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Barriers and Facilitators to Guideline-Adherent Pulse Oximetry Use in Bronchiolitis
Continuous pulse oximetry monitoring (cSpO2) in children with bronchiolitis is associated with increased rates of hospital admission, longer lengths of stay, more frequent treatment with supplemental oxygen, alarm fatigue, and higher hospital cost. There is no evidence that it improves clinical outcomes.1-7 The safety of reducing cSpO2 for stable bronchiolitis patients (ie, those who are clinically well and not requiring supplemental oxygen) has been assessed in quality improvement initiatives8-10 and a randomized controlled trial.2 These studies showed no increase in intensive care unit transfers, codes, or readmissions associated with reduced cSpO2. Current national guidelines from the American Academy of Pediatrics5 and the Society of Hospital Medicine Choosing Wisely in Pediatric Hospital Medicine workgroup4 support limiting monitoring of children with bronchiolitis. Despite this, the practice of cSpO2 in stable bronchiolitis patients off supplemental oxygen remains widespread.11,12
Deimplementation, defined as reducing or stopping low-value or ineffective healthcare practices,13,14 is a discrete focus area within implementation science. Deimplementation research involves the reduction of unnecessary and overused services for which there is potential for harm or no benefit.15,16 In pediatrics, there are a number of potential targets for deimplementation,4,17-20 including cSpO2 for stable infants with bronchiolitis, but efforts to reduce low-value practices have met limited success to date. 21,22
Implementation science offers rigorous methods for advancing the development and evaluation of strategies for deimplementation.23 In particular, implementation science frameworks can facilitate our understanding of relevant contextual factors that may hinder or help efforts to deimplement low-value practices. To develop broadly applicable strategies to reduce monitoring overuse, it is important to understand the barriers, facilitators, and contextual factors (eg, clinical, political, interpersonal) that contribute to guideline-discordant cSpO2 in hospitalized bronchiolitis patients. Further, the process by which one can develop a rigorous understanding of these factors and how they may impact deimplementation efforts could generalize to other scenarios in pediatrics where overuse remains an issue.
The goal of this study was to use semistructured interviews, informed by an established implementation science framework, specifically the Consolidated Framework for Implementation Research (CFIR),24 to (1) identify barriers and facilitators to deimplementing unnecessary cSpO2, and (2) develop strategies to deimplement cSpO2 in a multicenter cohort of hospital-based clinician and administrative stakeholders.
METHODS
Study Setting
This multicenter qualitative study using semistructured interviews took place within the Eliminating Monitor Overuse (EMO) SpO2 study. The EMO SpO2 study established rates of cSpO2 in bronchiolitis patients not receiving supplemental oxygen or not receiving room air flow at 56 hospitals across the United States and in Canada from December 1, 2018, through March 31, 2019.12 The study identified hospital-level risk-adjusted cSpO2 rates ranging from 6% to 82%. A description of the EMO SpO2 study methods25 and its findings12 have been published elsewhere.
Participants
We approached EMO study site principal investigators at 12 hospitals: the two highest- and two lowest-use hospitals within three hospital types (ie, freestanding children’s hospitals, children’s hospitals within large general hospitals, and community hospitals). We collaborated with the participating site principal investigators (n = 12), who were primarily hospitalist physicians in leadership roles, to recruit a purposive sample of additional stakeholders including bedside nurses (n = 12), hospitalist physicians (n = 15), respiratory therapists (n = 9), and hospital administrators (n = 8) to participate in semistructured interviews. Interviews were conducted until we achieved thematic saturation within each stakeholder group and within the high and low performing strata (total 56 interviews). Participants were asked to self-report basic demographic information (see Appendix, interview guide) as required by the study funder and to allow us to comment on the representativeness of the participant group.
Procedure
The interview guide was informed by the CFIR, a comprehensive framework detailing contextual factors that require consideration when planning for the implementation of a health service intervention. Table 1 details the CFIR domains with study-related examples. The interview guide (Appendix) provided limited clinical context apart from the age, diagnosis, and oxygen requirement for the population of interest to promote a broad array of responses and to avoid anchoring on specific clinical scenarios. Interviews were conducted by master’s degree or doctoral-level research coordinators with qualitative interviewing experience and supervised by a medical anthropologist and qualitative methods expert (F.K.B.). Prior to engaging in audio recorded phone interviews, the interviewer explained the risks and benefits of participating. Participants were compensated $50. Audio recordings were transcribed, deidentified, and uploaded to NVivo 12 Plus (QSR International) for data management.
The Institutional Review Boards of Children’s Hospital of Philadelphia, Pennsylvania, and the University of Pennsylvania in Philadelphia determined that the study met eligibility criteria for IRB exemption.
Data Analysis
Using an integrated approach to codebook development,26 a priori codes were developed using constructs from the CFIR. Additional codes were added by the research team following a close reading of the first five transcripts.27,28 Each code was defined, including decision rules for its application. Two research coordinators independently coded each transcript. Using the intercoder reliability function within NVivo, the coders established strong interrater reliability accordance scores (
RESULTS
Barriers and facilitators to deimplementation were identified in multiple domains of the CFIR: outer setting, inner setting, characteristics of the individuals, and intervention characteristics (Table 1). Participants also suggested strategies to facilitate deimplementation in response to some identified barriers. See Table 2 for participant demographics and Table 3 for illustrative participant quotations.
Barriers
Outer Setting: Clinician Perceptions of Parental Discomfort With Discontinuing Monitoring
Participants mentioned parental preferences as a barrier to discontinuing cSpO2, noting that parents seem to take comfort in watching the numbers on the monitor screen and are reluctant to have it withdrawn. Clinicians noted that parents sometimes put the monitor back on their child after a clinician removed it or have expressed concern that their unmonitored child was not receiving the same level of care as other patients who were being monitored. In these scenarios, clinicians reported they have found it helpful to educate caregivers about when cSpO2 is and is not appropriate.
Inner Setting: Unclear or Nonexistent Guideline to Discontinue cSpO2
Guidelines to discontinue cSpO2 reportedly did not exist at all institutions. If a guideline did exist, lack of clarity or conflicting guidelines about when to use oxygen presented a barrier. Participants suggested that a clear guideline or additional oversight to ensure all clinicians are informed of the procedure for discontinuing cSpO2 may help prevent miscommunication. Participants noted that their electronic health record (EHR) order sets commonly included cSpO2 orders and that removing that option would facilitate deimplementation.
Inner Setting: Difficulty Educating All Staff
Participants noted difficulty with incorporating education about discontinuing cSpO2 to all clinicians, particularly to those who are nightshift only or to rotating staff or trainees. This created barriers for frequent re-education because these staff are not familiar with the policies and procedures of the unit, which is crucial to developing a culture that supports the deimplementation of cSpO2. Participants suggested that recurring education about procedures for discontinuing cSpO2 should target trainees, new nurses, and overnight nurses. This would help to ensure that the guideline is uniformly followed.
Inner Setting: Culture of High cSpO2 Use
Participants from high-use sites discussed a culture driven by readily available monitoring features or an expectation that monitoring indicates higher-quality care. Participants from low-use sites discussed increased cSpO2 driven by clinicians who were accustomed to caring for higher-acuity patients, for whom continuous monitoring is likely appropriate, and were simultaneously caring for stable bronchiolitis patients.
Some suggested that visual cues would be useful to clinicians to sustain awareness about a cSpO2 deimplementation guideline. It was also suggested that audit and feedback techniques like posting unit deimplementation statistics and creating a competition among units by posting unit performance could facilitate deimplementation. Additionally, some noted that visual aids in common spaces would be useful to remind clinicians and to engage caregivers about discontinuing cSpO2.
Characteristics of Individuals: Clinician Discomfort Discontinuing cSpO2
One frequently cited barrier across participants is that cSpO2 provides “peace of mind” to alert clinicians to patients with low oxygen saturations that might otherwise be missed. Participants identified that clinician discomfort with reducing cSpO2 may be driven by inexperienced clinicians less familiar with the bronchiolitis disease process, such as trainees, new nurses, or rotating clinicians unaccustomed to pediatric care. Trainees and new nurses were perceived as being more likely to work at night when there are fewer clinicians to provide patient care. Additionally, participants perceived that night shift clinicians favored cSpO2 because they could measure vital signs without waking patients and families.
Clinicians discussed that discontinuing cSpO2 would require alternative methods for assessing patient status, particularly for night shift nurses. Participants suggested strategies including changes to pulse oximetry assessment procedures to include more frequent “spot checks,” incorporation of assessments during sleep events (eg, naps) to ensure the patient does not experience desaturations during sleep, and training nurses to become more comfortable with suctioning patients. Suggestions also included education on the typical features of transient oxygen desaturations in otherwise stable patients with bronchiolitis2 to bolster clinical confidence for clinicians unfamiliar with caring for bronchiolitis patients. Participants perceived that education about appropriate vs inappropriate use may help to empower clinicians to employ cSpO2 appropriately.
Facilitators
Outer Setting: Standards and Evidence From Research, Professional Organizations, and Leaders in the Field
Many participants expressed the importance of consistent guidelines that are advocated by thought leaders in the field, supported by robust evidence, and consistent with approaches at peer hospitals. The more authoritative support a guideline has, the more comfortable people are adopting it and taking it seriously. Additionally, consistent education about guidelines was desired. Participants noted that all clinicians should be receiving education related to the American Academy of Pediatrics (AAP) Bronchiolitis and Choosing Wisely® guidelines, ranging from a one-time update to annually. Continual updates and re-education sessions for clinicians who shared evidence about how cSpO2 deimplementation could improve the quality of patient care by shortening hospital length of stay and lowering cost were suggested strategies.
Inner Setting: Leadership
Participants noted that successful deimplementation depends upon the presence of a champion or educator who will be able to lead the institutional charge in making practice change. This is typically an individual who is trusted at the institution, experienced in their field, or already doing implementation work. This could be either a single individual (champion) or a team. The most commonly noted clinician roles to engage in a leadership role or team were physicians and nurses.
Participants noted that a change in related clinical care pathways or EHR order sets would require cooperation from multiple clinical disciplines, administrators, and information technology leaders and explained that messaging and education about the value of the change would facilitate buy-in from those clinicians.
Inner Setting: EHR Support for Guidelines
Participants often endorsed the use of an order set within the EHR that supports guidelines and includes reminders to decrease cSpO2. These reminders could come up when supplemental oxygen is discontinued or occur regularly throughout the patient’s stay to prompt the clinician to consider discontinuing cSpO2.
Intervention Characteristics/Inner Setting: Clear Bronchiolitis Guidelines
The presence of a well-articulated hospital policy that delineates the appropriate and inappropriate use of cSpO2 in bronchiolitis was mentioned as another facilitator of deimplementation.
DISCUSSION
Results of this qualitative study of stakeholders across hospitals with high and low cSpO2 use illustrated the complexities involved with deimplementation of cSpO2 in pediatric patients hospitalized with bronchiolitis. We identified numerous barriers spanning the CFIR constructs, including unclear or absent guidelines for stopping cSpO2, clinician knowledge and comfort with bronchiolitis disease features, and unit culture. This suggests that multicomponent strategies that target various domains and a variety of stakeholders are needed to deimplement cSpO2 use for stable bronchiolitis patients. Participants also identified facilitators, including clear cSpO2 guidelines, supportive leaders and champions, and EHR modifications, that provide insight into strategies that may help sites reduce their use of cSpO2. Additionally, participants also provided concrete, actionable suggestions for ways to reduce unnecessary monitoring that will be useful in informing promising deimplementation strategies for subsequent trials.
The importance of having specific and well-known guidelines from trusted sources, such as the AAP, about cSpO2 and bronchiolitis treatment that are thoughtfully integrated in the EHR came through in multiple themes of our analysis. Prior studies on the effect of guidelines on clinical practice have suggested that rigorously designed guidelines can positively impact practice.29 Participants also noted that cSpO2 guidelines should be authoritative and that knowledge of guideline adoption by peer institutions was a facilitator of adoption. Usability issues negatively impact clinicians’ ability to follow guidelines.30 Further, prior studies have demonstrated that EHR integration of guidelines can change practice.31-33 Based on our findings, incorporating clear guidelines into commonly used formats, such as EHR order sets, could be an important deimplementation tool for cSpO2 in stable bronchiolitis patients.
Education about and awareness of cSpO2 guidelines was described as an important facilitator for appropriate cSpO2 use and was suggested as a potential deimplementation strategy. Participants noted that educational need may vary by stakeholder group. For example, education may facilitate obtaining buy-in from hospital leaders, which is necessary to support changes to the EHR. Education incorporating information on the typical features of bronchiolitis and examples of appropriate and inappropriate cSpO2 use was suggested for clinical team members. The limitations of education as a stand-alone deimplementation strategy were also noted, and participants highlighted challenges such as time needed for education and the need for ongoing education for rotating trainees. Inner and outer setting barriers, such as a perceived “culture of high pulse oximetryuse” and patient and family expectations, could also make education less effective as a stand-alone strategy. That—coupled with evidence that education and training alone are generally insufficient for producing reliable, sustained behavior change34,35—suggests that a multifaceted approach will be important.
Our respondents consider parental perceptions and preference in their practice, which provides nuance to recent studies suggesting that parents prefer continuous monitors when their child is hospitalized with bronchiolitis. Chi et al described the impact of a brief educational intervention on parental preferences for monitoring children hospitalized for bronchiolitis.36 This work suggests that educational interventions aimed at families should be considered in future (de)implementation studies because they may indirectly impact clinician behavior. Future studies should directly assess parental discomfort with discontinuing monitoring. Participants highlighted the link between knowledge and confidence in caring for typical bronchiolitis patients and monitoring practice, perceiving that less experienced clinicians are more likely to rely on cSpO2. Participants at high-use sites emphasized the expectation that monitoring should occur during hospitalizations. This reflection is particularly pertinent for bronchiolitis, a disease characterized by frequent, self-resolving desaturations even after hospital discharge.3 This may reinforce a perceived need to capture and react to these desaturation events even though they are expected in bronchiolitis and can occur in healthy infants.37 Some participants suggested that continuous monitoring be replaced with “nap tests” (ie, assessment for desaturations during a nap prior to discharge); however, like cSpO2 in stable infants with bronchiolitis, this is another low-value practice. Otherwise healthy infants with mild to moderate disease are unlikely to subsequently worsen after showing signs of clinical improvement.38 Nap tests are likely to lead to infants who are clinically improving being placed unnecessarily back on oxygen in reaction to the transient desaturations. Participants’ perception about the importance of cSpO2 in bronchiolitis management, despite evidence suggesting it is a low-value practice, underscores the importance of not simply telling clinicians to stop cSpO2. Employing strategies that replace continuous monitoring with another acceptable and feasible alternative (eg, regular clinician assessments including intermittent pulse oximetry checks) should be considered when planning for deimplementation.39
Previous studies indicate that continuous monitoring can affect clinician decision-making, independent of other factors,6,40 despite limited evidence that continuous monitors improve patient outcomes.1-7 Studies have demonstrated noticeable increase in admissions based purely on pulse oximetry values,40 with no evidence that this type of admission changes outcomes for bronchiolitis patients.6 One previous, single-center study identified inexperience as a potential driver for monitor use,41 and studies in adult populations have suggested that clinicians overestimate the value that continuous monitoring contributes to patient care,42,43 which promotes guideline-discordant use. Our study provides novel insight into the issue of monitoring in bronchiolitis. Our results suggest that there is a need to shift organizational cultures around monitoring (which likely vary based on a range of factors) and that educational strategies addressing typical disease course, especially desaturations, in bronchiolitis will be an essential component in any deimplementation effort.
This study is strengthened by its sample of diverse stakeholder groups from multiple US health systems. Additionally, we interviewed individuals at sites with high cSpO2 rates and at sites with low rates, as well as from community hospitals, children’s hospitals within general hospitals, and freestanding children’s hospitals, which allows us to understand barriers high-use sites encounter and facilitators of lower cSpO2 rates at low-use sites. We also employed an interview approach informed by an established implementation science framework. Nonetheless, several limitations exist. First, participants at low-use sites did not necessarily have direct experience with a previous deimplementation effort to reduce cSpO2. Additionally, participants were predominantly White and female; more diverse perspectives would strengthen confidence in the generalizability of our findings. While thematic saturation was achieved within each stakeholder group and within the high- and low-use strata, we interviewed fewer administrators and respiratory therapists relative to other stakeholder groups. Nevertheless, our conclusions were validated by our interdisciplinary stakeholder panel. As noted by participants, family preferences may influence clinician practice, and parents were not interviewed for this study. The information gleaned from the present study will inform the development of strategies to deimplement unnecessary cSpO2 in pediatric hospitals, which we aim to rigorously evaluate in a future trial.
CONCLUSION
We identified barriers and facilitators to deimplementation of cSpO2 for stable patients with bronchiolitis across children’s hospitals with high and low utilization of cSpO2. These themes map to multiple CFIR domains and, along with participant-suggested strategies, can directly inform an approach to cSpO2 deimplementation in a range of inpatient settings. Based on these data, future deimplementation efforts should focus on clear protocols for use and discontinuation of cSpO2, EHR changes, and regular bronchiolitis education for hospital staff that emphasizes reducing unnecessary cSpO2 utilization.
ACKNOWLEDGMENTS
We acknowledge the NHLBI scientists who contributed their expertise to this project as part of the U01 Cooperative Agreement funding mechanism as federal employees conducting their official job duties: Lora Reineck, MD, MS, Karen Bienstock, MS, and Cheryl Boyce, PhD. We thank the Executive Council of the Pediatric Research in Inpatient Settings (PRIS) Network for their contributions to the early scientific development of this project. The Network assessed a Collaborative Support Fee for access to the hospitals and support of this project. We thank the PRIS Network collaborators for their major contributions to data collection measuring utilization to identify the hospitals we subsequently chose for this project. We thank Claire Bocage and the Mixed Methods Research Lab for major help in data management and data analysis.
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12. Bonafide CP, Xiao R, Brady PW, et al. Prevalence of continuous pulse oximetry monitoring in hospitalized children with bronchiolitis not requiring supplemental oxygen. JAMA. 2020;323(15):1467-1477. https://doi.org/10.1001/jama.2020.2998
13. van Bodegom-Vos L, Davidoff F, Marang-van de Mheen PJ. Implementation and de-implementation: two sides of the same coin? BMJ Qual Saf. 2017;26(6):495-501. https://doi.org/10.1136/bmjqs-2016-005473
14. McKay VR, Morshed AB, Brownson RC, Proctor EK, Prusaczyk B. Letting go: conceptualizing intervention de-implementation in public health and social service settings. Am J Community Psychol. 2018;62(1-2):189-202. https://doi.org/10.1002/ajcp.12258
15. Brownlee S, Chalkidou K, Doust J, et al. Evidence for overuse of medical services around the world. Lancet. 2017;390(10090):156-168. https://doi.org/10.1016/s0140-6736(16)32585-5
16. Chassin MR, Galvin RW. The urgent need to improve health care quality. Institute of Medicine National roundtable on health care quality. JAMA. 1998;280(11):1000-1005. https://doi.org/10.1001/jama.280.11.1000
17. Coon ER, Young PC, Quinonez RA, Morgan DJ, Dhruva SS, Schroeder AR. 2017 update on pediatric medical overuse: a review. JAMA Pediatr. 2018;172(5):482-486. https://doi.org/10.1001/jamapediatrics.2017.5752
18. Schuh S, Babl FE, Dalziel SR, et al; Pediatric Emergency Research Networks (PERN). Practice variation in acute bronchiolitis: a Pediatric Emergency Research Networks study. Pediatrics. 2017;140(6):e20170842. https://doi.org/10.1542/peds.2017-0842
19. Lewis-de Los Angeles WW, Thurm C, Hersh AL, et al. Trends in intravenous antibiotic duration for urinary tract infections in young infants. Pediatrics. 2017;140(6):e20171021. https://doi.org/10.1542/peds.2017-1021
20. Parikh K, Hall M, Mittal V, et al. Establishing benchmarks for the hospitalized care of children with asthma, bronchiolitis, and pneumonia. Pediatrics. 2014;134(3):555-562. https://doi.org/10.1542/peds.2014-1052
21. Ralston SL, Garber MD, Rice-Conboy E, et al; Value in Inpatient Pediatrics Network Quality Collaborative for Improving Hospital Compliance with AAP Bronchiolitis Guideline (BQIP). A multicenter collaborative to reduce unnecessary care in inpatient bronchiolitis. Pediatrics. 2016;137(1):e20150851. https://doi.org/10.1542/peds.2015-0851
22. Reyes MA, Etinger V, Hall M, et al. Impact of the Choosing Wisely((R)) Campaign recommendations for hospitalized children on clinical practice: trends from 2008 to 2017. J Hosp Med. 2020;15(2):68-74. https://doi.org/10.12788/jhm.3291
23. Norton WE, Chambers DA. Unpacking the complexities of de-implementing inappropriate health interventions. Implement Sci. 2020;15(1):2. https://doi.org/10.1186/s13012-019-0960-9
24. Damschroder LJ, Aron DC, Keith RE, Kirsh SR, Alexander JA, Lowery JC. Fostering implementation of health services research findings into practice: a consolidated framework for advancing implementation science. Implement Sci. 2009;4:50. https://doi.org/10.1186/1748-5908-4-50
25. Rasooly IR, Beidas RS, Wolk CB, et al. Measuring overuse of continuous pulse oximetry in bronchiolitis and developing strategies for large-scale deimplementation: study protocol for a feasibility trial. Pilot Feasibility Stud. 2019;5:68. https://doi.org/10.1186/s40814-019-0453-2
26. Bradley EH, Curry LA, Devers KJ. Qualitative data analysis for health services research: developing taxonomy, themes, and theory. Health Serv Res. 2007;42(4):1758-1772. https://doi.org/10.1111/j.1475-6773.2006.00684.x
27. Glaser BG, Strauss AL. The Discovery of Grounded Theory: Strategies for Qualitative Research. Aldine Pub. Co.; 1967.
28. Charmaz K. Grounded Theory: Objectivist and Constructivist Methods. In: Denzin NK, Lincoln Y, eds. Handbook of Qualitative Research. 2nd ed. Sage Publications; 2000:509-535.
29. Grimshaw JM, Russell IT. Effect of clinical guidelines on medical practice: a systematic review of rigorous evaluations. Lancet. 1993;342(8883):1317-1322. https://doi.org/10.1016/0140-6736(93)92244-n
30. Cabana MD, Rand CS, Powe NR, et al. Why don’t physicians follow clinical practice guidelines? a framework for improvement. JAMA. 1999;282(15):1458-1465. https://doi.org/10.1001/jama.282.15.1458
31. Dressler R, Dryer MM, Coletti C, Mahoney D, Doorey AJ. Altering overuse of cardiac telemetry in non-intensive care unit settings by hardwiring the use of American Heart Association guidelines. JAMA Intern Med. 2014;174(11):1852-1854. https://doi.org/10.1001/jamainternmed.2014.4491
32. Forrest CB, Fiks AG, Bailey LC, et al. Improving adherence to otitis media guidelines with clinical decision support and physician feedback. Pediatrics. 2013;131(4):e1071-e1081. https://doi.org/10.1542/peds.2012-1988
33. Fiks AG, Grundmeier RW, Mayne S, et al. Effectiveness of decision support for families, clinicians, or both on HPV vaccine receipt. Pediatrics. 2013;131(6):1114-1124. https://doi.org/10.1542/peds.2012-3122
34. Nolan T, Resar R, Griffin F, Gordon AB. Improving the Reliability of Health Care. Institute for Healthcare Improvement; 2004. http://www.ihi.org/resources/Pages/IHIWhitePapers/ImprovingtheReliabilityofHealthCare.aspx
35. Beidas RS, Kendall PC. Training Therapists in evidence-based practice: a critical review of studies from a systems-contextual perspective. Clin Psychol (New York). 2010;17(1):1-30. https://doi.org/10.1111/j.1468-2850.2009.01187.x
36. Chi KW, Coon ER, Destino L, Schroeder AR. Parental perspectives on continuous pulse oximetry use in bronchiolitis hospitalizations. Pediatrics. 2020;146(2):e20200130. https://doi.org/10.1542/peds.2020-0130
37. Hunt CE, Corwin MJ, Lister G, et al. Longitudinal assessment of hemoglobin oxygen saturation in healthy infants during the first 6 months of age. Collaborative Home Infant Monitoring Evaluation (CHIME) Study Group. J Pediatr. 1999;135(5):580-586. https://doi.org/10.1016/s0022-3476(99)70056-9
38. Mansbach JM, Clark S, Piedra PA, et al; MARC-30 Investigators. Hospital course and discharge criteria for children hospitalized with bronchiolitis. J Hosp Med. 2015;10(4):205-211. https://doi.org/10.1002/jhm.2318
39. Burton C, Williams L, Bucknall T, et al. Understanding how and why de-implementation works in health and care: research protocol for a realist synthesis of evidence. Syst Rev. 2019;8(1):194. https://doi.org/10.1186/s13643-019-1111-840. Mallory MD, Shay DK, Garrett J, Bordley WC. Bronchiolitis management preferences and the influence of pulse oximetry and respiratory rate on the decision to admit. Pediatrics. 2003;111(1):e45-51. https://doi.org/10.1542/peds.111.1.e45.
41. Schondelmeyer AC, Jenkins AM, Allison B, et al. Factors influencing use of continuous physiologic monitors for hospitalized pediatric patients. Hosp Pediatr. 2019;9(6):423-428. https://doi.org/10.1542/hpeds.2019-0007
42. Najafi N, Auerbach A. Use and outcomes of telemetry monitoring on a medicine service. Arch Intern Med. 2012;172(17):1349-1350. https://doi.org/10.1001/archinternmed.2012.3163
43. Estrada CA, Rosman HS, Prasad NK, et al. Role of telemetry monitoring in the non-intensive care unit. Am J Cardiol. 1995;76(12):960-965. https://doi.org/10.1016/s0002-9149(99)80270-7
Continuous pulse oximetry monitoring (cSpO2) in children with bronchiolitis is associated with increased rates of hospital admission, longer lengths of stay, more frequent treatment with supplemental oxygen, alarm fatigue, and higher hospital cost. There is no evidence that it improves clinical outcomes.1-7 The safety of reducing cSpO2 for stable bronchiolitis patients (ie, those who are clinically well and not requiring supplemental oxygen) has been assessed in quality improvement initiatives8-10 and a randomized controlled trial.2 These studies showed no increase in intensive care unit transfers, codes, or readmissions associated with reduced cSpO2. Current national guidelines from the American Academy of Pediatrics5 and the Society of Hospital Medicine Choosing Wisely in Pediatric Hospital Medicine workgroup4 support limiting monitoring of children with bronchiolitis. Despite this, the practice of cSpO2 in stable bronchiolitis patients off supplemental oxygen remains widespread.11,12
Deimplementation, defined as reducing or stopping low-value or ineffective healthcare practices,13,14 is a discrete focus area within implementation science. Deimplementation research involves the reduction of unnecessary and overused services for which there is potential for harm or no benefit.15,16 In pediatrics, there are a number of potential targets for deimplementation,4,17-20 including cSpO2 for stable infants with bronchiolitis, but efforts to reduce low-value practices have met limited success to date. 21,22
Implementation science offers rigorous methods for advancing the development and evaluation of strategies for deimplementation.23 In particular, implementation science frameworks can facilitate our understanding of relevant contextual factors that may hinder or help efforts to deimplement low-value practices. To develop broadly applicable strategies to reduce monitoring overuse, it is important to understand the barriers, facilitators, and contextual factors (eg, clinical, political, interpersonal) that contribute to guideline-discordant cSpO2 in hospitalized bronchiolitis patients. Further, the process by which one can develop a rigorous understanding of these factors and how they may impact deimplementation efforts could generalize to other scenarios in pediatrics where overuse remains an issue.
The goal of this study was to use semistructured interviews, informed by an established implementation science framework, specifically the Consolidated Framework for Implementation Research (CFIR),24 to (1) identify barriers and facilitators to deimplementing unnecessary cSpO2, and (2) develop strategies to deimplement cSpO2 in a multicenter cohort of hospital-based clinician and administrative stakeholders.
METHODS
Study Setting
This multicenter qualitative study using semistructured interviews took place within the Eliminating Monitor Overuse (EMO) SpO2 study. The EMO SpO2 study established rates of cSpO2 in bronchiolitis patients not receiving supplemental oxygen or not receiving room air flow at 56 hospitals across the United States and in Canada from December 1, 2018, through March 31, 2019.12 The study identified hospital-level risk-adjusted cSpO2 rates ranging from 6% to 82%. A description of the EMO SpO2 study methods25 and its findings12 have been published elsewhere.
Participants
We approached EMO study site principal investigators at 12 hospitals: the two highest- and two lowest-use hospitals within three hospital types (ie, freestanding children’s hospitals, children’s hospitals within large general hospitals, and community hospitals). We collaborated with the participating site principal investigators (n = 12), who were primarily hospitalist physicians in leadership roles, to recruit a purposive sample of additional stakeholders including bedside nurses (n = 12), hospitalist physicians (n = 15), respiratory therapists (n = 9), and hospital administrators (n = 8) to participate in semistructured interviews. Interviews were conducted until we achieved thematic saturation within each stakeholder group and within the high and low performing strata (total 56 interviews). Participants were asked to self-report basic demographic information (see Appendix, interview guide) as required by the study funder and to allow us to comment on the representativeness of the participant group.
Procedure
The interview guide was informed by the CFIR, a comprehensive framework detailing contextual factors that require consideration when planning for the implementation of a health service intervention. Table 1 details the CFIR domains with study-related examples. The interview guide (Appendix) provided limited clinical context apart from the age, diagnosis, and oxygen requirement for the population of interest to promote a broad array of responses and to avoid anchoring on specific clinical scenarios. Interviews were conducted by master’s degree or doctoral-level research coordinators with qualitative interviewing experience and supervised by a medical anthropologist and qualitative methods expert (F.K.B.). Prior to engaging in audio recorded phone interviews, the interviewer explained the risks and benefits of participating. Participants were compensated $50. Audio recordings were transcribed, deidentified, and uploaded to NVivo 12 Plus (QSR International) for data management.
The Institutional Review Boards of Children’s Hospital of Philadelphia, Pennsylvania, and the University of Pennsylvania in Philadelphia determined that the study met eligibility criteria for IRB exemption.
Data Analysis
Using an integrated approach to codebook development,26 a priori codes were developed using constructs from the CFIR. Additional codes were added by the research team following a close reading of the first five transcripts.27,28 Each code was defined, including decision rules for its application. Two research coordinators independently coded each transcript. Using the intercoder reliability function within NVivo, the coders established strong interrater reliability accordance scores (
RESULTS
Barriers and facilitators to deimplementation were identified in multiple domains of the CFIR: outer setting, inner setting, characteristics of the individuals, and intervention characteristics (Table 1). Participants also suggested strategies to facilitate deimplementation in response to some identified barriers. See Table 2 for participant demographics and Table 3 for illustrative participant quotations.
Barriers
Outer Setting: Clinician Perceptions of Parental Discomfort With Discontinuing Monitoring
Participants mentioned parental preferences as a barrier to discontinuing cSpO2, noting that parents seem to take comfort in watching the numbers on the monitor screen and are reluctant to have it withdrawn. Clinicians noted that parents sometimes put the monitor back on their child after a clinician removed it or have expressed concern that their unmonitored child was not receiving the same level of care as other patients who were being monitored. In these scenarios, clinicians reported they have found it helpful to educate caregivers about when cSpO2 is and is not appropriate.
Inner Setting: Unclear or Nonexistent Guideline to Discontinue cSpO2
Guidelines to discontinue cSpO2 reportedly did not exist at all institutions. If a guideline did exist, lack of clarity or conflicting guidelines about when to use oxygen presented a barrier. Participants suggested that a clear guideline or additional oversight to ensure all clinicians are informed of the procedure for discontinuing cSpO2 may help prevent miscommunication. Participants noted that their electronic health record (EHR) order sets commonly included cSpO2 orders and that removing that option would facilitate deimplementation.
Inner Setting: Difficulty Educating All Staff
Participants noted difficulty with incorporating education about discontinuing cSpO2 to all clinicians, particularly to those who are nightshift only or to rotating staff or trainees. This created barriers for frequent re-education because these staff are not familiar with the policies and procedures of the unit, which is crucial to developing a culture that supports the deimplementation of cSpO2. Participants suggested that recurring education about procedures for discontinuing cSpO2 should target trainees, new nurses, and overnight nurses. This would help to ensure that the guideline is uniformly followed.
Inner Setting: Culture of High cSpO2 Use
Participants from high-use sites discussed a culture driven by readily available monitoring features or an expectation that monitoring indicates higher-quality care. Participants from low-use sites discussed increased cSpO2 driven by clinicians who were accustomed to caring for higher-acuity patients, for whom continuous monitoring is likely appropriate, and were simultaneously caring for stable bronchiolitis patients.
Some suggested that visual cues would be useful to clinicians to sustain awareness about a cSpO2 deimplementation guideline. It was also suggested that audit and feedback techniques like posting unit deimplementation statistics and creating a competition among units by posting unit performance could facilitate deimplementation. Additionally, some noted that visual aids in common spaces would be useful to remind clinicians and to engage caregivers about discontinuing cSpO2.
Characteristics of Individuals: Clinician Discomfort Discontinuing cSpO2
One frequently cited barrier across participants is that cSpO2 provides “peace of mind” to alert clinicians to patients with low oxygen saturations that might otherwise be missed. Participants identified that clinician discomfort with reducing cSpO2 may be driven by inexperienced clinicians less familiar with the bronchiolitis disease process, such as trainees, new nurses, or rotating clinicians unaccustomed to pediatric care. Trainees and new nurses were perceived as being more likely to work at night when there are fewer clinicians to provide patient care. Additionally, participants perceived that night shift clinicians favored cSpO2 because they could measure vital signs without waking patients and families.
Clinicians discussed that discontinuing cSpO2 would require alternative methods for assessing patient status, particularly for night shift nurses. Participants suggested strategies including changes to pulse oximetry assessment procedures to include more frequent “spot checks,” incorporation of assessments during sleep events (eg, naps) to ensure the patient does not experience desaturations during sleep, and training nurses to become more comfortable with suctioning patients. Suggestions also included education on the typical features of transient oxygen desaturations in otherwise stable patients with bronchiolitis2 to bolster clinical confidence for clinicians unfamiliar with caring for bronchiolitis patients. Participants perceived that education about appropriate vs inappropriate use may help to empower clinicians to employ cSpO2 appropriately.
Facilitators
Outer Setting: Standards and Evidence From Research, Professional Organizations, and Leaders in the Field
Many participants expressed the importance of consistent guidelines that are advocated by thought leaders in the field, supported by robust evidence, and consistent with approaches at peer hospitals. The more authoritative support a guideline has, the more comfortable people are adopting it and taking it seriously. Additionally, consistent education about guidelines was desired. Participants noted that all clinicians should be receiving education related to the American Academy of Pediatrics (AAP) Bronchiolitis and Choosing Wisely® guidelines, ranging from a one-time update to annually. Continual updates and re-education sessions for clinicians who shared evidence about how cSpO2 deimplementation could improve the quality of patient care by shortening hospital length of stay and lowering cost were suggested strategies.
Inner Setting: Leadership
Participants noted that successful deimplementation depends upon the presence of a champion or educator who will be able to lead the institutional charge in making practice change. This is typically an individual who is trusted at the institution, experienced in their field, or already doing implementation work. This could be either a single individual (champion) or a team. The most commonly noted clinician roles to engage in a leadership role or team were physicians and nurses.
Participants noted that a change in related clinical care pathways or EHR order sets would require cooperation from multiple clinical disciplines, administrators, and information technology leaders and explained that messaging and education about the value of the change would facilitate buy-in from those clinicians.
Inner Setting: EHR Support for Guidelines
Participants often endorsed the use of an order set within the EHR that supports guidelines and includes reminders to decrease cSpO2. These reminders could come up when supplemental oxygen is discontinued or occur regularly throughout the patient’s stay to prompt the clinician to consider discontinuing cSpO2.
Intervention Characteristics/Inner Setting: Clear Bronchiolitis Guidelines
The presence of a well-articulated hospital policy that delineates the appropriate and inappropriate use of cSpO2 in bronchiolitis was mentioned as another facilitator of deimplementation.
DISCUSSION
Results of this qualitative study of stakeholders across hospitals with high and low cSpO2 use illustrated the complexities involved with deimplementation of cSpO2 in pediatric patients hospitalized with bronchiolitis. We identified numerous barriers spanning the CFIR constructs, including unclear or absent guidelines for stopping cSpO2, clinician knowledge and comfort with bronchiolitis disease features, and unit culture. This suggests that multicomponent strategies that target various domains and a variety of stakeholders are needed to deimplement cSpO2 use for stable bronchiolitis patients. Participants also identified facilitators, including clear cSpO2 guidelines, supportive leaders and champions, and EHR modifications, that provide insight into strategies that may help sites reduce their use of cSpO2. Additionally, participants also provided concrete, actionable suggestions for ways to reduce unnecessary monitoring that will be useful in informing promising deimplementation strategies for subsequent trials.
The importance of having specific and well-known guidelines from trusted sources, such as the AAP, about cSpO2 and bronchiolitis treatment that are thoughtfully integrated in the EHR came through in multiple themes of our analysis. Prior studies on the effect of guidelines on clinical practice have suggested that rigorously designed guidelines can positively impact practice.29 Participants also noted that cSpO2 guidelines should be authoritative and that knowledge of guideline adoption by peer institutions was a facilitator of adoption. Usability issues negatively impact clinicians’ ability to follow guidelines.30 Further, prior studies have demonstrated that EHR integration of guidelines can change practice.31-33 Based on our findings, incorporating clear guidelines into commonly used formats, such as EHR order sets, could be an important deimplementation tool for cSpO2 in stable bronchiolitis patients.
Education about and awareness of cSpO2 guidelines was described as an important facilitator for appropriate cSpO2 use and was suggested as a potential deimplementation strategy. Participants noted that educational need may vary by stakeholder group. For example, education may facilitate obtaining buy-in from hospital leaders, which is necessary to support changes to the EHR. Education incorporating information on the typical features of bronchiolitis and examples of appropriate and inappropriate cSpO2 use was suggested for clinical team members. The limitations of education as a stand-alone deimplementation strategy were also noted, and participants highlighted challenges such as time needed for education and the need for ongoing education for rotating trainees. Inner and outer setting barriers, such as a perceived “culture of high pulse oximetryuse” and patient and family expectations, could also make education less effective as a stand-alone strategy. That—coupled with evidence that education and training alone are generally insufficient for producing reliable, sustained behavior change34,35—suggests that a multifaceted approach will be important.
Our respondents consider parental perceptions and preference in their practice, which provides nuance to recent studies suggesting that parents prefer continuous monitors when their child is hospitalized with bronchiolitis. Chi et al described the impact of a brief educational intervention on parental preferences for monitoring children hospitalized for bronchiolitis.36 This work suggests that educational interventions aimed at families should be considered in future (de)implementation studies because they may indirectly impact clinician behavior. Future studies should directly assess parental discomfort with discontinuing monitoring. Participants highlighted the link between knowledge and confidence in caring for typical bronchiolitis patients and monitoring practice, perceiving that less experienced clinicians are more likely to rely on cSpO2. Participants at high-use sites emphasized the expectation that monitoring should occur during hospitalizations. This reflection is particularly pertinent for bronchiolitis, a disease characterized by frequent, self-resolving desaturations even after hospital discharge.3 This may reinforce a perceived need to capture and react to these desaturation events even though they are expected in bronchiolitis and can occur in healthy infants.37 Some participants suggested that continuous monitoring be replaced with “nap tests” (ie, assessment for desaturations during a nap prior to discharge); however, like cSpO2 in stable infants with bronchiolitis, this is another low-value practice. Otherwise healthy infants with mild to moderate disease are unlikely to subsequently worsen after showing signs of clinical improvement.38 Nap tests are likely to lead to infants who are clinically improving being placed unnecessarily back on oxygen in reaction to the transient desaturations. Participants’ perception about the importance of cSpO2 in bronchiolitis management, despite evidence suggesting it is a low-value practice, underscores the importance of not simply telling clinicians to stop cSpO2. Employing strategies that replace continuous monitoring with another acceptable and feasible alternative (eg, regular clinician assessments including intermittent pulse oximetry checks) should be considered when planning for deimplementation.39
Previous studies indicate that continuous monitoring can affect clinician decision-making, independent of other factors,6,40 despite limited evidence that continuous monitors improve patient outcomes.1-7 Studies have demonstrated noticeable increase in admissions based purely on pulse oximetry values,40 with no evidence that this type of admission changes outcomes for bronchiolitis patients.6 One previous, single-center study identified inexperience as a potential driver for monitor use,41 and studies in adult populations have suggested that clinicians overestimate the value that continuous monitoring contributes to patient care,42,43 which promotes guideline-discordant use. Our study provides novel insight into the issue of monitoring in bronchiolitis. Our results suggest that there is a need to shift organizational cultures around monitoring (which likely vary based on a range of factors) and that educational strategies addressing typical disease course, especially desaturations, in bronchiolitis will be an essential component in any deimplementation effort.
This study is strengthened by its sample of diverse stakeholder groups from multiple US health systems. Additionally, we interviewed individuals at sites with high cSpO2 rates and at sites with low rates, as well as from community hospitals, children’s hospitals within general hospitals, and freestanding children’s hospitals, which allows us to understand barriers high-use sites encounter and facilitators of lower cSpO2 rates at low-use sites. We also employed an interview approach informed by an established implementation science framework. Nonetheless, several limitations exist. First, participants at low-use sites did not necessarily have direct experience with a previous deimplementation effort to reduce cSpO2. Additionally, participants were predominantly White and female; more diverse perspectives would strengthen confidence in the generalizability of our findings. While thematic saturation was achieved within each stakeholder group and within the high- and low-use strata, we interviewed fewer administrators and respiratory therapists relative to other stakeholder groups. Nevertheless, our conclusions were validated by our interdisciplinary stakeholder panel. As noted by participants, family preferences may influence clinician practice, and parents were not interviewed for this study. The information gleaned from the present study will inform the development of strategies to deimplement unnecessary cSpO2 in pediatric hospitals, which we aim to rigorously evaluate in a future trial.
CONCLUSION
We identified barriers and facilitators to deimplementation of cSpO2 for stable patients with bronchiolitis across children’s hospitals with high and low utilization of cSpO2. These themes map to multiple CFIR domains and, along with participant-suggested strategies, can directly inform an approach to cSpO2 deimplementation in a range of inpatient settings. Based on these data, future deimplementation efforts should focus on clear protocols for use and discontinuation of cSpO2, EHR changes, and regular bronchiolitis education for hospital staff that emphasizes reducing unnecessary cSpO2 utilization.
ACKNOWLEDGMENTS
We acknowledge the NHLBI scientists who contributed their expertise to this project as part of the U01 Cooperative Agreement funding mechanism as federal employees conducting their official job duties: Lora Reineck, MD, MS, Karen Bienstock, MS, and Cheryl Boyce, PhD. We thank the Executive Council of the Pediatric Research in Inpatient Settings (PRIS) Network for their contributions to the early scientific development of this project. The Network assessed a Collaborative Support Fee for access to the hospitals and support of this project. We thank the PRIS Network collaborators for their major contributions to data collection measuring utilization to identify the hospitals we subsequently chose for this project. We thank Claire Bocage and the Mixed Methods Research Lab for major help in data management and data analysis.
Continuous pulse oximetry monitoring (cSpO2) in children with bronchiolitis is associated with increased rates of hospital admission, longer lengths of stay, more frequent treatment with supplemental oxygen, alarm fatigue, and higher hospital cost. There is no evidence that it improves clinical outcomes.1-7 The safety of reducing cSpO2 for stable bronchiolitis patients (ie, those who are clinically well and not requiring supplemental oxygen) has been assessed in quality improvement initiatives8-10 and a randomized controlled trial.2 These studies showed no increase in intensive care unit transfers, codes, or readmissions associated with reduced cSpO2. Current national guidelines from the American Academy of Pediatrics5 and the Society of Hospital Medicine Choosing Wisely in Pediatric Hospital Medicine workgroup4 support limiting monitoring of children with bronchiolitis. Despite this, the practice of cSpO2 in stable bronchiolitis patients off supplemental oxygen remains widespread.11,12
Deimplementation, defined as reducing or stopping low-value or ineffective healthcare practices,13,14 is a discrete focus area within implementation science. Deimplementation research involves the reduction of unnecessary and overused services for which there is potential for harm or no benefit.15,16 In pediatrics, there are a number of potential targets for deimplementation,4,17-20 including cSpO2 for stable infants with bronchiolitis, but efforts to reduce low-value practices have met limited success to date. 21,22
Implementation science offers rigorous methods for advancing the development and evaluation of strategies for deimplementation.23 In particular, implementation science frameworks can facilitate our understanding of relevant contextual factors that may hinder or help efforts to deimplement low-value practices. To develop broadly applicable strategies to reduce monitoring overuse, it is important to understand the barriers, facilitators, and contextual factors (eg, clinical, political, interpersonal) that contribute to guideline-discordant cSpO2 in hospitalized bronchiolitis patients. Further, the process by which one can develop a rigorous understanding of these factors and how they may impact deimplementation efforts could generalize to other scenarios in pediatrics where overuse remains an issue.
The goal of this study was to use semistructured interviews, informed by an established implementation science framework, specifically the Consolidated Framework for Implementation Research (CFIR),24 to (1) identify barriers and facilitators to deimplementing unnecessary cSpO2, and (2) develop strategies to deimplement cSpO2 in a multicenter cohort of hospital-based clinician and administrative stakeholders.
METHODS
Study Setting
This multicenter qualitative study using semistructured interviews took place within the Eliminating Monitor Overuse (EMO) SpO2 study. The EMO SpO2 study established rates of cSpO2 in bronchiolitis patients not receiving supplemental oxygen or not receiving room air flow at 56 hospitals across the United States and in Canada from December 1, 2018, through March 31, 2019.12 The study identified hospital-level risk-adjusted cSpO2 rates ranging from 6% to 82%. A description of the EMO SpO2 study methods25 and its findings12 have been published elsewhere.
Participants
We approached EMO study site principal investigators at 12 hospitals: the two highest- and two lowest-use hospitals within three hospital types (ie, freestanding children’s hospitals, children’s hospitals within large general hospitals, and community hospitals). We collaborated with the participating site principal investigators (n = 12), who were primarily hospitalist physicians in leadership roles, to recruit a purposive sample of additional stakeholders including bedside nurses (n = 12), hospitalist physicians (n = 15), respiratory therapists (n = 9), and hospital administrators (n = 8) to participate in semistructured interviews. Interviews were conducted until we achieved thematic saturation within each stakeholder group and within the high and low performing strata (total 56 interviews). Participants were asked to self-report basic demographic information (see Appendix, interview guide) as required by the study funder and to allow us to comment on the representativeness of the participant group.
Procedure
The interview guide was informed by the CFIR, a comprehensive framework detailing contextual factors that require consideration when planning for the implementation of a health service intervention. Table 1 details the CFIR domains with study-related examples. The interview guide (Appendix) provided limited clinical context apart from the age, diagnosis, and oxygen requirement for the population of interest to promote a broad array of responses and to avoid anchoring on specific clinical scenarios. Interviews were conducted by master’s degree or doctoral-level research coordinators with qualitative interviewing experience and supervised by a medical anthropologist and qualitative methods expert (F.K.B.). Prior to engaging in audio recorded phone interviews, the interviewer explained the risks and benefits of participating. Participants were compensated $50. Audio recordings were transcribed, deidentified, and uploaded to NVivo 12 Plus (QSR International) for data management.
The Institutional Review Boards of Children’s Hospital of Philadelphia, Pennsylvania, and the University of Pennsylvania in Philadelphia determined that the study met eligibility criteria for IRB exemption.
Data Analysis
Using an integrated approach to codebook development,26 a priori codes were developed using constructs from the CFIR. Additional codes were added by the research team following a close reading of the first five transcripts.27,28 Each code was defined, including decision rules for its application. Two research coordinators independently coded each transcript. Using the intercoder reliability function within NVivo, the coders established strong interrater reliability accordance scores (
RESULTS
Barriers and facilitators to deimplementation were identified in multiple domains of the CFIR: outer setting, inner setting, characteristics of the individuals, and intervention characteristics (Table 1). Participants also suggested strategies to facilitate deimplementation in response to some identified barriers. See Table 2 for participant demographics and Table 3 for illustrative participant quotations.
Barriers
Outer Setting: Clinician Perceptions of Parental Discomfort With Discontinuing Monitoring
Participants mentioned parental preferences as a barrier to discontinuing cSpO2, noting that parents seem to take comfort in watching the numbers on the monitor screen and are reluctant to have it withdrawn. Clinicians noted that parents sometimes put the monitor back on their child after a clinician removed it or have expressed concern that their unmonitored child was not receiving the same level of care as other patients who were being monitored. In these scenarios, clinicians reported they have found it helpful to educate caregivers about when cSpO2 is and is not appropriate.
Inner Setting: Unclear or Nonexistent Guideline to Discontinue cSpO2
Guidelines to discontinue cSpO2 reportedly did not exist at all institutions. If a guideline did exist, lack of clarity or conflicting guidelines about when to use oxygen presented a barrier. Participants suggested that a clear guideline or additional oversight to ensure all clinicians are informed of the procedure for discontinuing cSpO2 may help prevent miscommunication. Participants noted that their electronic health record (EHR) order sets commonly included cSpO2 orders and that removing that option would facilitate deimplementation.
Inner Setting: Difficulty Educating All Staff
Participants noted difficulty with incorporating education about discontinuing cSpO2 to all clinicians, particularly to those who are nightshift only or to rotating staff or trainees. This created barriers for frequent re-education because these staff are not familiar with the policies and procedures of the unit, which is crucial to developing a culture that supports the deimplementation of cSpO2. Participants suggested that recurring education about procedures for discontinuing cSpO2 should target trainees, new nurses, and overnight nurses. This would help to ensure that the guideline is uniformly followed.
Inner Setting: Culture of High cSpO2 Use
Participants from high-use sites discussed a culture driven by readily available monitoring features or an expectation that monitoring indicates higher-quality care. Participants from low-use sites discussed increased cSpO2 driven by clinicians who were accustomed to caring for higher-acuity patients, for whom continuous monitoring is likely appropriate, and were simultaneously caring for stable bronchiolitis patients.
Some suggested that visual cues would be useful to clinicians to sustain awareness about a cSpO2 deimplementation guideline. It was also suggested that audit and feedback techniques like posting unit deimplementation statistics and creating a competition among units by posting unit performance could facilitate deimplementation. Additionally, some noted that visual aids in common spaces would be useful to remind clinicians and to engage caregivers about discontinuing cSpO2.
Characteristics of Individuals: Clinician Discomfort Discontinuing cSpO2
One frequently cited barrier across participants is that cSpO2 provides “peace of mind” to alert clinicians to patients with low oxygen saturations that might otherwise be missed. Participants identified that clinician discomfort with reducing cSpO2 may be driven by inexperienced clinicians less familiar with the bronchiolitis disease process, such as trainees, new nurses, or rotating clinicians unaccustomed to pediatric care. Trainees and new nurses were perceived as being more likely to work at night when there are fewer clinicians to provide patient care. Additionally, participants perceived that night shift clinicians favored cSpO2 because they could measure vital signs without waking patients and families.
Clinicians discussed that discontinuing cSpO2 would require alternative methods for assessing patient status, particularly for night shift nurses. Participants suggested strategies including changes to pulse oximetry assessment procedures to include more frequent “spot checks,” incorporation of assessments during sleep events (eg, naps) to ensure the patient does not experience desaturations during sleep, and training nurses to become more comfortable with suctioning patients. Suggestions also included education on the typical features of transient oxygen desaturations in otherwise stable patients with bronchiolitis2 to bolster clinical confidence for clinicians unfamiliar with caring for bronchiolitis patients. Participants perceived that education about appropriate vs inappropriate use may help to empower clinicians to employ cSpO2 appropriately.
Facilitators
Outer Setting: Standards and Evidence From Research, Professional Organizations, and Leaders in the Field
Many participants expressed the importance of consistent guidelines that are advocated by thought leaders in the field, supported by robust evidence, and consistent with approaches at peer hospitals. The more authoritative support a guideline has, the more comfortable people are adopting it and taking it seriously. Additionally, consistent education about guidelines was desired. Participants noted that all clinicians should be receiving education related to the American Academy of Pediatrics (AAP) Bronchiolitis and Choosing Wisely® guidelines, ranging from a one-time update to annually. Continual updates and re-education sessions for clinicians who shared evidence about how cSpO2 deimplementation could improve the quality of patient care by shortening hospital length of stay and lowering cost were suggested strategies.
Inner Setting: Leadership
Participants noted that successful deimplementation depends upon the presence of a champion or educator who will be able to lead the institutional charge in making practice change. This is typically an individual who is trusted at the institution, experienced in their field, or already doing implementation work. This could be either a single individual (champion) or a team. The most commonly noted clinician roles to engage in a leadership role or team were physicians and nurses.
Participants noted that a change in related clinical care pathways or EHR order sets would require cooperation from multiple clinical disciplines, administrators, and information technology leaders and explained that messaging and education about the value of the change would facilitate buy-in from those clinicians.
Inner Setting: EHR Support for Guidelines
Participants often endorsed the use of an order set within the EHR that supports guidelines and includes reminders to decrease cSpO2. These reminders could come up when supplemental oxygen is discontinued or occur regularly throughout the patient’s stay to prompt the clinician to consider discontinuing cSpO2.
Intervention Characteristics/Inner Setting: Clear Bronchiolitis Guidelines
The presence of a well-articulated hospital policy that delineates the appropriate and inappropriate use of cSpO2 in bronchiolitis was mentioned as another facilitator of deimplementation.
DISCUSSION
Results of this qualitative study of stakeholders across hospitals with high and low cSpO2 use illustrated the complexities involved with deimplementation of cSpO2 in pediatric patients hospitalized with bronchiolitis. We identified numerous barriers spanning the CFIR constructs, including unclear or absent guidelines for stopping cSpO2, clinician knowledge and comfort with bronchiolitis disease features, and unit culture. This suggests that multicomponent strategies that target various domains and a variety of stakeholders are needed to deimplement cSpO2 use for stable bronchiolitis patients. Participants also identified facilitators, including clear cSpO2 guidelines, supportive leaders and champions, and EHR modifications, that provide insight into strategies that may help sites reduce their use of cSpO2. Additionally, participants also provided concrete, actionable suggestions for ways to reduce unnecessary monitoring that will be useful in informing promising deimplementation strategies for subsequent trials.
The importance of having specific and well-known guidelines from trusted sources, such as the AAP, about cSpO2 and bronchiolitis treatment that are thoughtfully integrated in the EHR came through in multiple themes of our analysis. Prior studies on the effect of guidelines on clinical practice have suggested that rigorously designed guidelines can positively impact practice.29 Participants also noted that cSpO2 guidelines should be authoritative and that knowledge of guideline adoption by peer institutions was a facilitator of adoption. Usability issues negatively impact clinicians’ ability to follow guidelines.30 Further, prior studies have demonstrated that EHR integration of guidelines can change practice.31-33 Based on our findings, incorporating clear guidelines into commonly used formats, such as EHR order sets, could be an important deimplementation tool for cSpO2 in stable bronchiolitis patients.
Education about and awareness of cSpO2 guidelines was described as an important facilitator for appropriate cSpO2 use and was suggested as a potential deimplementation strategy. Participants noted that educational need may vary by stakeholder group. For example, education may facilitate obtaining buy-in from hospital leaders, which is necessary to support changes to the EHR. Education incorporating information on the typical features of bronchiolitis and examples of appropriate and inappropriate cSpO2 use was suggested for clinical team members. The limitations of education as a stand-alone deimplementation strategy were also noted, and participants highlighted challenges such as time needed for education and the need for ongoing education for rotating trainees. Inner and outer setting barriers, such as a perceived “culture of high pulse oximetryuse” and patient and family expectations, could also make education less effective as a stand-alone strategy. That—coupled with evidence that education and training alone are generally insufficient for producing reliable, sustained behavior change34,35—suggests that a multifaceted approach will be important.
Our respondents consider parental perceptions and preference in their practice, which provides nuance to recent studies suggesting that parents prefer continuous monitors when their child is hospitalized with bronchiolitis. Chi et al described the impact of a brief educational intervention on parental preferences for monitoring children hospitalized for bronchiolitis.36 This work suggests that educational interventions aimed at families should be considered in future (de)implementation studies because they may indirectly impact clinician behavior. Future studies should directly assess parental discomfort with discontinuing monitoring. Participants highlighted the link between knowledge and confidence in caring for typical bronchiolitis patients and monitoring practice, perceiving that less experienced clinicians are more likely to rely on cSpO2. Participants at high-use sites emphasized the expectation that monitoring should occur during hospitalizations. This reflection is particularly pertinent for bronchiolitis, a disease characterized by frequent, self-resolving desaturations even after hospital discharge.3 This may reinforce a perceived need to capture and react to these desaturation events even though they are expected in bronchiolitis and can occur in healthy infants.37 Some participants suggested that continuous monitoring be replaced with “nap tests” (ie, assessment for desaturations during a nap prior to discharge); however, like cSpO2 in stable infants with bronchiolitis, this is another low-value practice. Otherwise healthy infants with mild to moderate disease are unlikely to subsequently worsen after showing signs of clinical improvement.38 Nap tests are likely to lead to infants who are clinically improving being placed unnecessarily back on oxygen in reaction to the transient desaturations. Participants’ perception about the importance of cSpO2 in bronchiolitis management, despite evidence suggesting it is a low-value practice, underscores the importance of not simply telling clinicians to stop cSpO2. Employing strategies that replace continuous monitoring with another acceptable and feasible alternative (eg, regular clinician assessments including intermittent pulse oximetry checks) should be considered when planning for deimplementation.39
Previous studies indicate that continuous monitoring can affect clinician decision-making, independent of other factors,6,40 despite limited evidence that continuous monitors improve patient outcomes.1-7 Studies have demonstrated noticeable increase in admissions based purely on pulse oximetry values,40 with no evidence that this type of admission changes outcomes for bronchiolitis patients.6 One previous, single-center study identified inexperience as a potential driver for monitor use,41 and studies in adult populations have suggested that clinicians overestimate the value that continuous monitoring contributes to patient care,42,43 which promotes guideline-discordant use. Our study provides novel insight into the issue of monitoring in bronchiolitis. Our results suggest that there is a need to shift organizational cultures around monitoring (which likely vary based on a range of factors) and that educational strategies addressing typical disease course, especially desaturations, in bronchiolitis will be an essential component in any deimplementation effort.
This study is strengthened by its sample of diverse stakeholder groups from multiple US health systems. Additionally, we interviewed individuals at sites with high cSpO2 rates and at sites with low rates, as well as from community hospitals, children’s hospitals within general hospitals, and freestanding children’s hospitals, which allows us to understand barriers high-use sites encounter and facilitators of lower cSpO2 rates at low-use sites. We also employed an interview approach informed by an established implementation science framework. Nonetheless, several limitations exist. First, participants at low-use sites did not necessarily have direct experience with a previous deimplementation effort to reduce cSpO2. Additionally, participants were predominantly White and female; more diverse perspectives would strengthen confidence in the generalizability of our findings. While thematic saturation was achieved within each stakeholder group and within the high- and low-use strata, we interviewed fewer administrators and respiratory therapists relative to other stakeholder groups. Nevertheless, our conclusions were validated by our interdisciplinary stakeholder panel. As noted by participants, family preferences may influence clinician practice, and parents were not interviewed for this study. The information gleaned from the present study will inform the development of strategies to deimplement unnecessary cSpO2 in pediatric hospitals, which we aim to rigorously evaluate in a future trial.
CONCLUSION
We identified barriers and facilitators to deimplementation of cSpO2 for stable patients with bronchiolitis across children’s hospitals with high and low utilization of cSpO2. These themes map to multiple CFIR domains and, along with participant-suggested strategies, can directly inform an approach to cSpO2 deimplementation in a range of inpatient settings. Based on these data, future deimplementation efforts should focus on clear protocols for use and discontinuation of cSpO2, EHR changes, and regular bronchiolitis education for hospital staff that emphasizes reducing unnecessary cSpO2 utilization.
ACKNOWLEDGMENTS
We acknowledge the NHLBI scientists who contributed their expertise to this project as part of the U01 Cooperative Agreement funding mechanism as federal employees conducting their official job duties: Lora Reineck, MD, MS, Karen Bienstock, MS, and Cheryl Boyce, PhD. We thank the Executive Council of the Pediatric Research in Inpatient Settings (PRIS) Network for their contributions to the early scientific development of this project. The Network assessed a Collaborative Support Fee for access to the hospitals and support of this project. We thank the PRIS Network collaborators for their major contributions to data collection measuring utilization to identify the hospitals we subsequently chose for this project. We thank Claire Bocage and the Mixed Methods Research Lab for major help in data management and data analysis.
1. Cunningham S, Rodriguez A, Adams T, et al; Bronchiolitis of Infancy Discharge Study (BIDS) group. Oxygen saturation targets in infants with bronchiolitis (BIDS): a double-blind, randomised, equivalence trial. Lancet. 2015;386(9998):1041-1048. https://doi.org/10.1016/s0140-6736(15)00163-4
2. McCulloh R, Koster M, Ralston S, et al. Use of intermittent vs continuous pulse oximetry for nonhypoxemic infants and young children hospitalized for bronchiolitis: a randomized clinical trial. JAMA Pediatr. 2015;169(10):898-904. https://doi.org/10.1001/jamapediatrics.2015.1746
3. Principi T, Coates AL, Parkin PC, Stephens D, DaSilva Z, Schuh S. Effect of oxygen desaturations on subsequent medical visits in infants discharged from the emergency department with bronchiolitis. JAMA Pediatr. 2016;170(6):602-608. https://doi.org/10.1001/jamapediatrics.2016.0114
4. Quinonez RA, Garber MD, Schroeder AR, et al. Choosing wisely in pediatric hospital medicine: five opportunities for improved healthcare value. J Hosp Med. 2013;8(9):479-485. Quinonez RA, Garber MD, Schroeder AR, et al. Choosing wisely in pediatric hospital medicine: five opportunities for improved healthcare value. J Hosp Med. 2013;8(9):479-485. https://doi.org/10.1002/jhm.2064
5. Ralston SL, Lieberthal AS, Meissner HC, et al. Clinical practice guideline: the diagnosis, management, and prevention of bronchiolitis. Pediatrics. 2014;134(5):e1474-e1502. https://doi.org/10.1542/peds.2014-2742
6. Schuh S, Freedman S, Coates A, et al. Effect of oximetry on hospitalization in bronchiolitis: a randomized clinical trial. JAMA. 2014;312(7):712-718. https://doi.org/10.1001/jama.2014.8637
7. Schuh S, Kwong JC, Holder L, Graves E, Macdonald EM, Finkelstein Y. Predictors of critical care and mortality in bronchiolitis after emergency department discharge. J Pediatr. 2018;199:217-222 e211. https://doi.org/10.1016/j.jpeds.2018.04.010
8. Schondelmeyer AC, Simmons JM, Statile AM, et al. Using quality improvement to reduce continuous pulse oximetry use in children with wheezing. Pediatrics. 2015;135(4):e1044-e1051. https://doi.org/10.1542/peds.2014-2295
9. Mittal S, Marlowe L, Blakeslee S, et al. Successful use of quality improvement methodology to reduce inpatient length of stay in bronchiolitis through judicious use of intermittent pulse oximetry. Hosp Pediatr. 2019;9(2):73-78. https://doi.org/10.1542/hpeds.2018-0023
10. Heneghan M, Hart J, Dewan M, et al. No Cause for Alarm: Decreasing inappropriate pulse oximetry use in bronchiolitis. Hosp Pediatr. 2018;8(2):109-111. https://doi.org/10.1542/hpeds.2017-0126
11. Ralston S, Garber M, Narang S, et al. Decreasing unnecessary utilization in acute bronchiolitis care: results from the value in inpatient pediatrics network. J Hosp Med. 2013;8(1):25-30. https://doi.org/10.1002/jhm.1982
12. Bonafide CP, Xiao R, Brady PW, et al. Prevalence of continuous pulse oximetry monitoring in hospitalized children with bronchiolitis not requiring supplemental oxygen. JAMA. 2020;323(15):1467-1477. https://doi.org/10.1001/jama.2020.2998
13. van Bodegom-Vos L, Davidoff F, Marang-van de Mheen PJ. Implementation and de-implementation: two sides of the same coin? BMJ Qual Saf. 2017;26(6):495-501. https://doi.org/10.1136/bmjqs-2016-005473
14. McKay VR, Morshed AB, Brownson RC, Proctor EK, Prusaczyk B. Letting go: conceptualizing intervention de-implementation in public health and social service settings. Am J Community Psychol. 2018;62(1-2):189-202. https://doi.org/10.1002/ajcp.12258
15. Brownlee S, Chalkidou K, Doust J, et al. Evidence for overuse of medical services around the world. Lancet. 2017;390(10090):156-168. https://doi.org/10.1016/s0140-6736(16)32585-5
16. Chassin MR, Galvin RW. The urgent need to improve health care quality. Institute of Medicine National roundtable on health care quality. JAMA. 1998;280(11):1000-1005. https://doi.org/10.1001/jama.280.11.1000
17. Coon ER, Young PC, Quinonez RA, Morgan DJ, Dhruva SS, Schroeder AR. 2017 update on pediatric medical overuse: a review. JAMA Pediatr. 2018;172(5):482-486. https://doi.org/10.1001/jamapediatrics.2017.5752
18. Schuh S, Babl FE, Dalziel SR, et al; Pediatric Emergency Research Networks (PERN). Practice variation in acute bronchiolitis: a Pediatric Emergency Research Networks study. Pediatrics. 2017;140(6):e20170842. https://doi.org/10.1542/peds.2017-0842
19. Lewis-de Los Angeles WW, Thurm C, Hersh AL, et al. Trends in intravenous antibiotic duration for urinary tract infections in young infants. Pediatrics. 2017;140(6):e20171021. https://doi.org/10.1542/peds.2017-1021
20. Parikh K, Hall M, Mittal V, et al. Establishing benchmarks for the hospitalized care of children with asthma, bronchiolitis, and pneumonia. Pediatrics. 2014;134(3):555-562. https://doi.org/10.1542/peds.2014-1052
21. Ralston SL, Garber MD, Rice-Conboy E, et al; Value in Inpatient Pediatrics Network Quality Collaborative for Improving Hospital Compliance with AAP Bronchiolitis Guideline (BQIP). A multicenter collaborative to reduce unnecessary care in inpatient bronchiolitis. Pediatrics. 2016;137(1):e20150851. https://doi.org/10.1542/peds.2015-0851
22. Reyes MA, Etinger V, Hall M, et al. Impact of the Choosing Wisely((R)) Campaign recommendations for hospitalized children on clinical practice: trends from 2008 to 2017. J Hosp Med. 2020;15(2):68-74. https://doi.org/10.12788/jhm.3291
23. Norton WE, Chambers DA. Unpacking the complexities of de-implementing inappropriate health interventions. Implement Sci. 2020;15(1):2. https://doi.org/10.1186/s13012-019-0960-9
24. Damschroder LJ, Aron DC, Keith RE, Kirsh SR, Alexander JA, Lowery JC. Fostering implementation of health services research findings into practice: a consolidated framework for advancing implementation science. Implement Sci. 2009;4:50. https://doi.org/10.1186/1748-5908-4-50
25. Rasooly IR, Beidas RS, Wolk CB, et al. Measuring overuse of continuous pulse oximetry in bronchiolitis and developing strategies for large-scale deimplementation: study protocol for a feasibility trial. Pilot Feasibility Stud. 2019;5:68. https://doi.org/10.1186/s40814-019-0453-2
26. Bradley EH, Curry LA, Devers KJ. Qualitative data analysis for health services research: developing taxonomy, themes, and theory. Health Serv Res. 2007;42(4):1758-1772. https://doi.org/10.1111/j.1475-6773.2006.00684.x
27. Glaser BG, Strauss AL. The Discovery of Grounded Theory: Strategies for Qualitative Research. Aldine Pub. Co.; 1967.
28. Charmaz K. Grounded Theory: Objectivist and Constructivist Methods. In: Denzin NK, Lincoln Y, eds. Handbook of Qualitative Research. 2nd ed. Sage Publications; 2000:509-535.
29. Grimshaw JM, Russell IT. Effect of clinical guidelines on medical practice: a systematic review of rigorous evaluations. Lancet. 1993;342(8883):1317-1322. https://doi.org/10.1016/0140-6736(93)92244-n
30. Cabana MD, Rand CS, Powe NR, et al. Why don’t physicians follow clinical practice guidelines? a framework for improvement. JAMA. 1999;282(15):1458-1465. https://doi.org/10.1001/jama.282.15.1458
31. Dressler R, Dryer MM, Coletti C, Mahoney D, Doorey AJ. Altering overuse of cardiac telemetry in non-intensive care unit settings by hardwiring the use of American Heart Association guidelines. JAMA Intern Med. 2014;174(11):1852-1854. https://doi.org/10.1001/jamainternmed.2014.4491
32. Forrest CB, Fiks AG, Bailey LC, et al. Improving adherence to otitis media guidelines with clinical decision support and physician feedback. Pediatrics. 2013;131(4):e1071-e1081. https://doi.org/10.1542/peds.2012-1988
33. Fiks AG, Grundmeier RW, Mayne S, et al. Effectiveness of decision support for families, clinicians, or both on HPV vaccine receipt. Pediatrics. 2013;131(6):1114-1124. https://doi.org/10.1542/peds.2012-3122
34. Nolan T, Resar R, Griffin F, Gordon AB. Improving the Reliability of Health Care. Institute for Healthcare Improvement; 2004. http://www.ihi.org/resources/Pages/IHIWhitePapers/ImprovingtheReliabilityofHealthCare.aspx
35. Beidas RS, Kendall PC. Training Therapists in evidence-based practice: a critical review of studies from a systems-contextual perspective. Clin Psychol (New York). 2010;17(1):1-30. https://doi.org/10.1111/j.1468-2850.2009.01187.x
36. Chi KW, Coon ER, Destino L, Schroeder AR. Parental perspectives on continuous pulse oximetry use in bronchiolitis hospitalizations. Pediatrics. 2020;146(2):e20200130. https://doi.org/10.1542/peds.2020-0130
37. Hunt CE, Corwin MJ, Lister G, et al. Longitudinal assessment of hemoglobin oxygen saturation in healthy infants during the first 6 months of age. Collaborative Home Infant Monitoring Evaluation (CHIME) Study Group. J Pediatr. 1999;135(5):580-586. https://doi.org/10.1016/s0022-3476(99)70056-9
38. Mansbach JM, Clark S, Piedra PA, et al; MARC-30 Investigators. Hospital course and discharge criteria for children hospitalized with bronchiolitis. J Hosp Med. 2015;10(4):205-211. https://doi.org/10.1002/jhm.2318
39. Burton C, Williams L, Bucknall T, et al. Understanding how and why de-implementation works in health and care: research protocol for a realist synthesis of evidence. Syst Rev. 2019;8(1):194. https://doi.org/10.1186/s13643-019-1111-840. Mallory MD, Shay DK, Garrett J, Bordley WC. Bronchiolitis management preferences and the influence of pulse oximetry and respiratory rate on the decision to admit. Pediatrics. 2003;111(1):e45-51. https://doi.org/10.1542/peds.111.1.e45.
41. Schondelmeyer AC, Jenkins AM, Allison B, et al. Factors influencing use of continuous physiologic monitors for hospitalized pediatric patients. Hosp Pediatr. 2019;9(6):423-428. https://doi.org/10.1542/hpeds.2019-0007
42. Najafi N, Auerbach A. Use and outcomes of telemetry monitoring on a medicine service. Arch Intern Med. 2012;172(17):1349-1350. https://doi.org/10.1001/archinternmed.2012.3163
43. Estrada CA, Rosman HS, Prasad NK, et al. Role of telemetry monitoring in the non-intensive care unit. Am J Cardiol. 1995;76(12):960-965. https://doi.org/10.1016/s0002-9149(99)80270-7
1. Cunningham S, Rodriguez A, Adams T, et al; Bronchiolitis of Infancy Discharge Study (BIDS) group. Oxygen saturation targets in infants with bronchiolitis (BIDS): a double-blind, randomised, equivalence trial. Lancet. 2015;386(9998):1041-1048. https://doi.org/10.1016/s0140-6736(15)00163-4
2. McCulloh R, Koster M, Ralston S, et al. Use of intermittent vs continuous pulse oximetry for nonhypoxemic infants and young children hospitalized for bronchiolitis: a randomized clinical trial. JAMA Pediatr. 2015;169(10):898-904. https://doi.org/10.1001/jamapediatrics.2015.1746
3. Principi T, Coates AL, Parkin PC, Stephens D, DaSilva Z, Schuh S. Effect of oxygen desaturations on subsequent medical visits in infants discharged from the emergency department with bronchiolitis. JAMA Pediatr. 2016;170(6):602-608. https://doi.org/10.1001/jamapediatrics.2016.0114
4. Quinonez RA, Garber MD, Schroeder AR, et al. Choosing wisely in pediatric hospital medicine: five opportunities for improved healthcare value. J Hosp Med. 2013;8(9):479-485. Quinonez RA, Garber MD, Schroeder AR, et al. Choosing wisely in pediatric hospital medicine: five opportunities for improved healthcare value. J Hosp Med. 2013;8(9):479-485. https://doi.org/10.1002/jhm.2064
5. Ralston SL, Lieberthal AS, Meissner HC, et al. Clinical practice guideline: the diagnosis, management, and prevention of bronchiolitis. Pediatrics. 2014;134(5):e1474-e1502. https://doi.org/10.1542/peds.2014-2742
6. Schuh S, Freedman S, Coates A, et al. Effect of oximetry on hospitalization in bronchiolitis: a randomized clinical trial. JAMA. 2014;312(7):712-718. https://doi.org/10.1001/jama.2014.8637
7. Schuh S, Kwong JC, Holder L, Graves E, Macdonald EM, Finkelstein Y. Predictors of critical care and mortality in bronchiolitis after emergency department discharge. J Pediatr. 2018;199:217-222 e211. https://doi.org/10.1016/j.jpeds.2018.04.010
8. Schondelmeyer AC, Simmons JM, Statile AM, et al. Using quality improvement to reduce continuous pulse oximetry use in children with wheezing. Pediatrics. 2015;135(4):e1044-e1051. https://doi.org/10.1542/peds.2014-2295
9. Mittal S, Marlowe L, Blakeslee S, et al. Successful use of quality improvement methodology to reduce inpatient length of stay in bronchiolitis through judicious use of intermittent pulse oximetry. Hosp Pediatr. 2019;9(2):73-78. https://doi.org/10.1542/hpeds.2018-0023
10. Heneghan M, Hart J, Dewan M, et al. No Cause for Alarm: Decreasing inappropriate pulse oximetry use in bronchiolitis. Hosp Pediatr. 2018;8(2):109-111. https://doi.org/10.1542/hpeds.2017-0126
11. Ralston S, Garber M, Narang S, et al. Decreasing unnecessary utilization in acute bronchiolitis care: results from the value in inpatient pediatrics network. J Hosp Med. 2013;8(1):25-30. https://doi.org/10.1002/jhm.1982
12. Bonafide CP, Xiao R, Brady PW, et al. Prevalence of continuous pulse oximetry monitoring in hospitalized children with bronchiolitis not requiring supplemental oxygen. JAMA. 2020;323(15):1467-1477. https://doi.org/10.1001/jama.2020.2998
13. van Bodegom-Vos L, Davidoff F, Marang-van de Mheen PJ. Implementation and de-implementation: two sides of the same coin? BMJ Qual Saf. 2017;26(6):495-501. https://doi.org/10.1136/bmjqs-2016-005473
14. McKay VR, Morshed AB, Brownson RC, Proctor EK, Prusaczyk B. Letting go: conceptualizing intervention de-implementation in public health and social service settings. Am J Community Psychol. 2018;62(1-2):189-202. https://doi.org/10.1002/ajcp.12258
15. Brownlee S, Chalkidou K, Doust J, et al. Evidence for overuse of medical services around the world. Lancet. 2017;390(10090):156-168. https://doi.org/10.1016/s0140-6736(16)32585-5
16. Chassin MR, Galvin RW. The urgent need to improve health care quality. Institute of Medicine National roundtable on health care quality. JAMA. 1998;280(11):1000-1005. https://doi.org/10.1001/jama.280.11.1000
17. Coon ER, Young PC, Quinonez RA, Morgan DJ, Dhruva SS, Schroeder AR. 2017 update on pediatric medical overuse: a review. JAMA Pediatr. 2018;172(5):482-486. https://doi.org/10.1001/jamapediatrics.2017.5752
18. Schuh S, Babl FE, Dalziel SR, et al; Pediatric Emergency Research Networks (PERN). Practice variation in acute bronchiolitis: a Pediatric Emergency Research Networks study. Pediatrics. 2017;140(6):e20170842. https://doi.org/10.1542/peds.2017-0842
19. Lewis-de Los Angeles WW, Thurm C, Hersh AL, et al. Trends in intravenous antibiotic duration for urinary tract infections in young infants. Pediatrics. 2017;140(6):e20171021. https://doi.org/10.1542/peds.2017-1021
20. Parikh K, Hall M, Mittal V, et al. Establishing benchmarks for the hospitalized care of children with asthma, bronchiolitis, and pneumonia. Pediatrics. 2014;134(3):555-562. https://doi.org/10.1542/peds.2014-1052
21. Ralston SL, Garber MD, Rice-Conboy E, et al; Value in Inpatient Pediatrics Network Quality Collaborative for Improving Hospital Compliance with AAP Bronchiolitis Guideline (BQIP). A multicenter collaborative to reduce unnecessary care in inpatient bronchiolitis. Pediatrics. 2016;137(1):e20150851. https://doi.org/10.1542/peds.2015-0851
22. Reyes MA, Etinger V, Hall M, et al. Impact of the Choosing Wisely((R)) Campaign recommendations for hospitalized children on clinical practice: trends from 2008 to 2017. J Hosp Med. 2020;15(2):68-74. https://doi.org/10.12788/jhm.3291
23. Norton WE, Chambers DA. Unpacking the complexities of de-implementing inappropriate health interventions. Implement Sci. 2020;15(1):2. https://doi.org/10.1186/s13012-019-0960-9
24. Damschroder LJ, Aron DC, Keith RE, Kirsh SR, Alexander JA, Lowery JC. Fostering implementation of health services research findings into practice: a consolidated framework for advancing implementation science. Implement Sci. 2009;4:50. https://doi.org/10.1186/1748-5908-4-50
25. Rasooly IR, Beidas RS, Wolk CB, et al. Measuring overuse of continuous pulse oximetry in bronchiolitis and developing strategies for large-scale deimplementation: study protocol for a feasibility trial. Pilot Feasibility Stud. 2019;5:68. https://doi.org/10.1186/s40814-019-0453-2
26. Bradley EH, Curry LA, Devers KJ. Qualitative data analysis for health services research: developing taxonomy, themes, and theory. Health Serv Res. 2007;42(4):1758-1772. https://doi.org/10.1111/j.1475-6773.2006.00684.x
27. Glaser BG, Strauss AL. The Discovery of Grounded Theory: Strategies for Qualitative Research. Aldine Pub. Co.; 1967.
28. Charmaz K. Grounded Theory: Objectivist and Constructivist Methods. In: Denzin NK, Lincoln Y, eds. Handbook of Qualitative Research. 2nd ed. Sage Publications; 2000:509-535.
29. Grimshaw JM, Russell IT. Effect of clinical guidelines on medical practice: a systematic review of rigorous evaluations. Lancet. 1993;342(8883):1317-1322. https://doi.org/10.1016/0140-6736(93)92244-n
30. Cabana MD, Rand CS, Powe NR, et al. Why don’t physicians follow clinical practice guidelines? a framework for improvement. JAMA. 1999;282(15):1458-1465. https://doi.org/10.1001/jama.282.15.1458
31. Dressler R, Dryer MM, Coletti C, Mahoney D, Doorey AJ. Altering overuse of cardiac telemetry in non-intensive care unit settings by hardwiring the use of American Heart Association guidelines. JAMA Intern Med. 2014;174(11):1852-1854. https://doi.org/10.1001/jamainternmed.2014.4491
32. Forrest CB, Fiks AG, Bailey LC, et al. Improving adherence to otitis media guidelines with clinical decision support and physician feedback. Pediatrics. 2013;131(4):e1071-e1081. https://doi.org/10.1542/peds.2012-1988
33. Fiks AG, Grundmeier RW, Mayne S, et al. Effectiveness of decision support for families, clinicians, or both on HPV vaccine receipt. Pediatrics. 2013;131(6):1114-1124. https://doi.org/10.1542/peds.2012-3122
34. Nolan T, Resar R, Griffin F, Gordon AB. Improving the Reliability of Health Care. Institute for Healthcare Improvement; 2004. http://www.ihi.org/resources/Pages/IHIWhitePapers/ImprovingtheReliabilityofHealthCare.aspx
35. Beidas RS, Kendall PC. Training Therapists in evidence-based practice: a critical review of studies from a systems-contextual perspective. Clin Psychol (New York). 2010;17(1):1-30. https://doi.org/10.1111/j.1468-2850.2009.01187.x
36. Chi KW, Coon ER, Destino L, Schroeder AR. Parental perspectives on continuous pulse oximetry use in bronchiolitis hospitalizations. Pediatrics. 2020;146(2):e20200130. https://doi.org/10.1542/peds.2020-0130
37. Hunt CE, Corwin MJ, Lister G, et al. Longitudinal assessment of hemoglobin oxygen saturation in healthy infants during the first 6 months of age. Collaborative Home Infant Monitoring Evaluation (CHIME) Study Group. J Pediatr. 1999;135(5):580-586. https://doi.org/10.1016/s0022-3476(99)70056-9
38. Mansbach JM, Clark S, Piedra PA, et al; MARC-30 Investigators. Hospital course and discharge criteria for children hospitalized with bronchiolitis. J Hosp Med. 2015;10(4):205-211. https://doi.org/10.1002/jhm.2318
39. Burton C, Williams L, Bucknall T, et al. Understanding how and why de-implementation works in health and care: research protocol for a realist synthesis of evidence. Syst Rev. 2019;8(1):194. https://doi.org/10.1186/s13643-019-1111-840. Mallory MD, Shay DK, Garrett J, Bordley WC. Bronchiolitis management preferences and the influence of pulse oximetry and respiratory rate on the decision to admit. Pediatrics. 2003;111(1):e45-51. https://doi.org/10.1542/peds.111.1.e45.
41. Schondelmeyer AC, Jenkins AM, Allison B, et al. Factors influencing use of continuous physiologic monitors for hospitalized pediatric patients. Hosp Pediatr. 2019;9(6):423-428. https://doi.org/10.1542/hpeds.2019-0007
42. Najafi N, Auerbach A. Use and outcomes of telemetry monitoring on a medicine service. Arch Intern Med. 2012;172(17):1349-1350. https://doi.org/10.1001/archinternmed.2012.3163
43. Estrada CA, Rosman HS, Prasad NK, et al. Role of telemetry monitoring in the non-intensive care unit. Am J Cardiol. 1995;76(12):960-965. https://doi.org/10.1016/s0002-9149(99)80270-7
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Email: [email protected]; Telephone: 513-803-9158; Twitter: @SchondelmeyerMD.