New York City 1990-2000: growing inequalities in service use? Soc Sci Med. 2004;59(2):361-376.

4. Silver E, Mulvey EP, Swanson JW. Neighborhood structural characteristic and mental disorder: Faris and Dunham revisited. Soc Sci Med. 2002;55(8):1457-1470.

5. MacKinnon RA, Michels R, Buckley PJ. The psychiatric interview in clinical practice. 2nd ed. Arlington VA: American Psychiatric Publishing Inc.; 2006.

References

1. McCarthy JF, Valenstein M, Blow FC. Residential mobility among patients in the VA health system: associations with psychiatric morbidity geographic accessibility, and continuity of care. Adm Policy Ment Health. 2007;34(5):448-455.

2. DeVerteuil G, Hinds A, Lix L, et al. Mental health and the city: intra-urban mobility among individuals with schizophrenia. Health Place. 2007;13(2):310-323.

3. Almog M, Curtis S, Copeland A, et al. Geographical variation in acute psychiatric admissions within New York City 1990-2000: growing inequalities in service use? Soc Sci Med. 2004;59(2):361-376.

4. Silver E, Mulvey EP, Swanson JW. Neighborhood structural characteristic and mental disorder: Faris and Dunham revisited. Soc Sci Med. 2002;55(8):1457-1470.

5. MacKinnon RA, Michels R, Buckley PJ. The psychiatric interview in clinical practice. 2nd ed. Arlington VA: American Psychiatric Publishing Inc.; 2006.

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The most powerful placebo is not a pill

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The placebo effect—when a patient’s symptoms improve with an inert pill—is widely recognized in medicine. Placebo has an especially important role in psychiatry, especially given the fact that a substantial proportion of patients with mood, anxiety, or psychotic disorders improve and experience some side effects with placebo in double-blind studies conducted by drug manufacturers as part of FDA registration trials.

On the other hand, non-psychiatric medical disorders such as pneumonia and diabetes are unlikely to improve with placebo. Thus, psychiatric brain disorders appear to be particularly susceptible to the placebo effect, which implies it could be harnessed in psychiatric care. A component of every medication prescribed in psychiatry is a variable placebo effect in addition to the actual pharmacodynamic effects.

Some physicians (including non-psychiatrists) openly admit to using placebo—which is sold as Obecalp capsules—to treat patients with vague aches, pains, insomnia, or low energy. Some published studies have shown patients respond to inert pills even when the physician tells them in advance they will be receiving a placebo!1 This reflects the power of the placebo effect programmed in the human brain, which may have an evolutionary advantage of instilling hope and sustaining faith things will get better despite serious physical or psychological adversity.

What health care professionals often overlook is that the placebo effect transcends the pill itself. The most powerful placebo is the psychiatrist or nurse practitioner who prescribes the pill. In fact, the placebo effect of a clinician occurs even without prescribing any medication.

The shape and color of a placebo pill may endow it with a greater effect (eg, a red and blue striped placebo caplet looks more impressive and may project an aura of being more effective than a plain white tablet). Similarly, a patient is influenced positively or negatively by a range of attributes that characterize his or her psychiatrist, and the totality of the impressions (positive or negative) the psychiatrist “projects” may enhance or detract from whatever treatment is administered, including medication or psychotherapy. This is why different prescribers may achieve disparate results when prescribing the same psychotropic.

Many subtle and not-so-subtle verbal and nonverbal aspects of a clinician can project an “aura” of competence and trust for the patient, which will contribute to a better treatment outcome because of the patient’s stronger unconscious expectation of improvement. These include the psychiatrist’s grooming and clothing, his facial expression and demeanor, the neatness of his desk, the décor of his office, the cleanliness of the waiting room, even the appearance of the neighborhood where his clinic is located. Wearing a white coat instead of street clothes can evoke the image of a physician/healer, which is a strong positive placebo effect that can be exploited for many patients. Direct eye contact an open body posture, a firm, reassuring voice, and a handshake or caring pat on the back at the end of the session when appropriate all contribute to patient improvement even before he or she ingests any pills. A psychiatrist can enhance the response and tolerability of a drug by expressing confidence in the medication and assuring the patient if taken as prescribed the medication will help and will be tolerable according to published studies. Even slight uncertainty by the psychiatrist about the potential usefulness of a medication—even if realistic—may compromise the patient’s response.

Take the following extreme illustration of a psychiatrist whose image projects a powerful negative placebo effect that could undermine therapeutic outcome and even patient adherence: Dr. X works in a dilapidated building in a downtrodden neighborhood. Several furniture pieces in his waiting room are torn or broken. The carpet is worn and features several stains. His office is poorly lit and reeks of mildew and stale cigarette butts. He barely looks at the patient but types on a laptop as the patient speaks. Dr. X is dressed in a casual sports shirt and blue jeans. His hair is disheveled. The floor of his office is littered with piles of journals and books. Dr. X speaks in a hurried, impatient tone and often interrupts the patient to ask a barrage of questions unrelated to what the patient was talking about. Occasionally, Dr. X stops typing, leans back in his worn creaky chair, crosses his arms, and just stares at the patient. He then abruptly ends the session because “there are many other patients waiting.” He scribbles a prescription, slides it over the desk to the patient, and says “Here, take this until next visit and we’ll see if it works for you.” The psychiatrist never leaves his chair and keeps typing as the patient dejectedly leaves the office.

Dr. X clearly has squandered the valuable placebo effect inherent in his role that not only can enhance the medication efficacy but also usually bolsters the therapeutic alliance. The many negative aspects of his demeanor, behavior, relatedness, and office probably will decrease the likelihood of a good outcome in his patient

Every clinician can achieve better treatment results by creating a set of positive personal and environmental cues to reinforce that powerful and intangible force that expedites the relief of psychiatric symptoms. It would be folly to squander the remarkable placebo inherent in us “healers.”

References

 

1. Kaptchuk TJ, Friedlander E, Kelley JM, et al. Placebos without deception: a randomized controlled trial in irritable bowel syndrome. PLoS One. 2010;5(12):1-7.

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The placebo effect—when a patient’s symptoms improve with an inert pill—is widely recognized in medicine. Placebo has an especially important role in psychiatry, especially given the fact that a substantial proportion of patients with mood, anxiety, or psychotic disorders improve and experience some side effects with placebo in double-blind studies conducted by drug manufacturers as part of FDA registration trials.

On the other hand, non-psychiatric medical disorders such as pneumonia and diabetes are unlikely to improve with placebo. Thus, psychiatric brain disorders appear to be particularly susceptible to the placebo effect, which implies it could be harnessed in psychiatric care. A component of every medication prescribed in psychiatry is a variable placebo effect in addition to the actual pharmacodynamic effects.

Some physicians (including non-psychiatrists) openly admit to using placebo—which is sold as Obecalp capsules—to treat patients with vague aches, pains, insomnia, or low energy. Some published studies have shown patients respond to inert pills even when the physician tells them in advance they will be receiving a placebo!1 This reflects the power of the placebo effect programmed in the human brain, which may have an evolutionary advantage of instilling hope and sustaining faith things will get better despite serious physical or psychological adversity.

What health care professionals often overlook is that the placebo effect transcends the pill itself. The most powerful placebo is the psychiatrist or nurse practitioner who prescribes the pill. In fact, the placebo effect of a clinician occurs even without prescribing any medication.

The shape and color of a placebo pill may endow it with a greater effect (eg, a red and blue striped placebo caplet looks more impressive and may project an aura of being more effective than a plain white tablet). Similarly, a patient is influenced positively or negatively by a range of attributes that characterize his or her psychiatrist, and the totality of the impressions (positive or negative) the psychiatrist “projects” may enhance or detract from whatever treatment is administered, including medication or psychotherapy. This is why different prescribers may achieve disparate results when prescribing the same psychotropic.

Many subtle and not-so-subtle verbal and nonverbal aspects of a clinician can project an “aura” of competence and trust for the patient, which will contribute to a better treatment outcome because of the patient’s stronger unconscious expectation of improvement. These include the psychiatrist’s grooming and clothing, his facial expression and demeanor, the neatness of his desk, the décor of his office, the cleanliness of the waiting room, even the appearance of the neighborhood where his clinic is located. Wearing a white coat instead of street clothes can evoke the image of a physician/healer, which is a strong positive placebo effect that can be exploited for many patients. Direct eye contact an open body posture, a firm, reassuring voice, and a handshake or caring pat on the back at the end of the session when appropriate all contribute to patient improvement even before he or she ingests any pills. A psychiatrist can enhance the response and tolerability of a drug by expressing confidence in the medication and assuring the patient if taken as prescribed the medication will help and will be tolerable according to published studies. Even slight uncertainty by the psychiatrist about the potential usefulness of a medication—even if realistic—may compromise the patient’s response.

Take the following extreme illustration of a psychiatrist whose image projects a powerful negative placebo effect that could undermine therapeutic outcome and even patient adherence: Dr. X works in a dilapidated building in a downtrodden neighborhood. Several furniture pieces in his waiting room are torn or broken. The carpet is worn and features several stains. His office is poorly lit and reeks of mildew and stale cigarette butts. He barely looks at the patient but types on a laptop as the patient speaks. Dr. X is dressed in a casual sports shirt and blue jeans. His hair is disheveled. The floor of his office is littered with piles of journals and books. Dr. X speaks in a hurried, impatient tone and often interrupts the patient to ask a barrage of questions unrelated to what the patient was talking about. Occasionally, Dr. X stops typing, leans back in his worn creaky chair, crosses his arms, and just stares at the patient. He then abruptly ends the session because “there are many other patients waiting.” He scribbles a prescription, slides it over the desk to the patient, and says “Here, take this until next visit and we’ll see if it works for you.” The psychiatrist never leaves his chair and keeps typing as the patient dejectedly leaves the office.

Dr. X clearly has squandered the valuable placebo effect inherent in his role that not only can enhance the medication efficacy but also usually bolsters the therapeutic alliance. The many negative aspects of his demeanor, behavior, relatedness, and office probably will decrease the likelihood of a good outcome in his patient

Every clinician can achieve better treatment results by creating a set of positive personal and environmental cues to reinforce that powerful and intangible force that expedites the relief of psychiatric symptoms. It would be folly to squander the remarkable placebo inherent in us “healers.”

The placebo effect—when a patient’s symptoms improve with an inert pill—is widely recognized in medicine. Placebo has an especially important role in psychiatry, especially given the fact that a substantial proportion of patients with mood, anxiety, or psychotic disorders improve and experience some side effects with placebo in double-blind studies conducted by drug manufacturers as part of FDA registration trials.

On the other hand, non-psychiatric medical disorders such as pneumonia and diabetes are unlikely to improve with placebo. Thus, psychiatric brain disorders appear to be particularly susceptible to the placebo effect, which implies it could be harnessed in psychiatric care. A component of every medication prescribed in psychiatry is a variable placebo effect in addition to the actual pharmacodynamic effects.

Some physicians (including non-psychiatrists) openly admit to using placebo—which is sold as Obecalp capsules—to treat patients with vague aches, pains, insomnia, or low energy. Some published studies have shown patients respond to inert pills even when the physician tells them in advance they will be receiving a placebo!1 This reflects the power of the placebo effect programmed in the human brain, which may have an evolutionary advantage of instilling hope and sustaining faith things will get better despite serious physical or psychological adversity.

What health care professionals often overlook is that the placebo effect transcends the pill itself. The most powerful placebo is the psychiatrist or nurse practitioner who prescribes the pill. In fact, the placebo effect of a clinician occurs even without prescribing any medication.

The shape and color of a placebo pill may endow it with a greater effect (eg, a red and blue striped placebo caplet looks more impressive and may project an aura of being more effective than a plain white tablet). Similarly, a patient is influenced positively or negatively by a range of attributes that characterize his or her psychiatrist, and the totality of the impressions (positive or negative) the psychiatrist “projects” may enhance or detract from whatever treatment is administered, including medication or psychotherapy. This is why different prescribers may achieve disparate results when prescribing the same psychotropic.

Many subtle and not-so-subtle verbal and nonverbal aspects of a clinician can project an “aura” of competence and trust for the patient, which will contribute to a better treatment outcome because of the patient’s stronger unconscious expectation of improvement. These include the psychiatrist’s grooming and clothing, his facial expression and demeanor, the neatness of his desk, the décor of his office, the cleanliness of the waiting room, even the appearance of the neighborhood where his clinic is located. Wearing a white coat instead of street clothes can evoke the image of a physician/healer, which is a strong positive placebo effect that can be exploited for many patients. Direct eye contact an open body posture, a firm, reassuring voice, and a handshake or caring pat on the back at the end of the session when appropriate all contribute to patient improvement even before he or she ingests any pills. A psychiatrist can enhance the response and tolerability of a drug by expressing confidence in the medication and assuring the patient if taken as prescribed the medication will help and will be tolerable according to published studies. Even slight uncertainty by the psychiatrist about the potential usefulness of a medication—even if realistic—may compromise the patient’s response.

Take the following extreme illustration of a psychiatrist whose image projects a powerful negative placebo effect that could undermine therapeutic outcome and even patient adherence: Dr. X works in a dilapidated building in a downtrodden neighborhood. Several furniture pieces in his waiting room are torn or broken. The carpet is worn and features several stains. His office is poorly lit and reeks of mildew and stale cigarette butts. He barely looks at the patient but types on a laptop as the patient speaks. Dr. X is dressed in a casual sports shirt and blue jeans. His hair is disheveled. The floor of his office is littered with piles of journals and books. Dr. X speaks in a hurried, impatient tone and often interrupts the patient to ask a barrage of questions unrelated to what the patient was talking about. Occasionally, Dr. X stops typing, leans back in his worn creaky chair, crosses his arms, and just stares at the patient. He then abruptly ends the session because “there are many other patients waiting.” He scribbles a prescription, slides it over the desk to the patient, and says “Here, take this until next visit and we’ll see if it works for you.” The psychiatrist never leaves his chair and keeps typing as the patient dejectedly leaves the office.

Dr. X clearly has squandered the valuable placebo effect inherent in his role that not only can enhance the medication efficacy but also usually bolsters the therapeutic alliance. The many negative aspects of his demeanor, behavior, relatedness, and office probably will decrease the likelihood of a good outcome in his patient

Every clinician can achieve better treatment results by creating a set of positive personal and environmental cues to reinforce that powerful and intangible force that expedites the relief of psychiatric symptoms. It would be folly to squander the remarkable placebo inherent in us “healers.”

References

 

1. Kaptchuk TJ, Friedlander E, Kelley JM, et al. Placebos without deception: a randomized controlled trial in irritable bowel syndrome. PLoS One. 2010;5(12):1-7.

References

 

1. Kaptchuk TJ, Friedlander E, Kelley JM, et al. Placebos without deception: a randomized controlled trial in irritable bowel syndrome. PLoS One. 2010;5(12):1-7.

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Pharmacologic treatment of borderline personality disorder

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Pharmacologic treatment of borderline personality disorder

As psychiatry’s understanding of borderline personality disorder (BPD) grows, the literature clearly describes the seriousness of BPD, as well as these patients’ high utilization of treatment. Pharmacotherapy for BPD remains controversial. The most recent American Psychiatric Association practice guidelines focus on using symptom domains of this heterogeneous illness to guide medication selection, yet when these guidelines were published, there was a lack of data to support this recommendation.1

This article evaluates medications for BPD and emerging data supporting matching medications to BPD symptom domains, with an emphasis on making choices that advance clinical practice. We conclude by reviewing studies of combined pharmacotherapy and dialectical behavior therapy (DBT) and describing how a multidisciplinary team approach can enhance BPD treatment.

Early research

Early studies of pharmacotherapy for BPD began after the development of the Diagnostic Interview for Borderlines2,3 and DSM-III criteria for BPD.4 Researchers recruited patients who fulfilled the diagnostic criteria; however, these participants’ symptom profiles were highly heterogeneous. Although such studies can be useful when starting to test new treatments—especially if they are able to show efficacy over placebo or explore safety—they are less helpful in guiding clinical practice.

During the 1980s, low doses of first-generation antipsychotics were evaluated based on hypotheses that BPD was related to schizophrenia. Case series5 and placebo-controlled trials6,7 pointed to symptom reduction over time and greater than placebo for BPD patients. Interestingly, in a small study of BPD inpatients, Soloff et al8 compared the first-generation antipsychotic haloperidol to amitriptyline and found amitriptyline led to symptom worsening in some patients. Cowdry and Gardner9 compared alprazolam, carbamazepine, trifluoperazine, and tranylcypromine in a double-blind, placebo-controlled crossover trial of 16 female BPD outpatients. They found antipsychotics were not useful. Further, the study found behavioral disinhibition when a benzodiazepine (alprazolam) was used alone in impulsive patients.

These studies provided a basis for the idea that medications could help reduce BPD symptoms. However, some early investigators noted that antipsychotics’ side effects led some patients to discontinue treatment.6

Next-generation studies

Antidepressants. Interest in exploring pharmacologic treatments for BPD diminished after the early efficacy trials. Several events led to a reemergence of this interest, including the FDA’s approval of the selective serotonin reuptake inhibitor fluoxetine for depression in 1987. Some investigators hypothesized fluoxetine’s antidepressant properties could help treat BPD symptoms and perhaps the serotonin reuptake action could diminish impulsivity.10 Case series and a double-blind, placebo-controlled trial11 demonstrated fluoxetine’s efficacy in BPD. In 1 study, Salzman et al12 found fluoxetine’s greatest impact was on “anger,” a major affective dimension of BPD.

Mood stabilizers. When valproic acid emerged as a successful treatment for bipolar disorder, researchers turned their attention to mood-stabilizing anticonvulsants for BPD. Numerous case series and controlled trials provided evidence of its efficacy.13,14 This was the first time subtypes of BPD patients were tested prospectively—with the hypothesis that the mood-stabilizing anticonvulsants would diminish impulsivity and aggression. The positive results of Hollander et al13 and Frankenburg and Zanarini14 in assessing divalproex in BPD patients with bipolar II disorder has implications for targeted treatment (discussed below).

Newer antipsychotics. The introduction of second-generation antipsychotics (SGA) led some researchers to explore whether these agents could decrease BPD symptoms. Case series15 and some (but not all) placebo-controlled trials have demonstrated benefit from SGAs such as olanzapine,16-18 aripiprazole,19 and quetiapine.20,21 Initial research on risperidone22 and ziprasidone also suggested efficacy for BPD. Two placebo-controlled studies of olanzapine examined which symptom groups were most helped; each reported a broad effect.16,17 However, not all studies of SGAs for BPD patients have been positive.18 Further, metabolic side effects have been noted for several SGAs, including olanzapine.18

Omega-3 fatty acids. Some studies examining omega-3 fatty acids have sparked an ongoing interest in this compound. In an 8-week, double-blind, pilot study of 30 women with BPD, Zanarini23 found omega-3 fatty acids demonstrated efficacy over placebo.

Targeted treatment

Most studies of BPD pharmacotherapy have used a classic clinical trial design, which does not easily translate into recommendations regarding medication selection for individual patients, especially those with BPD and comorbid illnesses. Also, existing trials have not fully explored starting doses, and no maintenance studies have been published. Therefore, many clinical application questions remain unresolved. However, some early treatment recommendations are supported by recent meta-analyses that demonstrate effects of medication classes for specific symptom domains.

 

 

Careful identification of comorbid psychiatric disorders is a rational first step. Diagnosing comorbid disorders, such as bipolar disorder, will determine medication choice and impact length of treatment. In a double-blind study of 30 women with BPD and comorbid bipolar II disorder, Frankenburg and Zanarini14 found divalproex had a statistically significant effect compared with placebo and could be considered for this specific population.

When treating a BPD patient who has a comorbid illness, it is important not to ignore BPD symptoms. The chronic emotional dysregulation and ongoing safety issues require psychiatrists to educate patients about these symptoms and to address them in a multidisciplinary manner.

Clarifying prominent symptom domains can help steer pharmacologic management. Many trials have attempted to focus on specific symptom domains, including cognitive-perceptual disturbances, impulsivity, and affective dysregulation. Table 124 lists BPD symptom domains and associated characteristics.

Table 1

Symptom domains of BPD

Cognitive-perceptual symptoms
Suspiciousness
Referential thinking
Paranoid ideation
Illusions
Derealization
Depersonalization
Hallucination-like symptoms
Impulsive-behavioral dyscontrol
Impulsive aggression
Deliberate self-harm
Impulsive sexual behavior
Substance abuse
Impulsive spending
Affective dysregulation
Mood lability
Rejection sensitivity
Intense anger out of proportion to the stimuli
Sudden depressive mood episodes
BPD: borderline personality disorder
Source: Reference 24

Dosing strategy

Developing a medication management strategy for BPD patients requires a thoughtful approach. When faced with a patient who has overwhelming distress, it is tempting to start with high medication doses; however, clinical experience suggests starting cautiously with lower doses will yield better tolerability and adherence. Based on our clinical experience, patients with BPD tend to be highly perceptive to physiologic stimuli and medication side effects.

Further research is needed to answer clinical questions regarding optimal dosing strategy and treatment, but some studies suggest when using SGAs, doses equivalent to one-third or one-half the dose used for treating schizophrenia may be appropriate.1,2,17,18 However, for fluoxetine, investigators have espoused using a dosage higher than generally used for depression.10 For mood-stabilizing anticonvulsants, almost all studies employed the same doses used for bipolar disorder.25 Some studies of valproic acid have verified appropriate blood levels—generally 50 to 100 μg/mL.

Controlled trials have not determined whether medications for patients with BPD should be used briefly during times of stress or for longer periods. Many studies of medication for BPD have been relatively brief trials that explored whether the drug has any potential efficacy. In our opinion, this issue currently is being addressed in clinical practice in a trial-and-error manner.

Clues to targeted treatment

Although pharmacotherapy for BPD subtypes remains controversial, recent meta-analyses by Ingenhoven24 and Nose26 and a Cochrane Review27 (with subsequent online update28) have identified evidence that supports the use of specific medications for treating BPD symptoms. These studies’ authors acknowledge replication studies are required because of the limited nature of the available data. In contrast, a meta-analysis conducted by the National Collaborating Centre for Mental Health29 did not identify sufficient evidence for medication use in BPD on which to base official guidelines to advise health care providers in the United Kingdom. The only medication recommendation in this meta-analysis is to consider prescribing short-term sedative antihistamines during crises; this recommendation is not supported by any clinical trial.

In a meta-analysis of 21 placebo-controlled trials of patients with BPD and/or schizotypal personality disorder, Inghoven et al24 used multiple domains and subdomains, including cognitive-perceptual symptoms, impulsive-behavioral dyscontrol, affective dysregulation, anger, and mood lability, to assess the efficacy of medication use (Table 2).24 They found:

  • Antipsychotics seemed to have a moderate effect on cognitive-perceptual symptoms and a moderate-to-large effect on anger.
  • Antidepressants had a small effect on anxiety, but no other domains.
  • Mood stabilizers had a very large effect on impulsive-behavioral dyscontrol and anger, a large effect on anxiety, and a moderate effect on depressed mood.
  • Regarding global functioning, mood stabilizers had a greater effect than antipsychotics. Both led to greater change than antidepressants.

A 2010 Cochrane Review meta-analysis initially conducted by Leib27 with subsequent online update by Stoffers28 included 28 studies with a total of 1,742 patients and also identified symptom-targeted BPD domains. This study analyzed pooled data and found support for the use of specific medications, including certain antipsychotics, mood stabilizers, and antidepressants, for specific BPD symptoms (Table 3).28 The authors recommended data be interpreted cautiously, however, because many of the clinical trials included in their meta-analysis have not been replicated and generalizability from research populations to clinical populations is not well understood.

 

 

Table 2

Which medications improve which BPD symptoms?

MedicationSymptom domainEffect
AntipsychoticsCognitive-perceptualModerate
AngerModerate/large
AntidepressantsAnxietySmall
AngerSmall
Mood stabilizersImpulsive-behavioral dyscontrolVery large
AngerVery large
AnxietyLarge
Depressed moodModerate
BPD: borderline personality disorder
Source: Reference 24

Table 3

Pharmacotherapy for BPD: Results of a Cochrane review

ClassMedication(s)
Cognitive-perceptual symptoms
AntipsychoticsOlanzapine, aripiprazole
Impulsive-behavioral dyscontrol
Mood stabilizersTopiramate, lamotrigine
AntipsychoticsAripiprazole
Affective dysregulation
AntidepressantsAmitriptylinea (depressed mood)
Mood stabilizersTopiramate, lamotrigine (anger), valproate (depressed mood)
AntipsychoticsHaloperidol (anger), olanzapine, aripiprazole
Omega-3 fatty acidsFish oil (depression)
Suicidal behavior/suicidality
AntipsychoticsFlupenthixol decanoate
Omega-3 fatty acidsFish oil
Interpersonal problems
AntipsychoticsAripiprazole
Mood stabilizersValproate, topiramate
No improvement on any outcome: ziprasidone, thiothixene, phenelzine, fluoxetine, fluvoxamine, carbamazepine
aDo not prescribe to suicidal patients
BPD: borderline personality disorder
Source: Reference 28

DBT and pharmacotherapy

As is the case with many studies of psychiatric medications, early efficacy studies of pharmacotherapy for BPD did not include structured psychosocial treatment. In 2 double-blind, placebo-controlled trials with a total of 84 patients receiving DBT, those assigned to olanzapine had better outcomes on objective rating scales than those on placebo.30,31 Similar trials testing fluoxetine showed no advantage for the drug over placebo.32 In a pilot study by Moen et al,25 17 patients were assigned to “condensed DBT” before being randomized to divalproex extended release or placebo. Two patients remitted in the first 4 weeks and continued to improve without medication. If replicated, this finding may point to a targeted approach to the timing of medication initiation.

Clinical recommendations

Randomized, placebo-controlled BPD trials have demonstrated striking improvements in patients in placebo groups, which may be attributed to the powerful therapeutic impact of regular, structured, nonjudgmental interactions within a research protocol. Prescribers can enhance a medication’s therapeutic effect by keeping in mind the same principles that apply to treatment of other common psychiatric disorders.

Patients with BPD respond well to validation of their symptoms and their experience. Tell patients you take their BPD symptoms seriously and acknowledge their distress. The goal is to partner with patients to improve function, decrease reactivity, and reduce emotional pain. When working with BPD patients, it is appropriate to communicate a sense of optimism and hopefulness about their prognosis and treatment. Performing this approach in a caring way will better preserve the therapeutic alliance.

Additional suggestions based on our clinical experience include:

  • Provide regular medication management visits.
  • Consider using a structured symptom rating scale to evaluate symptoms over time, such as the Zanarini Rating Scale for Borderline Personality Disorder33 or Borderline Evaluation of Severity Over Time.34
  • Educate patients with BPD about the disorder by making the appropriate diagnosis and providing reputable educational materials (see Related Resources).
  • Do not diagnose a patient with BPD as having bipolar disorder unless they clearly meet criteria for bipolar disorder.
  • Communicate your limitations in advance.
  • Orient the patient to the possibility of needing to try different medications to determine the most helpful agent or combination.
  • Do not de-emphasize risks of medications or side effects. Serious symptoms require medications that bear a risk of side effects; communicate these risks to patients and carefully weigh the risk-benefit profile.
  • Inform patients you will be responsive to making appropriate changes if problems arise that are associated with pharmacotherapy and outweigh the benefit of medication.

Multidisciplinary teamwork

Best outcomes for patients with BPD are facilitated by a collaborative team effort. Such an approach addresses both the psychological and biologic underpinnings of the disorder and can significantly decrease the possibility of “splitting” among team members. To determine ways in which a therapist and physician may work together, clinicians should discuss the:

  • meaning of medication to the therapist, psychiatrist, and patient
  • potential benefits and limitations of medication
  • the role of medication in the patient’s overall treatment.35

Patients with BPD experience emotional crisis. At times, prescribing patterns unfortunately reflect the practice of adding medications to address emotional crisis. This practice may partially account for the high rates of polypharmacy in BPD patients.36 Patients with BPD will benefit from interacting with a clinician whose approach is responsive, validating, and non-reactive to the patient’s symptoms and experiences. A comprehensive treatment approach includes screening and treating comorbid conditions, providing education about the diagnosis, and multidisciplinary involvement combined with rational, targeted pharmacotherapy.

Related Resources

  • Friedel RO. Borderline personality disorder demystified: an essential guide for understanding and living with BPD. New York, NY: Marlowe & Company; 2004.
  • Chapman A, Gratz K. Borderline personality disorder survival guide: everything you need to know about living with BPD. Oakland, CA: New Harbinger Publications, Inc; 2007.
  • National Education Alliance for Borderline Personality Disorder. www.borderlinepersonalitydisorder.com.

Drug Brand Names

  • Alprazolam • Xanax
  • Amitriptyline • Elavil
  • Aripiprazole • Abilify
  • Carbamazepine • Tegretol
  • Fluoxetine • Prozac
  • Fluvoxamine • Luvox
  • Haloperidol • Haldol
  • Lamotrigine • Lamictal
  • Olanzapine • Zyprexa
  • Phenelzine • Nardil
  • Quetiapine • Seroquel
  • Risperidone • Risperdal
  • Thiothixene • Navane
  • Topiramate • Topamax, Topiragen
  • Tranylcypromine • Parnate
  • Trifluoperazine • Stelazine
  • Valproic acid • Depakote
  • Ziprasidone • Geodon

Disclosure

 

 

Dr. Nelson receives research/grant support from the Minnesota Medical Foundation.

Dr. Schulz receives research/grant support from AstraZeneca, Otsuka, and Rules-Based Medicine and is a consultant to Bioavail, Bristol-Myers Squibb, and Eli Lilly and Company.

References

1. American Psychiatric Association Practice Guidelines. Practice guideline for the treatment of patients with borderline personality disorder. American Psychiatric Association. Am J Psychiatry. 2001;158(10 suppl):1-52.

2. Barrash J, Kroll J, Carey K, et al. Discriminating borderline disorder from other personality disorders. Cluster analysis of the diagnostic interview for borderlines. Arch Gen Psychiatry. 1983;40(12):1297-1302.

3. Kety SS, Rosenthal D, Wender PH, et al. Mental illness in the biological and adoptive families of adopted individuals who have become schizophrenic: a preliminary report based on psychiatric interviews. Proc Annu Meet Am Psychopathol Assoc. 1975;(63):147-165.

4. Diagnostic and statistical manual of mental disorders, 3rd ed. Washington DC: American Psychiatric Association; 1980.

5. Serban G, Siegel S. Response of borderline and schizotypal patients to small doses of thiothixene and haloperidol. Am J Psychiatry. 1984;141(11):1455-1458.

6. Goldberg SC, Schulz SC, Schulz PM, et al. Borderline and schizotypal personality disorders treated with low-dose thiothixene vs placebo. Arch Gen Psychiatry. 1986;43(7):680-686.

7. Soloff PH, George A, Nathan RS, et al. Progress in pharmacotherapy of borderline disorders. A double-blind study of amitriptyline, haloperidol, and placebo. Arch Gen Psychiatry. 1986;43(7):691-697.

8. Soloff PH, George A, Nathan RS, et al. Paradoxical effects of amitriptyline on borderline patients. Am J Psychiatry. 1986;143(12):1603-1635.

9. Cowdry RW, Gardner DL. Pharmacotherapy of borderline personality disorder. Alprazolam carbamazepine, trifluoperazine, and tranylcypromine. Arch Gen Psychiatry. 1988;45(2):111-119.

10. Markovitz PJ, Calabrese JR, Schulz SC, et al. Fluoxetine in the treatment of borderline and schizotypal personality disorders. Am J Psychiatry. 1991;148(8):1064-1067.

11. Coccaro EF, Kavoussi RJ. Fluoxetine and impulsive aggressive behavior in personality-disordered subjects. Arch Gen Psychiatry. 1997;54(12):1081-1088.

12. Salzman C, Wolfson AN, Schatzberg A, et al. Effect of fluoxetine on anger in symptomatic volunteers with borderline personality disorder. J Clin Psychopharmacol. 1995;15(1):23-29.

13. Hollander E, Tracy KA, Swann AC, et al. Divalproex in the treatment of impulsive aggression: efficacy in cluster B personality disorders. Neuropsychopharmacology. 2003;28(6):1186-1197.

14. Frankenburg FR, Zanarini MC. Divalproex sodium treatment of women with borderline personality disorder and bipolar II disorder: a double-blind placebo-controlled pilot study. J Clin Psychiatry. 2002;63(5):442-446.

15. Schulz SC, Camlin KL, Berry SA, et al. Olanzapine safety and efficacy in patients with borderline personality disorder and comorbid dysthymia. Biol Psychiatry. 1999;46(10):1429-1435.

16. Bogenschutz MP, George Nurnberg H. Olanzapine versus placebo in the treatment of borderline personality disorder. J Clin Psychiatry. 2004;65(1):104-109.

17. Zanarini MC, Frankenburg FR. Olanzapine treatment of female borderline personality disorder patients: a double-blind placebo-controlled pilot study. J Clin Psychiatry. 2001;62(11):849-854.

18. Schulz SC, Zanarini MC, Bateman A, et al. Olanzapine for the treatment of borderline personality disorder: variable dose 12-week randomised double-blind placebo-controlled study. Br J Psychiatry. 2008;193(6):485-492.

19. Nickel MK, Muehlbacher M, Nickel C, et al. Aripiprazole in the treatment of patients with borderline personality disorder: a double-blind, placebo-controlled study. Am J Psychiatry. 2006;163(5):833-838.

20. Adityanjee, Romine A, Brown E, et al. Quetiapine in patients with borderline personality disorder: an open-label trial. Ann Clin Psychiatry. 2008;20(4):219-226.

21. Villeneuve E, Lemelin S. Open-label study of atypical neuroleptic quetiapine for treatment of borderline personality disorder: impulsivity as main target. J Clin Psychiatry. 2005;66(10):1298-1303.

22. Rocca P, Marchiaro L, Cocuzza E, et al. Treatment of borderline personality disorder with risperidone. J Clin Psychiatry. 2002;63(3):241-244.

23. Zanarini MC, Frankenburg FR. Omega-3 fatty acid treatment of women with borderline personality disorder: a double-blind placebo-controlled pilot study. Am J Psychiatry. 2003;160(1):167-169.

24. Ingenhoven T, Lafay P, Rinne T, et al. Effectiveness of pharmacotherapy for severe personality disorders: meta-analyses of randomized controlled trials. J Clin Psychiatry. 2010;71(1):14-25.

25. Moen Moore R, Miller M, Lee S, et al. Extended release divalproex for borderline personality disorder. Poster presented at: U. S. Psychiatric and Mental Health Congress; October 13-16, 2007; Orlando, FL.

26. Nose M, Cipriani A, Biancosino B, et al. Efficacy of pharmacotherapy against core traits of borderline personality disorder: meta-analysis of randomized controlled trials. Int Clin Psychopharmacol. 2006;21(6):345-353.

27. Lieb K, Völlm B, Rücker G, et al. Pharmacotherapy for borderline personality disorder: Cochrane Systematic Review of Randomised Trials. Br J Psychiatry. 2010;196(1):4-12.

28. Stoffers J, Völlm BA, Rücker G, et al. Pharmacological interventions for borderline personality disorder. Cochrane Database Syst Rev. 2010;(6):CD005653.-

29. National Collaborating Centre for Mental Health. Borderline personality disorder: the NICE guideline on treatment and management. National clinical practice guideline no. 78. London United Kingdom: RCPsych Publications; 2009.

30. Linehan MM, McDavid JD, Brown MZ, et al. Olanzapine plus dialectical behavior therapy for women with high irritability who meet criteria for borderline personality disorder: a double-blind, placebo-controlled pilot study. J Clin Psychiatry. 2008;69(6):999-1005.

31. Soler J, Pascual JC, Campins J, et al. Double-blind, placebo-controlled study of dialectical behavior therapy plus olanzapine for borderline personality disorder. Am J Psychiatry. 2005;162(6):1221-1224.

32. Simpson EB, Yen S, Costello E, et al. Combined dialectical behavior therapy and fluoxetine in the treatment of borderline personality disorder. J Clin Psychiatry. 2004;65(3):379-385.

33. Zanarini MC, Vujanovic AA, Parachini EA, et al. Zanarini Rating Scale for Borderline Personality Disorder (ZAN-BPD): a continuous measure of DSM-IV borderline psychopathology. J Pers Disord. 2003;17(3):233-242.

34. Pfohl B, Blum N, St John D, et al. Reliability and validity of the Borderline Evaluation of Severity Over Time (BEST): a self-rated scale to measure severity and change in persons with borderline personality disorder. J Pers Disord. 2009;23(3):281-293.

35. Silk KR. Collaborative treatment for patients with personality disorders. In: Riba MB Balon R, eds. Psychopharmacology and psychotherapy: a collaborative approach. Washington, DC: American Psychiatric Press; 1999:221–277.

36. Zanarini MC. Update on pharmacotherapy of borderline personality disorder. Curr Psychiatry Rep. 2004;6(1):66-70.

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Assistant Professor, Department of Psychiatry, University of Minnesota Medical School, Minneapolis, MN
Charles S. Schulz, MD
Professor and Head, Donald W. Hastings Endowed Chair, Department of Psychiatry, University of Minnesota Medical School, Minneapolis, MN

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As psychiatry’s understanding of borderline personality disorder (BPD) grows, the literature clearly describes the seriousness of BPD, as well as these patients’ high utilization of treatment. Pharmacotherapy for BPD remains controversial. The most recent American Psychiatric Association practice guidelines focus on using symptom domains of this heterogeneous illness to guide medication selection, yet when these guidelines were published, there was a lack of data to support this recommendation.1

This article evaluates medications for BPD and emerging data supporting matching medications to BPD symptom domains, with an emphasis on making choices that advance clinical practice. We conclude by reviewing studies of combined pharmacotherapy and dialectical behavior therapy (DBT) and describing how a multidisciplinary team approach can enhance BPD treatment.

Early research

Early studies of pharmacotherapy for BPD began after the development of the Diagnostic Interview for Borderlines2,3 and DSM-III criteria for BPD.4 Researchers recruited patients who fulfilled the diagnostic criteria; however, these participants’ symptom profiles were highly heterogeneous. Although such studies can be useful when starting to test new treatments—especially if they are able to show efficacy over placebo or explore safety—they are less helpful in guiding clinical practice.

During the 1980s, low doses of first-generation antipsychotics were evaluated based on hypotheses that BPD was related to schizophrenia. Case series5 and placebo-controlled trials6,7 pointed to symptom reduction over time and greater than placebo for BPD patients. Interestingly, in a small study of BPD inpatients, Soloff et al8 compared the first-generation antipsychotic haloperidol to amitriptyline and found amitriptyline led to symptom worsening in some patients. Cowdry and Gardner9 compared alprazolam, carbamazepine, trifluoperazine, and tranylcypromine in a double-blind, placebo-controlled crossover trial of 16 female BPD outpatients. They found antipsychotics were not useful. Further, the study found behavioral disinhibition when a benzodiazepine (alprazolam) was used alone in impulsive patients.

These studies provided a basis for the idea that medications could help reduce BPD symptoms. However, some early investigators noted that antipsychotics’ side effects led some patients to discontinue treatment.6

Next-generation studies

Antidepressants. Interest in exploring pharmacologic treatments for BPD diminished after the early efficacy trials. Several events led to a reemergence of this interest, including the FDA’s approval of the selective serotonin reuptake inhibitor fluoxetine for depression in 1987. Some investigators hypothesized fluoxetine’s antidepressant properties could help treat BPD symptoms and perhaps the serotonin reuptake action could diminish impulsivity.10 Case series and a double-blind, placebo-controlled trial11 demonstrated fluoxetine’s efficacy in BPD. In 1 study, Salzman et al12 found fluoxetine’s greatest impact was on “anger,” a major affective dimension of BPD.

Mood stabilizers. When valproic acid emerged as a successful treatment for bipolar disorder, researchers turned their attention to mood-stabilizing anticonvulsants for BPD. Numerous case series and controlled trials provided evidence of its efficacy.13,14 This was the first time subtypes of BPD patients were tested prospectively—with the hypothesis that the mood-stabilizing anticonvulsants would diminish impulsivity and aggression. The positive results of Hollander et al13 and Frankenburg and Zanarini14 in assessing divalproex in BPD patients with bipolar II disorder has implications for targeted treatment (discussed below).

Newer antipsychotics. The introduction of second-generation antipsychotics (SGA) led some researchers to explore whether these agents could decrease BPD symptoms. Case series15 and some (but not all) placebo-controlled trials have demonstrated benefit from SGAs such as olanzapine,16-18 aripiprazole,19 and quetiapine.20,21 Initial research on risperidone22 and ziprasidone also suggested efficacy for BPD. Two placebo-controlled studies of olanzapine examined which symptom groups were most helped; each reported a broad effect.16,17 However, not all studies of SGAs for BPD patients have been positive.18 Further, metabolic side effects have been noted for several SGAs, including olanzapine.18

Omega-3 fatty acids. Some studies examining omega-3 fatty acids have sparked an ongoing interest in this compound. In an 8-week, double-blind, pilot study of 30 women with BPD, Zanarini23 found omega-3 fatty acids demonstrated efficacy over placebo.

Targeted treatment

Most studies of BPD pharmacotherapy have used a classic clinical trial design, which does not easily translate into recommendations regarding medication selection for individual patients, especially those with BPD and comorbid illnesses. Also, existing trials have not fully explored starting doses, and no maintenance studies have been published. Therefore, many clinical application questions remain unresolved. However, some early treatment recommendations are supported by recent meta-analyses that demonstrate effects of medication classes for specific symptom domains.

 

 

Careful identification of comorbid psychiatric disorders is a rational first step. Diagnosing comorbid disorders, such as bipolar disorder, will determine medication choice and impact length of treatment. In a double-blind study of 30 women with BPD and comorbid bipolar II disorder, Frankenburg and Zanarini14 found divalproex had a statistically significant effect compared with placebo and could be considered for this specific population.

When treating a BPD patient who has a comorbid illness, it is important not to ignore BPD symptoms. The chronic emotional dysregulation and ongoing safety issues require psychiatrists to educate patients about these symptoms and to address them in a multidisciplinary manner.

Clarifying prominent symptom domains can help steer pharmacologic management. Many trials have attempted to focus on specific symptom domains, including cognitive-perceptual disturbances, impulsivity, and affective dysregulation. Table 124 lists BPD symptom domains and associated characteristics.

Table 1

Symptom domains of BPD

Cognitive-perceptual symptoms
Suspiciousness
Referential thinking
Paranoid ideation
Illusions
Derealization
Depersonalization
Hallucination-like symptoms
Impulsive-behavioral dyscontrol
Impulsive aggression
Deliberate self-harm
Impulsive sexual behavior
Substance abuse
Impulsive spending
Affective dysregulation
Mood lability
Rejection sensitivity
Intense anger out of proportion to the stimuli
Sudden depressive mood episodes
BPD: borderline personality disorder
Source: Reference 24

Dosing strategy

Developing a medication management strategy for BPD patients requires a thoughtful approach. When faced with a patient who has overwhelming distress, it is tempting to start with high medication doses; however, clinical experience suggests starting cautiously with lower doses will yield better tolerability and adherence. Based on our clinical experience, patients with BPD tend to be highly perceptive to physiologic stimuli and medication side effects.

Further research is needed to answer clinical questions regarding optimal dosing strategy and treatment, but some studies suggest when using SGAs, doses equivalent to one-third or one-half the dose used for treating schizophrenia may be appropriate.1,2,17,18 However, for fluoxetine, investigators have espoused using a dosage higher than generally used for depression.10 For mood-stabilizing anticonvulsants, almost all studies employed the same doses used for bipolar disorder.25 Some studies of valproic acid have verified appropriate blood levels—generally 50 to 100 μg/mL.

Controlled trials have not determined whether medications for patients with BPD should be used briefly during times of stress or for longer periods. Many studies of medication for BPD have been relatively brief trials that explored whether the drug has any potential efficacy. In our opinion, this issue currently is being addressed in clinical practice in a trial-and-error manner.

Clues to targeted treatment

Although pharmacotherapy for BPD subtypes remains controversial, recent meta-analyses by Ingenhoven24 and Nose26 and a Cochrane Review27 (with subsequent online update28) have identified evidence that supports the use of specific medications for treating BPD symptoms. These studies’ authors acknowledge replication studies are required because of the limited nature of the available data. In contrast, a meta-analysis conducted by the National Collaborating Centre for Mental Health29 did not identify sufficient evidence for medication use in BPD on which to base official guidelines to advise health care providers in the United Kingdom. The only medication recommendation in this meta-analysis is to consider prescribing short-term sedative antihistamines during crises; this recommendation is not supported by any clinical trial.

In a meta-analysis of 21 placebo-controlled trials of patients with BPD and/or schizotypal personality disorder, Inghoven et al24 used multiple domains and subdomains, including cognitive-perceptual symptoms, impulsive-behavioral dyscontrol, affective dysregulation, anger, and mood lability, to assess the efficacy of medication use (Table 2).24 They found:

  • Antipsychotics seemed to have a moderate effect on cognitive-perceptual symptoms and a moderate-to-large effect on anger.
  • Antidepressants had a small effect on anxiety, but no other domains.
  • Mood stabilizers had a very large effect on impulsive-behavioral dyscontrol and anger, a large effect on anxiety, and a moderate effect on depressed mood.
  • Regarding global functioning, mood stabilizers had a greater effect than antipsychotics. Both led to greater change than antidepressants.

A 2010 Cochrane Review meta-analysis initially conducted by Leib27 with subsequent online update by Stoffers28 included 28 studies with a total of 1,742 patients and also identified symptom-targeted BPD domains. This study analyzed pooled data and found support for the use of specific medications, including certain antipsychotics, mood stabilizers, and antidepressants, for specific BPD symptoms (Table 3).28 The authors recommended data be interpreted cautiously, however, because many of the clinical trials included in their meta-analysis have not been replicated and generalizability from research populations to clinical populations is not well understood.

 

 

Table 2

Which medications improve which BPD symptoms?

MedicationSymptom domainEffect
AntipsychoticsCognitive-perceptualModerate
AngerModerate/large
AntidepressantsAnxietySmall
AngerSmall
Mood stabilizersImpulsive-behavioral dyscontrolVery large
AngerVery large
AnxietyLarge
Depressed moodModerate
BPD: borderline personality disorder
Source: Reference 24

Table 3

Pharmacotherapy for BPD: Results of a Cochrane review

ClassMedication(s)
Cognitive-perceptual symptoms
AntipsychoticsOlanzapine, aripiprazole
Impulsive-behavioral dyscontrol
Mood stabilizersTopiramate, lamotrigine
AntipsychoticsAripiprazole
Affective dysregulation
AntidepressantsAmitriptylinea (depressed mood)
Mood stabilizersTopiramate, lamotrigine (anger), valproate (depressed mood)
AntipsychoticsHaloperidol (anger), olanzapine, aripiprazole
Omega-3 fatty acidsFish oil (depression)
Suicidal behavior/suicidality
AntipsychoticsFlupenthixol decanoate
Omega-3 fatty acidsFish oil
Interpersonal problems
AntipsychoticsAripiprazole
Mood stabilizersValproate, topiramate
No improvement on any outcome: ziprasidone, thiothixene, phenelzine, fluoxetine, fluvoxamine, carbamazepine
aDo not prescribe to suicidal patients
BPD: borderline personality disorder
Source: Reference 28

DBT and pharmacotherapy

As is the case with many studies of psychiatric medications, early efficacy studies of pharmacotherapy for BPD did not include structured psychosocial treatment. In 2 double-blind, placebo-controlled trials with a total of 84 patients receiving DBT, those assigned to olanzapine had better outcomes on objective rating scales than those on placebo.30,31 Similar trials testing fluoxetine showed no advantage for the drug over placebo.32 In a pilot study by Moen et al,25 17 patients were assigned to “condensed DBT” before being randomized to divalproex extended release or placebo. Two patients remitted in the first 4 weeks and continued to improve without medication. If replicated, this finding may point to a targeted approach to the timing of medication initiation.

Clinical recommendations

Randomized, placebo-controlled BPD trials have demonstrated striking improvements in patients in placebo groups, which may be attributed to the powerful therapeutic impact of regular, structured, nonjudgmental interactions within a research protocol. Prescribers can enhance a medication’s therapeutic effect by keeping in mind the same principles that apply to treatment of other common psychiatric disorders.

Patients with BPD respond well to validation of their symptoms and their experience. Tell patients you take their BPD symptoms seriously and acknowledge their distress. The goal is to partner with patients to improve function, decrease reactivity, and reduce emotional pain. When working with BPD patients, it is appropriate to communicate a sense of optimism and hopefulness about their prognosis and treatment. Performing this approach in a caring way will better preserve the therapeutic alliance.

Additional suggestions based on our clinical experience include:

  • Provide regular medication management visits.
  • Consider using a structured symptom rating scale to evaluate symptoms over time, such as the Zanarini Rating Scale for Borderline Personality Disorder33 or Borderline Evaluation of Severity Over Time.34
  • Educate patients with BPD about the disorder by making the appropriate diagnosis and providing reputable educational materials (see Related Resources).
  • Do not diagnose a patient with BPD as having bipolar disorder unless they clearly meet criteria for bipolar disorder.
  • Communicate your limitations in advance.
  • Orient the patient to the possibility of needing to try different medications to determine the most helpful agent or combination.
  • Do not de-emphasize risks of medications or side effects. Serious symptoms require medications that bear a risk of side effects; communicate these risks to patients and carefully weigh the risk-benefit profile.
  • Inform patients you will be responsive to making appropriate changes if problems arise that are associated with pharmacotherapy and outweigh the benefit of medication.

Multidisciplinary teamwork

Best outcomes for patients with BPD are facilitated by a collaborative team effort. Such an approach addresses both the psychological and biologic underpinnings of the disorder and can significantly decrease the possibility of “splitting” among team members. To determine ways in which a therapist and physician may work together, clinicians should discuss the:

  • meaning of medication to the therapist, psychiatrist, and patient
  • potential benefits and limitations of medication
  • the role of medication in the patient’s overall treatment.35

Patients with BPD experience emotional crisis. At times, prescribing patterns unfortunately reflect the practice of adding medications to address emotional crisis. This practice may partially account for the high rates of polypharmacy in BPD patients.36 Patients with BPD will benefit from interacting with a clinician whose approach is responsive, validating, and non-reactive to the patient’s symptoms and experiences. A comprehensive treatment approach includes screening and treating comorbid conditions, providing education about the diagnosis, and multidisciplinary involvement combined with rational, targeted pharmacotherapy.

Related Resources

  • Friedel RO. Borderline personality disorder demystified: an essential guide for understanding and living with BPD. New York, NY: Marlowe & Company; 2004.
  • Chapman A, Gratz K. Borderline personality disorder survival guide: everything you need to know about living with BPD. Oakland, CA: New Harbinger Publications, Inc; 2007.
  • National Education Alliance for Borderline Personality Disorder. www.borderlinepersonalitydisorder.com.

Drug Brand Names

  • Alprazolam • Xanax
  • Amitriptyline • Elavil
  • Aripiprazole • Abilify
  • Carbamazepine • Tegretol
  • Fluoxetine • Prozac
  • Fluvoxamine • Luvox
  • Haloperidol • Haldol
  • Lamotrigine • Lamictal
  • Olanzapine • Zyprexa
  • Phenelzine • Nardil
  • Quetiapine • Seroquel
  • Risperidone • Risperdal
  • Thiothixene • Navane
  • Topiramate • Topamax, Topiragen
  • Tranylcypromine • Parnate
  • Trifluoperazine • Stelazine
  • Valproic acid • Depakote
  • Ziprasidone • Geodon

Disclosure

 

 

Dr. Nelson receives research/grant support from the Minnesota Medical Foundation.

Dr. Schulz receives research/grant support from AstraZeneca, Otsuka, and Rules-Based Medicine and is a consultant to Bioavail, Bristol-Myers Squibb, and Eli Lilly and Company.

As psychiatry’s understanding of borderline personality disorder (BPD) grows, the literature clearly describes the seriousness of BPD, as well as these patients’ high utilization of treatment. Pharmacotherapy for BPD remains controversial. The most recent American Psychiatric Association practice guidelines focus on using symptom domains of this heterogeneous illness to guide medication selection, yet when these guidelines were published, there was a lack of data to support this recommendation.1

This article evaluates medications for BPD and emerging data supporting matching medications to BPD symptom domains, with an emphasis on making choices that advance clinical practice. We conclude by reviewing studies of combined pharmacotherapy and dialectical behavior therapy (DBT) and describing how a multidisciplinary team approach can enhance BPD treatment.

Early research

Early studies of pharmacotherapy for BPD began after the development of the Diagnostic Interview for Borderlines2,3 and DSM-III criteria for BPD.4 Researchers recruited patients who fulfilled the diagnostic criteria; however, these participants’ symptom profiles were highly heterogeneous. Although such studies can be useful when starting to test new treatments—especially if they are able to show efficacy over placebo or explore safety—they are less helpful in guiding clinical practice.

During the 1980s, low doses of first-generation antipsychotics were evaluated based on hypotheses that BPD was related to schizophrenia. Case series5 and placebo-controlled trials6,7 pointed to symptom reduction over time and greater than placebo for BPD patients. Interestingly, in a small study of BPD inpatients, Soloff et al8 compared the first-generation antipsychotic haloperidol to amitriptyline and found amitriptyline led to symptom worsening in some patients. Cowdry and Gardner9 compared alprazolam, carbamazepine, trifluoperazine, and tranylcypromine in a double-blind, placebo-controlled crossover trial of 16 female BPD outpatients. They found antipsychotics were not useful. Further, the study found behavioral disinhibition when a benzodiazepine (alprazolam) was used alone in impulsive patients.

These studies provided a basis for the idea that medications could help reduce BPD symptoms. However, some early investigators noted that antipsychotics’ side effects led some patients to discontinue treatment.6

Next-generation studies

Antidepressants. Interest in exploring pharmacologic treatments for BPD diminished after the early efficacy trials. Several events led to a reemergence of this interest, including the FDA’s approval of the selective serotonin reuptake inhibitor fluoxetine for depression in 1987. Some investigators hypothesized fluoxetine’s antidepressant properties could help treat BPD symptoms and perhaps the serotonin reuptake action could diminish impulsivity.10 Case series and a double-blind, placebo-controlled trial11 demonstrated fluoxetine’s efficacy in BPD. In 1 study, Salzman et al12 found fluoxetine’s greatest impact was on “anger,” a major affective dimension of BPD.

Mood stabilizers. When valproic acid emerged as a successful treatment for bipolar disorder, researchers turned their attention to mood-stabilizing anticonvulsants for BPD. Numerous case series and controlled trials provided evidence of its efficacy.13,14 This was the first time subtypes of BPD patients were tested prospectively—with the hypothesis that the mood-stabilizing anticonvulsants would diminish impulsivity and aggression. The positive results of Hollander et al13 and Frankenburg and Zanarini14 in assessing divalproex in BPD patients with bipolar II disorder has implications for targeted treatment (discussed below).

Newer antipsychotics. The introduction of second-generation antipsychotics (SGA) led some researchers to explore whether these agents could decrease BPD symptoms. Case series15 and some (but not all) placebo-controlled trials have demonstrated benefit from SGAs such as olanzapine,16-18 aripiprazole,19 and quetiapine.20,21 Initial research on risperidone22 and ziprasidone also suggested efficacy for BPD. Two placebo-controlled studies of olanzapine examined which symptom groups were most helped; each reported a broad effect.16,17 However, not all studies of SGAs for BPD patients have been positive.18 Further, metabolic side effects have been noted for several SGAs, including olanzapine.18

Omega-3 fatty acids. Some studies examining omega-3 fatty acids have sparked an ongoing interest in this compound. In an 8-week, double-blind, pilot study of 30 women with BPD, Zanarini23 found omega-3 fatty acids demonstrated efficacy over placebo.

Targeted treatment

Most studies of BPD pharmacotherapy have used a classic clinical trial design, which does not easily translate into recommendations regarding medication selection for individual patients, especially those with BPD and comorbid illnesses. Also, existing trials have not fully explored starting doses, and no maintenance studies have been published. Therefore, many clinical application questions remain unresolved. However, some early treatment recommendations are supported by recent meta-analyses that demonstrate effects of medication classes for specific symptom domains.

 

 

Careful identification of comorbid psychiatric disorders is a rational first step. Diagnosing comorbid disorders, such as bipolar disorder, will determine medication choice and impact length of treatment. In a double-blind study of 30 women with BPD and comorbid bipolar II disorder, Frankenburg and Zanarini14 found divalproex had a statistically significant effect compared with placebo and could be considered for this specific population.

When treating a BPD patient who has a comorbid illness, it is important not to ignore BPD symptoms. The chronic emotional dysregulation and ongoing safety issues require psychiatrists to educate patients about these symptoms and to address them in a multidisciplinary manner.

Clarifying prominent symptom domains can help steer pharmacologic management. Many trials have attempted to focus on specific symptom domains, including cognitive-perceptual disturbances, impulsivity, and affective dysregulation. Table 124 lists BPD symptom domains and associated characteristics.

Table 1

Symptom domains of BPD

Cognitive-perceptual symptoms
Suspiciousness
Referential thinking
Paranoid ideation
Illusions
Derealization
Depersonalization
Hallucination-like symptoms
Impulsive-behavioral dyscontrol
Impulsive aggression
Deliberate self-harm
Impulsive sexual behavior
Substance abuse
Impulsive spending
Affective dysregulation
Mood lability
Rejection sensitivity
Intense anger out of proportion to the stimuli
Sudden depressive mood episodes
BPD: borderline personality disorder
Source: Reference 24

Dosing strategy

Developing a medication management strategy for BPD patients requires a thoughtful approach. When faced with a patient who has overwhelming distress, it is tempting to start with high medication doses; however, clinical experience suggests starting cautiously with lower doses will yield better tolerability and adherence. Based on our clinical experience, patients with BPD tend to be highly perceptive to physiologic stimuli and medication side effects.

Further research is needed to answer clinical questions regarding optimal dosing strategy and treatment, but some studies suggest when using SGAs, doses equivalent to one-third or one-half the dose used for treating schizophrenia may be appropriate.1,2,17,18 However, for fluoxetine, investigators have espoused using a dosage higher than generally used for depression.10 For mood-stabilizing anticonvulsants, almost all studies employed the same doses used for bipolar disorder.25 Some studies of valproic acid have verified appropriate blood levels—generally 50 to 100 μg/mL.

Controlled trials have not determined whether medications for patients with BPD should be used briefly during times of stress or for longer periods. Many studies of medication for BPD have been relatively brief trials that explored whether the drug has any potential efficacy. In our opinion, this issue currently is being addressed in clinical practice in a trial-and-error manner.

Clues to targeted treatment

Although pharmacotherapy for BPD subtypes remains controversial, recent meta-analyses by Ingenhoven24 and Nose26 and a Cochrane Review27 (with subsequent online update28) have identified evidence that supports the use of specific medications for treating BPD symptoms. These studies’ authors acknowledge replication studies are required because of the limited nature of the available data. In contrast, a meta-analysis conducted by the National Collaborating Centre for Mental Health29 did not identify sufficient evidence for medication use in BPD on which to base official guidelines to advise health care providers in the United Kingdom. The only medication recommendation in this meta-analysis is to consider prescribing short-term sedative antihistamines during crises; this recommendation is not supported by any clinical trial.

In a meta-analysis of 21 placebo-controlled trials of patients with BPD and/or schizotypal personality disorder, Inghoven et al24 used multiple domains and subdomains, including cognitive-perceptual symptoms, impulsive-behavioral dyscontrol, affective dysregulation, anger, and mood lability, to assess the efficacy of medication use (Table 2).24 They found:

  • Antipsychotics seemed to have a moderate effect on cognitive-perceptual symptoms and a moderate-to-large effect on anger.
  • Antidepressants had a small effect on anxiety, but no other domains.
  • Mood stabilizers had a very large effect on impulsive-behavioral dyscontrol and anger, a large effect on anxiety, and a moderate effect on depressed mood.
  • Regarding global functioning, mood stabilizers had a greater effect than antipsychotics. Both led to greater change than antidepressants.

A 2010 Cochrane Review meta-analysis initially conducted by Leib27 with subsequent online update by Stoffers28 included 28 studies with a total of 1,742 patients and also identified symptom-targeted BPD domains. This study analyzed pooled data and found support for the use of specific medications, including certain antipsychotics, mood stabilizers, and antidepressants, for specific BPD symptoms (Table 3).28 The authors recommended data be interpreted cautiously, however, because many of the clinical trials included in their meta-analysis have not been replicated and generalizability from research populations to clinical populations is not well understood.

 

 

Table 2

Which medications improve which BPD symptoms?

MedicationSymptom domainEffect
AntipsychoticsCognitive-perceptualModerate
AngerModerate/large
AntidepressantsAnxietySmall
AngerSmall
Mood stabilizersImpulsive-behavioral dyscontrolVery large
AngerVery large
AnxietyLarge
Depressed moodModerate
BPD: borderline personality disorder
Source: Reference 24

Table 3

Pharmacotherapy for BPD: Results of a Cochrane review

ClassMedication(s)
Cognitive-perceptual symptoms
AntipsychoticsOlanzapine, aripiprazole
Impulsive-behavioral dyscontrol
Mood stabilizersTopiramate, lamotrigine
AntipsychoticsAripiprazole
Affective dysregulation
AntidepressantsAmitriptylinea (depressed mood)
Mood stabilizersTopiramate, lamotrigine (anger), valproate (depressed mood)
AntipsychoticsHaloperidol (anger), olanzapine, aripiprazole
Omega-3 fatty acidsFish oil (depression)
Suicidal behavior/suicidality
AntipsychoticsFlupenthixol decanoate
Omega-3 fatty acidsFish oil
Interpersonal problems
AntipsychoticsAripiprazole
Mood stabilizersValproate, topiramate
No improvement on any outcome: ziprasidone, thiothixene, phenelzine, fluoxetine, fluvoxamine, carbamazepine
aDo not prescribe to suicidal patients
BPD: borderline personality disorder
Source: Reference 28

DBT and pharmacotherapy

As is the case with many studies of psychiatric medications, early efficacy studies of pharmacotherapy for BPD did not include structured psychosocial treatment. In 2 double-blind, placebo-controlled trials with a total of 84 patients receiving DBT, those assigned to olanzapine had better outcomes on objective rating scales than those on placebo.30,31 Similar trials testing fluoxetine showed no advantage for the drug over placebo.32 In a pilot study by Moen et al,25 17 patients were assigned to “condensed DBT” before being randomized to divalproex extended release or placebo. Two patients remitted in the first 4 weeks and continued to improve without medication. If replicated, this finding may point to a targeted approach to the timing of medication initiation.

Clinical recommendations

Randomized, placebo-controlled BPD trials have demonstrated striking improvements in patients in placebo groups, which may be attributed to the powerful therapeutic impact of regular, structured, nonjudgmental interactions within a research protocol. Prescribers can enhance a medication’s therapeutic effect by keeping in mind the same principles that apply to treatment of other common psychiatric disorders.

Patients with BPD respond well to validation of their symptoms and their experience. Tell patients you take their BPD symptoms seriously and acknowledge their distress. The goal is to partner with patients to improve function, decrease reactivity, and reduce emotional pain. When working with BPD patients, it is appropriate to communicate a sense of optimism and hopefulness about their prognosis and treatment. Performing this approach in a caring way will better preserve the therapeutic alliance.

Additional suggestions based on our clinical experience include:

  • Provide regular medication management visits.
  • Consider using a structured symptom rating scale to evaluate symptoms over time, such as the Zanarini Rating Scale for Borderline Personality Disorder33 or Borderline Evaluation of Severity Over Time.34
  • Educate patients with BPD about the disorder by making the appropriate diagnosis and providing reputable educational materials (see Related Resources).
  • Do not diagnose a patient with BPD as having bipolar disorder unless they clearly meet criteria for bipolar disorder.
  • Communicate your limitations in advance.
  • Orient the patient to the possibility of needing to try different medications to determine the most helpful agent or combination.
  • Do not de-emphasize risks of medications or side effects. Serious symptoms require medications that bear a risk of side effects; communicate these risks to patients and carefully weigh the risk-benefit profile.
  • Inform patients you will be responsive to making appropriate changes if problems arise that are associated with pharmacotherapy and outweigh the benefit of medication.

Multidisciplinary teamwork

Best outcomes for patients with BPD are facilitated by a collaborative team effort. Such an approach addresses both the psychological and biologic underpinnings of the disorder and can significantly decrease the possibility of “splitting” among team members. To determine ways in which a therapist and physician may work together, clinicians should discuss the:

  • meaning of medication to the therapist, psychiatrist, and patient
  • potential benefits and limitations of medication
  • the role of medication in the patient’s overall treatment.35

Patients with BPD experience emotional crisis. At times, prescribing patterns unfortunately reflect the practice of adding medications to address emotional crisis. This practice may partially account for the high rates of polypharmacy in BPD patients.36 Patients with BPD will benefit from interacting with a clinician whose approach is responsive, validating, and non-reactive to the patient’s symptoms and experiences. A comprehensive treatment approach includes screening and treating comorbid conditions, providing education about the diagnosis, and multidisciplinary involvement combined with rational, targeted pharmacotherapy.

Related Resources

  • Friedel RO. Borderline personality disorder demystified: an essential guide for understanding and living with BPD. New York, NY: Marlowe & Company; 2004.
  • Chapman A, Gratz K. Borderline personality disorder survival guide: everything you need to know about living with BPD. Oakland, CA: New Harbinger Publications, Inc; 2007.
  • National Education Alliance for Borderline Personality Disorder. www.borderlinepersonalitydisorder.com.

Drug Brand Names

  • Alprazolam • Xanax
  • Amitriptyline • Elavil
  • Aripiprazole • Abilify
  • Carbamazepine • Tegretol
  • Fluoxetine • Prozac
  • Fluvoxamine • Luvox
  • Haloperidol • Haldol
  • Lamotrigine • Lamictal
  • Olanzapine • Zyprexa
  • Phenelzine • Nardil
  • Quetiapine • Seroquel
  • Risperidone • Risperdal
  • Thiothixene • Navane
  • Topiramate • Topamax, Topiragen
  • Tranylcypromine • Parnate
  • Trifluoperazine • Stelazine
  • Valproic acid • Depakote
  • Ziprasidone • Geodon

Disclosure

 

 

Dr. Nelson receives research/grant support from the Minnesota Medical Foundation.

Dr. Schulz receives research/grant support from AstraZeneca, Otsuka, and Rules-Based Medicine and is a consultant to Bioavail, Bristol-Myers Squibb, and Eli Lilly and Company.

References

1. American Psychiatric Association Practice Guidelines. Practice guideline for the treatment of patients with borderline personality disorder. American Psychiatric Association. Am J Psychiatry. 2001;158(10 suppl):1-52.

2. Barrash J, Kroll J, Carey K, et al. Discriminating borderline disorder from other personality disorders. Cluster analysis of the diagnostic interview for borderlines. Arch Gen Psychiatry. 1983;40(12):1297-1302.

3. Kety SS, Rosenthal D, Wender PH, et al. Mental illness in the biological and adoptive families of adopted individuals who have become schizophrenic: a preliminary report based on psychiatric interviews. Proc Annu Meet Am Psychopathol Assoc. 1975;(63):147-165.

4. Diagnostic and statistical manual of mental disorders, 3rd ed. Washington DC: American Psychiatric Association; 1980.

5. Serban G, Siegel S. Response of borderline and schizotypal patients to small doses of thiothixene and haloperidol. Am J Psychiatry. 1984;141(11):1455-1458.

6. Goldberg SC, Schulz SC, Schulz PM, et al. Borderline and schizotypal personality disorders treated with low-dose thiothixene vs placebo. Arch Gen Psychiatry. 1986;43(7):680-686.

7. Soloff PH, George A, Nathan RS, et al. Progress in pharmacotherapy of borderline disorders. A double-blind study of amitriptyline, haloperidol, and placebo. Arch Gen Psychiatry. 1986;43(7):691-697.

8. Soloff PH, George A, Nathan RS, et al. Paradoxical effects of amitriptyline on borderline patients. Am J Psychiatry. 1986;143(12):1603-1635.

9. Cowdry RW, Gardner DL. Pharmacotherapy of borderline personality disorder. Alprazolam carbamazepine, trifluoperazine, and tranylcypromine. Arch Gen Psychiatry. 1988;45(2):111-119.

10. Markovitz PJ, Calabrese JR, Schulz SC, et al. Fluoxetine in the treatment of borderline and schizotypal personality disorders. Am J Psychiatry. 1991;148(8):1064-1067.

11. Coccaro EF, Kavoussi RJ. Fluoxetine and impulsive aggressive behavior in personality-disordered subjects. Arch Gen Psychiatry. 1997;54(12):1081-1088.

12. Salzman C, Wolfson AN, Schatzberg A, et al. Effect of fluoxetine on anger in symptomatic volunteers with borderline personality disorder. J Clin Psychopharmacol. 1995;15(1):23-29.

13. Hollander E, Tracy KA, Swann AC, et al. Divalproex in the treatment of impulsive aggression: efficacy in cluster B personality disorders. Neuropsychopharmacology. 2003;28(6):1186-1197.

14. Frankenburg FR, Zanarini MC. Divalproex sodium treatment of women with borderline personality disorder and bipolar II disorder: a double-blind placebo-controlled pilot study. J Clin Psychiatry. 2002;63(5):442-446.

15. Schulz SC, Camlin KL, Berry SA, et al. Olanzapine safety and efficacy in patients with borderline personality disorder and comorbid dysthymia. Biol Psychiatry. 1999;46(10):1429-1435.

16. Bogenschutz MP, George Nurnberg H. Olanzapine versus placebo in the treatment of borderline personality disorder. J Clin Psychiatry. 2004;65(1):104-109.

17. Zanarini MC, Frankenburg FR. Olanzapine treatment of female borderline personality disorder patients: a double-blind placebo-controlled pilot study. J Clin Psychiatry. 2001;62(11):849-854.

18. Schulz SC, Zanarini MC, Bateman A, et al. Olanzapine for the treatment of borderline personality disorder: variable dose 12-week randomised double-blind placebo-controlled study. Br J Psychiatry. 2008;193(6):485-492.

19. Nickel MK, Muehlbacher M, Nickel C, et al. Aripiprazole in the treatment of patients with borderline personality disorder: a double-blind, placebo-controlled study. Am J Psychiatry. 2006;163(5):833-838.

20. Adityanjee, Romine A, Brown E, et al. Quetiapine in patients with borderline personality disorder: an open-label trial. Ann Clin Psychiatry. 2008;20(4):219-226.

21. Villeneuve E, Lemelin S. Open-label study of atypical neuroleptic quetiapine for treatment of borderline personality disorder: impulsivity as main target. J Clin Psychiatry. 2005;66(10):1298-1303.

22. Rocca P, Marchiaro L, Cocuzza E, et al. Treatment of borderline personality disorder with risperidone. J Clin Psychiatry. 2002;63(3):241-244.

23. Zanarini MC, Frankenburg FR. Omega-3 fatty acid treatment of women with borderline personality disorder: a double-blind placebo-controlled pilot study. Am J Psychiatry. 2003;160(1):167-169.

24. Ingenhoven T, Lafay P, Rinne T, et al. Effectiveness of pharmacotherapy for severe personality disorders: meta-analyses of randomized controlled trials. J Clin Psychiatry. 2010;71(1):14-25.

25. Moen Moore R, Miller M, Lee S, et al. Extended release divalproex for borderline personality disorder. Poster presented at: U. S. Psychiatric and Mental Health Congress; October 13-16, 2007; Orlando, FL.

26. Nose M, Cipriani A, Biancosino B, et al. Efficacy of pharmacotherapy against core traits of borderline personality disorder: meta-analysis of randomized controlled trials. Int Clin Psychopharmacol. 2006;21(6):345-353.

27. Lieb K, Völlm B, Rücker G, et al. Pharmacotherapy for borderline personality disorder: Cochrane Systematic Review of Randomised Trials. Br J Psychiatry. 2010;196(1):4-12.

28. Stoffers J, Völlm BA, Rücker G, et al. Pharmacological interventions for borderline personality disorder. Cochrane Database Syst Rev. 2010;(6):CD005653.-

29. National Collaborating Centre for Mental Health. Borderline personality disorder: the NICE guideline on treatment and management. National clinical practice guideline no. 78. London United Kingdom: RCPsych Publications; 2009.

30. Linehan MM, McDavid JD, Brown MZ, et al. Olanzapine plus dialectical behavior therapy for women with high irritability who meet criteria for borderline personality disorder: a double-blind, placebo-controlled pilot study. J Clin Psychiatry. 2008;69(6):999-1005.

31. Soler J, Pascual JC, Campins J, et al. Double-blind, placebo-controlled study of dialectical behavior therapy plus olanzapine for borderline personality disorder. Am J Psychiatry. 2005;162(6):1221-1224.

32. Simpson EB, Yen S, Costello E, et al. Combined dialectical behavior therapy and fluoxetine in the treatment of borderline personality disorder. J Clin Psychiatry. 2004;65(3):379-385.

33. Zanarini MC, Vujanovic AA, Parachini EA, et al. Zanarini Rating Scale for Borderline Personality Disorder (ZAN-BPD): a continuous measure of DSM-IV borderline psychopathology. J Pers Disord. 2003;17(3):233-242.

34. Pfohl B, Blum N, St John D, et al. Reliability and validity of the Borderline Evaluation of Severity Over Time (BEST): a self-rated scale to measure severity and change in persons with borderline personality disorder. J Pers Disord. 2009;23(3):281-293.

35. Silk KR. Collaborative treatment for patients with personality disorders. In: Riba MB Balon R, eds. Psychopharmacology and psychotherapy: a collaborative approach. Washington, DC: American Psychiatric Press; 1999:221–277.

36. Zanarini MC. Update on pharmacotherapy of borderline personality disorder. Curr Psychiatry Rep. 2004;6(1):66-70.

References

1. American Psychiatric Association Practice Guidelines. Practice guideline for the treatment of patients with borderline personality disorder. American Psychiatric Association. Am J Psychiatry. 2001;158(10 suppl):1-52.

2. Barrash J, Kroll J, Carey K, et al. Discriminating borderline disorder from other personality disorders. Cluster analysis of the diagnostic interview for borderlines. Arch Gen Psychiatry. 1983;40(12):1297-1302.

3. Kety SS, Rosenthal D, Wender PH, et al. Mental illness in the biological and adoptive families of adopted individuals who have become schizophrenic: a preliminary report based on psychiatric interviews. Proc Annu Meet Am Psychopathol Assoc. 1975;(63):147-165.

4. Diagnostic and statistical manual of mental disorders, 3rd ed. Washington DC: American Psychiatric Association; 1980.

5. Serban G, Siegel S. Response of borderline and schizotypal patients to small doses of thiothixene and haloperidol. Am J Psychiatry. 1984;141(11):1455-1458.

6. Goldberg SC, Schulz SC, Schulz PM, et al. Borderline and schizotypal personality disorders treated with low-dose thiothixene vs placebo. Arch Gen Psychiatry. 1986;43(7):680-686.

7. Soloff PH, George A, Nathan RS, et al. Progress in pharmacotherapy of borderline disorders. A double-blind study of amitriptyline, haloperidol, and placebo. Arch Gen Psychiatry. 1986;43(7):691-697.

8. Soloff PH, George A, Nathan RS, et al. Paradoxical effects of amitriptyline on borderline patients. Am J Psychiatry. 1986;143(12):1603-1635.

9. Cowdry RW, Gardner DL. Pharmacotherapy of borderline personality disorder. Alprazolam carbamazepine, trifluoperazine, and tranylcypromine. Arch Gen Psychiatry. 1988;45(2):111-119.

10. Markovitz PJ, Calabrese JR, Schulz SC, et al. Fluoxetine in the treatment of borderline and schizotypal personality disorders. Am J Psychiatry. 1991;148(8):1064-1067.

11. Coccaro EF, Kavoussi RJ. Fluoxetine and impulsive aggressive behavior in personality-disordered subjects. Arch Gen Psychiatry. 1997;54(12):1081-1088.

12. Salzman C, Wolfson AN, Schatzberg A, et al. Effect of fluoxetine on anger in symptomatic volunteers with borderline personality disorder. J Clin Psychopharmacol. 1995;15(1):23-29.

13. Hollander E, Tracy KA, Swann AC, et al. Divalproex in the treatment of impulsive aggression: efficacy in cluster B personality disorders. Neuropsychopharmacology. 2003;28(6):1186-1197.

14. Frankenburg FR, Zanarini MC. Divalproex sodium treatment of women with borderline personality disorder and bipolar II disorder: a double-blind placebo-controlled pilot study. J Clin Psychiatry. 2002;63(5):442-446.

15. Schulz SC, Camlin KL, Berry SA, et al. Olanzapine safety and efficacy in patients with borderline personality disorder and comorbid dysthymia. Biol Psychiatry. 1999;46(10):1429-1435.

16. Bogenschutz MP, George Nurnberg H. Olanzapine versus placebo in the treatment of borderline personality disorder. J Clin Psychiatry. 2004;65(1):104-109.

17. Zanarini MC, Frankenburg FR. Olanzapine treatment of female borderline personality disorder patients: a double-blind placebo-controlled pilot study. J Clin Psychiatry. 2001;62(11):849-854.

18. Schulz SC, Zanarini MC, Bateman A, et al. Olanzapine for the treatment of borderline personality disorder: variable dose 12-week randomised double-blind placebo-controlled study. Br J Psychiatry. 2008;193(6):485-492.

19. Nickel MK, Muehlbacher M, Nickel C, et al. Aripiprazole in the treatment of patients with borderline personality disorder: a double-blind, placebo-controlled study. Am J Psychiatry. 2006;163(5):833-838.

20. Adityanjee, Romine A, Brown E, et al. Quetiapine in patients with borderline personality disorder: an open-label trial. Ann Clin Psychiatry. 2008;20(4):219-226.

21. Villeneuve E, Lemelin S. Open-label study of atypical neuroleptic quetiapine for treatment of borderline personality disorder: impulsivity as main target. J Clin Psychiatry. 2005;66(10):1298-1303.

22. Rocca P, Marchiaro L, Cocuzza E, et al. Treatment of borderline personality disorder with risperidone. J Clin Psychiatry. 2002;63(3):241-244.

23. Zanarini MC, Frankenburg FR. Omega-3 fatty acid treatment of women with borderline personality disorder: a double-blind placebo-controlled pilot study. Am J Psychiatry. 2003;160(1):167-169.

24. Ingenhoven T, Lafay P, Rinne T, et al. Effectiveness of pharmacotherapy for severe personality disorders: meta-analyses of randomized controlled trials. J Clin Psychiatry. 2010;71(1):14-25.

25. Moen Moore R, Miller M, Lee S, et al. Extended release divalproex for borderline personality disorder. Poster presented at: U. S. Psychiatric and Mental Health Congress; October 13-16, 2007; Orlando, FL.

26. Nose M, Cipriani A, Biancosino B, et al. Efficacy of pharmacotherapy against core traits of borderline personality disorder: meta-analysis of randomized controlled trials. Int Clin Psychopharmacol. 2006;21(6):345-353.

27. Lieb K, Völlm B, Rücker G, et al. Pharmacotherapy for borderline personality disorder: Cochrane Systematic Review of Randomised Trials. Br J Psychiatry. 2010;196(1):4-12.

28. Stoffers J, Völlm BA, Rücker G, et al. Pharmacological interventions for borderline personality disorder. Cochrane Database Syst Rev. 2010;(6):CD005653.-

29. National Collaborating Centre for Mental Health. Borderline personality disorder: the NICE guideline on treatment and management. National clinical practice guideline no. 78. London United Kingdom: RCPsych Publications; 2009.

30. Linehan MM, McDavid JD, Brown MZ, et al. Olanzapine plus dialectical behavior therapy for women with high irritability who meet criteria for borderline personality disorder: a double-blind, placebo-controlled pilot study. J Clin Psychiatry. 2008;69(6):999-1005.

31. Soler J, Pascual JC, Campins J, et al. Double-blind, placebo-controlled study of dialectical behavior therapy plus olanzapine for borderline personality disorder. Am J Psychiatry. 2005;162(6):1221-1224.

32. Simpson EB, Yen S, Costello E, et al. Combined dialectical behavior therapy and fluoxetine in the treatment of borderline personality disorder. J Clin Psychiatry. 2004;65(3):379-385.

33. Zanarini MC, Vujanovic AA, Parachini EA, et al. Zanarini Rating Scale for Borderline Personality Disorder (ZAN-BPD): a continuous measure of DSM-IV borderline psychopathology. J Pers Disord. 2003;17(3):233-242.

34. Pfohl B, Blum N, St John D, et al. Reliability and validity of the Borderline Evaluation of Severity Over Time (BEST): a self-rated scale to measure severity and change in persons with borderline personality disorder. J Pers Disord. 2009;23(3):281-293.

35. Silk KR. Collaborative treatment for patients with personality disorders. In: Riba MB Balon R, eds. Psychopharmacology and psychotherapy: a collaborative approach. Washington, DC: American Psychiatric Press; 1999:221–277.

36. Zanarini MC. Update on pharmacotherapy of borderline personality disorder. Curr Psychiatry Rep. 2004;6(1):66-70.

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Pharmacologic treatment of borderline personality disorder
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pharmacologic; borderline personality disorder; BPD; pharmacotherapy; Katharine Nelson; S. Charles Schulz; antidepressants; mood stabilizers; newer antipsychotics; omega-3 fatty acids;
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