Role of the Kidney in Type 2 Diabetes and Mechanism of Action of Sodium Glucose Cotransporter-2 Inhibitors

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Role of the Kidney in Type 2 Diabetes and Mechanism of Action of Sodium Glucose Cotransporter-2 Inhibitors

While type 2 diabetes (T2D) is commonly seen in primary care, it is difficult to manage successfully over time. This series offers brief eNewsletters written by clinical experts that are designed to assist in the clinical management of patients with T2D.

This third eNewsletter in the series, entitled, Role of the Kidney in Type 2 Diabetes and Mechanism of Action of Sodium Glucose Cotransporter-2 Inhibitors, was written by Matthew L. Mintz, MD. It explores how the kidney helps to maintain glucose homeostasis and how dysfunctional glucose reabsorption by the sodium-glucose cotransporter-2 (SGLT-2) contributes to the pathophysiology of T2D. The effect of SGLT-2 inhibitors on glycemic control, body weight, blood pressure, and uric acid levels in patients with T2D are also discussed.

Click here to read the supplement

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While type 2 diabetes (T2D) is commonly seen in primary care, it is difficult to manage successfully over time. This series offers brief eNewsletters written by clinical experts that are designed to assist in the clinical management of patients with T2D.

This third eNewsletter in the series, entitled, Role of the Kidney in Type 2 Diabetes and Mechanism of Action of Sodium Glucose Cotransporter-2 Inhibitors, was written by Matthew L. Mintz, MD. It explores how the kidney helps to maintain glucose homeostasis and how dysfunctional glucose reabsorption by the sodium-glucose cotransporter-2 (SGLT-2) contributes to the pathophysiology of T2D. The effect of SGLT-2 inhibitors on glycemic control, body weight, blood pressure, and uric acid levels in patients with T2D are also discussed.

Click here to read the supplement

While type 2 diabetes (T2D) is commonly seen in primary care, it is difficult to manage successfully over time. This series offers brief eNewsletters written by clinical experts that are designed to assist in the clinical management of patients with T2D.

This third eNewsletter in the series, entitled, Role of the Kidney in Type 2 Diabetes and Mechanism of Action of Sodium Glucose Cotransporter-2 Inhibitors, was written by Matthew L. Mintz, MD. It explores how the kidney helps to maintain glucose homeostasis and how dysfunctional glucose reabsorption by the sodium-glucose cotransporter-2 (SGLT-2) contributes to the pathophysiology of T2D. The effect of SGLT-2 inhibitors on glycemic control, body weight, blood pressure, and uric acid levels in patients with T2D are also discussed.

Click here to read the supplement

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The Role of Hysteroscopy in Minimally Invasive Management of Intrauterine Health

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The Role of Hysteroscopy in Minimally Invasive Management of Intrauterine Health

This supplement highlights the benefits of using the Symphion™ Tissue Removal System for diagnostic and operative hysteroscopy.  

 

Faculty/Faculty Disclosure

Linda D. Bradley, MD

Obstetrics, Gynecology and Women’s

  Health Institute,

Cleveland Clinic,

Cleveland, Ohio, USA

 

Competing Interest and Financial Disclosures:  Dr. Bradley reports that she has received grant/research/clinical trial support from Bayer Healthcare Pharmaceuticals Inc. She is a consultant and on the advisory board for Bayer Healthcare Pharmaceuticals Inc., Boston Scientific Corporation, and Smith & Nephew; she is on the advisory board for Patient-Centered Outcomes Research Institute; she is on the speakers' bureau for Smith & Nephew (Medtronic); she is on the scientific advisory panel for Karl Storz; and she is on the data safety and monitoring board for Gynesonics. 

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This supplement highlights the benefits of using the Symphion™ Tissue Removal System for diagnostic and operative hysteroscopy.  

 

Faculty/Faculty Disclosure

Linda D. Bradley, MD

Obstetrics, Gynecology and Women’s

  Health Institute,

Cleveland Clinic,

Cleveland, Ohio, USA

 

Competing Interest and Financial Disclosures:  Dr. Bradley reports that she has received grant/research/clinical trial support from Bayer Healthcare Pharmaceuticals Inc. She is a consultant and on the advisory board for Bayer Healthcare Pharmaceuticals Inc., Boston Scientific Corporation, and Smith & Nephew; she is on the advisory board for Patient-Centered Outcomes Research Institute; she is on the speakers' bureau for Smith & Nephew (Medtronic); she is on the scientific advisory panel for Karl Storz; and she is on the data safety and monitoring board for Gynesonics. 

This supplement highlights the benefits of using the Symphion™ Tissue Removal System for diagnostic and operative hysteroscopy.  

 

Faculty/Faculty Disclosure

Linda D. Bradley, MD

Obstetrics, Gynecology and Women’s

  Health Institute,

Cleveland Clinic,

Cleveland, Ohio, USA

 

Competing Interest and Financial Disclosures:  Dr. Bradley reports that she has received grant/research/clinical trial support from Bayer Healthcare Pharmaceuticals Inc. She is a consultant and on the advisory board for Bayer Healthcare Pharmaceuticals Inc., Boston Scientific Corporation, and Smith & Nephew; she is on the advisory board for Patient-Centered Outcomes Research Institute; she is on the speakers' bureau for Smith & Nephew (Medtronic); she is on the scientific advisory panel for Karl Storz; and she is on the data safety and monitoring board for Gynesonics. 

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The Role of Hysteroscopy in Minimally Invasive Management of Intrauterine Health
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Management of Daily Glycemic Fluctuations in Patients With Type 2 Diabetes

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Management of Daily Glycemic Fluctuations in Patients With Type 2 Diabetes

While type 2 diabetes is commonly seen in primary care, it is difficult to manage successfully over time. This series offers brief eNewsletters written by clinical experts that are designed to assist in the clinical management of patients with type 2 diabetes.

This second eNewsletter in the series entitled "Management of Daily Glycemic Fluctuations in Patients With Type 2 Diabetes" was written by Pamela R. Kushner, MD. This article measures of daily glucose control—specifically glycemic fluctuations and their importance in type 2 diabetes. This article examines how glycemic fluctuations are measured, their clinical implications, and potential clinical approaches for their management.

Click here to read the supplement

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Funding for this newsletter series was provided by AstraZeneca
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Funding for this newsletter series was provided by AstraZeneca

While type 2 diabetes is commonly seen in primary care, it is difficult to manage successfully over time. This series offers brief eNewsletters written by clinical experts that are designed to assist in the clinical management of patients with type 2 diabetes.

This second eNewsletter in the series entitled "Management of Daily Glycemic Fluctuations in Patients With Type 2 Diabetes" was written by Pamela R. Kushner, MD. This article measures of daily glucose control—specifically glycemic fluctuations and their importance in type 2 diabetes. This article examines how glycemic fluctuations are measured, their clinical implications, and potential clinical approaches for their management.

Click here to read the supplement

While type 2 diabetes is commonly seen in primary care, it is difficult to manage successfully over time. This series offers brief eNewsletters written by clinical experts that are designed to assist in the clinical management of patients with type 2 diabetes.

This second eNewsletter in the series entitled "Management of Daily Glycemic Fluctuations in Patients With Type 2 Diabetes" was written by Pamela R. Kushner, MD. This article measures of daily glucose control—specifically glycemic fluctuations and their importance in type 2 diabetes. This article examines how glycemic fluctuations are measured, their clinical implications, and potential clinical approaches for their management.

Click here to read the supplement

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Management of Daily Glycemic Fluctuations in Patients With Type 2 Diabetes
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Calcipotriene-Betamethasone Dipropionate Foam in the Management of Psioriasis: A Panoramic View of Available Studies with Emphasis on Clinical Relevance

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Calcipotriene-Betamethasone Dipropionate Foam in the Management of Psoriasis: A Panoramic View of Available Studies with Emphasis on Clinical Relevance

In this supplement you will learn about:

  • The formulation characteristics of calcipotriene-betamethasone dipropionate aerosol foam (Cal/BD-AF)
  • The efficacy and safety of Cal/BD-AF
  • The results of Phase III clinical trials completed with Cal/BD-AF

Author
James Q. Del Rosso, DO, FAOCD, FAAD
Adjunct Clinical Professor (Dermatology), Touro University Nevada, Henderson, Nevada

Lakes Dermatology and Del Rosso Dermatology Research Center, Las Vegas, Nevada

 

Dr. Del Rosso discloses that he is a consultant, speaker, and researcher for LEO Pharma Inc. Related to this subject area he is also a consultant, speaker, and/or researcher for Aqua Pharmaceuticals/Almirall, S.A.; Bayer AG; Celgene Corporation; Galderma Laboratories, L.P.; Genentech, Inc.; Novan, Inc.; Novartis Pharmaceuticals Corporation; Pfizer Inc. /Anacor Pharmaceuticals, Inc.; PharmaDerm; Promius Pharma, LLC; Sun Pharmaceutical Industries, Ltd.; and Valeant Pharmaceuticals International, Inc.


Click here to download this supplement. 

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A supplement to Dermatology News™. This supplement was sponsored by LEO Pharma …

In this supplement you will learn about:

  • The formulation characteristics of calcipotriene-betamethasone dipropionate aerosol foam (Cal/BD-AF)
  • The efficacy and safety of Cal/BD-AF
  • The results of Phase III clinical trials completed with Cal/BD-AF

Author
James Q. Del Rosso, DO, FAOCD, FAAD
Adjunct Clinical Professor (Dermatology), Touro University Nevada, Henderson, Nevada

Lakes Dermatology and Del Rosso Dermatology Research Center, Las Vegas, Nevada

 

Dr. Del Rosso discloses that he is a consultant, speaker, and researcher for LEO Pharma Inc. Related to this subject area he is also a consultant, speaker, and/or researcher for Aqua Pharmaceuticals/Almirall, S.A.; Bayer AG; Celgene Corporation; Galderma Laboratories, L.P.; Genentech, Inc.; Novan, Inc.; Novartis Pharmaceuticals Corporation; Pfizer Inc. /Anacor Pharmaceuticals, Inc.; PharmaDerm; Promius Pharma, LLC; Sun Pharmaceutical Industries, Ltd.; and Valeant Pharmaceuticals International, Inc.


Click here to download this supplement. 

In this supplement you will learn about:

  • The formulation characteristics of calcipotriene-betamethasone dipropionate aerosol foam (Cal/BD-AF)
  • The efficacy and safety of Cal/BD-AF
  • The results of Phase III clinical trials completed with Cal/BD-AF

Author
James Q. Del Rosso, DO, FAOCD, FAAD
Adjunct Clinical Professor (Dermatology), Touro University Nevada, Henderson, Nevada

Lakes Dermatology and Del Rosso Dermatology Research Center, Las Vegas, Nevada

 

Dr. Del Rosso discloses that he is a consultant, speaker, and researcher for LEO Pharma Inc. Related to this subject area he is also a consultant, speaker, and/or researcher for Aqua Pharmaceuticals/Almirall, S.A.; Bayer AG; Celgene Corporation; Galderma Laboratories, L.P.; Genentech, Inc.; Novan, Inc.; Novartis Pharmaceuticals Corporation; Pfizer Inc. /Anacor Pharmaceuticals, Inc.; PharmaDerm; Promius Pharma, LLC; Sun Pharmaceutical Industries, Ltd.; and Valeant Pharmaceuticals International, Inc.


Click here to download this supplement. 

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Calcipotriene-Betamethasone Dipropionate Foam in the Management of Psoriasis: A Panoramic View of Available Studies with Emphasis on Clinical Relevance
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Nonsteroidal Anti-inflammatory Drugs and Cardiovascular Risk: Where Are We Today?

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Nonsteroidal Anti-inflammatory Drugs and Cardiovascular Risk: Where Are We Today?

Topics

  • Historical Overview
  • Mechanistic Basis for a Cardiovascular Hazard
  • Evidence from Meta-Analyses
  • Cardiovascular Risk
  • Implications for Patient Management

 

Faculty/Faculty Disclosure:
Gary Rouff, MD
Clinical Professor of Family Medicine,
Department of Family Practice,
Michigan State University
College of Medicine, Director of Clinical
Research, Westside Family Medical Center
Kalamazoo, MI

 

Dr. Rouff discloses that he has no real or apparent conflict of interest to report

 

Click Here to Read Supplement

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Topics

  • Historical Overview
  • Mechanistic Basis for a Cardiovascular Hazard
  • Evidence from Meta-Analyses
  • Cardiovascular Risk
  • Implications for Patient Management

 

Faculty/Faculty Disclosure:
Gary Rouff, MD
Clinical Professor of Family Medicine,
Department of Family Practice,
Michigan State University
College of Medicine, Director of Clinical
Research, Westside Family Medical Center
Kalamazoo, MI

 

Dr. Rouff discloses that he has no real or apparent conflict of interest to report

 

Click Here to Read Supplement

Topics

  • Historical Overview
  • Mechanistic Basis for a Cardiovascular Hazard
  • Evidence from Meta-Analyses
  • Cardiovascular Risk
  • Implications for Patient Management

 

Faculty/Faculty Disclosure:
Gary Rouff, MD
Clinical Professor of Family Medicine,
Department of Family Practice,
Michigan State University
College of Medicine, Director of Clinical
Research, Westside Family Medical Center
Kalamazoo, MI

 

Dr. Rouff discloses that he has no real or apparent conflict of interest to report

 

Click Here to Read Supplement

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Nonsteroidal Anti-inflammatory Drugs and Cardiovascular Risk: Where Are We Today?
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Finding a Better Approach to Diagnosing Abnormal Uterine Bleeding

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Finding a Better Approach to Diagnosing Abnormal Uterine Bleeding

Click here to download the PDF.

Despite advances in diagnostic medicine, the evaluation of abnormal uterine bleeding (AUB) remains a challenge for physicians.  In this supplement, learn about:

  • Pathophysiology and differential diagnosis of AUB
  • The limitations of blind endometrial biopsy
  • The differences between diagnostic hysteroscopy options

 

Author

Steven R. Goldstein, MD

Professor of Obstetrics and Gynecology

New York University School of Medicine

Immediate Past President

American Institute of Ultrasound in Medicine

Director of Gynecologic Ultrasound and Co-Director of Bone Densitometry

New York University Medical Center

New York, New York

 

DISCLOSURES

Dr. Goldstein discloses that he is a paid consultant for CooperSurgical.

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Click here to download the PDF.

Despite advances in diagnostic medicine, the evaluation of abnormal uterine bleeding (AUB) remains a challenge for physicians.  In this supplement, learn about:

  • Pathophysiology and differential diagnosis of AUB
  • The limitations of blind endometrial biopsy
  • The differences between diagnostic hysteroscopy options

 

Author

Steven R. Goldstein, MD

Professor of Obstetrics and Gynecology

New York University School of Medicine

Immediate Past President

American Institute of Ultrasound in Medicine

Director of Gynecologic Ultrasound and Co-Director of Bone Densitometry

New York University Medical Center

New York, New York

 

DISCLOSURES

Dr. Goldstein discloses that he is a paid consultant for CooperSurgical.

Click here to download the PDF.

Despite advances in diagnostic medicine, the evaluation of abnormal uterine bleeding (AUB) remains a challenge for physicians.  In this supplement, learn about:

  • Pathophysiology and differential diagnosis of AUB
  • The limitations of blind endometrial biopsy
  • The differences between diagnostic hysteroscopy options

 

Author

Steven R. Goldstein, MD

Professor of Obstetrics and Gynecology

New York University School of Medicine

Immediate Past President

American Institute of Ultrasound in Medicine

Director of Gynecologic Ultrasound and Co-Director of Bone Densitometry

New York University Medical Center

New York, New York

 

DISCLOSURES

Dr. Goldstein discloses that he is a paid consultant for CooperSurgical.

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Finding a Better Approach to Diagnosing Abnormal Uterine Bleeding
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Fostering surgical innovation: The path forward

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Fostering surgical innovation: The path forward
How do we get past the current “chill” on innovation in gynecologic surgery? By talking to innovators themselves, we can discuss and dissect the process, and focus on moving forward.

Click here to download the PDF.

 

Key learning objectives


The faculty for this roundtable aim to:

  1. Explain the process for bringing an innovation to market, including the roles of surgeon inventor, engineer, manufacturer, and industry
  2. Discuss best practices, based on lessons learned, when pursuing an innovative idea for patient care
  3. Articulate ways to improve upon the entire development process for new techniques, devices, etc, being brought to the FDA for possible approval and to market for patient use.
Author and Disclosure Information

Eric R. Sokol, MD
Associate Professor, Obstetrics and Gynecology and Urology
Co-Chief, Urogynecology and Pelvic Reconstructive Surgery
Faculty Fellow, Stanford Biodesign Innovation Program
Stanford University School of Medicine
Stanford, California

Elise M. DeVries, BS
Medical Device Consulting
Biodesign Innovation Fellow
Stanford University Biodesign Innovation Program
Stanford, California

Cheryl B. Iglesia, MD
Director, Section of Female Pelvic Medicine and Reconstructive Surgery
MedStar Washington Hospital Center
Professor, Obstetrics and Gynecology and Urology
Georgetown University School of Medicine
Washington, DC
Member, OBG Management Board of Editors

Peter L. Rosenblatt, MD
Assistant Professor, Obstetrics, Gynecology and Reproductive Biology
Harvard Medical School
Director of Urogynecology
Mount Auburn Hospital
Cambridge, Massachusetts

The authors report no financial relationships relevant to this article.

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Eric R. Sokol, MD
Associate Professor, Obstetrics and Gynecology and Urology
Co-Chief, Urogynecology and Pelvic Reconstructive Surgery
Faculty Fellow, Stanford Biodesign Innovation Program
Stanford University School of Medicine
Stanford, California

Elise M. DeVries, BS
Medical Device Consulting
Biodesign Innovation Fellow
Stanford University Biodesign Innovation Program
Stanford, California

Cheryl B. Iglesia, MD
Director, Section of Female Pelvic Medicine and Reconstructive Surgery
MedStar Washington Hospital Center
Professor, Obstetrics and Gynecology and Urology
Georgetown University School of Medicine
Washington, DC
Member, OBG Management Board of Editors

Peter L. Rosenblatt, MD
Assistant Professor, Obstetrics, Gynecology and Reproductive Biology
Harvard Medical School
Director of Urogynecology
Mount Auburn Hospital
Cambridge, Massachusetts

The authors report no financial relationships relevant to this article.

Author and Disclosure Information

Eric R. Sokol, MD
Associate Professor, Obstetrics and Gynecology and Urology
Co-Chief, Urogynecology and Pelvic Reconstructive Surgery
Faculty Fellow, Stanford Biodesign Innovation Program
Stanford University School of Medicine
Stanford, California

Elise M. DeVries, BS
Medical Device Consulting
Biodesign Innovation Fellow
Stanford University Biodesign Innovation Program
Stanford, California

Cheryl B. Iglesia, MD
Director, Section of Female Pelvic Medicine and Reconstructive Surgery
MedStar Washington Hospital Center
Professor, Obstetrics and Gynecology and Urology
Georgetown University School of Medicine
Washington, DC
Member, OBG Management Board of Editors

Peter L. Rosenblatt, MD
Assistant Professor, Obstetrics, Gynecology and Reproductive Biology
Harvard Medical School
Director of Urogynecology
Mount Auburn Hospital
Cambridge, Massachusetts

The authors report no financial relationships relevant to this article.

How do we get past the current “chill” on innovation in gynecologic surgery? By talking to innovators themselves, we can discuss and dissect the process, and focus on moving forward.
How do we get past the current “chill” on innovation in gynecologic surgery? By talking to innovators themselves, we can discuss and dissect the process, and focus on moving forward.

Click here to download the PDF.

 

Key learning objectives


The faculty for this roundtable aim to:

  1. Explain the process for bringing an innovation to market, including the roles of surgeon inventor, engineer, manufacturer, and industry
  2. Discuss best practices, based on lessons learned, when pursuing an innovative idea for patient care
  3. Articulate ways to improve upon the entire development process for new techniques, devices, etc, being brought to the FDA for possible approval and to market for patient use.

Click here to download the PDF.

 

Key learning objectives


The faculty for this roundtable aim to:

  1. Explain the process for bringing an innovation to market, including the roles of surgeon inventor, engineer, manufacturer, and industry
  2. Discuss best practices, based on lessons learned, when pursuing an innovative idea for patient care
  3. Articulate ways to improve upon the entire development process for new techniques, devices, etc, being brought to the FDA for possible approval and to market for patient use.
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Fostering surgical innovation: The path forward
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Intake of Vitamins and Minerals Is Inadequate for Most Americans: What Should We Advise Patients About Supplements?

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Intake of Vitamins and Minerals Is Inadequate for Most Americans: What Should We Advise Patients About Supplements?

This supplement examines the role of vitamin and mineral supplements in increasing nutrient intake and reducing nutrient deficiencies and inadequacies. Although research is needed to study the effects of dietary supplements on chronic disease outcomes, US health care providers need to know how to advise their patients about adding vitamins and minerals to their diets.

Click here to read supplement

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This supplement examines the role of vitamin and mineral supplements in increasing nutrient intake and reducing nutrient deficiencies and inadequacies. Although research is needed to study the effects of dietary supplements on chronic disease outcomes, US health care providers need to know how to advise their patients about adding vitamins and minerals to their diets.

Click here to read supplement

This supplement examines the role of vitamin and mineral supplements in increasing nutrient intake and reducing nutrient deficiencies and inadequacies. Although research is needed to study the effects of dietary supplements on chronic disease outcomes, US health care providers need to know how to advise their patients about adding vitamins and minerals to their diets.

Click here to read supplement

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Intake of Vitamins and Minerals Is Inadequate for Most Americans: What Should We Advise Patients About Supplements?
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